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| Curative effect analysis of Letrozole combined with Clomifene Citrate Capsules in the treatment of patients with polycystic ovary syndrome |
| YANG Ting WANG Jie YANG Lei |
| Department of Gynecology, Baoji Fuyou Health Hospital, Shaanxi Province, Baoji 721000, China |
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Abstract Objective To explore the effect of Letrozole combined with Clomiphene Citrate Capsules on patients with polycystic ovary syndrome. Methods Ninety PCOS patients with the treatment of ovulation in Baoji Fuyou Health Hospital from January 1st, 2013 to August 30th, 2017 were selected, patients were divided into three groups according to the different methods of treatment, 30 case in each groups. The control group was treated by Clomifene Citrate Capsules 50 mg/d, po, qd. The observation group 1 was treated by Letrozole 2.5 mg/d, po, qd, on the basis of the treatment of control group, while the observation group 2 was treated with Letrozole 5.0 mg/d, po, qd, all patients were treated for 5 days. On the 10th day of the menstrual cycle, the vaginal ultrasound was used to monitor follicular development and endometrial conditions, the thickness of uterine membrane, the number of mature follicle and the thickness of endometrium were recorded, the ovulation rate and pregnancy rate of each group were caculated. Levels of the LH, E2, T, FSH of the three groups were detected by chemiluminescent immunoassay. Results The thickness of uterine membrane of observing group 1 and observing group 2 was higher than that of control group at HCG day, the number of mature follicle and palace film thickness of the observation group 1 and 2 were obviously higher than those of the control group, the ovulation rate and pregnancy rate of observation group 1 and 2 was higher than the control group, the differences were statistically significant (P < 0.05). The ovulation rate and pregnancy rate of observation group 2 was higher than the observation group 1, the difference was statistically significant (P < 0.05). On HCG injection day, levels of LH and T in the observation group 1 and 2 were higher than that of the control group, level of E2 was lower than that of the control group, the differences were statistically significant (P < 0.05). The level of FSH in the observation group 2 was lower than that in the control group, and the level of E2 was lower than that of observation group 1, the differences were statistically significant (P < 0.05). Conclusion Letrozole combined with Clomifene Citrate Capsules can increase the thickness of uterine membrane of patients with polycystic ovary syndrome, improve the ovulation rate and pregnancy rate, and the effect of 5.0 mg/d Lytrizole combined with Clomifene Citrate Capsules has more obvious effect.
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