注射用丹参多酚酸对缺血性脑卒中患者hs-CRP水平和血液流变参数的影响

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Abstract Objective To observe the effect of Salvianolate Lyophilized Injection on the level of hypersensitive C-reactive protein (hs-CRP) and hemorheological parameters in patients with cerebral ischemic stroke. Methods From January 2016 to December 2018, 100 patients with cerebral ischemic stroke admitted to the First Central Hospital of Baoding were divided into the control group and the observation group according to the random number table, method with 50 cases in each group. The control group received conventional treatment, and the observation group was treated with Salvianolate Lyophilized Injection on the basis of conventional treatment. Changes in the National Institutes of health stroke scale (NIHSS) score, serum hs-CRP levels, and hemorheological parameters were observed after 2 weeks of treatment. Results After treatment, the NIHSS scores of the two groups were lower than those before treatment, and the NIHSS scores of the observation group were lower than the control group, the differences were highly statistically significant (P ＜ 0.01). The serum hs-CRP levels in the two groups were lower than those before treatment, and the serum hs-CRP levels in the observation group were lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). The plasma viscosity, whole blood viscosity were high, whole blood viscosity was low, and erythrocyte specific volume were lower than before treatment, and the observation goup was lower than control group and the difference was statistically significant (P ＜ 0.05). Conclusion Salvianolate Lyophilized Injection can effectively improve the neurological damage in patients with ischemic stroke, reduce serum hs-CRP levels and regulate hemorheological parameters.

Key words： Salvianolate Lyophilized Injection Cerebral ischemic stroke Hypersensitive C-reactive protein Hemorheological parameters

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	GAO Aimin WANG Ning QIAN Qian LIU Yonggang REN Cuijian QI Weijing

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GAO Aimin WANG Ning QIAN Qian LIU Yonggang REN Cuijian QI Weijing. Effect of Salvianolate Lyophilized Injection on hs-CRP level and hemorheological parameters in patients with cerebral ischemic stroke[J]. 中国医药导报, 2019, 16(22): 162-165.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I22/162

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