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2019 Vol. 16, No. 22 Published: 2019-08-05

	7	Study on the effect and mechanism of total saponins of panax notoginseng on late-life anxiety
		DU Yao1,2 LI Xin1 ZHANG Guixian1 YUAN Yajin1 ZHOU Ningna1
		Objective To explore the effect and mechanism of total saponins of Panax notoginseng leaves (tSPNL) on late-life anxiety. Methods Fifty aging male mice (12 months) were reared in group (n = 15, normal control group) or isolation (n = 60) according to the random number table method. After 4 weeks, the isolated rearing animal were then randomly divided into model group (vehicle), Diazepam (BDZ) group, tSPNL 500 group (500 mg/kg tSPNL) and tSPNL 100 group (100 mg/kg tSPNL). All mice were intragastrically administered desired compounds once a day for consecutive 14 days. The anxiety-like behaviors were evaluated by elevated plus maze (EPM), and levels of GABA and BDNF in hippocampus were determined by enzyme linked immunosorbent assay after the behavior test. In another set, aging male mice (n = 135) were rearing isolated for 4 weeks and were then randomly divided into model (vehicle), BDZ group, fluoxetine group, tSPNL 500 group. After administration of desired compounds intragastrically once a day for 14 days, animals underwent intraventricular injection of either BDNF receptor TrkB antagonist K252a or GABAA receptor antagonist Bicuculline (Bic), and the anxiety-like behaviors were measured by EPM 1 hour later. Results Compared with model group, the percentage of open arm time (OT%) increased significantly in tSPNL 500 group (P < 0.01), and the levels of BDNF and GABA also increased in hippocampus significantly (P < 0.05 or P < 0.01). After intraventricular injection of K252a and Bic, OT% in tSPNL 500 group decreased significantly (P < 0.05). Conclusion tSPNL can alleviate the anxiety-like behaviors in aging mice, and the mechanism is involved in BDNF-GABA signaling pathway, which may restore the GABAergic plasticity by increasing BDNF levels, thereby reducing the anxiety susceptibility of aging mice.
		2019 Vol. 16 (22): 7-11 [Abstract] ( 196 ) HTML (1 KB) PDF (837 KB) ( 173 )

	12	Effects of high glucose on the expression and function of glucagon receptor in the liver
		LIU Mengdan JI Linlin YE Yang ZHU Chaoyu XIAO Yuanyuan GAO Qingge WEI Li
		Objective To investigate the changes of the expression and function of glucagon receptor (GCGR) in db/db mice liver and hepatocellular carcinoma cell line HepG2 cells treated with high glucose. Methods Intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT) were performed in both db/db mice and control mice. The blood of mice in the two groups was collected for biochemical test; the expression of GCGR, protein kinase A (PKA) and phosphorylated protein kinase A (p-PKA) in the liver of the two groups were detected by Western blot or immunohistochemistry. The expression of GCGR in HepG2 cells treated with high glucose (30 mmol/L) in different glucose concentrations or different time gradients was detected by Western blot without stimulation of glucagon (GLN). Under GLN stimulation, the expression of GCGR, PKA and p-PKA proteins in HepG2 cells treated with high glucose at different time gradients was also detected by Western blot. Results Compared with control mice, the expressions of GCGR were markedly elevated in liver of db/db mice, but phosphorylated PKA levels were decreased (P ＜ 0.05 or P ＜ 0.01). GCGR protein expressions were increased following the growth of glucose concentrations in HepG2 cells, meanwhile, the expressions of GCGR protein were decreased at first, then increased with time extended (all P ＜ 0.01). Under GLN stimulation, the GCGR protein levels were upregulated by high glucose in a time-dependent manner (P ＜ 0.01). However, p-PKA/PKA levels were decreased compared with control group (0 h) (P < 0.05 or P ＜ 0.01). Conclusion Chronic hyperglycemia can increase the expression of GCGR in the liver and lead to glucagon resistance in the liver.
		2019 Vol. 16 (22): 12-16 [Abstract] ( 305 ) HTML (1 KB) PDF (977 KB) ( 111 )

	17	Protective effect of snail homogenate enema on ulcerative colitis in rats
		FAN Zhiyuan YU Qiuyu LI Huan SU Xiaojiao SHENG Yanmei
		Objective To investigate whether snail homogenate has protective effect on ulcerative colitis in rats. Methods Rat model of acute Ulcerative Colitis induced by glacial acetic acid. Forty male Sprague-Dawley rats aged 6-7 weeks were randomly divided into model group, blank group, snail homogenate high (1.0 g/kg) and low (0.5 g/kg) dose groups according to random number table, with 10 rats in each group. After the model was completed, the high (1.0 g/kg) and low (0.5 g/kg) dose groups were given snail homogenate continuously for 7 days in the rectum, and the blank group and the model group were given the same volume of normal saline. The main signs and fecal traits of the rats were observed daily, and body weight changes were calculated and fecal scores were performed. At the end of the experiment, the rats were sacrificed and the target colon segment was taken. The coefficient of intestinal weight was calculated and the pathological tissue was detected by HE staining. Results Compared with model group, the symptoms in rats of high-dose group and low-dose group were significantly improved, the degree of weight gain of rats increased significantly (P ＜ 0.05 or P ＜ 0.01), and intestinal weighting coefficient reduced significantly (P ＜ 0.05 or P ＜ 0.01), a significant decrease in fecal scores of high-dose group began on day 4 after administration (P ＜ 0.01). Meanwhile, the scores of inflammatory cell infiltration depth and ulcer depth in the high-dose group were significantly different from those in the model group (P ＜ 0.01). Conclusion Snail homogenate can improve the physical signs, increase body weight, reduce diarrhea, and fight colonic hyperplasia and inflammatory reaction in rats with ulcerative colitis, especially at high doses.
		2019 Vol. 16 (22): 17-20,25 [Abstract] ( 183 ) HTML (1 KB) PDF (705 KB) ( 58 )

	21	Effect of Shenfu Injection on immunoregulation and inflammatory factors in septic mice
		ZHAO Fengli1 XIAN Shaoxiang2 LUO Yuanyuan1 WANG Yixin3 XU Yunsheng1 LIN Xinfeng1
		Objective To investigate the effects of Shenfu Injection on immuno regulation and inflammatory factors in septic mice. Methods A total of 120 10-week-old SPF male C57BL/6 mice were selected and divided into control group, sham operation group, septic model group and Shenfu Injection treatment group according to random number table method, with 30 rats in each group. A septic mice model was prepared by cecal ligation and perforation. The control group, sham-operated group and sepsis model group were given intraperitoneal injection of saline [4 mL/(kg·BW) for 3 days] respectively on the first day after operation, and Shenfu Injection group was given intraperitoneal injection of Shenfu Injection [4 mL/(kg·BW) for 3 days] at the same time. T lymphocyte subsets in each group were detected by enzyme-linked immunosorbent assay, hematoxylin-eosin staining was used to evaluate organ pathological damage and inflammatory cell infiltration. Results Compared with the control group, the levels of interleukin-4 (IL-4), IL-17, interferon γ (IFN-γ), IL-10 and IFN-γ/IL-4, IL-10/IL-17 in sham operation group had no significant difference (P > 0.05). Compared with sham-operated group, the levels of IFN-γ and IL-10 in sepsis model group were significantly decreased, IL-4 and IL-17 were significantly increased, and IFN-γ/IL-4 and IL-10/IL-17 were significantly decreased, the differences were statistically significant (P < 0.05), and its pathological damage of heart, lung and kidney was serious, and the infiltration of inflammatory cells was increased (P < 0.05). Compared with sepsis model group, the levels of IFN-γ and IL-10 increased, IL-4 and IL-17 decreased, IFN-γ/IL-4 and IL-10/IL-17 increased in Shenfu injection treatment group, but were lower than those in control group, the difference were statistically significant (P < 0.05), and its pathological damage of organs was relieved and the infiltration of inflammatory cells was alleviated (all P < 0.05). Conclusion Shenfu Injection can regulate the immune system of sepsis mice, inhibit inflammation and alleviate organ damage.
		2019 Vol. 16 (22): 21-25 [Abstract] ( 214 ) HTML (1 KB) PDF (697 KB) ( 90 )

	26	Changes of C-type natriuretic peptide expression in different tissues of mice with chronic stress-induced depression
		REN Jingyi1 FU Yuanyuan1 JING Xiaotong2 SU Yujiao2 SHI Xiaorui2 DU Yuru2 SHI Haishui2
		Objective To investigate the effects of C-type natriuretic peptide (CNP) expression in different tissues and serum of mice with chronic stress-induced depression. Methods Twenty male ICR mice were selected and divided into control group and stress group according to the random number table method with 10 mice in each group. Chronic mild stress (CMS) method was used to establish depression mice model. After animal behavior test, samples were taken and the levels of CNP in hippocampus, liver, kidney, heart and serum were quantitatively analyzed by enzyme-linked immunosorbent assay (ELISA). Results The results of behavioral test showed that compared with the control group, the preference value of sugar and water in stress group was significantly reduced, the immobility latency of forced swimming test and tail suspension test were significantly shortened, and the immobility time of forced swimming was significantly prolonged, the differences were statistically significant (P < 0.05). There was no significant difference in total water intake between the two groups (P > 0.05). Compared with the control group, the levels of CNP in the heart, kidney and serum of the stress group increased significantly (all P < 0.05). Conclusion Chronic stress can significantly increase the levels of CNP in heart, kidney and serum, suggesting that the changes of CNP expression in peripheral tissues may be related to the occurrence and development of stress-induced depression.
		2019 Vol. 16 (22): 26-29 [Abstract] ( 181 ) HTML (1 KB) PDF (391 KB) ( 140 )

