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2023 Vol. 20, No. 17
Published: 2023-06-15
 
 
4 Study on the rules of injury-treating medication in Buyao of the Wounded Department based on data mining
ZHOU Shibo ZHAO He YU Xing
DOI: 10.20047/j.issn1673-7210.2023.17.01
Objective To explore the drug law of treating bone injury in “Buyao of the Wounded Department”. Methods  The internal and external prescriptions for the treatment of injuries were sorted out, and the meridian normalization and efficacy of the drugs were summarized by referring to the Pharmacopoeia of the People’s Republic of China and traditional Chinese medicine. SPSS Modeler 14.1 was used for complex network diagram display and association rule analysis. Results A total of 95 prescriptions for internal administration and 35 for external use were involved. There were 24 traditional Chinese medicine with a frequency of ≥10 times for internal administration; 16 tastes of external drugs ≥five times; for internal and external use, most drugs were warm, mainly sweet, bitter, and sweet. Return to the meridian to see more heart, liver; the main effect was to promote blood stasis and tonify deficiency. Association rules showed that 13 groups of internal core drugs such as Rhizoma Ligustici Chuanxiong-Radix Angelicae Sinensis, and five groups of external core drugs such as Olibanum and Myrrha. Cluster analysis included four types of drugs for internal use and three types of drugs for external use. Conclusion The book takes promoting blood circulation and removing blood stasis, tonifying qi and blood, collecting soreness and generating muscle as the main ideas, and uses internal medicines such as Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong as well as external medicines such as Olibanum and Myrrha to treat orthopedic diseases, providing certain references for clinical treatment of orthopedic diseases.
2023 Vol. 20 (17): 4-8 [Abstract] ( 22 ) HTML (1 KB)  PDF (1014 KB)  ( 52 )
9 Study on the related mechanism of Di’ao Xinxuekang in the treatment of cardiac neurosis based on network pharmacology and molecular docking
BAO Baiyi1 SUN Meiling1 CHEN Xiang1 CAO Zhaoliu2 TANG Shubing3 LI Xin1
DOI: 10.20047/j.issn1673-7210.2023.17.02
Objective To explore the targets and mechanisms of Di’ao Xinxuekang in the intervention of cardiac neurosis by network pharmacology data and molecular docking, and to provide theoretical basis and ideas for its clinical use. Methods The CNKI, Wanfang Data, VIP, and SinoMed were searched for the related literatures of Di’ao Xinxuekang, yellow Chinese yam, Chuanshanlong, and Chuanlong yam from the inception to September 2022, and the works of Di’ao Xinxuekang were also searched. Based on the network pharmacology method, the traditional Chinese medicine system pharmacology database and analysis platform was used, the main active ingredients and action targets of Di’ao Xinxuekang were obtained. Genecards, OMIM, PharmGKB, and TTD gene databases were used to screen out the pathogenic genes of cardiac neurosis, and the intersection between them and the drug-acting genes was used to construct the regulatory network. The core genes were selected by network topology calculation for GO analysis and KEGG analysis, and the drug active ingredients were used for molecular docking with the core genes. Combined with relevant studies, the mechanism of Di’ao Xinxuekang in the intervention of cardiac neurosis was analyzed and predicted. Results A total of 14 main active ingredients and 43 predicted targets of Di’ao Xinxuekang were obtained. There were 41 intersection targets with cardiac neurosis, among which SLC6A2, SLC6A4, MAOA, and other proteins may be the key targets for the intervention of cardiac neurosis. Molecular docking of the key targets and their corresponding active components showed that the active components of Di’ao Xinxuekang had a strong binding ability to the corresponding core targets. Conclusion The intervention of Di’ao Xinxuekang in cardiac neurosis involves multi-targets, multi-processes, and multi-pathways.
