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| Reserch progress of glutamate receptor and schizophrenia treatment |
| WANG Yingyi LYU Qinyu LU Yanhua YI Zhenghui |
| General Psychiatry, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 201108, China |
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Abstract Schizophrenia is a group of serious mental diseases without specific causes, with a high prevalence rate, high disability rate and a heavy social burden. The global prevalence of schizophrenia is 1%. At present, antipsychotic drugs can well control the positive symptoms, but the negative symptoms and cognitive impairment of patients have not been effectively treated. Currently, it is generally believed that the defect of N-methyl D-aspartate receptor is the main cause of negative symptoms and cognitive impairment in patients with schizophrenia. Therefore, glutamate receptor has gradually become a key target for the development of a new generation of antipsychotic drugs. In this paper, we will summarize the progress of glutamate receptor-related drugs for schizophrenia in recent years in order to provide some suggestions for future clinic and researches in this field.
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