|
|
|
| The relationship between the expressions of aldehyde dehydrogenase 1, breast cancer resistance protein in breast cancer tissues and pathological features of breast cancer |
| LIANG Faqing1 DU Zhenggui1 HE Yangjun2 |
1.Department of Breast Surgery, West China Hospital of Sichuan University, Sichuan Province, Chengdu 610041, China;
2.Department of Surgery, Chengdu Seventh People′s Hospital, Sichuan Province, Chengdu 610041, China |
|
|
|
Abstract Objective To investigate the relationship between aldehyde dehydrogenase 1 (ALDH1), breast cancer resistance protein (BCRP) expressions in tumor tissues and pathological features of breast cancer. Methods From January 2013 to March 2016, 84 patients with breast cancer in West China Hospital of Sichuan University and the normal breast tissues (adjacent tissues) which was used for control group is defined as the edge of cancer tissueedge greater than 1 cm were selected. The expression of ALDH1 and BCRP protein was detected by immunohistochemistry. Results The expression rates of ALDH1 and BCRP protein in breast cancer tissues were significantly higher than those in adjacent tissues (P < 0.01). The positive rates of ALDH1 and BCRP protein expression in patients with axillary lymph node metastasis were significantly higher than those in patients without axillary lymph node metastasis (P < 0.05). The positive rate of BCRP protein expression in estrogen receptor (ER) positive patients was significantly higher than that in ER negative patients (P < 0.05). The expression of ALDH1 and BCRP protein was not correlated with age, menopause, tumor size, histological grade, TNM stage and progesterone receptor (PR) (P > 0.05). There was no correlation between the expression of ALDH1 and BCRP protein in breast cancer (rs=-0.092, P > 0.05). Conclusion ALDH1 and BCRP may play an important role in the development of breast cancer, which may be involved in the tumor invasion, metastasis etc.
|
|
|
|
|
|
[1] Siegel RL，Miller KD，Jemal A，et al. Cancer Statistics [J]. CA Cancer J Clin，2016，66（1）：7-30.
[2] 陈思颖，蔡江霞，张蔚鹏，等.紫杉醇诱导的乳腺癌耐药细胞的蛋白质组学研究[J].中国药学杂志，2014，22（10）：825-832.
[3] 岳玉函，曹海玲，袁静，等.乳腺癌组织中耐药蛋白的表达及化疗耐药性的相关性研究[J].内蒙古医科大学报，2014，25（3）：211-216.
[4] 任香，舒春贵.HIF-1α和BCRP在乳腺浸润性导管癌组织中的表达及临床意义[J].中国癌症防治杂志，2014，32（3）：289-291.
[5] Sarika PR，Nirmala RJ. Curcumin loaded gum arabic aldehyde-gelatin nanogels for breast cancer therapy [J]. Mater Sci Eng C Mater Biol Appl，2016，65（6）：331-337.
[6] 连臻强，王颀.遗传性乳腺癌的易感基因检测与咨询策略[J].医学与哲学，2016，37（18）：11-13.
[7] 汤静.2013年杭州市归因于吸烟的肺癌、胃癌、乳腺癌疾病负担研究[D].杭州：杭州师范大学，2016.
[8] Asadi S，Nazirzadeh A. Genomic analysis of one allele of a gene HER2/NEU，ERBB1，BRCA1，BRC [J]. 2016.
[9] Nandekar PP，Khomane K，Chaudhary V，et al. Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism [J]. Eur J Med Chem，2016， 115：82-93.
[10] 韩明利，吴诚义，莫志强，等.外源性TGF-β1诱导人乳腺癌MCF-7细胞的乙醛脱氢酶1 mRNA及蛋白表达[J].复旦学报：医学版，2011，22（4）：340-342.
[11] 王征，张浩，李伟汉，等.乙醛脱氢酶1在浸润性乳腺癌局部复发组织中的表达及意义[J].广东医学，2014，34（16）：2589-2591.
[12] 王兴，姜真，孙长岗.乙醛脱氢酶1与乳腺癌耐药蛋白在乳腺癌中的表达及相关性研究[J].中国癌症杂志，2014， 25（3）：175-181.
[13] 蔡建英，吴诚义.乳腺癌中乙醛脱氢酶1与上皮性钙黏蛋白、神经性钙黏蛋白关系的研究[J].中国医药生物术，2014，24（3）：231-233.
[14] 关欣，董毅，邹亚斌，等.乙醛脱氢酶1在肿瘤细胞质中表达和肿瘤细胞基质中表达与乳腺癌患者预后关系的临床研究[J].中国妇幼保健，2016，31（13）：2736-2738.
[15] Xu LI，Huang S，Gaili AN，et al. Clinical significance of ALDH1 expression in breast cancer：aMeta analysis [J]. Chinese Journal of Difficult & Complicated Cases，2016.
[16] Horimoto Y，Arakawa A，Sasahara N，et al. Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases [J]. PLoS One，2016，11（10）：e0165253.
[17] Thomas ML，De Antueno R，Coyle KM，et al. Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3 [J]. Molecular Oncology，2016，10（9）：1485-1496.
[18] 刘新丽，李伟东，刘芳芳，等.乳腺浸润微乳头状癌中乙醛脱氢酶-1表型细胞的研究[J].中华内分泌外科杂志，2014，25（2）：93-100.
[19] 王瑾.乙醛脱氢酶在乳腺癌中的研究进展[J].蚌埠医学院学报，2012，37（7）：874-876.
[20] 侯亮，冯海利.脑胶质瘤组织中P-gp、MRP、BCRP的表达及临床意义[J].中国医药导报，2017，14（35）：12-15. |
|
|
|
