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| Correlation study of high frequency ultrasonography in early diagnosis and laboratory index of rheumatoid arthritis |
| XU Jun FENG Zhipeng MA Yan TENG Shaohua WANG Yinqi LONG Xiaona PENG Hongying |
| Department of Nephrotic Rheumatism, the Affiliated Baiyun Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550014, China |
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Abstract Objective To explore the value of early diagnosis of high frequency ultrasound (HF) on rheumatoid arthritis (RA), and analyze its correlation with the laboratory index. Methods Forty-five cases of RA [according to 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria] treated in the Affiliated Baiyun Hospital of Guizhou Medical University and Affiliated Hospital of Guizhou Medical University from June 2014 to June 2017 were analyzed retrospectively. During the same period, 45 cases with at least one joint synovitis, not diagnosed with RA were selected as non-RA control group. HF was used to observe 28 joints in both group, including hydrops articuli, synovial thickness, blood flow signals and bone erosion, and the 4 indicators were semi quantitative scored (0-3 scores). The ultrasonic scores were the sum of 28 joints, then the ultrasonic scores of 2 groups were compared. At the same time, rheumatoid factor (RF), anti cyclic citrullinated peptide antibody (anti-CCP), CRP and erythrocyte sedimentation rate (ESR) were detected. Spearman correlation analysis was used to evaluate the correlation between ultrasonic scores and the laboratory indices. Results ①Compared with non-RA group, joint effusion, synovial thickness, blood flow signals, bone erosion and ultrasonic scores of RA group were increased significantly (P ＜ 0.05); ②compared with non-RA group, the RF, anti-CCP, CRP and ESR of RA group were also significantly increased (P ＜ 0.05); ③in non-RA group there was no significant correlation of the ultrasonic scores with RF, anti-CCP, CRP and ESR (P ＞ 0.05), while the ultrasound scores in RA group were positively correlated with RF, anti-CCP and ESR (P ＜ 0.05). Conclusion HF can detect early lesions in RA diagnosis, and has a significantly positive correlation with laboratory indices as RF, anti-CCP, CRP and ESR. It can be used as an effective method for RA early diagnosis.
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