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| Effect of Sevoflurane combined with Remifentanil on cardiovascular protection and inflammation in cesarean section women with severe preeclampsia |
| CHEN Hao LI Huili ZHOU Changhao WANG Xin▲ |
| Department of Anesthesia and Surgery, the First Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050031, China |
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Abstract Objective To analyze the effect of Sevoflurane combined with Remifentanil on cardiovascular protection and inflammation in cesarean section women with severe preeclampsia. Methods Eighty cases of cesarean section women with severe preeclampsia who were admitted to the First Hospital of Hebei Medical University from March 2016 to January 2018 were selected as the study subjects. They were divided into two groups according to random number table method, 40 cases in each group. The control group was given Remifentanil only for anesthesia, while the observation group was given Sevoflurane combined with Remifentanil for anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), stroke index (SV), cardiac output (CO) and other hemodynamic indicators were observed in two groups at different time. Inflammatory indices such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were observed in two groups at different time. The incidence of adverse reactions to anesthesia in two groups of parturients was recorded. Results There was no significant difference in hemodynamic parameters between two groups before anesthesia (P > 0.05). There were significant differences in hemodynamic indexes after intubation, skin incision, delivery, suture and extubation between two groups (P < 0.05). There were significant differences in SBP and DBP levels between two groups after induction (P < 0.05). There was significant difference in hemodynamic indexes between two groups at different time points (P < 0.05). There was no significant difference in the level of inflammation before anesthesia between two groups (P > 0.05). There was a significant difference in the levels of inflammatory indexes between two groups at 6 hours after extubation and 24 hours after operation (P < 0.05). There was a significant difference in the level of inflammatory status indicators between two groups at different time points (P < 0.05). The incidence of adverse reactions of anesthesia in observation group was lower than that in control group (P < 0.05). Conclusion Sevoflurane combined with Remifentanil can maintain the stability of maternal hemodynamics, maintain the normal perfusion of important organs, maintain the body′s stability and reduce the body′s inflammatory response, which is worthy of clinical promotion and application.
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