2023 Vol. 20 (17): 9-13 [Abstract] ( 32 ) HTML (1 KB)  PDF (1836 KB)  ( 77 )
14 Effect of the acupuncture and moxibustion in the neurological function and treatment of injury in rats with acute intracranial hemorrhage
MA Xuemiao1 DU Ye2 CHENG Guangyu3 CHENG Weiping4
DOI: 10.20047/j.issn1673-7210.2023.17.03
Objective To observe the improvement effect of acupuncture on the neurological function and craniocerebral injury in rats with acute intracranial hemorrhage. Methods A total of 45 healthy male SD rats of about 220 g in 6-8 weeks were selected, and they were divided into sham operation group, model group and acupuncture group by random number table method, with 15 rats in each group; each group was divided into three points at 1, 3 d and 7 d, with 5 rats in each time. The cerebral hemorrhage rat model group was established by autologous blood injection; the sham operation group only drilled holes without injecting autologous blood; the acupuncture group adopted the treatment method of piercing from Baihui to Qubin. Ludmila Belayev’s neurological function score was used to evaluate the degree of neurological deficit in rats in each group. Western blot was used to detect the expression of CTRP3 and GPX4 proteins in brain tissue. The mitochondrial morphology of nerve cells in the brain tissue of rats in each group was observed by transmission electron microscope. qRT-PCR method was used to detect the specific expression of GFAP and EGFR mRNA in rat brain tissue. Results Compared with sham operation group, neurological function deficit score in model group increased at each time point (P＜0.05). Compared with model group, neurological impairment scores of acupuncture group decreased at 1 and 3 d, the differences were statistically significant (P＜0.05), but there was no statistically significant difference in systemic impairment score at 7 d(P＞0.05). Compared with sham operation group, levels of CTRP3 and GPX4 protein in model group were decreased at each time point, and the differences were statistically significant (P＜0.05). Compared with model group, CTRP3 and GPX4 protein expression levels in acupuncture group were up-regulated at each time point, and the differences were statistically significant (P＜0.05). Compared with sham operation group, mRNA levels of GFAP and EGFR in brain tissue of rats in model group increased at each time point, and the differences were statistically significant (P＜0.05). Compared with model group, mRNA levels of GFAP and EGFR in brain tissue of rats in acupuncture group were significantly decreased at each time point, and the differences were statistically significant (P＜0.05). Conclusion Acupuncture treatment can up-regulate the expression of CTRP3 and GPX4 proteins in brain tissue, reduce the mRNA levels of GFAP and EGFR, and restore the integrity of neuronal mitochondria, thereby improving the neuromuscular injury and neurological function of rats with acute cerebral hemorrhage, and play a protective role.
2023 Vol. 20 (17): 14-18 [Abstract] ( 22 ) HTML (1 KB)  PDF (819 KB)  ( 17 )
19 Experimental study of miR-325-3p regulating the proliferation, invasion, migration, and epithelial mesenchymal transformation of breast cancer cells by targeting FOXM1
WU Chenhao WANG Jing ZHOU Bei WAN Zhenlin
DOI: 10.20047/j.issn1673-7210.2023.17.04
Objective To investigate the regulation of miR-325-3p on proliferation, invasion, migration, and epithelial mesenchymal transformation (EMT) of breast cancer cells by targeting forkhead box protein (FOXM1). Methods MCF-7 cells were cultured and divided into NC group (transfected miRNA mimic negative control), miR-325-3p group (transfected miR-325-3p mimic), miR-NC group (transfected miRNA inhibitor negative control), miR-325-3p inhibitor group (transfected with miR-325-3p inhibitor), pcDNA3.1 group (transfected with pcDNA3.1 empty plasmid), FOXM1 group (transfected with PCDNA3.1-FoxM1), si-NC group (transfected with si-NC meaningless sequence), si-FOXM1 group (transfected with si-FOXM1 plasmid), miR-325-3p inhibitor+si-FOXM1 group (transfected with miR-325-3p inhibitor+si-FOXM1 plasmid), and miR-325-3p inhibitor+si-NC group (transfected with miR-325-3p inhibitor+si-NC meaningless sequence). CCK-8 was used to detect cell proliferation at 24, 48 h, and 72 h, Transwell assay was used to detect cell invasion, scratch assay was used to detect cell migration, the levels of miR-325-3p and FOXM1 mRNA were detected by RT-qPCR, the levels of FOXM1, E-cadherin, N-cadherin, and Vimentin protein were detected by Western blot, the targeting relationship between miR-325-3p and FOXM1 was detected by luciferase assay. Results The expression level of