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2018 Vol. 15, No. 14
Published: 2018-05-15
 
 
4 Laboratory animal research on the regulatory effects of recombinant growth hormone on lipid metabolism
LUO Yanfei Bulibur·Bahr Mireguli·Mimiti CAO Chen LIANG Ling
Objective To study the effect of growth hormone on lipid metabolism in animal experiments. Methods Be used 7-day-old mice to fed with a fat-increasing diet and a free diet respectively for 7 day, then super-high fat diet for 4 weeks to build obesity model, and were randomly divided into four groups. Each group was given rhGH 0.0, 0.1, 0.2, 0.3 U /(kg·d) intramuscularly and fed under the same conditions for two weeks. The changes of body weight, serum triglyceride, cholesterol, high and low density lipoprotein, leptin and insulin growth factor-1 were observed after one week and two weeks. Results Before and after the experiment, the indexes of mice were not significantly different (P > 0.05). The body weight, TG, TC, Leptin and LDL-C decreased significantly at 1 week and 2 weeks after injection, and decreased with the increase of time (P < 0.05). IGF-1 increased at 1 week and 2 weeks after injection, and increased with the increase of injection time (P < 0.05). There was no significant change in HDL-C before and after injection (P > 0.05). Body weight, TG, TC, Leptin and LDL-C increased with the increase of growth hormone concentration (P < 0.05). IGF-1 increased with the increase of growth hormone concentration (P < 0.05). Conclusion A certain dose of growth hormone has a certain regulation on lipid hormones, can improve the level of lipid metabolism, and with the dose increase, the more obvious effect.
2018 Vol. 15 (14): 4-7 [Abstract] ( 275 ) HTML (1 KB)  PDF (499 KB)  ( 81 )
8 The feasibility of serum microRNAs as biomarkers for molecular diagnosis of adenomyosis
XU Aiyun1 GUI Tao2 HUANG Meihua2 ZHU Li2 WAN Guiping2
Objective To explore the feasibility of using serum microRNAs as biomarkers for the molecular diagnosis of adenomyosis. Methods Seventy-eight patients with adenomyosis confirmed by the pathological diagnosis from March 2015 to March 2018 in Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine (here in after referred to as "our hospital") were selected as the study group. At the same time, 78 healthy subjects in our hospital physical examination center whose age, gender basically matched with the adenomyosis group were collected as the control group. All miRNAs in the serum of both groups were screened and validated using high-throughput sequencing technology. Results The expression level of microRNAs in the serum of the study group was significantly different from that in the control group (P < 0.05). There were 316 up-regulated miRNAs and 24 down-regulated miRNAs. After further screening and verification, 3 miRNAs were found to include miR-22-3p, miR-103a-3p, and miR-182-5p, and AUC were 0.900 (95% CI: 0.839-0.961) and 0.828 (95% CI: 0.747-0.909), 0.844 (95% CI: 0.766-0.921) respectively. Conclusion Serum microRNAs may be biomarkers for the diagnosis of adenomyosis.
2018 Vol. 15 (14): 8-11 [Abstract] ( 229 ) HTML (1 KB)  PDF (666 KB)  ( 100 )
12 The role of Hepatic insulin resistance in the pathogenesis of spontaneously diabetic OLETF rats
LI Jia1 XUE Yaoming2 PAN Yonghua2 ZHU Bo2 ZHANG Yan2
Objective To study the effects of hepatic insulin resistance, including the lipid deposition in livers, on preventing diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and explore the probability of new mechanism in preventing diabetes in laboratory animals. Methods Twenty male spontaneous diabetic OLETF rats were treated as OLETF (group OLETF). Ten male Long-Evans Tokushima Otsuka (LETO) rats were used as normal control group(group LETO). Blood glucose is determined by oral glucose tolerance test. Rats were sacrificed at 8, 32 and 40 weeks and liver tissue isolated. Serum triglyceride, serum cholesterol, and serum free fatty acid (FFA) were determined. The morphological changes of livers were measured by HE stain. Based on HE results, frozen liver sections of OLETF rats of 32-week-old and 40-week-old respectively were stained with fatty Sudan Ⅲ as well as PAS before and after amylase digestion, the purpose of which is to further clarify the nature of the lesions. Results OLETF rats developed diabetes since 23 weeks of age and the incidence rate of diabetes became higher with the time goes by until got to 92.9% at 40 weeks of age when the research came to the end. No rats have developed diabetes or IGT in group LETO. The serum triglyceride, serum cholesterol, serum FFA was significantly lower in group LETO than that of group OLETF since 32 weeks (P < 0.05). With the week age increasing, liver vacuolation in group OLETF became serious and it was suggested that there appeared a gradual increase on liver fat infiltration and glycogen accumulation with a further improvement on the specific staining of fat and glycogen; while there was no significant damage in the liver structure of group LETO. Conclusion Hepatic insulin resistance may play an important part in the onset of T2DM, and the improvement of hepatic insulin resistance may work as a probable mechanism of preventing diabetes.
2018 Vol. 15 (14): 12-16 [Abstract] ( 169 ) HTML (1 KB)  PDF (838 KB)  ( 57 )
17 Effects of high glucose state on oxidative stress in prostate cancer cells
ZHANG Zhitao1 ZHANG Hongyan2 NIU Fangfang1
Objective To explore the effects of high glucose state on oxidative stress in prostate cancer cells. Methods Human prostate cancer cell line LNCap was treated with different glucose concentrations, and the level of LNCap cells reactive oxygen species (ROS) was detected by DCFH-DA fluorescent probe. The hydrogen peroxide (H2O2), total superoxide dismutase (T-SOD), catalase (CAT) and glutathione peroxidase (GPX) kits were used to detect H2O2 level and antioxidant enzymes activities in LNCap cells. Western blot was used to detect the expression levels of SOD1 and SOD2 protein in LNCap cells. The level of H2O2 was detected after LNCap cells transfected with si-SOD2. Results The levels of ROS and H2O2 in LNCap cells were increased with the increase of glucose concentration, and were concentration-dependent (P < 0.05). The activities of T-SOD and CAT in LNCap cells  were increased significantly in the high glucose environment (P < 0.05), but there was no significant change in the activity of GPX (P > 0.05). In the high glucose environment, the expression level of SOD2 in LNCap cells was increased significantly (P < 0.05), but the expression level of SOD1 was not significantly changed (P > 0.05). After the SOD2 gene was silenced, the level of H2O2 in the LNCap cells was decreased significantly in the high glucose environment (P < 0.05). Conclusion High glucose state can promote the oxidative stress level of prostate cancer cells, and the increase of H2O2 level may be regulated by the expression of SOD2.
2018 Vol. 15 (14): 17-20 [Abstract] ( 230 ) HTML (1 KB)  PDF (753 KB)  ( 52 )
21 Research progress and clinical application prospect in 3D-sphere culture of mesenchymal stem cell with chitosan membrane
LI Huajie XU Xiongfeng QIU Bo
Mesenchymal stem cells (MSCs) with a wide range of sources and multipotential differentiation are thought as a new hope in the field of tissue repair and reconstruction. However, recent research shows that traditional adherent culture changes the initial growing environment of MSCs, leading to self-differentiation, stemness recession and other problems, which brings a negative effect to the treatment after in vivo transplantation. And the evidence suggests that, compared with the traditional adherent culture, the 3D-sphere culture plays a significant role in promoting the biological activity of MSCs. Chitosan membrane (CM) culture is a new type of biomaterial substrate-mediated multicellular spheroid cultivation for MSCs. This review discusses the CM culture of MSCs mainly from the change of morphology, biological functions and potential mechanisms, as well as its potential in clinical application.
2018 Vol. 15 (14): 21-25 [Abstract] ( 181 ) HTML (1 KB)  PDF (373 KB)  ( 119 )
26 Investigation and analysis of the content of China medical travel facilitator websites
YUAN Jian HOU Shengtian YANG Siqiu YU Haining
Objective To explore the development status of medical travel facilitators in China, in order to provide data reference for the study of Chinese medical tourism and China medical travel facilitators. Methods By studying the content of the website of China medical travel facilitators, the search statement was conducted with "medical tourism or overseas medical or cross-border medical treatment", and the contents of the website of the China medical travel facilitators appeared in the first 30 pages were investigated and analyzed. Results A total of 27 websites of China medical travel facilitators were included in the study, of which 18 were established in the past five years, 13 were located in Beijing and 16 had a registered capital of over 5 million. Diagnosis (85.2%) was the most common medical item. The main destinations were the United States, Japan and Germany; 27 websites had focused on health benefits, especially the authority of the hospital (25 cases), only 1 mention the risk of disclosure and legal protection; on the promotion, 17 websites put patient case as marketing means, 8 cases had referral qualification, 6 cases mentioned safety notice, 4 cases showed price details. Conclusion China medical travel facilitator is in the ascendant and its funding threshold is relatively high, mainly distributed in the eastern part of China. Medical welfare focuses on the authority of the hospital as the focus of publicity while neglecting potential risks; promotion in various forms, but lack of core competence in qualification, safety and price.
