布地奈德联合复方异丙托溴铵雾化吸入治疗围术期尘肺病的临床研究

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Abstract Objective To investigate the effects of aerosol inhalation of Budesonide combined with Compound Ipratropium Bromide in the treatment of patients with perioperative pneumoconiosis. Methods One hundred and thirty-nine patients with pneumoconiosis admitted to Guangzhou Twelfth People's Hospital Affiliated to Guangzhou Medical University from January 2014 to February 2017 were enrolled in this study, and they were divided into control group (69 cases) and treatment group (70 cases) by random number table method. Both groups were treated by whole-lung lavage (WLL) under general anesthesia. The treatment group was treated with aerosol inhalation of Budesnide combined with Compound Ipratropium Bromide during the period of 3 days before treatment and 3 days after treatment. The comprehensive score of clinical symptoms, lung function index, blood gas index and the sputum tumor necrosis factor -α (TNF-α), interleukin-1 (IL-1) levels of the two groups during the period of 3 days before treatment and 7 days after treatment were compared between the two groups. The adverse reactions during the treatment of the two groups were recorded. Results The comprehensive score of clinical symptoms of the two groups after treatment were significantly lower than those before treatment, the forced vital capacity (FVC), forced expiratory volume in one second (FEV1) of the two groups after treatment were significantly higher than those before treatment, and the improvement of comprehensive score of clinical symptoms, FVC, FEV1 in the treatment group was significantly better than those of the control group (P ＜ 0.05). The partial pressure of blood oxygen (PaO2) of the two groups after treatment were significantly higher than those before treatment, the arterial partial pressure of carbon dioxide (PaCO2) of the two groups after treatment were significantly lower than those before treatment, and the changes of PaO2, PaCO2 after treatment in the treatment group were significantly better than those of control group, the differences were statistically significant (P ＜ 0.05). The levels of sputum TNF-α, IL-1 in the two groups after treatment were significantly lower than those before treatment, and the levels of sputum TNF-α, IL-1 after treatment in the treatment group were significantly lower than those of the control group (P ＜ 0.05). The incidence of adverse reactions of hyoxemia, airway spasm, airway pressure increasing of the treatment group was significantly lower than that of the control group during the treatment, the difference was statistically significant (P ＜ 0.05). Conclusion Aerosol inhalation of Budesonide combined with Compound Ipratropium Bromide in the treatment of patients with pneumoconiosis who were given WLL can improve clinical efficacy of WLL, relieve clinical symptoms, improve pulmonary function and SpO2, decrease the levels of sputum inflammatory factors and reduce the occurrence of adverse reactions, and it is worthy of clinical promotion and application.

Key words： Budesonide Compound Ipratropium Bromide Whole-lung lavage Pneumoconiosis Efficacy

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	MAI Zijian1 YUAN Liling2 ZHAO Jian3

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MAI Zijian1 YUAN Liling2 ZHAO Jian3. Clinical research of aerosol inhalation of Budesnide combined with Compound Ipratropium Bromide in the treatment of patients with perioperative pneumoconiosis[J]. 中国医药导报, 2018, 15(14): 97-101.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I14/97

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