低钙透析联合HFHD对维持性血液透析的效果及对钙磷代谢的影响

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Abstract Objective To explore the effect of low-calcium dialysis combined with high-flux dialysis (HFHD) on uremia maintenance hemodialysis and its effect on calcium and phosphorus metabolism, so as to provide a basis for patient diagnosis and treatment. Methods The diagnosis and treatment of 81 patients with uremia maintenance hemodialysis who were admitted to Department of Nephrology, Ma’anshan People’s Hospital of Anhui Province from March 2017 to January 2020 were retrospectively analyzed. According to different treatment methods, they were divided into observation group (41 cases) and control group (40 cases). The control group was treated with normal calcium dialysis combined with HFHD, and the observation group was treated with low calcium dialysis combined with HFHD. After six months of treatment, serum calcium, phosphorus, parathyroid hormone (iPTH), renal function (serum creatinine [SCR], urea nitrogen [BUN] ), β2-microglobulin (β2-MG), C-reactive protein (CRP) levels and complications were compared. Results Compared with before treatment, after treatment, blood calcium, blood phosphorus and calcium phosphorus product in the two groups were significantly decreased, and observation group was significantly lower than control group (P ＜ 0.05); compared with before treatment, after treatment, SCR, BUN, β2-MG and iPTH levels in the two groups were significantly decreased (P ＜ 0.05), but there was no statistical significance between the two groups (P ＞ 0.05). After treatment, CRP levels in both groups were significantly decreased, and observation group was lower than control group (P ＜ 0.05); there was no significant difference in complications between the two groups (P ＞ 0.05). Conclusion Low calcium dialysis combined with HFHD in uremic maintenance hemodialysis has good effect, can significantly correct the disorder of serum calcium and phosphorus metabolism, improve renal function, reduce the body inflammatory reaction, with high safety, and can be widely used in clinic.

Key words： Uremia Maintenance hemodialysis High-flux Low calcium dialysis Renal function Calcium and phosphorus metabolism Inflammatory factors

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	ZHOU Qi QIAN Guangrong TANG Xiaofei

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ZHOU Qi QIAN Guangrong TANG Xiaofei. Effect of low calcium dialysis combined with HFHD on maintenance hemodialysis and calcium and phosphorus metabolism[J]. 中国医药导报, 2021, 18(10): 100-103.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I10/100

