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| Research progress of HOTAIR in breast cancer
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| MIAO Hui1 CHEN Jian2 |
| School of Basic Medicine, Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin 541001, China |
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Abstract Breast cancer is regarded as the first disease of modern women. According to statistics, its incidence rate is increasing at an extremely fast rate, and the mortality rate is as high as 0.114‰, which has become the main destroyer of modern women′s health and happy life. Therefore, the study and analysis of the evolution mechanism of breast cancer can effectively promote the research proces of breast cancer and its etiology and other aspects. At present, in some cancer studies, the occurrence and deterioration of the disease are closely related to the maladjustment of lncRNAs during their characterization. HOTAIR (Hox transcription antisense RNA) is exist in the Hox genes, its essence is a kind of biological process which can through the lncRNA trans activation combined with PRC2/LSD1, and reweave chromosome condition, promote epithelium-stroma transformation, and participate in the cell growth, is the core of the researchers studying cancer. This article reviews the research on the relationship between HOTAIR and breast cancer.
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