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| Changes of C-type natriuretic peptide expression in different tissues of mice with chronic stress-induced depression |
| REN Jingyi1 FU Yuanyuan1 JING Xiaotong2 SU Yujiao2 SHI Xiaorui2 DU Yuru2 SHI Haishui2 |
1.School of Public Health, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China;
2.Center of Neuroscience Research, Institute of Medical and Health Science, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China |
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Abstract Objective To investigate the effects of C-type natriuretic peptide (CNP) expression in different tissues and serum of mice with chronic stress-induced depression. Methods Twenty male ICR mice were selected and divided into control group and stress group according to the random number table method with 10 mice in each group. Chronic mild stress (CMS) method was used to establish depression mice model. After animal behavior test, samples were taken and the levels of CNP in hippocampus, liver, kidney, heart and serum were quantitatively analyzed by enzyme-linked immunosorbent assay (ELISA). Results The results of behavioral test showed that compared with the control group, the preference value of sugar and water in stress group was significantly reduced, the immobility latency of forced swimming test and tail suspension test were significantly shortened, and the immobility time of forced swimming was significantly prolonged, the differences were statistically significant (P < 0.05). There was no significant difference in total water intake between the two groups (P > 0.05). Compared with the control group, the levels of CNP in the heart, kidney and serum of the stress group increased significantly (all P < 0.05). Conclusion Chronic stress can significantly increase the levels of CNP in heart, kidney and serum, suggesting that the changes of CNP expression in peripheral tissues may be related to the occurrence and development of stress-induced depression.
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