	30	Determination of Aspirin in intracellular and extracellular fluid of human breast cancer cells by ultraviolet spectrophotometry
		ZHU Xingmei GAO Chen WANG Chuan WANG Guoquan WANG Bin LIU Jiping
		Objective To establish an ultraviolet spectrophotometric method for the determination of Aspirin in the intracellular and extracellular fluid of human breast cancer cell line MDA-MB-231 and to dynamically monitor the content of Aspirin in the intracellular and extracellular fluid. Methods The contents of Aspirin in intracellular and extracellular fluids were determined by ultraviolet spectrophotometry with a wavelength of 276 nm. Results In the range of 30~130 μg/mL, the linear relationship between Aspirin concentration and absorbance in the intracellular and extracellular fluid of human breast cancer cell line MDA-MB-231 were good. The regression equation were Y=0.007X-0.021 (r = 0.9995, n = 5); Y=0.006X+0.061 (r = 0.9995, n = 5); the average recoveries were 96.6% (RSD = 1.0%) and 98.4% (RSD = 0.8%), respectively; intraday precision RSD were 2.3% and 2.4%, daytime precision RSD were 2.2% and 2.3%, respectively. The limit of quantification of both intracellular and extracellular fluids was 20 μg/mL, the limit of detection of intracellular fluid was 10 μg/mL, and the limit of detection of extracellular fluid was 1.25 μg/mL. Conclusion Ultraviolet spectrophotometry can be used to determine the content of Aspirin in the intracellular and extracellular fluid of human breast cancer cell line MDA-MB-231. The method is simple, easy, accurate and reproducible.
		2019 Vol. 16 (22): 30-32,57 [Abstract] ( 166 ) HTML (1 KB) PDF (916 KB) ( 79 )

	33	Determination of p-hydroxycinnamic acid in Duchesnea indica (Andr.) by HPLC
		XU Congcong1,2 LIN Lu2 LIANG Huifen2 AN Hongmei3 HU Bing4 ZHANG Tong1,2 PU Yiqiong1
		Objective To establish a method for the determination of p-hydroxycinnamic in Duchesnea indica (Andr.) by HPLC. Methods Ultimate XB-C18（250 mm×4.6 mm, 5 μm） column was used as the column, acetonitrile-0.2% acetic acid solution (14∶86) was used as the mobile phase of the isocratic elution, with the detection wavelength of 300 nm and the flow rate of 1.0 mL/min. The column temperature maintained at 30℃. Results The concentration of hydroxycinnamic acid in the range of 0.413-26.450 μg/mL showed a good linear relationship with the peak area, with the equation of linear regression of Y=72.592X +1.1304 (r = 0.9999 ). The average recovery rate was 103.52% (RSD = 2.61%). The average content of p-hydroxycinnamic acid in 3 batches of Duchesnea indica (Andr.) determined was 0.11, 0.10 and 0.05 mg/g, respectively. Conclusion The method is convenient and rapid, and has good separation effect, high sensitivity and good repeatability. It can be used for quality control of Duchesnea indica (Andr.).
		2019 Vol. 16 (22): 33-37 [Abstract] ( 187 ) HTML (1 KB) PDF (667 KB) ( 75 )

	38	Establishment of a determination method for dissolution of Rosuvastatin Calcium Solid Dispersion Granules
		HUANG Heqian XU Jun CHEN Huan CAO Danjing XIAO Liqian
		Objective To establish a method for the determination of dissolution rate of Rosuvastatin Calcium Solid Dispersion Granules. Methods Rosuvastatin Calcium Solid Dispersion Granules were prepared by solid dispersion technology. The dissolution rate was determined by ultraviolet spectrophotometry. The ultraviolet detection wavelength was 241 nm. Methodological investigation was carried out, including precision, stability, reproducibility and recovery. Results At 6.0-22.0 mg/L, the linear relationship between the concentration of Rosuvastatin Calcium and absorbance was good. The linear regression equation was Y=0.032X+0.0292 (r = 0.999 95). The average recovery rate was 99.77%, RSD was 0.94%, RSD was 0.33% and the dissolution rate was over 90%. Conclusion This method can be used to determine the dissolution of Rosuvastatin Calcium Solid Dispersion Granules.
		2019 Vol. 16 (22): 38-41 [Abstract] ( 590 ) HTML (1 KB) PDF (570 KB) ( 458 )

	42	Reserch progress of glutamate receptor and schizophrenia treatment
		WANG Yingyi LYU Qinyu LU Yanhua YI Zhenghui
		Schizophrenia is a group of serious mental diseases without specific causes, with a high prevalence rate, high disability rate and a heavy social burden. The global prevalence of schizophrenia is 1%. At present, antipsychotic drugs can well control the positive symptoms, but the negative symptoms and cognitive impairment of patients have not been effectively treated. Currently, it is generally believed that the defect of N-methyl D-aspartate receptor is the main cause of negative symptoms and cognitive impairment in patients with schizophrenia. Therefore, glutamate receptor has gradually become a key target for the development of a new generation of antipsychotic drugs. In this paper, we will summarize the progress of glutamate receptor-related drugs for schizophrenia in recent years in order to provide some suggestions for future clinic and researches in this field.
		2019 Vol. 16 (22): 42-45,65 [Abstract] ( 157 ) HTML (1 KB) PDF (612 KB) ( 111 )

	46	Autophagy and cerebral ischemia
		PENG Yongjun1 QIAO Yu2 LI Zhongren2 FU Shuping2 CHU Jihong1 JIANG Pengjun1 ZHU Bingmei3
		Autophagy is closely related to cerebral ischemia, and the two interact with each other. Cerebral ischemia can stimulate autophagy, and meanwhile, autophagy can aggravate or reduce the damage of nerve cells after cerebral ischemia. Cerebral ischemia can lead to cell autophagy and cell autophagy activation moderately, conducive to the repair of nerve cell after cerebral ischemia, but excessive or insufficient cell autophagy activation, and can lead to cell apoptosis, increase brain damage, so the cell autophagy activation takes control and grasp the degrees, also need further to study the roles of autophagy in cerebral ischemia specific signal and interference signal pathways in concrete means and so on. This article explores the relationship between autophagy and cerebral ischemia at home and abroad in recent years, and to provide new ideas for its clinical research.
		2019 Vol. 16 (22): 46-49 [Abstract] ( 299 ) HTML (1 KB) PDF (620 KB) ( 134 )

	50	Research progress on relationship between long noncoding RNA and diabetic myocardial ischemia/reperfusion injury
		LI Wenyuan LI Wei LENG Yan XIONG Yonghong XIA Zhongyuan▲
		lncRNA is a member of the non-coding RNA family. Due to the development of biochip and sequencing technology, lncRNA does not have the function of encoding proteins, but its biological effects are constantly demonstrated. lncRNAs and miRNAs are coupled with each other and produce a clear effect in a number of pathological processes. Diabetic myocardial ischemic diseasesare the focus of perioperative prevention and treatment. lncRNAs are closely related to the occurrence and development of diabetic myocardial ischemia-reperfusion. This paper mainly describes the research progress on the relationship between the biological effects of lncRNA and ischemia-reperfusion of diabetic cardiomyopathy.
		2019 Vol. 16 (22): 50-53 [Abstract] ( 162 ) HTML (1 KB) PDF (587 KB) ( 128 )

	54	Research progress of HOTAIR in breast cancer
		MIAO Hui1 CHEN Jian2
		Breast cancer is regarded as the first disease of modern women. According to statistics, its incidence rate is increasing at an extremely fast rate, and the mortality rate is as high as 0.114‰, which has become the main destroyer of modern women′s health and happy life. Therefore, the study and analysis of the evolution mechanism of breast cancer can effectively promote the research proces of breast cancer and its etiology and other aspects. At present, in some cancer studies, the occurrence and deterioration of the disease are closely related to the maladjustment of lncRNAs during their characterization. HOTAIR (Hox transcription antisense RNA) is exist in the Hox genes, its essence is a kind of biological process which can through the lncRNA trans activation combined with PRC2/LSD1, and reweave chromosome condition, promote epithelium-stroma transformation, and participate in the cell growth, is the core of the researchers studying cancer. This article reviews the research on the relationship between HOTAIR and breast cancer.
		2019 Vol. 16 (22): 54-57 [Abstract] ( 201 ) HTML (1 KB) PDF (590 KB) ( 51 )