2018 Vol. 15 (14): 26-29,46 [Abstract] ( 196 ) HTML (1 KB)  PDF (683 KB)  ( 147 )
30 Research on correlation between helicobacter pylori infection, high sensitive C reactive protein and cardiac syndrome X  
LI Shijing1 ZHANG Liping2 PAN Liming1 FENG Jing1 WANG Jun1 ZOU Aichun1 WANG Dezhao3
Objective To explore the correlation between helicobacter pylori (Hp) infection, High sensitive C reactive protein (Hs-CRP) and cardiac syndrome X (CSX). Methods From January 2012 to December 2016, in Mentougou Hospital, the clinical data of 78 CSX patients (CSX group) were retrospectively analyzed, 80 healthy persons were selected as the control group. All patients were given 13C-breath test and Hs-CRP level test, meanwhile, medical history, blood routine, biochemical, glucose, microalbuminuria, glycosylated hemoglobin and carotid atherosclerosis were collected. The correlation between Hp infection, Hs-CRP level and CSX was evaluated. Results ①The positive rates of C-breath test and Hs-CRP in CSX group were significantly higher than that in control group (P < 0.05). ②Hs-CRP level in CSX group was significantly higher than that in control group (P < 0.05)。③Hp≥4‰，Hs-CRP>5 mg/L, diabetes mellitus, female were independent predictors for CSX (P < 0.05). Conclusion There  are  certain correlation between CSX and Hp infection, elevated levels of Hs-CRP. Hp infection, Hs-CRP may be involved in pathogenesis of CSX.
2018 Vol. 15 (14): 30-33 [Abstract] ( 208 ) HTML (1 KB)  PDF (569 KB)  ( 84 )
34 Risk factors of stable coronary heart disease and relationship with neutrophil/lymphocyte ratio
JIANG Yun1 WU Li1▲ ZHAO Long2
Objective To study the risk factors of stable coronary heart disease and relationship between neutrophil-to-lymphocyte ratio (NLR) and it. Methods From January to December 2016, in Yili Youyi Hospital, 600 patients with chest pain and suspected as coronary heart disease were retrospectively analyzed. According to the results of coronary angiography, patients were divided into coronary heart disease (CAD) group (n = 300) and control group (n = 300). Disease risk factors of general data in two groups were compared by single factor analysis, disease risk factors were screened by two classification Logistic regression analysis, the Gensini scores of patients with different NLR levels were compared, the value of NLR in the diagnosis of disease was analyzed by drawing ROC curve. Results The smoking history, hypertension history, diabetes history, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), hemoglobin, WBC and NLR in CAD group and control group were compared, the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that smoking (OR = 2.331, 95% CI: 1.590-4.505, P < 0.05), LDL-C (OR = 1.737, 95% CI: 1.327-2.274, P < 0.05), NLR (OR = 1.552, 95% CI: 1.230-3.329, P < 0.05) were independent risk factor for CHD patients, and HDL-C (OR = 0.456, 95% CI: 0.261-0.798, P < 0.05) was the independent protective factors for CAD patients. Gensini scores stratified in different NLR of CAD group were compared, the difference was statistically significant (P < 0.05), Gensini scores was significantly higher in patients with higher NLR (P < 0.05). ROC curve showed that the area under the curve was 0.834 (95% CI: 0.802-0.867), and when the NLR value was 2.5, the diagnosis efficiency was highest, the sensitivity was 77.0%, and the specificity was 80.7%. Conclusion NLR may be a good predictor of stable coronary heart disease.
2018 Vol. 15 (14): 34-37 [Abstract] ( 214 ) HTML (1 KB)  PDF (570 KB)  ( 66 )
38 Study on relationship between depression and angiotensin/aldosterone levels in patients with essential hypertension
CHEN Ying1 HU Yunzhao2 WU Yanting3▲ FAN Lijuan3
Objective To explore the relationship between depression and angiotensin/aldosterone levels in patients with essential hypertension. Methods From September 2015 to September 2017, in Shunde Hospital Affiliated to Southern Medical University, the patients with hypertension definited were selected as sample group (n = 129) at the same period, heathy outpatients were selected as control group (n = 66). Blood lipid and uric acid (UA) and other indicators, angiotensin (Ang-Ⅰ, Ang-Ⅱ) and aldosterone (ALD) concentration levels were measured. Self-rating scale (SDS) was used to score depression for each candidate, according to SDS results, patients with hypertension were further divided into two subgroups: depression group (n = 58) and non-depression group (n = 71). All the above data were statistically analyzed. Results The blood lipid index such as LDL-C, TC, TG and UA in sample group were significantly higher than control group, the differences were statistically significant (P < 0.05). There was no statistically significant difference in high density lipoprotein cholesterol (HDL-C) between the two groups (P > 0.05). The levels of Ang-Ⅰ, Ang-Ⅱ in the sample group were significantly higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of Ang-Ⅰ, Ang-Ⅱ in the hypertensive depression group were significantly higher than non-depression group, the differences were statistically significant (P < 0.05). Logistic analysis has shown that the risk factors of depressive disorder in patients with hypertension included serum lipid (OR = 1.84, 95%CI: 1.12-3.05, P < 0.05), Ang-Ⅰ(OR = 1.84, 95%CI: 1.18-8.10, P < 0.05) and Ang-Ⅱ(OR = 1.84, 95%CI: 1.05-3.58, P < 0.05) Conclusion Angiotensin is the independent risk factor for depression disorder in patients with hypertension, and the depression degree changed along with the serum angiotensin level.
2018 Vol. 15 (14): 38-41 [Abstract] ( 170 ) HTML (1 KB)  PDF (526 KB)  ( 124 )
42 Clinical effects of Butylphthalide Soft Capsules combined with Atorvastatin Calcium Tablets in treatment of patients  with vascular dementia
JIANG Ying
Objective To observe the effect of Butylphthalide Soft Capsules combined with Atorvastatin Calcium tablets in  treatment of patients with vascular dementia. Methods From August 2014 to August 2016, in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, 80 vascular dementia (VD) patient were selected and divided into observation group (40 cases) and control group (40 cases) according to randomization envelope method. The control group was treated with oral Butylphthalide Soft Capsules Tablets therapy，and the observation group were treated with Atorvastatin Calcium Tablets on the basis of the control group. The patients in the each group were treated for 2 months，the clinical curative effect of two groups after treatment were observed and recorded. The related scale of mini-mental state examination (MMSE) and activities of daily living (ADL) were compared between the two groups of observed before and after treatment. Blood lipid levels and superoxide dismutase (SOD) activity levels were compared the two groups before and after treatment. Results After the treatment, the total effective rate of the observation group was significantly higher than the control group, the differences were statistically significant (P < 0.05). After the treatment, the scores of MMSE in two groups were higher than before treatment, and the scores of MMSE in the observation group were significantly higher than the control group, the differences were statistically significant (P < 0.05); the ADL scores in two groups were lower than before treatment, the ADL scores in the observation group was significantly lower than the control group, the differences were statistically significant (P < 0.05). Compared with before the treatment, the TC, TG and LDL-C levels after the treatment significantly improved, and these in the observation group was significantly better than the control group, the differences were statistically significant (P < 0.05); compared with before the treatment, there was no significant difference of HDL-C levels in the control group after the treatment, the difference was not statistically significant (P > 0.05), the HDL-C level in the observation group after the treatment was significantly higher, and this was significantly higher than the control group, the differences were statistically significant (P < 0.05). After the treatment, the activity of SOD in the two groups was higher than that before the treatment, and the activity of SOD in observation group was significantly higher than in the control group, the differences were statistically significant (P < 0.05). There was no obvious adverse reactions observed after treatment in two groups. Conclusion Butylphthalide Soft Capsules combined with Atorvastatin Calcium Tablets has significant clinica effect in VD patients，which can significantly improve the blood lipid level， increase the activity of SOD, and effectively improve VD symptoms in patients with dementia and mental state, improve the quality of life of patients.
