血液灌流次数对重度有机磷农药中毒疗效的影响

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Abstract Objective To observe the effect of hemoperfusion frequency on the efficacy of severe organophosphorus pesticide poisoning. Methods Clinical data of 160 patients with severe organophosphorus pesticide poisoning admitted to Fuyang People’s Hospital, Anhui Province from January 2017 to February 2020 were retrospectively analyzed. Forty patients receiving conventional treatment were selected as the control group, 68 patients receiving single hemoperfusion therapy in addition to conventional treatment were selected as the single hemoperfusion group, and 52 patients receiving more than two times of hemoperfusion therapy in addition to conventional treatment were selected as the multiple hemoperfusion group. The efficacy, complications, fatality rate and cholinesterase activity of the three groups were compared. Results The mechanical ventilation time, coma time, hospital stay time and 80% recovery time of cholinesterase activity in the multiple hemoperfusion group and the single hemoperfusion group were shorter than those in the control group, and the multiple hemoperfusion group was shorter than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). The total dosage of Atropine and Pralidoxime Iodide in the multiple hemoperfusion group and the single hemoperfusion group were less than those in the control group, and the multiple hemoperfusion group was less than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). The rate of total complications and fatality in the multiple hemoperfusion group were lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). After three days of treatment, cholinesterase activity in the three groups was increased compared with before treatment, and the multiple hemoperfusion group and single hemoperfusion group were higher than the control group, and the multiple hemoperfusion group was higher than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). Conclusion Multiple hemoperfusion can improve the efficacy of severe organophosphorus pesticide poisoning and reduce complications.

Key words： Hemoperfusion Severe organophosphorus pesticide poisoning Frequency Efficacy

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	ZHAO Yang LI Caixia▲ WANG Haimei HUANG Kun

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ZHAO Yang LI Caixia▲ WANG Haimei HUANG Kun. Effect of hemoperfusion frequency on the efficacy of severe organophosphorus pesticide poisoning[J]. 中国医药导报, 2021, 18(10): 92-95.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I10/92

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