	58	Progress in the role of MicroRNAs in the healing of diabetic ulcer
		XING Ye YUAN Na HAN Rui
		Diabetic ulcer is one of the most serious complications of diabetes mellitus, but there is a lack of effective treatment and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the healing process of diabetic ulcer. Through regulating the expression of target genes, regulating growth factors, cytokines, signal pathways and so on, thus affecting hemostasis and anti-inflammation. In this paper, the promotion and inhibition of miRNAs on diabetic ulcer healing are reviewed in order to provide new ideas for the treatment and curative effect evaluation of diabetic ulcer.
		2019 Vol. 16 (22): 58-61 [Abstract] ( 140 ) HTML (1 KB) PDF (590 KB) ( 141 )

	62	Research progress of circulating tumor cells in colorectal cancer
		ZHANG Yue HAN Zhenguo
		In recent years, with the changes of lifestyle and diet structure, the incidence and mortality of colorectal cancer in China are on the rise. The detection of circulating tumor cells (CTC) in peripheral blood has important significance for the early diagnosis, therapeutic effect monitoring and prognosis assessment of colorectal cancer. CTC refers to the tumor cells that have separated from solid tumor and entered the peripheral blood circulation from the primary tumor or metastatic tumor due to spontaneous or clinical operation. Observing the number changes of CTC has important clinical significance for the individualized diagnosis and treatment of colorectal cancer. This article aims to review the recent progress of CTC detection technology and clinical research on diagnosis, treatment and prognosis of colorectal cancer.
		2019 Vol. 16 (22): 62-65 [Abstract] ( 258 ) HTML (1 KB) PDF (624 KB) ( 60 )

	66	Research progress of psychological state and nursing countermeasure of gynecological malignant tumor patients
		ZOU Xiangni1 ZHANG Min2
		Gynecological malignancy is a common malignancy nowadays, and ovary and cervix are its most common sites. Due to the particularity of its occurrence site and function, most patients will appear tense, anxiety, doubt, fear, avoidance, inferiority and pessimistic depression and other adverse psychological state, so it is more worthy of attention and care than other malignant tumors. Therefore, it puts forward the nursing countermeasures of scientific popularization and notification, psychological and spiritual behavior intervention and group intervention, so that patients can maintain a positive psychological state for a long time and cooperate with the treatment, in order to achieve the purpose of extending life and improving the quality of life, so it is summarized and summarized here.
		2019 Vol. 16 (22): 66-68,76 [Abstract] ( 255 ) HTML (1 KB) PDF (888 KB) ( 146 )

	69	SWOT analysis of OSCE in clinical competence training of medical students
		WANG Kuanlei1 WU Xueliang2 LIU Zhankuang3
		As an evaluation tool of clinical competence, objective structured clinical examination OSCE has been more and more accepted by medical education institutions at home and abroad. The First Affiliated Hospital of Hebei North University ("our hospital" for short) is the Clinical College of Hebei North University, clinical practice teaching plays an important role. This paper first expounds the current situation of OSCE in the training of medical students′clinical ability in our hospital. Secondly, it points out the advantages, disadvantages, opportunities and challenges of OSCE in the training of medical students′ clinical ability by using SWOT analysis method. Finally, combining with the SWOT analysis strategy, it puts forward that we should strengthen the construction of teaching staff, strengthen the construction of OSCE examination question bank and strengthen the construction of standardized patient team. To strengthen the training of students′clinical thinking ability, standardize the training and assessment of clinical skills, strengthen the training of medical students′ clinical ability, and strive to improve students′comprehensive quality and the quality of personnel training.
		2019 Vol. 16 (22): 69-72 [Abstract] ( 246 ) HTML (1 KB) PDF (503 KB) ( 214 )

	73	Home-school cooperation to build mental health of college students
		LI Binghan1 ZHANG Hui2
		With the increasingly prominent mental health problems of college students, neither family nor school can solve the problems alone. Home-school cooperation is a desirable solution, that is, families provide more support to schools, schools bring more guidance to families, and both sides more effectively communicate and cooperate to build psychological health of college students. This article through the literature from the necessity of the importance of family factors, parent-school cooperative, parent-school cooperative and the present situation and the existing problems for parent-school cooperative suggestions from four aspects, gradually in-depth discussed the fundamental factors that affect college students′ mental health and family school psychology education counseling problems existing in the dock with the family, and parent-school cooperative relevant suggestions are put forward.
		2019 Vol. 16 (22): 73-76 [Abstract] ( 204 ) HTML (1 KB) PDF (444 KB) ( 197 )

	77	Effect and mechanism discussion of Berberine combined with quadruple therapy in the treatment of Helicobacter pylori-positive peptic ulcer
		SHI Peng YAO Jie▲
		Objective To investigate the effect and possible mechanisms of Berberine combined with quadruple therapy in the treatment of Helicobacter pylori (Hp)-positive peptic ulcer. Methods Forty cases of Hp-positive peptic ulcer patients in the Sixth People′s Hospital of Chongqing City from December 2015 to February 2018 were collected and divided into combined group and control group by using random number table method, each group of 20 cases. Control group was treated with quadruple therapy, while combined group was treated with Berberine on the basis of quadruple therapy. The curative effect, eradication rate of Hp and adverse reactions of two groups were observed. The expression of COX-2 in gastric tissues of two groups before and after treatment was compared. Results There was no significant difference in total effective rate between two groups (P > 0.05). The eradication rate of Hp in combined group was higher than that in control group (P < 0.05). There was no significant difference in incidence of abdominal pain, abdominal distension, nausea, diarrhea and taste changes between two groups (P > 0.05). After treatment, the expression of COX-2 in gastric tissue of both groups was lower than those before treatment, and the expression of COX-2 in gastric tissues of combined group was lower than that of control group (P < 0.05). Conclusion Berberine combined with quadruple therapy is superior to quadruple therapy alone in the treatment of Hp-positive peptic ulcer. Berberine may promote ulcer healing and Hp eradication by inhibiting the expression of COX-2.
		2019 Vol. 16 (22): 77-79,86 [Abstract] ( 251 ) HTML (1 KB) PDF (665 KB) ( 97 )

	80	Antiviral effect of Gankangjian 2 on HBeAg positive chronic HBV carriers and its effect on T lymphocyte subsets
		ZHANG Shuangxi WANG Weiqiong HE Guomin QIU Lushan GUO Jieyi
		Objective To evaluate antiviral effect of Gankangjian 2 on HBeAg positive chronic HBV carriers and its effect on T lymphocyte subsets. Methods Forty-three HBeAg positive chronic HBV carriers who met the inclusion criteria in Shunde Hospital of Guangzhou University of Traditional Chinese Medicine from June 2014 to January 2017 were selected and divided into treatment group (21 cases) and control group (22 cases) by using random number table method. Treatment group was given Gankangjian 2 orally, one package, three times a day. Control group was given Glucurolactone orally, 0.2 g, three times a day. Virological indices, T lymphocyte subsets, three routine and renal function between two groups were observed before treatment and 72 weeks of after treatment. Results After treatment of 72 weeks, serum HBV-DNA level in treatment group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). After treatment of 72 weeks, serum HBeAg level in treatment group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). There were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+ between and within two groups (P > 0.05). After treatment of 72 weeks, there were no significant abnormalities in blood routine, urine routine, fecal routine and renal function in two groups. Conclusion Gankangjian 2 can effectively reduce the quantitative values of HBV-DNA and HBeAg in HBeAg-positive chronic HBV carriers. Traditional Chinese medicine has a definite effect on inhibiting HBV replication and regulating immune tolerance of hepatitis B.
		2019 Vol. 16 (22): 80-82,93 [Abstract] ( 171 ) HTML (1 KB) PDF (649 KB) ( 100 )

	83	Application effect of pre-hospital medical emergency telephone guidance in patients with acute coronary syndrome
		LI Liping XU Meiling WU Shuhong
		Objective To explore application effect of pre-hospital medical emergency telephone guidance in patients with acute coronary syndrome(ACS). Methods 267 ACS patients of 120 Emergency Center of Haikou City in Hainan Province ("our center" for short) from September 2017 to March 2018 were selected as the study subjects, 129 ACS patients in our center from September to December 2017 as control group, 138 ACS patients in our center from January to March 2018 as observation group. Control group did not receive medical guidance after receiving the emergency call, dispatching pre-hospital emergency personnel for on-site inspection, treatment and transshipment, while observation group received the emergency call and dispatched tasks at the same time to give telephone medical guidance to guide the rescuers in-situ rescue. The on-site treatment time, the remission rate of symptoms on arrival of pre-hospital emergency personnel, the satisfaction degree of family members in pre-hospital first aid and the incidence of malignant cardiovascular events before transporting to hospital were observed in two groups. Results There was no significant difference in the basic data of the first witness between two groups (P > 0.05). The time of on-site treatment in observation group was shorter than that in control group (P < 0.05). The remission rate of symptoms and the satisfaction degree of family members in pre-hospital care in observation group were higher than those in control group (P < 0.05). The incidence of malignant cardiovascular events in observation group was lower than that in control group (P < 0.05). Conclusion Pre-hospital medical emergency telephone guidance has a certain effect in the treatment of patients with acute coronary syndrome, which can make up for the lack of pre-hospital first aid knowledge to a certain extent.
		2019 Vol. 16 (22): 83-86 [Abstract] ( 178 ) HTML (1 KB) PDF (598 KB) ( 105 )