2018 Vol. 15 (14): 42-46 [Abstract] ( 764 ) HTML (1 KB)  PDF (560 KB)  ( 97 )
47 Effects of Aspirin, Clopidogrel combined with Tirofiban on platelet activity and prognosis in acute coronary syndrome patients with PCI
SONG Wei LIN Zujin CAI Haipeng
Objective To analyze the effect of Aspirin and Clopidogrel combined with Tirofiban on prognosis and platelet activity in acute coronary syndrome patients with PCI. Methods From January 2016 to August 2017, in Taizhou Central Hospital, 80 patients with acute coronary syndrome treated with PCI were selected, according to random envelope method, they were divided into the observation group and the control group, with 40 patients in each group. The control group was treated with Aspirin and Clopidogrel, and the observation group was treated with Aspirin and Clopidogrel combined with Tironon. The level of hs-CRP, sCD40L and PAR in the blood of the patients were detected, the incidence of adverse reaction was analyzed. Results After treatment, the level of hs-CRP and sCD40L in the observation group was significantly lower than those in the control group, the differences were statistically significant (P < 0.05). On 12 h given drugs, 6 h after finished given drugs, the level of PAR in the observation group was lower than that in the control group, the differences were statistically significant (P < 0.05), the level of PAR in two groups before treatment, On 12 h given drugs, 6 h after finished given drugs were compared, the differences were statistically significant (P < 0.05), the level of PAR before treatment was the highest, and the level of PAR on 12 h given drugs was the lowest. The bleeding and thrombocytopenia complications in the observation group and the control group were comapred, the differences were not statistically significant (P > 0.05). Conclusion The use of Aspirin, Clopidogrel and Tirofiban in the treatment of PCI patients with acute coronary syndrome can effectively inhibit platelet activity and improve the quality of the patients' prognosis, it has high clinical value.
2018 Vol. 15 (14): 47-49,66 [Abstract] ( 232 ) HTML (1 KB)  PDF (904 KB)  ( 166 )
50 Effect of minimally invasive puncture drainage combined with craniotomy in the treatment of hypertensive cerebral hemorrhage with sudden cerebral hernia and its effect on cerebral blood flow and prognosis
LI Kuizhi LEI Guoliang ZHANG Chenggui
Objective To explore the effect of minimally invasive puncture drainage combined with craniotomy in the treatment of hypertensive cerebral hemorrhage with sudden cerebral hernia and its effect on cerebral blood flow and prognosis. Methods Clinical data of 96 hypertensive intracerebral hemorrhage patients with sudden brain hernia from October 2015 to October 2017 were collected. According to the different operation method, forty-eight cases of minimally invasive puncture and drainage befor the craniotomy evacuation of hematoma and decompressive craniectomy were selected as observation group, and 48 cases of conventional treatment before the craniotomy evacuation of hematoma and decompressive craniectomy as control group. The TCD parameters, curative effect, NHISS score, GOS score and BI value of two groups were observed and compared. Results The total effective rate of the observation group was 91.67%, was higher than that of the control group (75.00%), the difference was statistically significant (P < 0.05). Compared with before operation, there were significant differences in Vm and PI 7 days, 1 month and 3 months after operation of the two groups (P < 0.05), there were significant differences in Vm and PI 7 days, 1 month and 3 months after operation between the two groups (P < 0.05). GOS score of the observation group was better than that of the control group, and BI score 3 months after operation was significantly better than that of the control group, the differences were statistically significant (P < 0.05). Conclusion The curative effect and cerebral blood flow and prognosis of minimally invasive drainage combined with craniotomy for the patients of hypertensive cerebral hemorrhage with sudden cerebral hernia are better than conventional craniotomy. It is an effective method for the patients of hypertensive cerebral hemorrhage with sudden cerebral hernia.
2018 Vol. 15 (14): 50-53 [Abstract] ( 227 ) HTML (1 KB)  PDF (379 KB)  ( 77 )
54 Study on the application value of color Doppler ultrasound and MVD in the evaluation diagnostic of recurrent spontaneous abortion in patients with endometrial receptivit
ZOU Shuwei1 HAN Yanfeng2 WU Xiuying1▲
Objective To discuss on the application value of color Doppler ultrasound and MVD in the evaluation diagnostic of recurrent spontaneous abortion in patients with endometrial receptivit. Methods From December 2016 to December 2017, 61 cases of recurrent spontaneous abortion as the object in Maternal and Child Health Hospital of Wenling were selected and divided into pregnancy group (n = 25) and non-pregnancy group (n = 36) according to whether had pregnancy. All the patients underwent color doppler ultrasound examination and endometrial biopsy, endometrial blood flow distribution, hemodynamic parameters and endometrial microvessel density (MVD) between the two groups were compared. Results There were no significant differences in age, abortion frequency, BMI and estrogen levels between the two groups (t = 0.382, 0.257, 0.644, 0.152, 0.243, all P > 0.05). There were no significant difference in the endometrial thickness, endometrial volume, uterine artery PI, RI and S/D indexes (t = 0.416, 0.117, 0.416, 1.046, 0.240, all P > 0.05), but the levels of PI, RI and S/D in uterine spiral blood were significantly higher than the non-pregnant group (t = 2.927, 3.062, 4.195, all P < 0.05). There was statistically significant in the average MVD between two groups (t = 8.515, P < 0.05). Conclusion There is a certain clinical value in evaluating endometrial receptivity in patients with recurrent spontaneous abortion by transvaginal color doppler ultrasonography, they can predict the patients′ pregnancy outcome through the detection of helical artery blood flow parameters, can provide guidance for clinical treatment for patients with recurrent spontaneous abortion by endometrial examination.
2018 Vol. 15 (14): 54-57 [Abstract] ( 670 ) HTML (1 KB)  PDF (525 KB)  ( 163 )
58 Effect of laparoscopic myomectomy on serum levels change of IGF-Ⅰ, TSGF and prognosis in patients with uterine fibroids after operation
LIANG Nannan1 LIN Lin1 XI Yi′nan2 LI Haize3
Objective To observe the effect of laparoscopic myomectomy on the levels change of serum insulin-like growth factor-Ⅰ(IGF-Ⅰ), tumor specific growth factor (TSGF) and prognosis in patients with uterine fibroids after operation. Methods The clinical data of 113 uterine fibroids patients treated in the Department of Obstetrics and Gynecology in Tangshan Hongci Hospital from June 2014 to June 2016 were analyzed retrospectively and grouped according to different methods of operation, the observation group (57 cases) receiving laparoscopic myomectomy, and the control group (56 cases) receiving traditional laparotomy. The surgical conditions, complications, the levels of serum IGF-Ⅰ and TSGF before and 2 d after operation and the uterine morphology, menstrual outcome, recurrence conditions 1 year after the operation of two groups were compared. Results Compared with the control group, the blood loss in the observation group was lower, the time of hospitalization, the duration of anal exhaust and the time of getting out of bed were shorter, and the differences were statistically significant (P < 0.01).The incidence of postoperative complications in the observation group was lower than that in the control group, and the differences were statistically significant (P < 0.05). The levels of serum IGF-Ⅰ and TSGF after 2 d of operation in two groups were lower than those before the operation, and the observation group was lower than the control group, the difference was statistically significant (P < 0.05). The proportion of uterine morphology and menstruation turning to normal in the observation group was higher than that in the control group in the 1 year after the operation, and the difference was statistically significant (P < 0.05). There was insignificant difference in the recurrence rate between the observation group and the control group in the 1 year after the operation (P > 0.05). Conclusion Laparoscopic myomectomy in patients with uterine fibroids can significantly reduce the incidence of complications, promote the recovery of patients, and reduce the serum levels of IGF-Ⅰ and TSGF.
2018 Vol. 15 (14): 58-61 [Abstract] ( 208 ) HTML (1 KB)  PDF (552 KB)  ( 49 )
67 Curative effect analysis of Letrozole combined with Clomifene Citrate Capsules in the treatment of patients with polycystic ovary syndrome
YANG Ting WANG Jie YANG Lei
Objective To explore the effect of Letrozole combined with Clomiphene Citrate Capsules on patients with polycystic ovary syndrome. Methods Ninety PCOS patients with the treatment of ovulation in Baoji Fuyou Health Hospital from January 1st, 2013 to August 30th, 2017 were selected, patients were divided into three groups according to the different methods of treatment, 30 case in each groups. The control group was treated by Clomifene Citrate Capsules 50 mg/d, po, qd. The observation group 1 was treated by Letrozole 2.5 mg/d, po, qd, on the basis of the treatment of control group, while the observation group 2 was treated with Letrozole 5.0 mg/d, po, qd, all patients were treated for 5 days. On the 10th day of the menstrual cycle, the vaginal ultrasound was used to monitor follicular development and endometrial conditions, the thickness of uterine membrane, the number of mature follicle and the thickness of endometrium were recorded, the ovulation rate and pregnancy rate of each group were caculated. Levels of the LH, E2, T, FSH of the three groups were detected by chemiluminescent immunoassay. Results The thickness of uterine membrane of observing group 1 and observing group 2 was higher than that of control group at HCG day, the number of mature follicle and palace film thickness of the observation group 1 and 2 were obviously higher than those of the control group, the ovulation rate and pregnancy rate of observation group 1 and 2 was higher than the control group, the differences were statistically significant (P < 0.05). The ovulation rate and pregnancy rate of observation group 2 was higher than the observation group 1, the difference was statistically significant (P < 0.05). On HCG injection day, levels of LH and T in the observation group 1 and 2 were higher than that of the control group, level of E2 was lower than that of the control group, the differences were statistically significant (P < 0.05). The level of FSH in the observation group 2 was lower than that in the control group, and the level of E2 was lower than that of observation group 1, the differences were statistically significant (P < 0.05). Conclusion Letrozole combined with Clomifene Citrate Capsules can increase the thickness of uterine membrane of patients with polycystic ovary syndrome, improve the ovulation rate and pregnancy rate, and the effect of 5.0 mg/d Lytrizole combined with Clomifene Citrate Capsules has more obvious effect.
