线粒体自噬在脓毒症中的研究进展

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Abstract Sepsis is a common disease in intensive care unit, which is characterized by high morbidity and mortality, and is easy to cause systemic multiple organ damage and even failure. At present, the treatment of sepsis mainly focuses on etiological treatment, fluid resuscitation, anti-infection and other targets, but the treatment effect is not good due to the rapid progress of the disease. Mitophagy can clear damaged, aged and dysfunctional mitochondria through Parkin-dependent and Parkin-independent pathways, effectively avoid excessive cell damage and maintain homeostasis of intracellular environment, which plays an important role in many diseases. Mitophagy, mediated by Parkin, Fun14 domain-containing protein 1, Bcl-2 interacting protein 3, dynamin related protein 1, can inhibit the release of inflammatory factors and reactive oxygen species, reduce the occurrence of multiple organ dysfunction, and play a protective role in sepsis. This article reviews the aspects of the mechanism and treatment of mitophagy in sepsis, so as to provide a new basis for the treatment of sepsis.

Key words： Mitophagy Sepsis Parkin Multiple organ dysfunction Therapy

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	ZHANG Xintong1 LIU Jingzhuo1 LI Pan1 MA Desheng1 MA Li2

Cite this article:

ZHANG Xintong1 LIU Jingzhuo1 LI Pan1 MA Desheng1 MA Li2. Research progress of mitophagy in sepsis[J]. 中国医药导报, 2021, 18(10): 39-42.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I10/39

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