	87	Correlation of anemia status and left ventricular diastolic function in patients with coronary heart disease
		XU Shiying1 YE Fang2 PI Lin1 HU Jiangqiao1 FU Lijuan1 ZHANG Mingming1
		Objective To investigate the correlation of anemia status and left ventricular diastolic function in patients with coronary heart disease. Methods The clinical data of 282 patients with coronary heart disease admitted to Department of Cardiology of Chuiyangliu Hospital Affiliated to Tsinghua University from January 2017 to April 2018 was analyzed retrospectively. According to whether there were anemia, the patients were divided into two groups, total 186 cases of patients without anemia were set as group A, total 96 cases of patients with anemia were set as group B. The age, blood pressure, body mass index (BMI), total cholesterol (TC), glycosylated hemoglobin (HbA1c), A peak, E/A, left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWT) and the proportion of complications of the two groups were compared, and the hemoglobin level and related clinical indicators were analyzed by multivariate linear regression analysis. Results The levels of BMI, TC, E/A and diastolic blood pressure of group B were lower than those of group A, the differences were statistically significant (P ＜ 0.05). The levels of age, HbAlc, peak A value, LVEDD and LVPWT of group B were significantly higher than those of group A, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of primary hypertension between the two groups (P ＞ 0.05). The incidence of diabetes and diastolic heart failure of group B was significantly higher than those of group A (P ＜ 0.05). Multivariate linear regression analysis showed that hemoglobin level was negatively correlated with age (β = 0.337) and positively correlated with E/A (β = 0.442), the differences were statistically significant (P ＜ 0.05). Conclusion The anemia status of patients with coronary heart disease can affect the left ventricular diastolic function. Therefore, it is necessary to pay attention to the correction of anemia in the course of clinical treatment, so as to protect cardiac function.
		2019 Vol. 16 (22): 87-89,97 [Abstract] ( 176 ) HTML (1 KB) PDF (612 KB) ( 188 )

	90	Effect of intestinal microecological preparation on complications after hemorrhoid stapler operation
		LI E1 XU Jia2 HE Yinghua1
		Objective To investigate the effect of intestinal microecological preparation on complications after hemorrhoid stapler operation. Methods Seventy patients underwent procedure for prolapse hemorrhoids (PPH) in the Anorectal Department of Guanganmen Hospital, China Academy of Chinese Medical Sciences from June 2017 to June 2018 were selected, patients were divided into observation group (n = 35) and control group (n = 35) by random number table method. Routine preoperative preparation was performed in the control group, and the observation group were given oral and retention enema of Bifidobacterium Triad and Subtilis Triad on the basis of the control group. Visual analogue scale (VAS) was used to compare the postoperative pain degree of the two groups, as well as the relief time of bleeding, anal distension and anastomotic inflammation degree of the two groups. Results VAS scores of the two groups on the first day after surgery showed no statistically significant difference (P ＞ 0.05). VAS score of observation group was lower than that of control group on the 7th day after the operation, and the difference was statistically significant (P ＜ 0.05). The incidence of postoperative bleeding and anal distension in the observation group was compared with that in the control group, and the difference was not statistically significant (P ＞ 0.05). Patients in the observation group had shorter time to relieve anal distention than those in the control group, and the difference was statistically significant (P ＜ 0.05). On the 7th day after the operation, the incidence of mild anastomotic inflammation was lower in the observation group than in the control group, with statistically significant difference (P ＜ 0.05). The anastomosis condition of observation group was better than that of control group on the 7th day and the 1st month after the operation, and the differences were statistically significant (P ＜ 0.05). No anastomotic leakage occurred in both groups within 1 month after operation. Conclusion The application of preoperative microecological preparation may reduce the postoperative pain of PPH, relieve the anal distension quickly, and decrease the incidence of anastomotic inflammation.
		2019 Vol. 16 (22): 90-93 [Abstract] ( 170 ) HTML (1 KB) PDF (598 KB) ( 80 )

	94	Clinical analysis of 17 cases with primary cough headache
		CAO Su1 XUE Zhanyou2▲ ZHANG Xiaoyi2 XU Li2 ZHAO Yuan2
		Objective To analyze the clinical characteristics of primary cough headache, to enhance the understanding for primary cough headache and improve the therapeutic effect. Methods A total of 17 patients with primary cough headache diagnosed and treated in the Headache Clinic of Department of Neurology in the 988th Hospital of PLA from January 2017 to January 2018 were collected to observe their clinical manifestations and therapeutic effects, and the summary and analysis was performed by combining with literatures. Results Among the 17 cases of patients, 11 cases were male and 6 cases were female, the onset age was ranged from 10 to 65 years old, and the medical history was ranged from 18 h to 4 months. Headache was given priority to side edge, the most common site was occipitalia, the nature of pain was various, which was given priority tothrobbing and needle-like pain. The degree of pain was mainly mild to moderate, the pain duration was short, which was shorter than 10 s in common. The headache of all patients got worse when they coughed, which could be also reduced byexertion, lowering head, vibration and laughter, accompanied by rhinobyon, nasal discharge and other concomitant symptoms. The patients had previous history of migraine, nummular headache and other types. Most of the imageological examination showed no obvious abnormal appearances. The symptoms could be relieved by oneself or after drug administration. Conclusion Primary cough headache is a rare headache disease, and the diagnosis mainly depends on clinical manifestations and imaging to exclude other diseases. The treatment of primary cough headache is mainly symptomatic treatment, which has good prognosis.
		2019 Vol. 16 (22): 94-97 [Abstract] ( 163 ) HTML (1 KB) PDF (641 KB) ( 54 )

	98	Application of the enhanced recovery after surgery concept of anesthesia management in kyphosis deformity surgery
		CAI Ning1 DAI Chenxu1 YU Haiyang2 ZHANG Xu2
		Objective To observe the clinical effect of anesthesia management strategy under the concept of enhanced recovery after surgery (ERAS) in kyphosis deformity surgery. Methods A total of 50 patients with moderate or severe kyphosis deformity who underwent elective spinal osteotomy in the People′s Hospital of Fuyang in Anhui Province from January 2014 to November 2018 were enrolled, they were divided into two groups according to random number table method: ERAS group (group C, n = 25) and control group (group E, n = 25). Group C was given the traditional perioperative management method and group E was given the perioperative management mode under the concept of ERAS, such as preoperative functional exercise, intraoperative lung protection, goal-oriented fluid therapy, blood protection, temperature protection and other measures, postoperative multi-mode analgesia. The concentrations of blood glucose (Glu), cortisol (Cor) and level of C-reactive protein (CRP) were measured before anesthesia (T0), after extubation (T1), 24 h (T2) and 48 h after surgery (T3), respectively. The recovery time, intraoperative blood loss, and VAS score within 48 h were recorded. The recovery time of the intestines, the time of eating, and the number of hospital stays were recorded. And the occurrence of postoperative adverse reactions were observed. Results Compared with group C, the concentrations of Glu, Cor and level of CRP at the timepoint of T1-T3 were significantly lower in group E (P < 0.05). The recovery time, intraoperative blood loss and VAS score within 48 h were lower (P < 0.05). The intestinal recovery time, eating time and hospitalization time of patients were significantly shorter (P < 0.05). The number of patients with adverse reactions such as conjunctival edema and nausea and vomiting decreased after operation (P < 0.05). Conclusion The anesthesia management strategy under the concept of ERAS in kyphosis deformity surgery can significantly inhibit the patient′s stress response and provide a good analgesic effect. It can reduce fewer postoperative adverse reactions, and promote patients early recovery.
		2019 Vol. 16 (22): 98-102 [Abstract] ( 201 ) HTML (1 KB) PDF (639 KB) ( 163 )