2018 Vol. 15 (14): 67-70 [Abstract] ( 257 ) HTML (1 KB)  PDF (527 KB)  ( 108 )
71 Evaluation and application of nutritional and immune status in the perioperative period of colorectal cancer
GUO Fei1 ZHANG Xiaoyang2 LV Yanqin1 WU Xueliang1 SUN Guangyuan1 LI Minghui1 XUE Jun1▲
Objective To analyze the perioperative nutritional and immune status of colorectal cancer, and to provide evidence for clinical application. Methods From January 2014 to 2016 December, 100 cases of rectal cancer treated in the First Affiliated Hospital of Hebei North University were divided into intervention group and control group with random envelopes, with 50 cases in each group. The control group was treated with routine intervention, and the intervention group was intervened with nutritional support scheme. One d and 7 d before operation, 1, 4, 8 d and 15 d after operation. The levels of CD3+ T cells, CD4+ T cells, CD8+ T cells, IgG, IgA, IgM, ALB, PA, Hb and TF were counted, and the incidence of adverse reactions was statistically analyzed. Results Compared with 1 d before operation, the proportion of CD3+ and CD4+ T cells of the two groups was significantly decreased at 1 d after the operation, and the proportion of CD8+ T cells was significantly higher than that of 1 d before the operation, the differences were statistically significant (P < 0.05). The proportion of CD3+ and CD4+ T cells in the intervention group was significantly higher than those of the control group, and the CD8+ T cells was significantly lower than that of the control group, the differences were statistically significant (P < 0.05). One day after the operation, the levels of IgG, IgA and IgM of the two groups were lower than those 1 d before the operation, and the differences were statistically significant (P < 0.05), 4 d after the operation. The level of standard mean improvement of two groups was significantly higher than that of 1 d after operation (P < 0.05), and the level of IgG, IgA and IgM in the blood of the intervention group was significantly higher than that of the control group at 15 d after the operation, and the difference was statistically significant (P < 0.05). The levels of ALB, PA, TF and Hb of the two groups were significantly lower than those of 1 d before the operation, and the difference was significantly lower than the 1 d before the operation, the differences were statistically significant (P < 0.05). Four days after the operation, each index in the two groups were better than 1 d after the operation, the differences were statistically significant (P < 0.05), and the levels of ALB, PA, TF and Hb of the intervention group were significantly higher than those of the control group at 15 d after the operation, and the differences were statistically significant (P < 0.05). The total incidence of reaction was significantly lower than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Nutrition supplementation in the perioperative period of colorectal cancer patients can effectively improve the nutritional and immune status of the patients and reduce the incidence of adverse reactions in patients.
2018 Vol. 15 (14): 71-75 [Abstract] ( 210 ) HTML (1 KB)  PDF (534 KB)  ( 59 )
76 The relationship between the expressions of aldehyde dehydrogenase 1, breast cancer resistance protein in breast cancer tissues and pathological features of breast cancer
LIANG Faqing1 DU Zhenggui1 HE Yangjun2
Objective To investigate the relationship between aldehyde dehydrogenase 1 (ALDH1), breast cancer resistance protein (BCRP) expressions in tumor tissues and pathological features of breast cancer. Methods From January 2013 to March 2016, 84 patients with breast cancer in West China Hospital of Sichuan University and the normal breast tissues (adjacent tissues) which was used for control group is defined as the edge of cancer tissueedge greater than 1 cm were selected. The expression of ALDH1 and BCRP protein was detected by immunohistochemistry. Results The expression rates of ALDH1 and BCRP protein in breast cancer tissues were significantly higher than those in adjacent tissues (P < 0.01). The positive rates of ALDH1 and BCRP protein expression in patients with axillary lymph node metastasis were significantly higher than those in patients without axillary lymph node metastasis (P < 0.05). The positive rate of BCRP protein expression in estrogen receptor (ER) positive patients was significantly higher than that in ER negative patients (P < 0.05). The expression of ALDH1 and BCRP protein was not correlated with age, menopause, tumor size, histological grade, TNM stage and progesterone receptor (PR) (P > 0.05). There was no correlation between the expression of ALDH1 and BCRP protein in breast cancer (rs=-0.092, P > 0.05). Conclusion ALDH1 and BCRP may play an important role in the development of breast cancer, which may be involved in the tumor invasion, metastasis etc.
2018 Vol. 15 (14): 76-79 [Abstract] ( 237 ) HTML (1 KB)  PDF (522 KB)  ( 69 )
80 Expression of MTSS1 and SOX2 in colon cancer tissue and its relationship with clinicopathological characteristics
LIU Qingbin1 CHEN Yanxin2 XIAO Fang2 ZHOU Ying2 ZHANG Hui2
Objective To analyze the relationship between the expression of MTSS-1 and SOX2  and clinicopathological in colon cancer. Methods From January 2016 to June 2017, 80 cases colon cancer patients， who were treated in Qinhuangdao City No.1 Hospital were selected as the research object， the levels of MTSS1 and SOX2 expression were tested by two step immunohistochemical method， and the clinical and pathological features of MTSS1 and SOX2 expression correlation were analyzed. Results The positive expressions of MTSS1 and SOX2 protein in colon cancer tissues were significantly lower than the adjacent contiguous zone, the differences were statistically significant (P < 0.01). The  positive expressions of MTSS1 and SOX2 were significant difference between the deposit rate of different degree of differentiation, lymph node metastasis and Dukes staging of cancer tissue, the differences were statistically significant（P < 0.01）. The degree of differentiation was the risk factor of MTSS1 positive expression （P < 0.05）. The degree of differentiation and lymph node metastasis were risk factors of positive expression of SOX2 （P < 0.05）. Conclusion The expression of MTSS1 and SOX2 in colon cancer tissues is closely related to the degree of differentiation， and the lymph node metastasis is significantly related to the expression of SOX2.
2018 Vol. 15 (14): 80-82 [Abstract] ( 218 ) HTML (1 KB)  PDF (490 KB)  ( 100 )
83 Clinical diagnosis and genetic mutation analysis of hereditary medullary thyroid carcinoma with CEA levels abnormal elevation as the initial clinical manifestation 
ZHANG Gang CHEN Yi XU Yan
In clinical work, patients with abnormal serum CEA (carcino-embryonic antigen) levels increased at first visit, in the conventional examination showed no signs of tumor, easily missed diagnosis of medullary thyroid carcinoma. PET/CT (positron-emission tomography/computer tomography) can provide clues for early localization of lesions. A case of abnormal increase of serum CEA level for the first time treated in Daping Hospital, the Army Military University, first of gastrointestinal tumors for examination had no system signs of tumor, further PET/CT examination revealed thyroid lesions. The postoperative pathology proved to be a thyroid medullary carcinoma. Further RET proto oncogene detection suggested that p.Cys634Tyr heterozygote mutation, two members of the family carrying the gene mutation. Both parathyroid hyperplasia and adrenal hyperplasia were found at the same time. The clinical manifestations of family patients may be in line with familial hereditary medullary thyroid carcinoma or multiple endocrine neoplasm type 2A (Family medullary thyroid carcinom/Multiple endocrine neoplasia type 2A; FMTC/MEN2A).
2018 Vol. 15 (14): 83-85,101 [Abstract] ( 203 ) HTML (1 KB)  PDF (893 KB)  ( 142 )
86 The relationships in plasma uric acid levels between patients with Parkinson disease and rapid-eye-movement sleep behavior disorder
LIU Jianghong1* LI Kai2* LI Ning1 DING Yan1 ZHANG Lichun3 ZHAI Yi1 WANG Yuping1 ZHAN Shuqin1▲
Objective To investigate the relationships in plasma uric acid levels between patients with Parkinson disease (PD) and rapid-eye-movement sleep behavior disorder (RBD). Methods Thirty-nine patients with idiopathic RBD (iRBD group), 43 patients with PD (PD group) and 128 healthy controls (healthy control group) were collected from Xuanwu Hospital, Capital Medical University from March 2016 to March 2017. All patients with iRBD were confirmed by clinical assessment and polysomnography. Subjects' plasma uric acid levels were measured. Two-way analysis of variance was used to examine abnormalities in uric acid levels in patients with iRBD and PD. Results The levels of serum uric acid in the iRBD group [(346.5±38.3) mmol/L] were significantly higher than that of the PD group [(236.5±49.8) mmol/L] and the healthy control group [(331.0±39.8) mmol/L], the differences were all statistically significant (P ＜ 0.01). But there was no significant difference between the PD group and the healthy control group (P ＞ 0.05). Conclusion Uric acid levels in PD patients are lower than those in healthy subjects and RBD patients, suggesting that low uric acid level may be a biological marker of PD.
