|
|
|
| Effect of photon rejuvenation technology combined with Compound Cortex Phellodendri Liquid in the treatment of patients with facial corticosteroid addictive dermatitis |
| SU Chunzhi LI Chaowei ZENG Zhouping |
| Department of Dermatology, Gaozhou People's Hospital, Guangdong Province, Gaozhou 525200, China |
|
|
|
Abstract Objective To explore the effect of photon rejuvenation technology combined with Compound Cortex Phellodendri Liquid in the treatment of patients with facial corticosteroid addictive dermatitis (FCAD). Methods Ninety-six cases of patients diagnosed as FCAD in Department of Dermatology, Gaozhou People's Hospital from June 2015 to May 2017 were randomly divided into 3 groups, with 32 patients in each group. The Cortex Phellodendri group was treated with Compound Cortex Phellodendri Liquid combined with Tacrolimus Ointment. The photon group was treated with Tacrolimus Ointment combined with photon rejuvenation technology. The combination group was treated with photon rejuvenation technology combined with tacrolimus ointment and Compound Cortex Phellodendri Liquid. The course of treatment was 8 weeks. Skin barrier function indices [transepidermal water loss (TEWL), the moisture and oil contents of skin], the therapeutic effect after treatment and the scores of dermatology life quality index (DLQI) before and after treatment were compared among the 3 groups. The therapeutic effects after treatment of the 3 groups were compared. The adverse reactions during treatment and relapse situation after treatment with a 8-week follow-up were recorded and compared. Results There were significant differences in the values of skin barrier function indices, the scores of DLQI and the therapeutic effect after treatment among the 3 groups (P ＜ 0.05). After treatment, TEWL score of the combination group was lower than the photon group and Cortex Phellodendri group, while the photon group was lower than the Cortex Phellodendri group (P ＜ 0.05). Moisture and oil contents of skin, the therapeutic effect distribution after treatment of the combination group were higher than the photon group and Cortex Phellodendri group, while the photon group was higher than the Cortex Phellodendri group, while the scores of DLQI of the combination group were lower than the photon group and Cortex Phellodendri group, which of photon group were lower than those of Cortex Phellodendri group (P ＜ 0.05). There were no statistically significant differences of adverse reactions among three groups (P ＞ 0.05). There was no recurrence situation in a 8-week follow-up after treatment among three groups. Conclusion The photon rejuvenation technology combined with Tacrolimus Ointment and Compound Cortex Phellodendri Liquid in the treatment of FCAD has obvious effect, which can significantly improve the skin barrier function and the quality of life. The treatment is safe and worth of clinical promotion.
|
|
|
|
|
|
[1] 赵婵.激素依赖性皮炎的诊断与外治疗法[J].长春中医药大学学报，2015，31（6）：1274-1276.
[2] 张玲.皮炎冲剂治疗血热型面部激素依赖性皮炎的临床研究[J].世界中西医结合杂志，2017，12（8）：100-103.
[3] 沈芳，谢韶琼，宋勋，等.复方黄柏液联合糖皮质激素乳膏治疗急性湿疹60例临床观察[J].中国皮肤性病学杂志，2015，29（12）：1314-1316.
[4] Kim BK，Lee NR，Park SY，et al. Efficacy of photodynamic therapy with laser pretreatment for actinic keratosis and photorejuvenation as evaluated by fluorescent imaging [J]. Photodermatol Photoimmunol Photomed，2015，31（1）：36-43.
[5] 孙文兰，魏烨平，于腾阳，等.综合疗法治疗面部激素依赖性皮炎的疗效观察[J].华南国防医学杂志，2015，29（5）：398-399.
[6] Finlay AY，Basra MK，Piguet V，et al. Dermatology life quality index（DLQI）：a paradigm shift to patient-centered outcomes [J]. J Invest Dermatol，2012，132（10）：2464-2465.
[7] 何雪冬.加味知柏地黄汤联合他克莫司软膏对阴虚内热型糖皮质激素依赖性皮炎患者皮肤屏障功能的影响[J].环球中医药，2017，10（1）：100-102.
[8] 范向华，施健，缪旭. 朗格汉斯细胞在初发及复发尖锐湿疣皮损中的形态学变化[J].中国皮肤性病学杂志，2016， 30（8）：787-789.
[9] Momota Y，Shimada K，Gin A，et al. Measurement of transepidermal water loss（TEWL） in cats with experimental skin barrier dysfunction using a closed chamber system [J]. Vet Dermatol，2016，27（5）：428-431.
[10] 李云珠，路雪艳，姜薇，等.青鹏软膏对皮肤干燥志愿者及特应性皮炎样小鼠模型皮肤屏障功能的影响[J].中华皮肤科杂志，2016，49（1）：43-47.
[11] 张辉，史龙强.他克莫司联合复方倍他米松对激素依赖性皮炎患者皮损评分及表皮含水量的影响[J].西部医学，2016，28（7）：987-990.
[12] D?觟lle S，Hielscher N，Bareille PJ，et al. Clinical efficacy and tolerability of a novel selective corticosteroid in atopic dermatitis-two randomised controlled trials [J]. Skin Pharmacol Physiol，2015，28（3）：159-166.
[13] 李卫民，倪红.他克莫司软膏治疗面部糖皮质激素依赖性皮炎临床疗效观察[J].解放军医学杂志，2015，40（8）：686-686.
[14] 潘勇华，蒋红，陈井霞，等.复方黄柏液处方优化及体外经皮渗透效果的研究[J].药学服务与研究，2017，17（5）：411-414.
[15] Martella A，Raichi M. Photo-epilation and Skin Photorejuvenation：An Update [J]. Dermat Rep，2017，9（1）：9-13.
[16] 徐永康.光子嫩肤在皮肤美容中的应用疗效[J].中国公共卫生，2015，22（3）：19-20.
[17] 赵俊英.强脉冲光治疗面部激素依赖性皮炎临床研究[J].中国麻风皮肤病杂志，2017，33（4）：229-230.
[18] 常杰平，冯秀凤，刘菁，等.光子嫩肤技术与微波治疗皮肤毛细血管扩张患者的临床疗效比较[J].实用临床医药杂志，2014，18（11）：100-101.
[19] 张莲，唐承伟，张爱华，等.126例面部糖皮质激素依赖性皮炎患者心理状况和生活质量调查分析[J].解放军预防医学杂志，2017，35（10）：123-125.
[20] 顾煜，李伟，海日古力·克比尔，等.复方黄柏液联合派瑞松治疗脂溢性皮炎的临床研究[J].现代生物医学进展，2016，16（12）：2284-2286. |
|
|
|