	103	Effect of Dexmedetomidine combined with Ropivacaine transversus abdominal plane block on analgesia after laparoscopic cryptorchidism in children
		FAN Yanting1 WU Guiyun2 BAI Xue1 WEI Wei1 XU Yingyi1▲
		Objective To investigate effect of Dexmedetomidine combined with Ropivacaine transversus abdominal plane block (TAPB) on analgesia after laparoscopic cryptorchidism in children. Methods Sixty children undergoing elective laparoscopic cryptorchidism in Anesthesia Department of Guangzhou Women and Children Medical Center from March to October 2018 were divided into control group (group C, Ropivacaine group) and Dexmedetomidine group (group D, Dexmedetomidine combined with Ropivacaine group) by using random number table method, 30 cases in each group. After tracheal intubation, bilateral TAPB was guided by ultrasound. All patients were treated with intravenous controlled analgesia pump (PCIA) after operation. The heart rate (HR) and mean arterial pressure (MAP) at admission (T1), 10 minutes after TAPB (T2), time of skin incision (T3) and end of operation (T4) were recorded. Ramsay and PAED scores were performed after operation. FLACC scores of children at 2, 6, 12, 24 and 48 hours after operation were recorded, and the times of PCIA pump pressing 48 hours after operation and total amount of Sufentanil used 24 hours after operation were recorded. Results There was no significant difference in HR and MAP levels at T1 and T4 between two groups (P > 0.05); there was significant difference in HR and MAP levels at T2 and T3 between two groups (P < 0.05). There was no significant difference in HR and MAP levels at different time in group C (P > 0.05), but there was significant difference in HR and MAP levels at different time in group D (P < 0.05). There was no significant difference in Ramsay score between two groups (P > 0.05). PAED score and incidence of restlessness in group D were significantly lower than those in group C (P < 0.05). There was no significant difference in FLACC score between two groups at 2 and 48 hours after operation (P > 0.05); FLACC score of group D at 6, 12 and 24 hours after operation was lower than that of group C (P < 0.05). There were significant differences in FLACC scores between 2 h hours and 6,12, 24 hours in group C (P < 0.05), and had no significant differences in FLACC scores at different time in group D (P > 0.05). The effective pressing times and actual pressing times of PCIA pump in group D 48 hours after operation were less than those in group C, with statistical significance (P < 0.05); total amount of Sufentanil used in group D 24 hours after operation was less than that in group C, with statistical significance (P < 0.05). Conclusion Dexmedetomidine combined with Ropivacaine TAPB can prolong the postoperative analgesic time and improve the analgesic effect of patients undergoing laparoscopic cryptorchidism, reduce the use of opioids after operation, and reduce the incidence of restlessness during recovery period.
		2019 Vol. 16 (22): 103-106,114 [Abstract] ( 204 ) HTML (1 KB) PDF (625 KB) ( 93 )

	107	Effect of Sevoflurane combined with Remifentanil on cardiovascular protection and inflammation in cesarean section women with severe preeclampsia
		CHEN Hao LI Huili ZHOU Changhao WANG Xin▲
		Objective To analyze the effect of Sevoflurane combined with Remifentanil on cardiovascular protection and inflammation in cesarean section women with severe preeclampsia. Methods Eighty cases of cesarean section women with severe preeclampsia who were admitted to the First Hospital of Hebei Medical University from March 2016 to January 2018 were selected as the study subjects. They were divided into two groups according to random number table method, 40 cases in each group. The control group was given Remifentanil only for anesthesia, while the observation group was given Sevoflurane combined with Remifentanil for anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), stroke index (SV), cardiac output (CO) and other hemodynamic indicators were observed in two groups at different time. Inflammatory indices such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were observed in two groups at different time. The incidence of adverse reactions to anesthesia in two groups of parturients was recorded. Results There was no significant difference in hemodynamic parameters between two groups before anesthesia (P > 0.05). There were significant differences in hemodynamic indexes after intubation, skin incision, delivery, suture and extubation between two groups (P < 0.05). There were significant differences in SBP and DBP levels between two groups after induction (P < 0.05). There was significant difference in hemodynamic indexes between two groups at different time points (P < 0.05). There was no significant difference in the level of inflammation before anesthesia between two groups (P > 0.05). There was a significant difference in the levels of inflammatory indexes between two groups at 6 hours after extubation and 24 hours after operation (P < 0.05). There was a significant difference in the level of inflammatory status indicators between two groups at different time points (P < 0.05). The incidence of adverse reactions of anesthesia in observation group was lower than that in control group (P < 0.05). Conclusion Sevoflurane combined with Remifentanil can maintain the stability of maternal hemodynamics, maintain the normal perfusion of important organs, maintain the body′s stability and reduce the body′s inflammatory response, which is worthy of clinical promotion and application.
		2019 Vol. 16 (22): 107-110 [Abstract] ( 135 ) HTML (1 KB) PDF (598 KB) ( 41 )

	111	Effect of CT-guided double-lumen bronchial catheterization on stress response protein level in patients
		WANG Benqi ZHAO Zhenru WANG Xin HU Jie PENG Yinming
		Objective To investigate the effect of CT-guided double-lumen bronchial catheterization on stress response protein level in patients. Methods 90 patients undergoing thoracic surgery under general anesthesia and one-lung ventilation from January 2016 to January 2018 in Chengde Central Hospital of Hebei Province were selected as the study subjects. They were divided into control group (n = 50) and observation group (n = 40) by random number table method. Patients in control group were treated with traditional intubation method, while patients in observation group were treated with double-lumen bronchial tube intubation guided by chest CT. The clinical effects and stress response protein levels before and after intubation were compared between two groups. Results There was no significant difference in one lung ventilation time and anesthesia time between two groups (P > 0.05); the intubation time of observation group was shorter than that of control group, and the number of intubation attempts of observation group was less than that of control group (P < 0.05). After intubation, MDA levels in both groups were significantly higher than those before intubation (P < 0.05), SOD and GSH-px levels were significantly lower than those before intubation (P < 0.05), and the changes in observation group were smaller (P < 0.05). After intubation, the levels of CRP, IL-1β and IL-6 in two groups were significantly higher than those before intubation (P < 0.05), and the changes in observation group were smaller (P < 0.05). The incidence of hoarseness and sore throat at 24 hours after operation in observation group was significantly lower than that in control group (P < 0.05). Conclusion Chest CT guided double-lumen bronchial catheter intubation has good clinical effect and less stimulation to stress response.
		2019 Vol. 16 (22): 111-114 [Abstract] ( 166 ) HTML (1 KB) PDF (597 KB) ( 140 )

	115	Clinical observation on the treatment of idiopathic trigeminal neuralgia by tempetature controlled radiofreguency ablation under CT guidance
		HE Haili1 YANG Liqiang2▲ SONG Shengwen3 GUO Yu′na2 WANG Qi2 HE Liangliang2 YUE Jianning2 WANG Xiaoping2 CAO Guoqing2
		Objective To study the clinical efficacy and complications of tempetature controlled radiofreguency ablation on treatment of idiopathic trigeminal neuralgia by CT guidance. Methods Forty-eight patients of idiopathic trigeminal neuralgia treated in Department of Pain, Xuanwu Hospital, Capital Medical University from September 2017 to April 2018 were enrolled into this study. The VAS, numbness score, complications and patients′ satisfaction before operation, and after operation for immediately (T1), 1 week (T2), 1 month (T3), 3 months (T4) were evaluated. Results Compared with the VAS of preoperative pain, postoperative pain at T1, T2, T3 and T4, was significantly relieved in all patients, with statistically significant differences (P < 0.05). All the 48 patients at T1, T2, T3 and T4 showed different degrees of facial numbness, which was mild and moderate, and did not affect daily life; major complications included 27 cases (56.25%) of decreased masticatory muscle strength, 1 case (2.08%) of corneal hypoesthesia, 3 cases (6.25%) of tinnitus, 1 case (2.08%) of runny nose. There were no serious complications such as visual impairment, intracranial infection, low cranial pressure headache and syncope. Conclusion CT guided tempetature controlled radiofreguency ablation is a safe and effective treatment for idiopathic trigeminal neuralgia.
		2019 Vol. 16 (22): 115-118 [Abstract] ( 169 ) HTML (1 KB) PDF (627 KB) ( 119 )

	119	Analysis of the distribution of cervical discogenic pain induced by low-temperature plasma gasification ablation
		HE Liangliang NI Jiaxiang CAO Guoqing GUO Yu′na YANG Liqiang▲
		Objective To investigate the distribution of cervical discogenic pain through the method of low-temperature plasma gasification ablation technology to induce pain. Methods From June to November 2018, 30 patients with cervical discogenic pain underwent CT-guided low-temperature plasma intervertebral disc gasification ablation in Department of Pain of Xuanwu Hospital, Capital Medical University were selected as research objects. During the operation, the pain-inducing region was recorded by the schematic diagram of the digital coding region of human body. Results The intervertebral disc segments of low-temperature plasma gasification ablation included 14 cases of C4-C5, 17 cases of C5-C6, and 5 cases of C6-C7, among which, the pain areas induced by C4-C5, C5-C6, and C6-C7 intervertebral disc included the cervical and shoulder junction, the posterior upper part of the trapquadratus, the scapula, the interscapula, the chest, and the posterior shoulder. The pain areas induced by C4-C5 intervertebral disc were inclined to the cephalic side, including the forehead, ears, posterior occipital, suboccipital and posterior cervical areas. The pain areas induced by C5-C6 intervertebral disc included posterior, anterior, cervico-shoulder junction, posterior and upper part of the trapezius, scapula, interscapula, chest, posterior shoulder, upper arm, forearm and thorax. The pain areas induced by C6-C7 intervertebral disc were inclined to the side of the foot, including the upper arm, forearm and thoracodorsal areas. Conclusion The distribution of cervical discogenic pain is regular, with overlap, limitation, direction and sequence.
		2019 Vol. 16 (22): 119-122 [Abstract] ( 179 ) HTML (1 KB) PDF (1251 KB) ( 35 )

