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| Study on the core drug combinations and mechanism of National Physician Master and Professor Lü Renhe in the treatment of diabetic nephropathy |
| CHE Biao1 SHAO Fan2 WANG Shidong1 CHEN Xiaoyu1 LI Na1 LI Xiaoran1 TANG Cheng1 |
| 1.Ward Two, Department of Nephropathy and Endocrinology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China; 2.Genelife Technology Co., Ltd., Beijing 100089, China |
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Abstract Objective To mine the core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy and explore its synergistic mechanism of multi-component, multi-target and multi-pathway. Methods The medical records of patients with diabetic nephropathy treated in the Outpatient Clinic of Professor Lü Renhe of Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to April 2019 were collected and the medical record database was established. The frequency statistics and association rules algorithm were used to mine the core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy, and the network pharmacology method was used to analyze the mechanism of the core drug combinations. Results The core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy were Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis. A total of 105 compounds were obtained, and 47 of them were the key targets of interaction with diseases. The 47 key targets were enriched and analyzed, which showed that the treatment of diabetic nephropathy with Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis may be related to proteoglycan in cancer, AGE-RAGE signal pathway in diabetic complications, cancer pathway, endocrine resistance, drug resistance of EGFR tyrosine kinase inhibitor, prostate cancer, and so on. Conclusion Professor Lü Renhe pays attention to the combination of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis in the treatment of diabetic nephropathy. This study preliminarily reveals the multi-component, multi-target and multi-pathway mechanism of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis, which provides a basis for the study of the molecular mechanism of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis.
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