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| Progress in the role of MicroRNAs in the healing of diabetic ulcer |
| XING Ye YUAN Na HAN Rui |
| The Second Department of Endocrinology, the First Affiliated Hospital of Kunming Medical University, Yunnan Province, Kunming 650000, China |
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Abstract Diabetic ulcer is one of the most serious complications of diabetes mellitus, but there is a lack of effective treatment and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the healing process of diabetic ulcer. Through regulating the expression of target genes, regulating growth factors, cytokines, signal pathways and so on, thus affecting hemostasis and anti-inflammation. In this paper, the promotion and inhibition of miRNAs on diabetic ulcer healing are reviewed in order to provide new ideas for the treatment and curative effect evaluation of diabetic ulcer.
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