|
|
|
| Biological characteristics study of CRBSI in patients with CVC |
| DOU Xinman1 MA Peifen1 NAN Ruiling2 ZHOU Linlin3 ZHANG Yabin3 LI Yumin4▲ |
1.Department of Nursing, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Wards Three of Emergency and Critical Care, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China;
3.College of Nursing, Lanzhou University, Gansu Province, Lanzhou 730000, China;
4.Key Laboratory of Digestive System Tumors of Gansu Province, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China |
|
|
|
Abstract Objective To investigate the bacterial biological characteristics of catheter-related bloodstream infection (CRBSI) in patients with central venous catheter (CVC) catheterization. Methods The bacterial biological characteristics of CRBSI in 16 841 patients with CVC catheterization in the Second Hospital of Lanzhou University from January 2012 to December 2015 were retrospectively analyzed. Hospital information system, laboratory information system and SPSS software were used to analyze the pathogenic microorganisms of CRBSI. Results There were 16 507 cases of single pathogen infection, 331 cases of double infection and 3 cases of triple infection. In total, 16 905 strains of pathogenic bacteria, 8709 strains of Gram-positive bacteria (51.4%), 7875 strains of Gram-negative bacteria (46.7%) and 321 strains of fungi (1.9%) were isolated. MRSA and CNS both showed strong resistance to Penicillin and Oxazacillin. Acinetobacter baumannii had a high resistance to antibiotics, Klebsiella pneumoniae had the highest resistance rate to Cefazolin (82.8%). The drug resistance rate of Pseudomonas aeruginosa to antibiotics was > 50%. Escherichia coli was highly resistant to Ampicillin and Cefazolin (> 70%). Conclusion Patients with CVC catheterization are prone to complicated CRBSI due to pathogenic bacteria infection or multiple complications, and may further develop sepsis or septic shock. The pathogens causing CRBSI are mainly Gram-positive bacteria, Gram-negative bacteria and fungi.
|
|
|
|
|
|
[1] Bleichmder F. Inra-arterielle therapie [J]. Klin Wochcrischr，1912，1：1503-1505.
[2] Shanmuganathan M，Goh BL，Lim CTS. Urgent start intermittent peritoneal dialysis leads to reduction of catheter-related infection and increased peritoneal dialysis penetration [J]. Am J Med Sci，2018，356（5）：476-480.
[3] Taylor JE，McDonald SJ，Tan K. Prevention of central venous catheter-related infection in the neonatal unit：a literature review [J]. J Matern Fetal Neonatal Med，2015，28（10）：1224-1230.
[4] Hallam C，Jackson T，Rajgopal A，et al. Establishing catheter-related bloodstream infection surveillance to drive improvement [J]. J Infect Prev，2018，19（4）：160-166.
[5] Wang H，Tong H，Liu H，et al. Effectiveness of antimicrobial-coated central venous catheters for preventing catheter-related blood-stream infections with the implementation of bundles：a systematic review and network meta-analysis [J]. Ann Intensive Care，2018，8（1）：71.
[6] 卫生部临床检验中心.全国临床检验操作规程[M].3版.北京：人民卫生出版社，2006：56-59.
[7] Yu W，Kim HK，Rauch S，et al. Pathogenic conversion of coagulase-negative staphylococci [J]. Microbes Infect，2017，19（2）：101-109.
[8] Bond A，Teubner A，Taylor M，et al. Assessing the impact of quality improvement measures on catheter related blood stream infections and catheter salvage：experience from a national intestinal failure unit [J]. Clin Nutr，2018，37（6 Pt A）：2097-2101.
[9] Talebi M，Shafiee M，Sadeghi J，et al. Genotypic diversity of methicillin-resistant coagulase-negative staphylococci isolated from inpatients and outpatients [J]. Microb Drug Resist，2016，22（2）：147-154.
[10] Gaerste-Díaz YC，Lozano-Zarain P，Torres C，et al. Genotyping of antimicrobial resistance and virulence in staphylococcus isolated from food of animal origin in mexico [J]. Indian J Microbiol，2018，58（4）：525-528.
[11] Dharmayanti A，Astrawinata D. Catheter-related blood stream infection in a patient with hemodialysis [J]. Acta Med Indones，2018，50（3）：244-252.
[12] Ohtake S，Takahashi H，Nakagawa M，et al. One percent chlorhexidine-alcohol for preventing central venous catheter-related infection during intensive chemotherapy for patients with haematologic malignancies [J]. J Infect Chemother，2018，24（7）：544-548.
[13] 张岩岩，朱婉，张静萍，等.多重耐药鲍曼不动杆菌血流感染危险因素分析[J].中国感染与化疗杂志，2017，17（2）：134-139.
[14] 周婷，梁秀婷，吴洁.多重耐药鲍曼不动杆菌血流感染患者临床特点和预后回顾性分析[J].中国医药导报，2017， 14（31）：60-63.
[15] 张洋洋，陈良安，张庆，等.鲍曼不动杆菌毒力机制研究进展[J].河北医学，2017，23（2）：340-343.
[16] 陈浩浩，蔡晓锐，汤丹灵，等.多重耐药鲍曼不动杆菌的耐药率演变及临床特征[J].中国医药导报，2018，15（20）：163-167.
[17] 张银维，周华，蔡洪流，等.鲍曼不动杆菌血流感染临床特征和死亡危险因素分析[J].中华内科杂志，2016，55（2）：121-126.
[18] 马永驰，潘亚萍，佘婷婷，等.产KPC肺炎克雷伯菌检测方法构建与耐药机制[J].安徽医科大学学报，2017， 52（8）：1173-1178.
[19] Zalas-Wi?誰cek P，Bogiel T，Wi■niewski K，et al. Diversity of extended-spectrum beta-lactamase-producing Escherichia coli rods [J]. Postepy Hig Med Dosw（Online），2017，71（0）：214-219.
[20] 侯盼飞，祝丽晶.超广谱β-内酰胺酶在多重耐药鲍曼不动杆菌中的作用[J].检验医学与临床，2016，13（17）：2484-2486.
[21] 史瑀，穆金智，殷翠香，等.产超广谱β-内酰胺酶细菌致社区感染与医院感染耐药性调查分析[J].中国现代医生，2018，56（23）：149-152.
[22] 卢滔，全晶晶，王燕飞，等.浙江省县市级医院社区发作大肠埃希菌和肺炎克雷伯菌血流感染患者产超广谱β-内酰胺酶情况分析[J].中华传染病杂志，2017，35（4）：198-202. |
|
|
|