miR-325-3p in miR-325-3p group was higher than that in NC group (P＜0.01), and the level of miR-325-3p in miR-325-3p inhibitor group was lower than that in miR-NC group (P＜0.01). At 48 h and 72 h, optical density (OD) value, invasion cell number, and migration of miR-325-3p group were lower than those of NC group (P＜0.01), while OD value, invasion cell number, and migration of miR-325-3p inhibitor group were higher than those of miR-NC group (P＜0.01). The expression level of E-cadherin protein in miR-325-3p group was higher than that in NC group, while the expression levels of Vimentin and N-cadherin protein in miR-325-3P group were lower than those in NC group (P＜0.01); the expression level of E-cadherin protein in miR-325-3p inhibitor group was lower than that in miR-NC group, while the expression levels of Vimentin and N-cadherin protein in miR-NC group were higher than those in miR -NC group (P＜0.01). The expression levels of FOXM1 protein and mRNA in FOXM1 group were higher than those in pcDNA3.1 group (P＜0.01); the expression levels of FOXM1 protein and mRNA in si-FOXM1 group were lower than those in si-NC group (P＜0.01). At 48 h and 72 h, OD value, invasion cell number, and migration in FOXM1 group were higher than those in pcDNA3.1 group (P＜0.01); OD value, invasion cell number, and migration of si-FOXM1 group were lower than those of si-NC group (P＜0.01). The expression level of E-cadherin protein in FOXM1 group was lower than that in pcDNA3.1 group, while the expression levels of Vimentin and N-cadherin protein in FXOM1 group were higher than those in pcDNA3.1 group (P＜0.01); the expression level of E-cadherin protein in si-FOXM1 group was higher than that in si-NC group, while the expression levels of Vimentin and N-cadherin protein were lower than those in Si-NC group (P＜0.01). At 48 h and 72 h, OD value, invasion cell number, and migration of miR-325-3p inhibitor+si-FOXM1 group were lower than those of miR-325-3p inhibitor+si-NC group (P＜0.01). The expression level of E-cadherin protein in miR-325-3p inhibitor+si-FOXM1 group was higher than that of miR-325-3p inhibitor+si-NC group, while the expression levels of Vimentin and N-cadherin protein were lower than those of miR-325-3p inhibitor+si-NC group (P＜0.01). The expression levels of FOXM1 protein and mRNA in miR-325-3p group were lower than those in NC group (P＜0.01); the expression levels of FOXM1 protein and mRNA of miR-325-3p inhibitor group were higher than those of miR-NC group (P＜0.01). There was no significant difference in luciferase activity between NC+WT-FOXM1 group and NC+MUT- FOXM1 group (P＞0.05); the luciferase activity of miR-325-3p+WT-FOXM1 group was lower than that of miR-325-3p+ MUT-FOXM1 group (P＜0.01). Conclusion miR-325-3p is underexpressed in breast cancer tissues, and overexpression of miR-325-3p can inhibit proliferation, invasion, migration, and EMT of breast cancer cells by targeting FOXM1.
2023 Vol. 20 (17): 19-25 [Abstract] ( 26 ) HTML (1 KB)  PDF (1868 KB)  ( 18 )
26 Action mechanism of hyperbaric oxygen on white matter damage in adult rats with hypoxic-ischemic encephalopathy
XUE Ruijun1 LI Wenping2 HUANG Weizhe3 PAN Shuyi1 GUO Dazhi1
DOI: 10.20047/j.issn1673-7210.2023.17.05
Objective To investigate the action mechanism of hyperbaric oxygen (HBO) on white matter damage in adult rats with hypoxic-ischemic encephalopathy. Methods Forty-eight ten- week-old clean grade male SD rats aged 300-350 g were divided into four groups by completely randomized method: control group (no treatment), sham operation group (the skin was sutured directly after only bilateral carotid arteries were exposed), model group (two weeks after bilateral carotid arteries were ligation, rats were placed in a sealed chamber with 8%O2 and 92%N2 mixture for three hours), HBO group (HBO treatment was immediately given on the basis of model group), 12 rats in each group. The learning and memory function was evaluated by water maze before modeling and in the 4th week respectively. Fast Blue staining was used to observe the white matter myelin sheath damage in rat hippocampus. The expressions of ionized calcium binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) in the hippocampus were determined by immunofluorescence method. The expressions of myelin basic protein (MBP), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in hippocampus were analyzed by Western blot. Results There were no significant differences in the average incubation period and the number of platform crossing between the sham operation group and the control group (P＞0.05). The average incubation period of the model group was longer than that of the control group, and