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| Monitoring and analysis of clinical isolates′ drug resistance in the First People's Hospital of Liangshan Yi Autonomous Prefecture, Sichuan Province from 2015 to 2017 |
| CHEN Xu ZHOU Wen WANG Lin LI Xiangchen CHEN Li |
| Department of Clinical laboratory, First Hospital of Liangshan Yi Autonomous Prefecture, Sicuan Province, Xichang 615000, China |
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Abstract Objective To investigate the clinical isolates and their changes in antimicrobial resistance in the First Hospital of Liangshan Yi Autonomous Prefecture of Sicuan Province ("our hospital" for short) from 2015 to 2017. Methods Automated bacterial identification and drug sensitivity system was used to explore the clinical specimens of microbial pathogens in our hospital from January 2015 to December 2017, and the drug susceptibility to conventional antibiotics was determined. The data was analyzed using WHONET 5.6 software. Results A total of 6529 non-duplicated clinical isolates was collected. Of the isolated germs, Gram-positive and Gram-negative bacteria accounted for 31.75% and 68.25%, respectively. The Gram-negative bacteria were mainly composed of Escherichia coli [1399 (21.43%)], Acinetobacter baumannii haemolyticus [1017 (15.58%)], Klebsiella pneumonia [518 (7.93%)] and Pseudomonas aeruginosa [324 (4.96%)]. The most common gram-positive bacteria were Staphylococcus aureus [782 (11.98%)], Streptococcus pneumoniae [261 (4.00%)], Staphylococcus epidermidis [199 (3.05%)] and Enterococcus faecium [196 (3.00%)]. The positive rate of extended-spectrum β-lactamase (ESBL) producing Escherichia coli was lower than before, but ESBL producing Klebsiella pneumoniae increased slightly. In addition, resistant multiple antibiotics of Acinetobacter Baumannii haemolyticus was severely. There were no methicillin resistant staphylococcus aureus, but 20 strains (14.49%) methicillin resistant coagulase negative staphylococci were isolated in 2017. Conclusion The problem of antimicrobial resistance is still serious. Measures, such as rational use of antibiotics, monitoring of drug resistance and medical asepsis, should be further strengthened.
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