2018 Vol. 15 (14): 86-88 [Abstract] ( 212 ) HTML (1 KB)  PDF (605 KB)  ( 72 )
89 Effect of sequential non-invasive ventilation for acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure
ZHONG Chunmiao JI Zhaohui ZHOU Pingping HU Xianquan FU Kai
Objective To explore the clinical value of noninvasive ventilation sequential (NIPPV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure. Methods One hundred and twenty patients with AECOPD complicated with respiratory failure treated in the First People's Hospital of Huzhou City from July 2015 to July 2017 were selected and they were divided into two groups by random number table, with 60 cases in each group. The control group received conventional invasive positive pressure ventilation (IPPV) and the observation group received NIPPV support. Clinical indicators, vital signs, N-terminal pro-brain natriuretic peptide (NT-proBNP), pulmonary infection and health status were compared between the two groups. Results The durations of intensive care, total duration of mechanical ventilation and invasive ventilation in the observation group were all shorter than those in control group, with statistically significant differences (P ＜ 0.05). In observation group, the re-intubation rate was 3.33% (2/60) and the incidence of ventilator-associated pneumonia (VAP) was 3.33% (2/60), while in the control group, the re-intubation rate was 15.00% (9/60) and the incidence of VAP was 16.67% (10/60), the differences between the two groups were statistically significant (P ＜ 0.05). The levels of heart rate (HR), respiratory rate (RR) and partial pressure of carbon dioxide (PaCO2) in the observation group were lower than those in the control group, and the levels of pH and partial pressure of blood oxygen (PaO2) were higher than those in the control group (P ＜ 0.05). Before treatment, the levels of NT-proBNP, clinical pulmonary infection score (CPIS) and acute physiology and chronic health evaluation (APACHE-Ⅱ) scores of lung infection in the two groups showed no significant differences (P ＞ 0.05). After treatment, the levels of NT-proBNP, CPIS and APACHE-Ⅱ scores in the observation group were lower than those in the control group, with significant differences (P ＜ 0.05). Conclusion For patients with AECOPD complicated with respiratory failure, NIPPV can help to shorten the ventilation duration, improve their vital signs, reduce the risk of lung infection, maintain good health status and enhance the clinical efficacy.
2018 Vol. 15 (14): 89-92,106 [Abstract] ( 192 ) HTML (1 KB)  PDF (599 KB)  ( 112 )
93 Correlation study of high frequency ultrasonography in early diagnosis and laboratory index of rheumatoid arthritis
XU Jun FENG Zhipeng MA Yan TENG Shaohua WANG Yinqi LONG Xiaona PENG Hongying
Objective To explore the value of early diagnosis of high frequency ultrasound (HF) on rheumatoid arthritis (RA), and analyze its correlation with the laboratory index. Methods Forty-five cases of RA [according to 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria] treated in the Affiliated Baiyun Hospital of Guizhou Medical University and Affiliated Hospital of Guizhou Medical University from June 2014 to June 2017 were analyzed retrospectively. During the same period, 45 cases with at least one joint synovitis, not diagnosed with RA were selected as non-RA control group. HF was used to observe 28 joints in both group, including hydrops articuli, synovial thickness, blood flow signals and bone erosion, and the 4 indicators were semi quantitative scored (0-3 scores). The ultrasonic scores were the sum of 28 joints, then the ultrasonic scores of 2 groups were compared. At the same time, rheumatoid factor (RF), anti cyclic citrullinated peptide antibody (anti-CCP), CRP and erythrocyte sedimentation rate (ESR) were detected. Spearman correlation analysis was used to evaluate the correlation between ultrasonic scores and the laboratory indices. Results ①Compared with non-RA group, joint effusion, synovial thickness, blood flow signals, bone erosion and ultrasonic scores of RA group were increased significantly (P ＜ 0.05); ②compared with non-RA group, the RF, anti-CCP, CRP and ESR of RA group were also significantly increased (P ＜ 0.05); ③in non-RA group there was no significant correlation of the ultrasonic scores with RF, anti-CCP, CRP and ESR (P ＞ 0.05), while the ultrasound scores in RA group were positively correlated with RF, anti-CCP and ESR (P ＜ 0.05). Conclusion HF can detect early lesions in RA diagnosis, and has a significantly positive correlation with laboratory indices as RF, anti-CCP, CRP and ESR. It can be used as an effective method for RA early diagnosis.
2018 Vol. 15 (14): 93-96 [Abstract] ( 222 ) HTML (1 KB)  PDF (804 KB)  ( 168 )
97 Clinical research of aerosol inhalation of Budesnide combined with Compound Ipratropium Bromide in the treatment of patients with perioperative pneumoconiosis
MAI Zijian1 YUAN Liling2 ZHAO Jian3
Objective To investigate the effects of aerosol inhalation of Budesonide combined with Compound Ipratropium Bromide in the treatment of patients with perioperative pneumoconiosis. Methods One hundred and thirty-nine patients with pneumoconiosis admitted to Guangzhou Twelfth People's Hospital Affiliated to Guangzhou Medical University from January 2014 to February 2017 were enrolled in this study, and they were divided into control group (69 cases) and treatment group (70 cases) by random number table method. Both groups were treated by whole-lung lavage (WLL) under general anesthesia. The treatment group was treated with aerosol inhalation of Budesnide combined with Compound Ipratropium Bromide during the period of 3 days before treatment and 3 days after treatment. The comprehensive score of clinical symptoms, lung function index, blood gas index and the sputum tumor necrosis factor -α (TNF-α), interleukin-1 (IL-1) levels of the two groups during the period of 3 days before treatment and 7 days after treatment were compared between the two groups. The adverse reactions during the treatment of the two groups were recorded. Results The comprehensive score of clinical symptoms of the two groups after treatment were significantly lower than those before treatment, the forced vital capacity (FVC), forced expiratory volume in one second (FEV1) of the two groups after treatment were significantly higher than those before treatment, and the improvement of comprehensive score of clinical symptoms, FVC, FEV1 in the treatment group was significantly better than those of the control group (P ＜ 0.05). The partial pressure of blood oxygen (PaO2) of the two groups after treatment were significantly higher than those before treatment, the arterial partial pressure of carbon dioxide (PaCO2) of the two groups after treatment were significantly lower than those before treatment, and the changes of PaO2, PaCO2 after treatment in the treatment group were significantly better than those of control group, the differences were statistically significant (P ＜ 0.05). The levels of sputum TNF-α, IL-1 in the two groups after treatment were significantly lower than those before treatment, and the levels of sputum TNF-α, IL-1 after treatment in the treatment group were significantly lower than those of the control group (P ＜ 0.05). The incidence of adverse reactions of hyoxemia, airway spasm, airway pressure increasing of the treatment group was significantly lower than that of the control group during the treatment, the difference was statistically significant (P ＜ 0.05). Conclusion Aerosol inhalation of Budesonide combined with Compound Ipratropium Bromide in the treatment of patients with pneumoconiosis who were given WLL can improve clinical efficacy of WLL, relieve clinical symptoms, improve pulmonary function and SpO2, decrease the levels of sputum inflammatory factors and reduce the occurrence of adverse reactions, and it is worthy of clinical promotion and application.
2018 Vol. 15 (14): 97-101 [Abstract] ( 190 ) HTML (1 KB)  PDF (590 KB)  ( 69 )
102 The significance of C677T mutation in type 2 diabetes mellitus combined with macrovascular complications
WANG Jinhui1 WANG Feifei1 LI Weimin2▲
Objective To investigate the possible association between MTHFR gene C677T mutation and type 2 diabetes mellitus (T2DM) combined with macrovascular complications. Methods Clinical data of 380 T2DM patients (218 simple T2DM and 162 T2DM patients with macrovascular complications) and 306 healthy controls were selected from the First Hospital of Harbin from October 2015 to January 2017. Blood genomic DNA was separated and the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) assay was used for genotyping of the MTHFR gene C677T mutation. Results The frequencies of TT genotypes and T alleles of the C677T mutation in MTHFR gene in T2DM patients with macrovascular complications were statistically significantly higher than those of simple T2DM patients (P < 0.01). The homocysteine level in genotypic TT patients was significantly higher than that of genotype CT and CC patients (P ＜ 0.05, P ＜ 0.01). Conclusion The combination of T2DM with macroangiopathy may be related with the mutation of the MTHFR gene C677T.