the number of platform crossing was lower than that of the control group (P＜0.05). The average incubation period of the HBO group was shorter than that of model group, and the number of platform crossing was higher than that of the model group (P＜0.05). The sham operation group was compared with the control group, the hippocampal staining degree of rats was basically the same, and there was no significant difference in myelin sheath. Compared with the control group, the hippocampal staining of rats was weakened, the myelin sheath was reduced, and vacuoles were appeared in some areas in the model group. Compared with the model group, hippocampal staining degree of rats was improved, myelin sheath was increased and regional vacuoles were decreased significantly in the HBO group. There was no significant difference in the number of GFAP-positive activated astrocytes and Iba-1 positive activated microglia in the hippocampus between the sham operation group and the control group (P＞0.05). The number of GFAP-positive activated astrocytes and Iba-1 positive activated microglia in the hippocampus of the model group was higher than that of the control group (P＜0.05). The number of GFAP-positive activated astrocytes and Iba-1 positive activated microglia in hippocampus of the HBO group was lower than that of the model group (P＜0.05). There were no significant differences in the expressions of MBP, IL-1β, IL-6, and TNF-α between the sham operation group and the control group (P＞0.05). The expression of MBP protein in the brain of the model group was lower than that of the control group, and the expressions of IL-1β, IL-6, and TNF-α were higher than those of the control group (P＜0.05). The expression of MBP protein in the HBO group was higher than that in the model group, but the expression levels of IL-1β, IL-6, and TNF-α in the HBO group were lower than that in the model group (P＜0.05). Conclusion HBO may reduce the activation of microglias and astrocytes in the hippocampus, inhibit the release of inflammatory factors, relieve myelin sheath damage, and promote myelin sheath regeneration, thereby improving the cognitive impairment of adult rats with hypoxic-ischemic encephalopathy.
2023 Vol. 20 (17): 26-30 [Abstract] ( 36 ) HTML (1 KB)  PDF (1466 KB)  ( 26 )
31 Current status and hotspot analysis of research on hallux valgus based on bibliometrics
SUN Xiaojie1 WANG Zidong2 WANG Shulong1 MA Zhanhua3 CHEN Zhaojun3
DOI: 10.20047/j.issn1673-7210.2023.17.06
Objective To analyze the literature related to hallux valgus in China, the research status and future development direction of hallux valgus are understood to provide scientific basis for the research in this field. Methods From January 1982 to December 2021, “hallux valgus” OR “hallux valgus” OR “hallux deformity” were searched by China National Knowledge Network. Statistical analysis was made on the publication time, publication sources, regions, disciplines involved and fund distribution of relevant literatures; by using bibliometric method and VOSviewer and CiteSpace software, the clustering situation of the current research team of bunion valgus was studied through co-authoricity analysis, and the current relevant research hotspots were studied through co-occurrence analysis. Results A total of 1 170 literatures on hallus valgus were retrieved, among which 857 were valid. The number of related literatures showed a trend of fluctuating year by year with a slow rise. Although the research institutions ware spread across most of the country, there was an imbalance in regional development, and the degree of cooperation between different regions, institutions of higher learning and authors was relatively small. The relevant literatures were published in more than 200 sources, which were relatively scattered. The National Natural Science Foundation of China provided the largest amount of funding for this research, but less than 20% of the literatures were funded by the foundation. The research focused on hallux valgus mainly include etiology, pathogenesis, surgical treatment, surgical efficacy, and complications. Conclusion In this study, it is found that the author team has been initially formed in the related research on hallus valgus, but the overall research level is still in a relatively immature stage, and the cooperation between the institutions and the authors is not strong, and the regional characteristics are prominent, so it is necessary to strengthen the communication and cooperation between the regional institutions. Hallux valgus researchers should improve the quality of scientific research and form more intensive evidence-based treatment.