[1] 李芸，胡天晓，郑朝霞，等.高通量透析联合低钙透析液对维持性血液透析患者甲状旁腺激素及钙磷代谢的影响[J].解放军医药杂志，2019，31（9）：51-55.
[2] 张雷，柯斯奇.高通量血液透析（HFHD）及血液透析滤过（HDF）治疗慢性肾衰竭尿毒症患者的临床疗效及对患者预后的研究进展[J].中国急救医学，2017，37（z1）：345-346.
[3] 张薇，郑艳宇，王晓琳.复方α酮酸片联合高通量透析对维持性血液透析患者营养状态、血脂及心血管钙化的影响[J].广西医科大学学报，2018，35（9）：1289-1293.
[4] 王叙芬，黄兵.不同血液净化方式对尿毒症钙磷代谢紊乱患者血磷、钙磷乘积和甲状旁腺激素水平的影响[J].海南医学，2017，28（14）：2354-2356.
[5] 李丽，徐成钢，陶煜，等.高通量血液透析与血液透析滤过对终末期肾病患者有效性及安全性的Meta分析[J].临床肾脏病杂志，2018，18（11）：15-23.
[6] 温玉.高通量血液透析联合低钙透析液与普通透析对尿毒症病人皮肤瘙痒评分及血生化指标的影响对比[J].安徽医药，2017，21（3）：496-500.
[7] 冷方南.肾衰尿毒症临床治疗学[M].北京：人民军医出版社，2011.
[8] 陈昕，张莹.血液透析联合血液灌流对尿毒症患者毒素清除率、炎性因子、钙磷代谢及免疫功能的影响[J].陕西医学杂志，2019，48（6）：770-773.
[9] 郑海瑞，贾卫国，王国强，等.不同透析方法对尿毒症患者钙磷代谢及PTH水平的影响[J].西南国防医药，2019， 29（5）：608-610.
[10] Masamitsu，Morishita，Nanae，et al. The differences in acid-base status and the calcium parathyroid axis between peritoneal dialysis and hemodialysis[J]. Clin Nephrol，2016，11（21）：451-453.
[11] 唐玲，邓晓风，代青，等.高通量血液透析对尿毒症患者心肌损伤标志物和心功能指标的影响[J].中华危重病急救医学，2017，29（6）：547-550.
[12] 王宇静.三种不同血液净化方式对尿毒症患者血清中β2-MG钙磷浓度及甲状旁腺激素水平的影响[J].河北医学，2019，25（8）：1295-1299.
[13] 熊轩，林小堃，胡建广，等.低钙透析液对维持性血液透析患者微炎症状态的影响及其机制研究[J].中国医药，2018，11（7）：1038-1042
[14] 唐俊，左满花.血液透析联合血液灌流对尿毒症患者透析效率、脂代谢及动脉粥样硬化的影响[J].海南医学院学报，2017，23（4）：497-500.
[15] Usta M，Ersoy A，Ayar Y，et al. The relationship between lymphocyte subsets，nutritional status and tuberculin reactivity in continuous ambulatory peritoneal dialysis and hemodialysis patients [J]. Int Urol Nephrol，2020，52（6）：1167-1172.
[16] 高世洪，刘强，谢聪聪，等.高通量透析对维持性血液透析患者钙磷代谢及血脂影响[J].安徽医学，2017，38（12）：1577-1579.
[17] 何桂芳，陈文丽，赖燕华，等.不同血液净化方式对维持性血液透析患者矿物质及骨代谢异常的治疗效果[J].临床肾脏病杂志，2019，19（6）：453-455.
[18] Chan L，Beers K，Yau AA，et al. Natural language processing of electronic health records is superior to billing codes to identify symptom burden in hemodialysis patients [J]. Kidney Int，2020，97（2）：383-392.
[19] 董艳华，王琳琳，朱桂栋.不同通透量血液透析对老年尿毒症患者甲状旁腺激素及钙、磷代谢的影响[J].临床误诊误治，2018，31（5）：94-98.
[20] 崔益鸿，黄路路.血液灌流联合血液透析滤过对尿毒症患者不良症状及生化指标的影响[J].中国临床研究， 2017， 30（9）：1204-1206.
[21] Colombo G，Reggiani F，Astori E，et al. Advanced oxidation protein products in nondiabetic end stage renal disease patients on maintenance haemodialysis[J]. Free Radic Res，2019，53（11/12）：1114-1124.
[22] 刘爱群，曾文笑，周梨花，等.血液透析联合血液灌流及护理干预对尿毒症患者睡眠质量的影响[J].基因组学与应用生物学，2017，36（7）：2747-2752.
[23] 陈望，何晓东，张鹏，等.血液灌流对维持性血液透析患者骨转化及心室结构的影响[J].医学研究杂志，2018， 47（1）：134-138.
[24] 李丹.维持性血液透析尿毒症患者微炎症状态与临床预后的相关性分析[J].中国医药科学，2020，10（21）：10-13.
[25] 汪晶晶.高通量血液透析对尿毒症患者钙磷代谢、iPTH及心功能的影响[J].医学临床研究，2018，35（10）：1959-1961.
[26] 盛丹虹，齐玲.高通量血液透析对尿毒症维持性血液透析患者超敏C反应蛋白、肿瘤坏死因子-α、血管内皮损伤因子影响的相关性研究[J].中国现代医生，2020， 58（29）：53-56.
[27] 刘博，王亚丽，柳冰.两种血液净化方式对慢性肾功能衰竭尿毒症患者肾功能指标及相关并发症的影响[J].临床和实验医学杂志，2020，19（21）：2319-2322.