2018 Vol. 15 (14): 102-106 [Abstract] ( 709 ) HTML (1 KB)  PDF (1027 KB)  ( 47 )
107 Effect of photon rejuvenation technology combined with Compound Cortex Phellodendri Liquid in the treatment of patients with facial corticosteroid addictive dermatitis
SU Chunzhi LI Chaowei ZENG Zhouping
Objective To explore the effect of photon rejuvenation technology combined with Compound Cortex Phellodendri Liquid in the treatment of patients with facial corticosteroid addictive dermatitis (FCAD). Methods Ninety-six cases of patients diagnosed as FCAD in Department of Dermatology, Gaozhou People's Hospital from June 2015 to May 2017 were randomly divided into 3 groups, with 32 patients in each group. The Cortex Phellodendri group was treated with Compound Cortex Phellodendri Liquid combined with Tacrolimus Ointment. The photon group was treated with Tacrolimus Ointment combined with photon rejuvenation technology. The combination group was treated with photon rejuvenation technology combined with tacrolimus ointment and Compound Cortex Phellodendri Liquid. The course of treatment was 8 weeks. Skin barrier function indices [transepidermal water loss (TEWL), the moisture and oil contents of skin], the therapeutic effect after treatment and the scores of dermatology life quality index (DLQI) before and after treatment were compared among the 3 groups. The therapeutic effects after treatment of the 3 groups were compared. The adverse reactions during treatment and relapse situation after treatment with a 8-week follow-up were recorded and compared. Results There were significant differences in the values of skin barrier function indices, the scores of DLQI and the therapeutic effect after treatment among the 3 groups (P ＜ 0.05). After treatment, TEWL score of the combination group was lower than the photon group and Cortex Phellodendri group, while the photon group was lower than the Cortex Phellodendri group (P ＜ 0.05). Moisture and oil contents of skin, the therapeutic effect distribution after treatment of the combination group were higher than the photon group and Cortex Phellodendri group, while the photon group was higher than the Cortex Phellodendri group, while the scores of DLQI of the combination group were lower than the photon group and Cortex Phellodendri group, which of photon group were lower than those of Cortex Phellodendri group (P ＜ 0.05). There were no statistically significant differences of adverse reactions among three groups (P ＞ 0.05). There was no recurrence situation in a 8-week follow-up after treatment among three groups. Conclusion The photon rejuvenation technology combined with Tacrolimus Ointment and Compound Cortex Phellodendri Liquid in the treatment of FCAD has obvious effect, which can significantly improve the skin barrier function and the quality of life. The treatment is safe and worth of clinical promotion.
2018 Vol. 15 (14): 107-110 [Abstract] ( 199 ) HTML (1 KB)  PDF (623 KB)  ( 114 )
111 The data-mining of ADR signals for Sorafenib
ZHOU Jian1 CHEN Li2
Objective To excavate the adverse drug reaction signals of molecular targeted antitumor drug Sorafenib, in order to provide references for safety medicinal practice. Methods Conduct data-mining on the reporting odds ratio (ROR) and proportional reporting ratio (PRR) in measures of disproportionality to the reports in 17 quarters (Q4, 2012 -Q4, 2016) in FDA Adverse Event Reporting System (FAERS). Results Seven hundred and seventy-seven Sorafenib adverse drug reaction signals were obtained with ROR and PRR methods. After the secondary screening, 68 Sorafenib adverse drug reaction signals were obtained, which were mainly concentrated in tumors, hepatobiliary, gastrointestinal and skin diseases. Conclusion In this study, ROR and PRR are effectively used to extract the adverse drug reaction signals of Sorafenib. It is recommended that the appropriate attentions should be paid to the possible adverse reactions caused by Sorafenib.
2018 Vol. 15 (14): 111-115 [Abstract] ( 176 ) HTML (1 KB)  PDF (440 KB)  ( 112 )
116 The influence of comprehensive intervention in antibiotic application during perioperative period of clean operation of primary hospitals
XIA Rongfen
Objective To explore the influence of comprehensive intervention in antibiotic application during perioperative period of clean operation of primary hospitals. Methods A total of 210 sample of the three typical typeⅠincisions in Yi′nan People′s Hospital of Linyi City (for short “our hospital”) from July to December 2016 was selected as control group. In addition, total of 210 sample of the three most typical typeⅠincisions from our hospital from July to December 2017 were selected as intervention group. The control group was given to routine perioperative prophylactic use of antibiotics, the intervention group was given to comprehensive intervention based on the control group. The general situation of prophylaxis drugs use, timing of prophylaxis antimicrobial drugs use, type of antimicrobial drugs use and the postoperative adverse reactions were compared. Results The utilization rate of antibacterial drugs in the intervention group was lower than that in the control group (P < 0.01). The rational use of the intervention group was superior to the control group (P < 0.05). There were 4 classes of 9 kinds of antibiotics in the control group, including Cephalosporins of 123 cases (67.2%), beta lactam/beta lactamase inhibitor of 37 cases (20.2%), the Penicillin of 18 cases (9.8%), monocyclic beta lactam of 5 cases (2.8%). There were involved 3 class of 9 kinds of antibiotics in the intervention group, in which, the use of cephalosporins rate increased significantly compared with the control group (92.0%), the use of beta lactam/beta lactamase inhibitor and penicillin class had declined significantly (4.0%, 4.0%), monocyclic beta lactam type (i.e., ammonia QuNa) was no use. The cases were all recovered after intervention, and there were no secondary infections and severe adverse reactions associated with the drug. Conclusion Through comprehensive intervention, the use of antibacterial drugs in our hospital has reduced obviously, and the timing of prevention is reasonable. But there are still parts of the problem, it still needs to continue to strengthen the intensity of intervention and regulation, to make antibiotic application during perioperative period of clean operation of primary hospitals tend to be more rationalization and standardization.
2018 Vol. 15 (14): 116-119 [Abstract] ( 167 ) HTML (1 KB)  PDF (431 KB)  ( 58 )
120 Application effect of enhanced recovery at perioperative period of laparoscopic pancreaticoduodenectomy 
WANG Huixin1 ZHANG Guangqing1▲ ZHOU Chunjiao2 LIN Lijun3 YU Wenqi4 CHEN Guihao3 CAI Bingqin2
Objective To study the application effect of enhanced recovery after surgery (ERAS) for laparoscopic pancreatoduodenectomy (LPD) patients. Methods From July 2013 and March 2017, in Guangdong Provincial Hospital of Traditional Chinese Medicine, the clinical data of 85 patients who underwent LPD were analyzed retrospectively. The 43 patients treated with ERAS measures were as ERAS group, and the 42 treated with conventional program were as control group. The intraoperative and postoperative situation were compared. Results There was no statistically significant difference in operation time and operative blood loss, rates of special complication, the operative mortality and relaparotomy in two groups (P > 0.05). Comapred with control group, the time of postoperative first flatus was earlier, postoperative length of stay and total length of stay were less, rate of overall complication was less in ERAS group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion The ERAS pathway is effective and safe for LPD patients.
2018 Vol. 15 (14): 120-123 [Abstract] ( 208 ) HTML (1 KB)  PDF (658 KB)  ( 104 )
124 Influence of traditional Chinese medicine comprehensive nursing intervention on patients with severe sepsis and gastrointestinal dysfunction
OUYANG Honglian LIAN Qiaolan FENG Weiyan DENG Linna
Objective To investigate the effect of traditional Chinese medicine comprehensive nursing on severe sepsis patients with gastrointestinal dysfunction. Methods From November 2016 to August 2017, in ICU, Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 80 severe sepsis patients with gastrointestinal dysfunction were selected, and they were divided into convention group and comprehensive group according to the random number table method, with 40 cases in each group. Conventional nursing was applied to the patients in the convention group, and the comprehensive nursing was applied to the comprehensive group on the basis of conventional nursing. The effect and influence of clinical intervention on patients of the two groups were compared. Results There was no statistically significant difference in APACHE-Ⅱ scores of two groups on 1st, 3rd day (P > 0.05), and the APACHE-Ⅱ scores decreased significantly with the prolongation of treatment time, on 7th day APACHE-Ⅱ scores of comprehensive group was significantly better than that of the convention group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference in the comfort score and sleep quality index of the two groups before intervention (P > 0.05), and after intervention, the comfort score and sleep quality index in the comprehensive group were better than those in the convention group, and the differences were statistically significant (P < 0.05). There was no statistically significant difference in pH and abdominal pressure of two groups before intervention (P > 0.05), after intervention, the pH and abdominal pressure of gastrointestinal mucosa in the comprehensive group were better than those in the convention group, the differences were statistically significant (P < 0.05). The hospitalization time, total hospitalization time and hospitalization expenses of the patients in the comprehensive group were less than those in the convention group, the differences were statistically significant (P < 0.05). After intervention, the total effective rate of gastrointestinal function improvement in the comprehensive group were higher than that in the convention group, the difference was statistically significant (P < 0.05). Conclusion After the intervention of traditional Chinese medicine, the clinical effect of patients significantly is improved, and the satisfaction degree of patients is improved. the intra-abdominal pressure, gastric acid pH and gastrointestinal function returnes to normal level, it is helpful to reduce their economic burden, and it is worthy of clinical promotion and application.