2023 Vol. 20 (17): 31-35,40 [Abstract] ( 16 ) HTML (1 KB)  PDF (1595 KB)  ( 149 )
36 Research progress in clinical treatment of advanced non-small cell lung cancer patients with human epidermal growth factor receptor 2 changes
ZHANG Mengke CAO Jingyan ZHOU Shuhan SUN Qingyu
DOI: 10.20047/j.issn1673-7210.2023.17.07
Human epidermal growth factor receptor 2 is one of the driver genes for non-small cell lung cancer and is associated with poor prognosis. Among tyrosine kinase inhibitors, Poziotinib and Pyrotinib have good efficacy; Mobotinib has a high affinity for exon 20 insertion mutations. Treatment with Trastuzumab can be used in patients with first-line progression. The efficacy of antibody drug conjugates is the most encouraging, and Trastuzumab-Deruxtecan has obtained unprecedented efficacy data. Although immune checkpoint inhibitors are not recommended, combination immunotherapy may bring new life to patients.
2023 Vol. 20 (17): 36-40 [Abstract] ( 12 ) HTML (1 KB)  PDF (550 KB)  ( 107 )
41 Research progress on traditional Chinese and western medicine of prevention and treatment of heart failure based on β adrenergic receptor signaling pathway
SHI Tianyun1 LU Cheng2 LIU Yongming1
DOI: 10.20047/j.issn1673-7210.2023.17.08
Heart failure is the terminal stage of heart disease caused by various causes, and abnormal β adrenergic receptor signaling pathway is one of the important pathophysiological mechanisms for the occurrence and development of heart failure. Three kinds of β adrenergic receptor mediated signaling pathways and abnormal number of receptors play different pathophysiological roles in the occurrence and development of heart failure, such as β1 adrenergic receptor mediated Ca2+/calmodulin dependent protein kinase Ⅱ signaling, β2 and β3 adrenergic receptor mediated Gi protein signaling. This article mainly reviews the different pathological significance of the three β adrenergic receptor signaling pathways in heart failure, and the research progress of traditional Chinese and western medicine in the prevention and treatment of heart failure by improving β adrenergic receptor signaling.
2023 Vol. 20 (17): 41-44,52 [Abstract] ( 18 ) HTML (1 KB)  PDF (623 KB)  ( 118 )
45 Research progress on intravenous lidocaine in general anesthesia of colorectal cancer patients
WU Yumin1 YAN Wenjun2 QU Song1 ZHANG Wenjie1
DOI: 10.20047/j.issn1673-7210.2023.17.09
Lidocaine, an amide based local anesthetic, has been widely recognized for its clinical effects during the perioperative period, whether used as a regional anesthetic or as an auxiliary drug for general anesthesia. Lidocaine intravenous injection has the effects of analgesia, sedation, anti-infection, organ protection, promoting gastrointestinal function recovery and inhibiting tumor cell recurrence and metastasis. Colorectal cancer patients are more common in middle-aged and elderly people, and due to factors such as decreased appetite and tumor bleeding in the early stages, patients may experience weight loss, anemia, and poor tolerance to surgery and anesthesia. This review elucidates the advantages of intravenous infusion of lidocaine in general anesthesia for colorectal cancer patients, aiming to optimize perioperative management and improve prognosis.
2023 Vol. 20 (17): 45-48 [Abstract] ( 14 ) HTML (1 KB)  PDF (587 KB)  ( 128 )
49 Research progress of surgical traumatic stress and proinflammatory cytokines
Subinuer Kurexi1 WANG Ke2 CHEN Tongyu1
DOI: 10.20047/j.issn1673-7210.2023.17.10
Surgical traumatic stress can initiate the immune inflammatory response and promote the release of a large number of proinflammatory cytokines. Excess production of proinflammatory cytokines can cause further damage to tissues and organs, affecting the prognosis and outcome of surgical patients. In the acute stage of surgical trauma, the inhibition of excessive proinflammatory cytokines is the key to reduce postoperative complications and promote the recovery of patients. Among them, proinflammatory cytokines interleukin-6, tumor necrosis factor-α, high mobility group box 1, and C-reactive protein have important effects on surgical traumatic stress. This paper will focus on the above four typical proinflammatory cytokines and explore the potential clinical application value of corresponding cytokine antagonists.
