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| Study on relationship between depression and angiotensin/aldosterone levels in patients with essential hypertension |
| CHEN Ying1 HU Yunzhao2 WU Yanting3▲ FAN Lijuan3 |
1.Medical Examination Center, Shunde Hospital Affiliated to Southern Medical University, Guangdong Province, Shunde 528330, China;
2.Cardiology Center, Shunde Hospital Affiliated to Southern Medical University, Guangdong Province, Shunde 528330 China;
3.the Second Outpatient Department, Shunde Hospital Affiliated to Southern Medical University, Guangdong Province, Shunde 528330, China |
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Abstract Objective To explore the relationship between depression and angiotensin/aldosterone levels in patients with essential hypertension. Methods From September 2015 to September 2017, in Shunde Hospital Affiliated to Southern Medical University, the patients with hypertension definited were selected as sample group (n = 129) at the same period, heathy outpatients were selected as control group (n = 66). Blood lipid and uric acid (UA) and other indicators, angiotensin (Ang-Ⅰ, Ang-Ⅱ) and aldosterone (ALD) concentration levels were measured. Self-rating scale (SDS) was used to score depression for each candidate, according to SDS results, patients with hypertension were further divided into two subgroups: depression group (n = 58) and non-depression group (n = 71). All the above data were statistically analyzed. Results The blood lipid index such as LDL-C, TC, TG and UA in sample group were significantly higher than control group, the differences were statistically significant (P < 0.05). There was no statistically significant difference in high density lipoprotein cholesterol (HDL-C) between the two groups (P > 0.05). The levels of Ang-Ⅰ, Ang-Ⅱ in the sample group were significantly higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of Ang-Ⅰ, Ang-Ⅱ in the hypertensive depression group were significantly higher than non-depression group, the differences were statistically significant (P < 0.05). Logistic analysis has shown that the risk factors of depressive disorder in patients with hypertension included serum lipid (OR = 1.84, 95%CI: 1.12-3.05, P < 0.05), Ang-Ⅰ(OR = 1.84, 95%CI: 1.18-8.10, P < 0.05) and Ang-Ⅱ(OR = 1.84, 95%CI: 1.05-3.58, P < 0.05) Conclusion Angiotensin is the independent risk factor for depression disorder in patients with hypertension, and the depression degree changed along with the serum angiotensin level.
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