2018 Vol. 15 (14): 124-128 [Abstract] ( 198 ) HTML (1 KB)  PDF  (0 KB)  ( 46 )
129 Influence of KAP intervention model combined with beck cognitive therapy on postoperative negative emotion and quality of life in patients with giant cell tumor of distal radius
SHI Jingjing HUANG Yanpeng HU Jiejing DONG Xuehong LU Xiaoqin DAI Qinguyu▲ HUANG Jianming
Objective To investigate the influence of KAP intervention model combined with Beck cognitive therapy on postoperative negative emotion and quality of life in patients with giant cell tumor of the distal radius. Methods From March 2014 to April 2017, in 174th Hospital of PLA, 46 patients with giant cell tumor of the distal radius were selected. They were divided into two groups according to the order of admission time, with 23 cases in each group. The two groups treated with fibula transplantation with vascular pedicle, the control group was given Beck cognitive therapy, and the experiment group was given KAP intervention model combined with Beck cognitive therapy. The nursing satisfaction of two groups was counted. The negative emotion [depression (HDMA), anxiety (HAMA)] and quality of life scores in the two groups before and after intervention were compared. Results There was no statistically significant difference in the negative emotion and quality of life scores between the two groups before intervention (P > 0.05). Compared with the control group, the scores of HDMA and HAMA were lower in the experiment group, and the scores of quality of life in each dimension were higher in the experiment group, the differences were statistically significant (P < 0.05). The nursing satisfaction in the experiment group was higher than the control group, the difference was statistically significant (P < 0.05). Conclusion The KAP intervention mode combined with Beck cognitive therapy in the treatment of giant cell tumor of the distal radius can improve the negative emotion and quality of life significantly, and it can further improve the nursing satisfaction. 
2018 Vol. 15 (14): 129-131,136 [Abstract] ( 267 ) HTML (1 KB)  PDF (667 KB)  ( 88 )
132 Construction on intervention model of personalized comfort nursing and narrative care in perioperative period of patients with excision of parotid tumor
TONG Junping1 WANG Ning2▲ LI Jing3 DONG Chuang4 LI Ning1
Objective To investigate the effect on construction of the intervention model of personalized comfort nursing and narrative care in perioperative period of patients with excision of parotid tumor. Methods From January 2014 to September 2017, in China National Petroleum Corporation Central Hospital, 96 patients undergoing elective general anaesthesia operation of parotid tumor were selected, according to the random number table method, they divided into usual ursing group (control group) and personalized comfort nursing combined with narrative care group (experiment group), with 48 cases in each group. the control group was given with usual care during the perioperative period, based on which the experiment group was implemented with the intervention model of personalized comfort nursing combined with "narrative care" for psychological care, then Zung anxiety and depression self-rating scale (SAS and SDS), KPS marking criterion and self-identity scale were used separately to evaluate the conditions of anxiety and depression, quality of life, sense of self-identity of all patients before and after  operation 1 week, patients′ complications after operation 1 week were conducted, the questionnaire on satisfaction to nursing was handed to the patients′ relatives and had a statistics. Results After surgery 1 week, the scores of SAS, SDS and sense of self-identity in the experiment group were significantly better than the control group, the differences were statistically significant (P < 0.05), the scores of SAS in two groups were lower than before operation, the differences were statistically significant (P < 0.05); socres of SDS in the experiment group were significantly lower than before operation, the differences were statistically significant (P < 0.05), there was no those statistically significant difference in the control group (P > 0.05); KPS increasement point in the experiment group was obviously higher than the control group, the differences were statistically significant (P < 0.05); compared with before operation, the scores of sense of self-identity only in the experiment group increased, the differences were statistically significant (P < 0.05), the Cronbach′s α of self-identity Scale was 0.85 after reliability analysis; the incision infection rate in the experiment group was lower than the control group, the difference was statistically significant (P < 0.05); the satisfaction of patients′ relatives in the experiment group was higher than the control group, the difference was statistically significant (P < 0.05). Conclusion During the process of providing nursing to the patients undergoing resection of parotid tumor, the implementation of personalized comfort nursing and narrative care may significantly improve the emotion of anxiety and depression and comfort degree, as well raise the quality of life and sense of self-identity of patients, meanwhile, reduce the postoperative incision infection rate, as well as greatly enhance the satisfaction of patients’ family members.
2018 Vol. 15 (14): 132-136 [Abstract] ( 140 ) HTML (1 KB)  PDF (665 KB)  ( 125 )
137 Application effect of childlike nursing intervention on polysomnography in preschool obese children
WEN Yumin LI Jiangli ZHAO Huadian HUANG Caifen
Objective To explore the application effect of playful nursing intervention on the improvement of polysomnography in pre-school children with obesity. Methods From June 2016 to October 2017, in Affiliated Hospital of Youjiang Medical University for Nationalities, 100 pre-school children with obesity received overnight sleep breathing monitoring were selected, according to random number table method, they were divided into study group and control group, with 50 cases in each group. The control group was given routine sleep monitoring and nursing, while the observation group was added the child-care intervention on the basis of the control group. And then, the degree of anxiety, success rate of sleep monitoring and satisfaction of family members before the intervention and during sleep monitoring were evaluated. Results There was no statistically significant difference in anxiety scores between the two groups one day before monitoring (P > 0.05). The anxiety scores in two groups were significantly higher than those before monitoring, the differences were statistically significant (P < 0.01), and that of the control group was higher than study group, the difference was statistically significant (P < 0.01). The success rate of sleep monitoring in the study group was higher than the control group, the difference was statistically significant (P < 0.05). The satisfaction degree of the family members in the study group was higher than that of the control group, the difference was statistically significant (P < 0.01).  Conclusion The implementation of playful nursing intervention in polysomnography of pre-school children with obesitycan effectively alleviate the anxiety level during sleep monitoring, improve the success rate of sleep monitoring and the satisfaction of family members, it is worth to be popularized.
2018 Vol. 15 (14): 137-140 [Abstract] ( 196 ) HTML (1 KB)  PDF (648 KB)  ( 58 )
141 Influence of rapid rehabilitation surgery nursing on postoperative complications, physical function and self-efficacy of patients with lumbar disc herniation
LI Guoping1 WANG Chenglian2▲ YIN Fang3 ZHU Xianyuan4 LIU Jing3 WANG Lijuan5
Objective To discuss the influence of rapid rehabilitation surgery nursing on postoperative complications, physical function and self-efficacy of patients with lumbar disc herniation. Methods From January 2014 to December 2015, in Weifang NO.2 People's Hospital, 98 patients with waist dish outstanding surgery were selected, according to random number table method, they were divided into control group and observation group, with 49 cases in each group, the control group was given routine nursing care, the observation group was given rapid rehabilitation surgery nursing on the bassis of control group, the perioperative indexes, postoperative complications and limb function improvement and life quality in two groups were compared. Results The anus exhausting time, eating time, postoperative walking time, postoperative hospitalization time in the observation group were less than those in the control group, the differences were statistically significant (P < 0.05). The incidences of incisional infection, pulmonary infection, urinary tract infection and lower extremity deep venous thrombosis were less than those in the control group, the differences were statistically significant (P < 0.05). After nursing 3 mooths, JOA score, quality of life scores and self-efficacy scores in two groups were higher than before nursing, and these in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Rapid rehabilitation surgery nursing using in lumbar disc herniation can reduce the incidence of postoperative complications, promote the improvement of limb function and improve the quality of life.
2018 Vol. 15 (14): 141-145 [Abstract] ( 180 ) HTML (1 KB)  PDF (658 KB)  ( 59 )
146 A case of tri-allele in TPOX was detected using Goldeneye 20A Kit for the first time
ZHOU Danhua1,2* HU Xijie1,2* ZHANG Tao1,2 WAN Weihong1,2 YU Jian2 LIU Zulin1,2 YU Limei1,2
This article reports one case of tri-allele detected in the TPOX locus of a child in duos. The Goldeneye 20A kit was used for detecting. The 3500DX genetic analyzer was used for electrophoresis and Genemapper genotyping software was used confirm its genotyping (8, 9, 11). When the tri-allelic gene is detected in the paternity test, under the premise of eliminating contamination, at least two kits are required to confirm the test to ensure the reliability of the identification and PI calculation. In order to improve the accuracy of the case report, the tri-allele test, the peak type analysis, the classification and judgment and the confirmation should be handled with care so that provides basic information for the analysis of the possible mechanisms of tri-allele.