	123	Summary of professor Meng Fengxian′s experience in treating gout
		ZHANG Chengcheng1 MENG Fengxian2 BU Xiangwei3 BAI Hua4
		Professor Meng Fengxian believes that dampness, heat, turbidity, blood stasis and toxicity are the main causes and pathogenesis of gout. In the acute stage of clinical syndrome differentiation, heat toxicity is the main point of syndrome differentiation, while in the chronic stage, phlegm and blood stasis are the main pathogenesis. Therapeutic measures include clearing away heat and detoxification, removing dampness and turbidity, removing blood stasis and relieving pain, tonifying kidney essence, eliminating metabolic pathological products, reducing blood uric acid and preventing kidney damage.
		2019 Vol. 16 (22): 123-125,130 [Abstract] ( 304 ) HTML (1 KB) PDF (695 KB) ( 91 )

	126	Analysis of prescription rules of Chinese medicine containing ephedra
		GAO Yue HUANG Zhengde LIU Shi LI Yue SUN Wanjin HU Xiaoxue
		Objective To analyze the prescription rules of Chinese patent medicine containing ephedra, and provide reference for the clinical use of traditional Chinese medicine and preliminary research of new drug. Methods Using traditional Chinese medicine inheritance support system (V2.5) software, the ephedrine formula contained in the Chinese Medicine Formulation of Set Prescription was collected and sorted to construct a related database. Using data mining methods, such as association rules and frequency statistics, the disease syndrome, common drug compatibility and prescription rules were analyzed, and the high frequency drug compositions and high frequency syndromes were analyzed in depth. Results There were 284 prescriptions containing ephedra, involving 589 flavors of traditional Chinese medicine. There were 28 commonly used drug compositions, 9 kinds of main diseases. The drug compositions of three high-frequency diseases such as “cough”, “caries” and “shrub” were analyzed. Ephedra plays a similar role in different drug compositions, all had the effect of pungent divergence and warmly dredging. Conclusion Most of the prescriptions containing ephedra in Chinese Medicine Formulation of Set Prescription have the effects of dissipating phlegm, relieving cough and dispelling pathogenic wind for relieving superficies syndrome. The medication is more concentrated and the prescription is clear. The rule of medication reflects the compatibility of ephedra in the treatment of different diseases, which can provide a basis for fully utilizing the efficacy of ephedra prescription and clinical scientific prescription.
		2019 Vol. 16 (22): 126-130 [Abstract] ( 164 ) HTML (1 KB) PDF (1165 KB) ( 72 )

	131	Clinical study of acupuncture exercise therapy combined with Chinese medicine hot compress in the treatment of acute lumbar sprain
		CHEN Wenjie1 CAO Yueqiang1 WANG Aimin2 BAI Ruyu2 ZHANG Zhigang3 ZHANG Ping3 XUE Yujuan3 YAN Jinsheng4
		Objective To observe the clinical effect of acupuncture exercise therapy combined with Chinese medicine hot compress in the treatment of acute lumbar sprain. Methods One hundred and twenty patients with acute lumbar sprain admitted to Sanhe Hospital and Sanhe Hospital of Traditional Chinese Medicine from April 2017 to December 2018 were selected as subjects, and they were divided into 2 groups by random number table method, with 60 cases in each group. The observation group was given acupuncture exercise therapy, taking the two points of fútù and xuánzhōng, and combined with hot compress of traditional Chinese medicine Carthami Flos, Spatholobi Caulis, Lycopodii Herba, Phryma Leptostachya, Chaenomelis Fructus, Benincasae Exocarpium, and so on. The control group was given ordinary acupuncture in double lateral lumbar vertebral jiájǐ, shènshù, zhìshì, dàchángshù, yāoyǎn, and combined with external use of Voltaren, 4 times a day, 5 days was taken as a course of treatment, after one course of treatment, the effect was evaluated. The visual analog scale (VAS) was used to compare the lumbago degree of the two groups before and after treatment. The lumbar mobility was detected before and after treatment, including lumbar anteflexion angle, rear protraction angle, right angle of curvature, and left-hand rotation angle. The clinical efficacy of acute lumbar sprain between the two groups was evaluated. Results There was no significant difference in VAS scores between the two groups before treatment (P ＞ 0.05). After treatment, the VAS scores of the two groups were lower than those before treatment (P < 0.05), which of the observation group were lower than those of the control group (P ＜ 0.05). There were no significant differences in all indices of lumbar mobility between the two groups before treatment (P ＞ 0.05). The indices of lumbar mobility of the two groups were higher than those before treatment (P ＜ 0.05), which of the observation group were higher than those of the control group (P ＜ 0.05). The effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Acupuncture exercise therapy combined with Chinese medicine hot compress for acute lumbar sprain has quick effect and less adverse reactions, the curative effect is better than ordinary acupuncture combined with Voltaren.
		2019 Vol. 16 (22): 131-134 [Abstract] ( 207 ) HTML (1 KB) PDF (728 KB) ( 46 )

	135	Clinical effect of auricular point pressing combined with traditional Chinese medicine on diarrhea after colorectal cancer operation with syndrome of spleen deficiency and dampness excessivenes
		JIANG Jiakang1 YANG Fan2 JIANG Qinghui3 ZHANG Qianshi2 CHI Wencheng1
		Objective To explore the clinical therapeutic effect of auricular acupoint pressing combined with traditional Chinese medicine in the treatment of diarrhea after colorectal cancer operation with syndrome of spleen deficiency and dampness excessiveness Methods The clinical data of 90 patients met with diarrhea after colorectal cancer operation with syndrome of spleen deficiency and dampness excessiveness and treated in the Outpatient Clinic of Professor Jiang Jiakang, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2016 to September 2018 was ananlyzed retrospectively. According to different treatment methods, they were divided into the treatment group and the control group, with 45 cases in each group. The control group was treated with Loperamide Hydrochloride Capsules for symptomatic treatment. The treatment group was treated with auricular acupoint pressing combined with Modified Shenling Baizhu Powder orally. The two groups were taken 14 days as an observation period. The clinical efficacy of the two groups was compared, the levels of inflammatory factors in the two groups were monitored before and after treatment, and the conditions of adverse reactions in the two groups after treatment were observed. Results The total effective rate of treatment group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the levels of tumor necrosis factor-α, interleukin-6 in the treatment group were lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). The incidence of adverse reactions in the treatment group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion In view of diarrhea after colorectal cancer operation with syndrome of spleen deficiency and dampness excessiveness, auricular acupoint pressing combined with traditional Chinese medicine can significantly decrease the levels of inflammatory factors, reduce the occurrence of adverse reactions, which has a significant clinical effect.
		2019 Vol. 16 (22): 135-139 [Abstract] ( 177 ) HTML (1 KB) PDF (720 KB) ( 124 )

	139	Professor Xie Jingri′s five effective applications of Gancao Xiexin Decoction
		WANG Haiqiang1 CAI Hongbo1 ZHENG Lihong2
		Professor Xie Jingri is a well-known Chinese medicine expert in the country. He is good at treating various medical diseases with traditional Chinese medicine. This article introduces five effective clinical cases of Professor Xie Jingri′s experience in using Gancao Xiexin Decoction, and elaborates on the differentiation and treatment of oral ulcers, chronic atrophic gastritis, chronic colitis, Sjogren′s syndrome and pruritus in different cases. Although the disease is different and the symptoms are different, it is reflected homotherapy for heteropathy in the treatment of different diseases. Meanwhile, this paper sorts out the clinical medical records according to the writing mode of clinical medical records, and analyzes each medical record in a concise and comprehensive manner. It will introduce professor Xie Jingri′s clinical experience from another aspect, reflect the thinking of traditional Chinese medicine, and provide reference for the same clinical practice.
		2019 Vol. 16 (22): 139-141,154 [Abstract] ( 192 ) HTML (1 KB) PDF (981 KB) ( 148 )

	142	Effect of Jianpi Liqi Decoction on gastrointestinal adverse reactions during perichemotherapy period
		XIAO Minwei XU Nie
		Objective To investigate the effect of Jianpi Liqi Decoction on the adverse reactions of digestive system such as nausea, vomiting and constipation in the perichemotherapy period of malignant tumor. Methods Eighty patients with tumors scheduled for containing Cisplatin chemotherapy in the Second Department of Oncology of Chengdu First People′s Hospital from June 2016 to April 2017 were divided into treatment group and control group according to the random number table method, with 40 cases in each group. The control group was treated with conventional antiemetic drugs, and the treatment group was given Jianpi Liqi Decoction in addition. The clinical efficacy, Karnofsky performance (KPS), and incidence and severity of adverse reactions in the digestive system were compared between the two groups. Results The total effective rate of the treatment group and the control group was 57.5% and 47.5%, respectively, and the difference was not statistically significant (P ＞ 0.05). The KPS score of the treatment group after chemotherapy was significantly higher than that of control group, and the difference was statistically significant (P ＜ 0.05). The effective rate of nausea and vomiting in the treatment group in 2-5 days after chemotherapy was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The constipation scores of the treatment group were significantly lower than those of the control group in 1-5 days after chemotherapy, the differences were highly statistically significant (P ＜ 0.01). Conclusion Jianpi Liqi Decoction combined with conventional antiemetic drugs can more effectively alleviate the adverse reactions such as gastrointestinal vomiting and constipation caused by chemotherapy, and has high safety, which is beneficial to improve the quality of life of patients with malignant tumor after chemotherapy.
		2019 Vol. 16 (22): 142-145 [Abstract] ( 159 ) HTML (1 KB) PDF (683 KB) ( 53 )

