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| Analysis of prescription rules of Chinese medicine containing ephedra |
| GAO Yue HUANG Zhengde LIU Shi LI Yue SUN Wanjin HU Xiaoxue |
| Department of Pharmaceutical Affairs, Hubei Provincial Hospital of TCM, Hubei Province, Wuhan 430061, China |
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Abstract Objective To analyze the prescription rules of Chinese patent medicine containing ephedra, and provide reference for the clinical use of traditional Chinese medicine and preliminary research of new drug. Methods Using traditional Chinese medicine inheritance support system (V2.5) software, the ephedrine formula contained in the Chinese Medicine Formulation of Set Prescription was collected and sorted to construct a related database. Using data mining methods, such as association rules and frequency statistics, the disease syndrome, common drug compatibility and prescription rules were analyzed, and the high frequency drug compositions and high frequency syndromes were analyzed in depth. Results There were 284 prescriptions containing ephedra, involving 589 flavors of traditional Chinese medicine. There were 28 commonly used drug compositions, 9 kinds of main diseases. The drug compositions of three high-frequency diseases such as “cough”, “caries” and “shrub” were analyzed. Ephedra plays a similar role in different drug compositions, all had the effect of pungent divergence and warmly dredging. Conclusion Most of the prescriptions containing ephedra in Chinese Medicine Formulation of Set Prescription have the effects of dissipating phlegm, relieving cough and dispelling pathogenic wind for relieving superficies syndrome. The medication is more concentrated and the prescription is clear. The rule of medication reflects the compatibility of ephedra in the treatment of different diseases, which can provide a basis for fully utilizing the efficacy of ephedra prescription and clinical scientific prescription.
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