帕金森病及快动眼期睡眠行为障碍患者血浆尿酸水平的关系

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Abstract Objective To investigate the relationships in plasma uric acid levels between patients with Parkinson disease (PD) and rapid-eye-movement sleep behavior disorder (RBD). Methods Thirty-nine patients with idiopathic RBD (iRBD group), 43 patients with PD (PD group) and 128 healthy controls (healthy control group) were collected from Xuanwu Hospital, Capital Medical University from March 2016 to March 2017. All patients with iRBD were confirmed by clinical assessment and polysomnography. Subjects' plasma uric acid levels were measured. Two-way analysis of variance was used to examine abnormalities in uric acid levels in patients with iRBD and PD. Results The levels of serum uric acid in the iRBD group [(346.5±38.3) mmol/L] were significantly higher than that of the PD group [(236.5±49.8) mmol/L] and the healthy control group [(331.0±39.8) mmol/L], the differences were all statistically significant (P ＜ 0.01). But there was no significant difference between the PD group and the healthy control group (P ＞ 0.05). Conclusion Uric acid levels in PD patients are lower than those in healthy subjects and RBD patients, suggesting that low uric acid level may be a biological marker of PD.

Key words： Parkinson disease Rapid-eye-movement sleep behavior disorder Uric acid

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	LIU Jianghong1* LI Kai2* LI Ning1 DING Yan1 ZHANG Lichun3 ZHAI Yi1 WANG Yuping1 ZHAN Shuqin1▲

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LIU Jianghong1* LI Kai2* LI Ning1 DING Yan1 ZHANG Lichun3 ZHAI Yi1 WANG Yuping1 ZHAN Shuqin1▲. The relationships in plasma uric acid levels between patients with Parkinson disease and rapid-eye-movement sleep behavior disorder[J]. 中国医药导报, 2018, 15(14): 86-88.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I14/86

[1] Gao X，O′Reilly ÉJ，Schwarzschild MA，et al. Prospective study of plasma urate and risk of Parkinson disease in men and women [J]. Neurology，2016，86（6）：520-526.
[2] IiR L，Ferrer JV，Rueda JJ，et al. Case-control study of markers of oxidative stress and metabolism of blood iron in Parkinson′s disease [J]. Rev Esp Salud Publica，2001， 75（1）：43-53.
[3] Andreadou E，Nikolaou C，Gournaras F，et al. Serum uric acid levels in patients with Parkinson's disease：their relationship to treatment and disease duration [J]. Clin Neurol Neurosurg，2009，111（9）：724-728.
[4] Högl B，Stefani A，Videnovic A. Idiopathic REM sleep behavior disorder and neurodegeneration-an update [J]. Nat Rev Neurol，2018，14（1）：40-55.
[5] Uribe-San R，Venegas P，López F，et al. Plasma urate in REM sleep behavior disorder [J]. Mov Disord，2013，28（8）：1150-1151.
[6] International classification of Sleep Disorders [S]. 3rd edn. Darien：American Academy of Sleep Medicine，2014.
[7] Postuma RB，Berg D，Stern M，et al. MDS clinical diagnostic criteria for Parkinson's disease [J]. Mov Disord，2015， 30（12）：1591-1601.
[8] 卢丽丽，马莉，王兆京，等.血清尿酸水平变化与帕金森病发病、临床参数的关系研究进展[J].山东医药，2017， 57（27）：106-108.
[9] 王引明，孔亮，胡玲玲.帕金森病患者尿酸、超氧化物歧化酶和血清营养指标的变化[J].中国现代药物应用，2013， 7（23）：76-77.
[10] Alonso A，Rodriguez LA. Gout and risk of Parkinson's disease：a prospective study [J]. Neurology，2007，69（17）：1696-1700.
[11] Davis JW，Grandineti A，Waslien CI，et al. Observations on serum uric acid and the risk of idiopathic Parkinson's disease [J]. Am J Epidemiol，1996，144（5）：480-484.
[12] De Lau LM，Koudstaal PJ，Hofman A，et al. Serum uric acid levels and the risk of Parkinson′s disease [J]. Ann Neurol，2005，58（5）：797-800.
[13] Weisskopf MG，Reilly EO，Chen H，et al. Plasma urate and risk of Parkinson disease [J]. Am J Epidemiol，2007， 166（5）：561-567.
[14] Uribe-San MR，Venegas FP，López IF，et al. Plasma urate in REM sleep behavior disorder [J]. Mov Disord，2013， 28（8）：1150-1151.
[15] Fan S，Cohen G. The oxidant stress hypothesis in Parkinson′s disease：evidence supporting it [J]. Ann Neurol，1992， 32（6）：804-812.
[16] Jeneer P. Oxidative stress in Parkinson's disease [J]. Ann Neurol，2003，53（suppl 3）：S26-S36.
[17] Danielson SR，Andersen JK. Oxidative and nitrative protein modifications in Parkinson' s disease [J]. Free Radic Biol Med，2008，44（10）：1787-1794.
[18] Swerdlow RH，Parks JK，Miller SW，et al. Origin and functional consequences of the complex I defect in Parkinson′s disease [J]. Ann Neurol，1996，40（4）：663-671.
[19] Chen H，Zhang SM，Schwarzshild MA，et al. Physical activity and the risk of Parkinson disease [J]. Neurology，2005， 64（4）：664-669.
[20] Ma L，Zhang L，Gao XH，et al. Dietary factors and smoking as risk for PD in a rural population in China：a nested case-control study [J]. Acta Neurol Scand，2006，113（4）：278-281.
[21] Park M，Ross GW，Petrovitch H，et al. Comsumtion of milk and calcium in mildlife and the future risk of Parkinson disease [J]. Neurology，2005，64（6）：1047-1051.
[22] Miyake Y，Fukushima K，Tanaka S，et al. Dietary intake of antioxidant vitamins and risk of Parkinson' s disease：a case-control study in Japan [J]. Europ J Neurol，2011， 18（1）：106-113.
[23] 刘佳，陈彪.血尿酸与帕金森病[J].中华临床医师杂志，2013，7（12）：5475-5478.