	146	Clinical effect of external washing of Jieyou Decoction in the treatment of diabetic foot
		SHI Wen HAN Hong
		Objective To explore the clinical effect of external washing of Jieyou Decoction in the treatment of diabetic foot. Methods Total of 99 cases of patients with diabetic foot met with the diagnostic criteria of Chinese and Western medicine in Department of Traditional Chinese Medicine of Beijing Sixth Hospital from January 2016 to June 2017 were selected. They were divided into treatment group and control group by 2∶1 through random number table method, with 66 cases in the treatment group and 33 cases in the control group. A total of 93 patients were included in this study, including 63 cases in the treatment group and 30 cases in the control group. The treatment group was taken external washing of Jieyou Decoction, the control group was treated with 5% Elikey Povidone Iodine Solution and washed with a 1∶5 dilution of 3000 mL. The curative effect, wound healing rate at different time points and adverse reactions of the two groups were compared. Followed up for half a year, the incidence of grade 4 to 5 of Wagner grading in the two groups was observed. Results The curative effect of treatment group was better than that of control group, the difference was highly statistically significant (P ＜ 0.01). There was no significant difference of the wound healing rate between the two groups at the 2nd and 4th week (P ＞ 0.05), while the wound healing rates of the treatment group were higher than thoes of the control group at the 6th and 8th week, the differences was statistically significant (P ＜ 0.05). Followed up for half a year, the incidence of grade 4 to 5 of Wagner grading in the control group was higher than the treatment group, the differences were statistically significant (P ＜ 0.05). No obvious adverse reactions were observed during the treatment. Conclusion The external washing of Jieyou Decoction has obvious healing effect for diabetic foot, which can effectively control the development of ulcer of diabetic foot.
		2019 Vol. 16 (22): 146-149 [Abstract] ( 151 ) HTML (1 KB) PDF (717 KB) ( 98 )

	150	Value of omni-directional M-mode echocardiography in the evaluation of left ventricular systolic function in patients with premature ventricular beat from right ventricular outflow tract
		LAI Baochun1 GUO Wei1▲ WANG Xinkang2 YE Zhensheng1
		Objective To evaluate the application value of omni-directional M-mode echocardiography in the evaluation of systolic function of left ventricular in patients with premature ventricular beat (PVB) from right ventricular outflow tract (RVOT). Methods From November 2015 to November 2018, 45 patients with PVB from RVOT admitted to Fujian Provincial Hospital were selected as the experimental group and 45 healthy people were selected as the control group. The peak myocardial systolic velocities were measured by OME at 6 sites of mitral annular during sinus rhythm and PVB beats respectively. Results At the normal sinus beat, the peak myocardial systolic velocities of mitral annular in the left ventricular anterior, lateral, and posterior segments of the experimental group in normal sinus rhythm were significantly decreased than those of the control group, the differences were statistically significant (P < 0.05). In the experimental group, the peak myocardial systolic velocities of mitral annular of all sites of in PVB were lower than those in the normal sinus rhythm, the differences were highly statistically significant (P < 0.01). Conclusion The peak myocardial systolic velocities can effectively evaluate the changes of left ventricular systolic function of the patients with PVB from RVOT.
		2019 Vol. 16 (22): 150-154 [Abstract] ( 152 ) HTML (1 KB) PDF (624 KB) ( 85 )

	155	Application of SWI in the hemorrhagic transformation after intravenous thrombolytic therapy with alteplase in patients with acute ischemic stroke
		WANG Ziran1 CUI Yansen1▲ ZHAO Guangjian1 ZHENG Mei1 DAI Shouping2 LIU Shulan2 SUN Quanyu2
		Objective To investigate the application effect of hemorrhagic transformation (HT) after intravenous thrombolytic therapy with alteplase in acute ischemic stroke (AIS) patients by susceptibility weighted imaging ( SWI). Methods Clinical data of 855 AIS patients who received intravenous alteplase therapy in Emergency Department of Linyi People′s Hospital Brain Hospital of Shandong Province from January 2016 to June 2018 were retrospectively analyzed, all patients were given SWI and brain CT detection respectively, two imaging methods were compared on the identification of cerebral hemorrhage after thrombolysis, and the incidence of cerebral hemorrhage of patents with different ECASS classification was observed. Results There were 133 (15.6%) patients with HT detected by SWI after thrombolysis, including 79 cases of hemorrhagic infarction (HI) -1, 33 cases of HI-2, 12 cases of parenchymal hematoma (PH) -1 and 9 cases of PH-2. There were 103 (12.0%) patients with HT detected by CT after thrombolysis, including 53 cases of HI-1, 29cases of HI-2, 12 cases of PH-1 and 9 cases of PH-2. The bleeding rate of HI-1 detected by SWI was higher than CT, the difference was statistically significant (P < 0.05); there was no statistically significant difference between the other types (P > 0.05). Conclusion SWI has a higher value in the detection of HT after intravenous thrombolytic therapy, with important clinical significance in the guidance of the antiplatelet or anticoagulant therapy for AIS patients．
		2019 Vol. 16 (22): 155-157 [Abstract] ( 173 ) HTML (1 KB) PDF (461 KB) ( 104 )

	158	Effect analysis of Solitaire stent mechanical thrombolysis combined with multimode vascular reoperation in the treatment of acute cerebral infarction
		LI Xiaoyong1 LIN Jianmei2
		Objective To approach effect of Solitaire stent mechanical thrombolysis combined with multimode vascular reoperation in the treatment acute cerebral infarction. Methods Clinical data of 99 patients with acute cerebral infarction in Neurology Department of Ziyang First People′s Hospital of Sichuan Province from January 2012 to October 2018 were analyzed, and they were grouped by different treatment methods, control group (49 cases) and detection group (50 cases). The control group was treated with Solitaire stent mechanical thrombolysis, while the observation group was treated with multimode vascular reoperation, including combined arterial embolization, balloon dilation and stent implantation etc, on the basis of the control group. The disease-successfully scabbed time, disease-vascular bypass time of patients in the two groups were observed; the National Institutes of health stroke scale (NIHSS) score and modified Rankin scale (mRS) score of patients in the two groups before and after intervention were observed; vascular bypass rate and clinical treatment total efficiency rate of patients in the two groups were observed. Results There were no statistically significant difference in disease-successfully scabbed time, disease-vascular bypass time, and NIHSS and mRS scores between two groups before intervention (P > 0.05). After intervention, the NIHSS score and mRS score of two groups were lower than before intervention, and those of the detection group were lower than the control group, the differences were statistical significance (P < 0.05). The vascular bypass rate and clinical treatment total efficiency rate were compared between two groups, the differences were statistical significance (P < 0.05). Conclusion Solitaire stent mechanical thrombolysis combined with multimode vascular reoperation in the treatment of acute cerebral infarction can improve the nerve function, increase vascular bypass and curative effect, it is worthy of clinical promotion and application.
		2019 Vol. 16 (22): 158-161 [Abstract] ( 168 ) HTML (1 KB) PDF (511 KB) ( 92 )

	162	Effect of Salvianolate Lyophilized Injection on hs-CRP level and hemorheological parameters in patients with cerebral ischemic stroke
		GAO Aimin WANG Ning QIAN Qian LIU Yonggang REN Cuijian QI Weijing
		Objective To observe the effect of Salvianolate Lyophilized Injection on the level of hypersensitive C-reactive protein (hs-CRP) and hemorheological parameters in patients with cerebral ischemic stroke. Methods From January 2016 to December 2018, 100 patients with cerebral ischemic stroke admitted to the First Central Hospital of Baoding were divided into the control group and the observation group according to the random number table, method with 50 cases in each group. The control group received conventional treatment, and the observation group was treated with Salvianolate Lyophilized Injection on the basis of conventional treatment. Changes in the National Institutes of health stroke scale (NIHSS) score, serum hs-CRP levels, and hemorheological parameters were observed after 2 weeks of treatment. Results After treatment, the NIHSS scores of the two groups were lower than those before treatment, and the NIHSS scores of the observation group were lower than the control group, the differences were highly statistically significant (P ＜ 0.01). The serum hs-CRP levels in the two groups were lower than those before treatment, and the serum hs-CRP levels in the observation group were lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). The plasma viscosity, whole blood viscosity were high, whole blood viscosity was low, and erythrocyte specific volume were lower than before treatment, and the observation goup was lower than control group and the difference was statistically significant (P ＜ 0.05). Conclusion Salvianolate Lyophilized Injection can effectively improve the neurological damage in patients with ischemic stroke, reduce serum hs-CRP levels and regulate hemorheological parameters.
		2019 Vol. 16 (22): 162-165 [Abstract] ( 158 ) HTML (1 KB) PDF (392 KB) ( 51 )

