AECOPD患者HRCT不同LAA分级血清CRP、IL-6、PCT水平变化及临床特征分析

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Abstract Objective To investigate the changes and clinical characteristics of serum C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT) levels in different low density attenuation regions (LAA) of high-resolution CT (HRCT) patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The 81 patients with AECOPD who were diagnosed and treated in Chizhou People’s Hospital from May 2017 to May 2020 were selected as the research objects. All patients underwent HRCT examination, according to the bronchial wall thickening and the degree of emphysema in the images, they were divided into three groups, type A group (33 cases): with or without bronchial wall thickening, three levels of total LAA score grade≤1 grade; type E group (22 cases): without bronchial wall thickening, three levels of total LAA score grade≥2 grade; type M group (26 cases): combined with bronchial wall thickening, three levels of total LAA score grade≥2 grade. The serum levels of CRP, IL-6, PCT and clinical characteristics of the three groups were compared. Results The serum levels of CRP, IL-6, and PCT in type M group were significantly higher than those in type A group and type E group, the difference were statistically significant (P ＜ 0.05); there was no statistically significant difference in serum CRP, IL-6, PCT levels between patients with type A group and type E group (P ＞ 0.05). The smoking index of type A group was significantly lower than that of type E group and type M group; the prealbumin level of type A group was significantly higher than that of type E group and type M group; the proportion of acute exacerbations≥2 times in the past one year in type A group was significantly lower than that in type E group and type M group; the partial pressure of carbon dioxide (PaCO2) in group A was significantly lower than that in type E group and type M group, the differences were statistically significant (P ＜ 0.05); there was no statistically significant difference between the clinical characteristics of patients with type E group and type M group (P ＞ 0.05). Conclusion The serum CRP, IL-6, PCT levels and clinical characteristics of AECOPD patients with different LAA grades of HRCT are different, which can be used as important indicators for patient condition prediction, formulation and implementation of personalized treatment plans.

Key words： Acute exacerbation of chronic obstructive pulmonary disease High-resolution CT Low-density attenuation area C-reactive protein Interleukin-6 Procalcitonin Clinical characteristics

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	ZHU Fan

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ZHU Fan. Changes and clinical characteristics of serum CRP, IL-6 and PCT in AECOPD patients with different LAA levels on HRCT[J]. 中国医药导报, 2021, 18(10): 104-107.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I10/104

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