2018 Vol. 15 (14): 146-148 [Abstract] ( 256 ) HTML (1 KB)  PDF (291 KB)  ( 123 )
149 The influence of confucianism for the development of the traditional health-care P.E. course of universities of Chinese medicine
WANG Bin1 SUN Rong2 HU Jun3 WU Zhikun1 GONG Bomin1
Traditional health-care P.E. course is the precious cultural heritage in our country. It is the characteristics course of universities of Chinese medicine. The article mainly discusses the Confucianism positive impact on the development of traditional health-care P.E. course of universities of Chinese medicine from the aspects of benevolence, righteousness, courtesy, wisdom and trust. The research suggests that Confucianism has laid a theoretical ethical and moral foundation for the traditional health-care P.E. course development.
2018 Vol. 15 (14): 149-152 [Abstract] ( 172 ) HTML (1 KB)  PDF (657 KB)  ( 116 )
153 Application status and countermeasures analysis of previewing triage in the outpatient management in general hospital
HU Yujie LI Ping YE Ling ZHANG Manli

Outpatient triage work is the first link and an important aspect of outpatient service. The accuracy and timeliness of triage work not only directly affect the quick and effective treatment, but also directly reflect the overall image of the outpatient and the professional skill of the nurses. This article reviews the status, existing problems, management mode of current hospital outpatient triage, to discuss outpatient triage work effect of improving clinic work efficiency, ensuring the treatment safety and promoting patients satisfaction, so as to provide a basis for building general hospitals' outpaitient triage management mode of general hospital and improving patients′ satisfaction of treatment.
2018 Vol. 15 (14): 153-156 [Abstract] ( 267 ) HTML (1 KB)  PDF (712 KB)  ( 114 )
157 Organization management and implementation of traditional Chinese medicine information standard research and development project
ZHANG Yiran1 ZHU Jiaqing2
The standardization of information in TCM is the premise and foundation for TCM informatization. In 2015, the national treasury allocated 10 million special funds to support 101 TCM information standard projects. This article introduces 101 TCM information standard project construction goals and principles, analyzes the overall situation of 101 TCM information standard projects, analyzes its frame structure from two aspects of standard professional nature and business domain, and elaborates 101 TCM information standard project organization management system, operating mechanism. Based on the organization and management model of 101 TCM information standard projects, the 101 TCM information standard preparation process was discussed and problems were raised. Thus, relevant suggestions and considerations on TCM information standardization construction were put forward.
2018 Vol. 15 (14): 157-162 [Abstract] ( 231 ) HTML (1 KB)  PDF (805 KB)  ( 126 )
163 Monitoring and analysis of clinical isolates′ drug resistance in the First People's Hospital of Liangshan Yi Autonomous Prefecture, Sichuan Province from 2015 to 2017
CHEN Xu ZHOU Wen WANG Lin LI Xiangchen CHEN Li
Objective To investigate the clinical isolates and their changes in antimicrobial resistance in the First Hospital of Liangshan Yi Autonomous Prefecture of Sicuan Province ("our hospital" for short) from 2015 to 2017. Methods Automated bacterial identification and drug sensitivity system was used to explore the clinical specimens of microbial pathogens in our hospital from January 2015 to December 2017, and the drug susceptibility to conventional antibiotics was determined. The data was analyzed using WHONET 5.6 software. Results A total of 6529 non-duplicated clinical isolates was collected. Of the isolated germs, Gram-positive and Gram-negative bacteria accounted for 31.75% and 68.25%, respectively. The Gram-negative bacteria were mainly composed of Escherichia coli [1399 (21.43%)], Acinetobacter baumannii haemolyticus [1017 (15.58%)], Klebsiella pneumonia [518 (7.93%)] and Pseudomonas aeruginosa [324 (4.96%)]. The most common gram-positive bacteria were Staphylococcus aureus [782 (11.98%)], Streptococcus pneumoniae [261 (4.00%)], Staphylococcus epidermidis [199 (3.05%)] and Enterococcus faecium [196 (3.00%)]. The positive rate of extended-spectrum β-lactamase (ESBL) producing Escherichia coli was lower than before, but ESBL producing Klebsiella pneumoniae increased slightly. In addition, resistant multiple antibiotics of Acinetobacter Baumannii haemolyticus was severely. There were no methicillin resistant staphylococcus aureus, but 20 strains (14.49%) methicillin resistant coagulase negative staphylococci were isolated in 2017. Conclusion The problem of antimicrobial resistance is still serious. Measures, such as rational use of antibiotics, monitoring of drug resistance and medical asepsis, should be further strengthened.
2018 Vol. 15 (14): 163-167,172 [Abstract] ( 216 ) HTML (1 KB)  PDF (755 KB)  ( 94 )
168 Research on the disbursement and budget management of scientific research expenditure
WANG Mingli WU Dan▲
It is an effective way to improve the system of scientific research expenditure to make the disbursement and budget management rationally. It is the core of the development of modern science and scientific innovation to learn about the strategy, direction and the development trend of the expenditure accurately, transfer the advantages of scientific and technological research and development into actual productivity, and improve the development of national economy. This article analyzes the international, domestic and interregional data of the ratio between the input and the expenditure of scientific research. Based on the disbursement principles and features, this article is expected to provide a basis for the research of expenditure management and the government support of scientific research input by analyzing the current situation, existence problems, development trend and signification of the budget management of scientific research expenditure.
2018 Vol. 15 (14): 168-172 [Abstract] ( 181 ) HTML (1 KB)  PDF (651 KB)  ( 55 )
173 Quality control of triage in diagnostic procedure for emergency intelligent triage system
WANG Jing SHENG Liping ZHAO Yan JIANG Cheng
Objective To explore the impact of quality control management on the triage procedure of emergency medical intelligent triage system. Methods The data of emergency medical intelligent triage system in the Emergency Department of Zhongnan Hospital of Wuhan University from February 28, 2014 to February 28, 2017 was collected, and they were divided into three phases every 12 months (phase 1 was from February 28, 2014 to February 28, 2015; phase 2 was from March 1, 2015 to February 28, 2016; phase 3 was from March 1, 2016 to February 28, 2017. The usage of the system was reported by the quality control management team regularly, and the situation was discussed, analyzed and supervised by the emergency department medical staff. The overall use qualified rate and the reason of failure rate ratio were observed in the process. Results From phase 1 to 3 in the emergency diagnosis system, the overall use qualified rate increased significantly (P ＜ 0.01), the reason of failure rate ratio changed significantly (P ＜ 0.01). Conclusion In the application process of emergency diagnosis and intelligent triage system, quality control management team can improve the triage procedure and the efficiency of emergency work.
2018 Vol. 15 (14): 173-176 [Abstract] ( 182 ) HTML (1 KB)  PDF (716 KB)  ( 77 )
177 Comparison of the cost-effectiveness of the lung CT and common chest radiographs in the screening of the patients in the physical examination
LU Feng ZHENG Yansong
Objective To evaluate the clinical value and health economics of chest X-ray and chest CT scan in health examination people. Methods The results of chest X-ray and chest CT scan in patients who received health examinations in Healthy Science Center of Chinese PLA General Hospital from October 2005 to February 2014 were analyzed. Results A total of 65 465 patients underwent chest X-ray examination, 10 874 patients had positive findings (positive rate was 16.61%), the total positive findings were 12 991 cases. A total of 46 406 patients underwent chest CT scanning, 21 583 patients had positive findings (positive rate was 46.51%), the total positive findings were 33 172 cases. Chest CT scanning was more effective in detecting the lesions compared with chest X-ray (46.51% vs. 16.61%, P < 0.05). In every different age group, chest CT showed higher positive findings rate than chest X-ray examination, the most obvious differences were in 40-＜50 years group (42.42% vs. 12.29%) and 50-＜60 years group (53.44% vs. 22.87%). Chest CT scan detected more lung lesions (16 072 cases vs. 3335 cases), more mediastinal lesions (276 cases vs. 98 cases), pleural lesions (6692 cases vs. 3148 cases), lymph node lesions (3172 cases vs. 190 cases) and abdominal diseases (3172 cases vs. 26 cases) than chest X-ray examination. Chest X-ray examination detected more spinal and thoracic lesions (2798 cases vs. 129 cases), heart and vascular diseases (3095 cases vs. 1837 cases) than chest CT (P < 0.05). The cost of chest CT scan for every single positive reporting was less than chest X-ray (433.67 yuan vs. 554.32 yuan). Conclusion For health examination, chest CT scan is more effective and more economic than chest X-ray examination.
2018 Vol. 15 (14): 177-180 [Abstract] ( 218 ) HTML (1 KB)  PDF (723 KB)  ( 98 )
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