	166	Correlation between the ratio of mean platelet volume to platelet count and left ventricular hypertrophy in patients with essential hypertension
		YIN Jilai GAO Fei LI Hao
		Objective To investigate the correlation between mean platelet volume (MPV)/platelet count (PLT) and left ventricular hypertrophy in patients with essential hypertension. Methods A total of 109 patients with essential hypertension admitted to the First Affiliated Hospital of Hainan Medical University from March 2016 to March 2018 were selected as subjects. All patients were examined by echocardiography and were divided into the left ventricular hypertrophy group (51 cases) and the non-left ventricular hypertrophy group (58 cases) according to the level of left ventricular myocardial mass index. The clinical data of gender, age, body mass index (BMI), systolic blood pressure and diastolic blood pressure were compared between the two groups. The levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), hemoglobin (HGB), red blood cell distribution width (RDW) and MPV/PLT were compared. Multivariate Logistic regression analysis was used to analyze the relationship between the above indexes and left ventricular hypertrophy in patients with essential hypertension. Results Systolic blood pressure in left ventricular hypertrophy group was higher than that in non-left ventricular hypertrophy group, the difference was statistically significant (P < 0.05). RDW in left ventricular hypertrophy group was higher than that in non-left ventricular hypertrophy group, while MPV/PLT in left ventricular hypertrophy group was lower than that in non-left ventricular hypertrophy group, the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that systolic blood pressure and RDW were independent risk factor for left ventricular hypertrophy in patients with essential hypertension, while MPV/PLT was protective factor (P < 0.05). Conclusion MPV/PLT is closely related to left ventricular hypertrophy in patients with essential hypertension. Detection of MPV/PLT in clinical work can help prevent target organ damage.
		2019 Vol. 16 (22): 166-169 [Abstract] ( 182 ) HTML (1 KB) PDF (469 KB) ( 105 )

	170	Changes and clinical significance of serum EMPs and hs-CRP in patients with acute myocardial infarction
		YUAN Xiaohong1 LI Peng2 LIU Junhui2
		Objective To investigate the changes of serum endothelial-derived microparticles (EMPs) and hypersensitive C-reactive protein (hs-CRP) levels in patients with acute myocardial infarction (AMI) and its clinical significance. Methods A total of 146 patients with AMI hospitalized in the Second Affiliated Hospital of Xi′an Jiaotong University (“our hospital” for short) from January 2016 to January 2018 were selected as the observation group. Another 50 non-AMI patients with ventricular premature contractions who were treated in our hospital in the same period were selected as the control group. The levels of serum EMPs and hs-CRP were detected and compared between the two groups. Gensini score was used to evaluate the degree of vascular stenosis in the observation group, and coronary angiography was used to detect the number of vascular lesions in the observation group. The serum levels of EMPs and hs-CRP in patients with different Gensini score and vessel lesion branches were compared. The correlation between serum level of EMPs and hs-CRP and Gensini score and coronary artery lesion branches were analyzed. Results The levels of serum EMPs and hs-CRP in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of Gensini score, the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of the number of vascular lesion branches, the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP were positively correlated with Gensini score and the number of coronary artery lesions (EMPs: r = 0.583, 0.527; P < 0.05, hs-CRP: r = 0.634, 0.582, P < 0.05). Conclusion The levels of serum EMPs and hs-CRP in patients with AMI are abnormally elevated, and their level are closely related to the severity and extent of coronary artery involvement. EMPs, hs-CRP may be used as markers for judging the severity of AMI.
		2019 Vol. 16 (22): 170-173 [Abstract] ( 185 ) HTML (1 KB) PDF (465 KB) ( 125 )

	174	Analysis on the fairness of the allocation of TCM hospitals in 31 provinces of China in 2016
		WANG Xi GUO Yiwei BAI Qian HUANG Lieyu LI Shuo YANG Yong SHI Xuefeng▲
		Objective To analyze the fairness of the financial input and resource allocation of Chinese medicine hospitals in 2016, and provide suggestions for the improvement of fairness. Methods Descriptive statistical analysis, Gini Coefficient and Lorenz curve were used to analyze the relevant indicators in the Chinese Statistical Yearbook of Chinese Medicine 2016 and the Chinese Statistical Yearbook 2017 and the fairness of financial investment and resource allocation in the national TCM hospitals in 2016 were studied. Results Between the provinces, the proportion of investment in Chinese medicine hospitals and medical and health institutions varied greatly, with the highest ratio being 2.75 times that of the lowest ratio. The number of TCM hospitals per million people was the highest in Qinghai Province, which was 6.46/1 million. The number of beds per 10 000 population was the highest in Beijing, and the number of beds was 10.48 per 10 000 people. The population of 10 000 people had the largest number of practitioners, at 7.83/10, 000. Conclusion There is still a lack of emphasis on the development of traditional Chinese medicine in various provinces in China. It is imperative to implement the Party′s policy of "Be Equal to Chinese and Western Medicine". Increasing investment in TCM undertakings and taking into account efficiency in the context of ensuring fairness are a good way for the development of TCM practitioners.
		2019 Vol. 16 (22): 174-177,184 [Abstract] ( 564 ) HTML (1 KB) PDF (1021 KB) ( 69 )

	178	Biological characteristics study of CRBSI in patients with CVC
		DOU Xinman1 MA Peifen1 NAN Ruiling2 ZHOU Linlin3 ZHANG Yabin3 LI Yumin4▲
		Objective To investigate the bacterial biological characteristics of catheter-related bloodstream infection (CRBSI) in patients with central venous catheter (CVC) catheterization. Methods The bacterial biological characteristics of CRBSI in 16 841 patients with CVC catheterization in the Second Hospital of Lanzhou University from January 2012 to December 2015 were retrospectively analyzed. Hospital information system, laboratory information system and SPSS software were used to analyze the pathogenic microorganisms of CRBSI. Results There were 16 507 cases of single pathogen infection, 331 cases of double infection and 3 cases of triple infection. In total, 16 905 strains of pathogenic bacteria, 8709 strains of Gram-positive bacteria (51.4%), 7875 strains of Gram-negative bacteria (46.7%) and 321 strains of fungi (1.9%) were isolated. MRSA and CNS both showed strong resistance to Penicillin and Oxazacillin. Acinetobacter baumannii had a high resistance to antibiotics, Klebsiella pneumoniae had the highest resistance rate to Cefazolin (82.8%). The drug resistance rate of Pseudomonas aeruginosa to antibiotics was > 50%. Escherichia coli was highly resistant to Ampicillin and Cefazolin (> 70%). Conclusion Patients with CVC catheterization are prone to complicated CRBSI due to pathogenic bacteria infection or multiple complications, and may further develop sepsis or septic shock. The pathogens causing CRBSI are mainly Gram-positive bacteria, Gram-negative bacteria and fungi.
		2019 Vol. 16 (22): 178-184 [Abstract] ( 1214 ) HTML (1 KB) PDF (1016 KB) ( 47 )

	185	Effect of cognitive behavioral intervention on relocation stress and caregiver burden of family members of ICU transferred patients
		CHEN Jing SHI Yan ZHENG Jie TANG Ling ZENG Min
		Objective To investigate effect of cognitive behavioral intervention on relocation stress and caregiver burden of family members of ICU transferred patients. Methods The family members of 94 patients admitted to the Chengdu First People′s Hospital from March 2017 to September 2018 and who had been treated and improved were selected as subjects. They were divided into intervention group and control group according to random number table method, each group of 47 cases. Both families was received routine transfer care, and cognitive behavior intervention was applied in intervention group on the basis of this. The relocation stress level and caregiver burden level of family members in two groups were assessed by ICU family relocation stress scale and main caregiver burden scale before transfer and on the 1st and 5th day after transfer. Results There was significant difference in relocation stress scores between two groups on the 1st and 5th day after transfer (P < 0.05). The relocation stress level score of intervention group on the 1st and 5th day of transfer was lower than that before transfer, and relocation stress level score of intervention group on the 5th day of transfer was lower than that on the 1st day of transfer, with statistical significance (P < 0.05). The relocation stress level score of control group on the 5th day after transfer was lower than that before transfer and on the 1st day after transfer, and the difference was statistically significant (P < 0.05). There was a significant difference in burden level of the main caregivers between two groups on the 5th day of transfer (P < 0.05). The burden level score of the main caregivers of two groups on the 5th day of transfer was higher than that before transfer, and the difference was statistically significant (P < 0.05). Conclusion Cognitive behavioral intervention can significantly improve relocation stress level and caregivers burden level of ICU patients′ family members, which has positive clinical significance.
		2019 Vol. 16 (22): 185-188 [Abstract] ( 714 ) HTML (1 KB) PDF (512 KB) ( 86 )

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