血清microRNAs作为生物标志物用于子宫腺肌病分子诊断中的可行性

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Abstract Objective To explore the feasibility of using serum microRNAs as biomarkers for the molecular diagnosis of adenomyosis. Methods Seventy-eight patients with adenomyosis confirmed by the pathological diagnosis from March 2015 to March 2018 in Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine (here in after referred to as "our hospital") were selected as the study group. At the same time, 78 healthy subjects in our hospital physical examination center whose age, gender basically matched with the adenomyosis group were collected as the control group. All miRNAs in the serum of both groups were screened and validated using high-throughput sequencing technology. Results The expression level of microRNAs in the serum of the study group was significantly different from that in the control group (P < 0.05). There were 316 up-regulated miRNAs and 24 down-regulated miRNAs. After further screening and verification, 3 miRNAs were found to include miR-22-3p, miR-103a-3p, and miR-182-5p, and AUC were 0.900 (95% CI: 0.839-0.961) and 0.828 (95% CI: 0.747-0.909), 0.844 (95% CI: 0.766-0.921) respectively. Conclusion Serum microRNAs may be biomarkers for the diagnosis of adenomyosis.

Key words： Serum microRNAs Adenomyosis Biomarkers Molecular diagnosis

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	XU Aiyun1 GUI Tao2 HUANG Meihua2 ZHU Li2 WAN Guiping2

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XU Aiyun1 GUI Tao2 HUANG Meihua2 ZHU Li2 WAN Guiping2. The feasibility of serum microRNAs as biomarkers for molecular diagnosis of adenomyosis[J]. 中国医药导报, 2018, 15(14): 8-11.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I14/8

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