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| The influence of comprehensive intervention in antibiotic application during perioperative period of clean operation of primary hospitals |
| XIA Rongfen |
| Pharmacy Department, Yi′nan People′s Hospital of Linyi City, Shandong Province, Yi′nan 276300, China |
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Abstract Objective To explore the influence of comprehensive intervention in antibiotic application during perioperative period of clean operation of primary hospitals. Methods A total of 210 sample of the three typical typeⅠincisions in Yi′nan People′s Hospital of Linyi City (for short “our hospital”) from July to December 2016 was selected as control group. In addition, total of 210 sample of the three most typical typeⅠincisions from our hospital from July to December 2017 were selected as intervention group. The control group was given to routine perioperative prophylactic use of antibiotics, the intervention group was given to comprehensive intervention based on the control group. The general situation of prophylaxis drugs use, timing of prophylaxis antimicrobial drugs use, type of antimicrobial drugs use and the postoperative adverse reactions were compared. Results The utilization rate of antibacterial drugs in the intervention group was lower than that in the control group (P < 0.01). The rational use of the intervention group was superior to the control group (P < 0.05). There were 4 classes of 9 kinds of antibiotics in the control group, including Cephalosporins of 123 cases (67.2%), beta lactam/beta lactamase inhibitor of 37 cases (20.2%), the Penicillin of 18 cases (9.8%), monocyclic beta lactam of 5 cases (2.8%). There were involved 3 class of 9 kinds of antibiotics in the intervention group, in which, the use of cephalosporins rate increased significantly compared with the control group (92.0%), the use of beta lactam/beta lactamase inhibitor and penicillin class had declined significantly (4.0%, 4.0%), monocyclic beta lactam type (i.e., ammonia QuNa) was no use. The cases were all recovered after intervention, and there were no secondary infections and severe adverse reactions associated with the drug. Conclusion Through comprehensive intervention, the use of antibacterial drugs in our hospital has reduced obviously, and the timing of prevention is reasonable. But there are still parts of the problem, it still needs to continue to strengthen the intensity of intervention and regulation, to make antibiotic application during perioperative period of clean operation of primary hospitals tend to be more rationalization and standardization.
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