贫血状态与冠心病患者左心室舒张功能的相关性

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Abstract Objective To investigate the correlation of anemia status and left ventricular diastolic function in patients with coronary heart disease. Methods The clinical data of 282 patients with coronary heart disease admitted to Department of Cardiology of Chuiyangliu Hospital Affiliated to Tsinghua University from January 2017 to April 2018 was analyzed retrospectively. According to whether there were anemia, the patients were divided into two groups, total 186 cases of patients without anemia were set as group A, total 96 cases of patients with anemia were set as group B. The age, blood pressure, body mass index (BMI), total cholesterol (TC), glycosylated hemoglobin (HbA1c), A peak, E/A, left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWT) and the proportion of complications of the two groups were compared, and the hemoglobin level and related clinical indicators were analyzed by multivariate linear regression analysis. Results The levels of BMI, TC, E/A and diastolic blood pressure of group B were lower than those of group A, the differences were statistically significant (P ＜ 0.05). The levels of age, HbAlc, peak A value, LVEDD and LVPWT of group B were significantly higher than those of group A, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of primary hypertension between the two groups (P ＞ 0.05). The incidence of diabetes and diastolic heart failure of group B was significantly higher than those of group A (P ＜ 0.05). Multivariate linear regression analysis showed that hemoglobin level was negatively correlated with age (β = 0.337) and positively correlated with E/A (β = 0.442), the differences were statistically significant (P ＜ 0.05). Conclusion The anemia status of patients with coronary heart disease can affect the left ventricular diastolic function. Therefore, it is necessary to pay attention to the correction of anemia in the course of clinical treatment, so as to protect cardiac function.

Key words： Anemia Coronary heart disease Left ventricular diastolic function Correlation

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	XU Shiying1 YE Fang2 PI Lin1 HU Jiangqiao1 FU Lijuan1 ZHANG Mingming1

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XU Shiying1 YE Fang2 PI Lin1 HU Jiangqiao1 FU Lijuan1 ZHANG Mingming1. Correlation of anemia status and left ventricular diastolic function in patients with coronary heart disease[J]. 中国医药导报, 2019, 16(22): 87-89,97.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I22/87

[1] 陈小玲，吴新华，陈章荣，等.云南地区慢性心力衰竭患者合并贫血的流行病学调查[J].中国现代医学杂志，2017， 27（6）：71-74.
[2] Qaseem A，Humphrey LL，Fitterman N，et al. Treatment of anemia in patients with heart disease：a clinical practice guideline from the American College of Physicians [J]. Ann Intern Med，2013，159（11）：1-32.
[3] Felker GM，Stough WG，Shaw LK，et al. Anaemia and coronary artery disease severity in patients with heart failure [J]. Eur J Heart Fail，2014，8（1）：54-57.
[4] 葛均波，方唯一.现代心脏病学进展2018[M].北京：科学出版社，2018：124-125.
[5] Patel B，Assaad M，Tolia S，et al. Mild anemia as a possible cause of false positive stress echocardiography in non-obstructive coronary artery disease：A pathophysiologic hypothesis [J]. Int J Cardiol，2016，15（1）：525-526.
[6] Rymer JA，Rao SV. Anemia and coronary artery disease：pathophysiology，prognosis，and treatment [J]. Coron Artery Dis，2018，29（2）：161-167.
[7] Salisbury AC. Marker or mediator? Is the link between anemia and outcomes in patients with coronary artery disease growing any clearer? [J]. J Thora Dis，2015，7（12）：E640.
[8] Ogami T，Matsue Y，Kawasumi R，et al. Prognostic implications of preoperative chronic kidney disease and anemia in patients undergoing coronary artery bypass graft surgery [J]. Surg Today，2016，47（2）：1-7.
[9] Carson JL，Brooks MM，Abbott JD，et al. Liberal Versus Restrictive Transfusion Thresholds For Patients With Symptomatic Coronary Artery Disease [J]. Am Heart J，2013， 165（6）：964-970.
[10] Kansagara D，Dyer E，Englander H，et al. Treatment of anemia in patients with heart disease：a systematic review [J]. Ann Int Med，2013，159（11）：746-757.
[11] 张秀丽，白小涓，韩璐璐，等.老年共病患者轻度贫血与体位性低血压的相关性研究[J].中华老年心脑血管病杂志，2017，19（2）：163-166.
[12] Goldberg JF，Shah MD，Kantor PF，et al. Prevalence and Severity of Anemia in Children Hospitalized with Acute Heart Failure [J]. Congenit Heart Dis，2016，11（6）：622-629.
[13] Desai AS，Bibbins-Domingo K，Shlipak MG，et al. Association between anaemia and N‐terminal pro‐B‐type natriuretic peptide（NT‐proBNP）：Findings from the Heart and Soul Study [J]. Eur J Heart Fail，2014，9（9）：886-891.
[14] Jan C. van den Berge，Alina A. Constantinescu，Ron T. van Domburg，et al. Renal function and anemia in relation to short- and long-term prognosis of patients with acute heart failure in the period 1985-2008：A clinical cohort study [J]. PLoS One，2018，13（8）：4242-4251.
[15] 林妍霞，齐国先.红细胞比容与冠心病关系的研究进展[J].心血管病学进展，2018，23（1）：117-119.
[16] 刘春霞，王金燕，吴红花.贫血性心脏病患者心力衰竭发生的临床特征分析[J].中国循证心血管医学杂志，2016，8（10）：1204-1206.
[17] 黄娟，汤圣兴.红细胞分布宽度与冠心病相关性的研究进展[J].安徽医学，2016，37（5）：639-641.
[18] Kitai Y，Ozasa N，Morimoto T，et al. Prognostic implications of anemia with or without chronic kidney disease in patients undergoing elective percutaneous coronary intervention [J]. Int J Cardiol，2013，168（6）：5221-5228.
[19] 向家培.炎症和心脏重构在慢性心力衰竭合并贫血中的作用[J].河北医药，2016，37（2）：258-260.
[20] 刘兴华，刘宗军.贫血和急性冠脉综合征预后关系的研究进展[J].岭南心血管病杂志，2018，33（1）：209-212.
[21] Wang LW，Huttner IG，Santiago CF，et al. Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models [J]. Dis Model Mech，2017，10（1）：63-76.