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| Effect of CT-guided double-lumen bronchial catheterization on stress response protein level in patients |
| WANG Benqi ZHAO Zhenru WANG Xin HU Jie PENG Yinming |
| Department of Anesthesiology, Chengde Central Hospital of Hebei Province, Hebei Province, Chengde 067000, China |
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Abstract Objective To investigate the effect of CT-guided double-lumen bronchial catheterization on stress response protein level in patients. Methods 90 patients undergoing thoracic surgery under general anesthesia and one-lung ventilation from January 2016 to January 2018 in Chengde Central Hospital of Hebei Province were selected as the study subjects. They were divided into control group (n = 50) and observation group (n = 40) by random number table method. Patients in control group were treated with traditional intubation method, while patients in observation group were treated with double-lumen bronchial tube intubation guided by chest CT. The clinical effects and stress response protein levels before and after intubation were compared between two groups. Results There was no significant difference in one lung ventilation time and anesthesia time between two groups (P > 0.05); the intubation time of observation group was shorter than that of control group, and the number of intubation attempts of observation group was less than that of control group (P < 0.05). After intubation, MDA levels in both groups were significantly higher than those before intubation (P < 0.05), SOD and GSH-px levels were significantly lower than those before intubation (P < 0.05), and the changes in observation group were smaller (P < 0.05). After intubation, the levels of CRP, IL-1β and IL-6 in two groups were significantly higher than those before intubation (P < 0.05), and the changes in observation group were smaller (P < 0.05). The incidence of hoarseness and sore throat at 24 hours after operation in observation group was significantly lower than that in control group (P < 0.05). Conclusion Chest CT guided double-lumen bronchial catheter intubation has good clinical effect and less stimulation to stress response.
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