2023 Vol. 20 (17): 49-52 [Abstract] ( 17 ) HTML (1 KB)  PDF (514 KB)  ( 23 )
53 Research progress on repair mechanism of electroacupuncture for sciatic nerve injury
WANG Jie CUI Jiawen
DOI: 10.20047/j.issn1673-7210.2023.17.11
The treatment of nerve injury has always been one of the difficult problems in clinical practice. Electroacupuncture, as a combination of traditional Chinese medicine and modern medicine, has been widely used in the treatment of sciatic nerve injury, but its mechanism is not fully understood. Therefore, by referring to the literature on the treatment of sciatic nerve injury by electroacupuncture in recent years, this paper introduces the effect of electroacupuncture on pain and motor function after sciatic nerve injury, and summarizes the possible therapeutic mechanism of electroacupuncture from four aspects, promoting Schwann cell proliferation, inhibiting inflammatory response, promoting neurotrophic factor secretion, and inhibiting neuronal apoptosis, and to provide reference and basis for clinical application and basic research.
2023 Vol. 20 (17): 53-56 [Abstract] ( 19 ) HTML (1 KB)  PDF (575 KB)  ( 99 )
57 Research progress on anti-tuberculosis effect of ion channel blockers
LUO Shuiqing1 ZENG Yali2
DOI: 10.20047/j.issn1673-7210.2023.17.12
Tuberculosis is a global public health disease caused by Mycobacterium tuberculosis (MTB) infection. The treatment of tuberculosis requires long-term use of multiple drugs, and becomes complicated and lengthy due to compliance and drug resistance. The sensitivity of MTB to drugs is to some extent determined by the interaction between bacteria and host macrophages. MTB mainly exists in macrophages after infecting the human body, and by inhibiting the physiological activity of macrophages, the body is in an infected state. Ion channel blockers regulate the concentration of signaling ions in macrophages by affecting the activity of ion channels, enhance the killing effect of host macrophages on MTB, and inhibit the activity of MTB efflux pumps, and improve the sensitivity of MTB to drugs. This article reviews some effective ion channel blockers for MTB and preliminarily explores their anti-tuberculosis mechanisms, hoping to provide new ideas for the development of new anti-tuberculosis drugs.
2023 Vol. 20 (17): 57-60 [Abstract] ( 14 ) HTML (1 KB)  PDF (527 KB)  ( 78 )
61 Analysis of intention and influencing factors of using “Internet + nursing service” in discharged patients with tube
HUANG Yan YUAN Wei LU Qinzhen
DOI: 10.20047/j.issn1673-7210.2023.17.13
Objective The intention to use “Internet + nursing service” and influencing factors of discharged patients with tube were analyzed. Methods By using convenience sampling Method, March 2020 to February 2022, the pipe out of the hospital patients in Nantong Sixth People’s Hospital were taken as the research object, the self-designed Tube discharge patients“Internet + nursing service” willingness to use survey questionnaire was used, and intend of “Internet + nursing service” was used on the single factor and multiple linear regression analysis. Results Among 241 patients, perceived usefulness was (16.72±3.15) points, perceived ease of use was (14.60±3.21) points, perceived risk was (15.68±3.24) points, perceived cost was (11.72±2.24) points, intention to use was (12.64±2.32) points, and use intention total score was (71.36±10.35) points. Univariate analysis showed that there were statistically significant differences in the intention to use “Internet + nursing service” among patients of different ages, educational level, residence, family economic status, and medical insurance mode (P＜0.05). Multiple linear regression analysis showed that age, economic status, and medical insurance were the influencing factors of using intention score (P＜0.05). Conclusion The willingness of discharged patients to use “Internet + nursing service” is lower than the medium level, which is related to age, education level, family average monthly income and medical insurance mode. Support and standardization construction of “Internet + nursing service” platform should be strengthened to improve the willingness of discharged patients with tubes to use.
2023 Vol. 20 (17): 61-64 [Abstract] ( 16 ) HTML (1 KB)  PDF (588 KB)  ( 120 )
65 Relationship between serum soluble intercellular adhesion molecule-1，soluble CD163 levels and in-stent restenosis after percutaneous coronary intervention in patients with unstable angina pectoris
CHEN Yang WU Ningning PANG Shengfeng
DOI: 10.20047/j.issn1673-7210.2023.17.14
Objective To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble CD163 (sCD163) levels and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with unstable angina pectoris(UAP). Methods A total of 182 UAP patients who underwent PCI in Taizhou Hospital of Traditional Chinese Medicine , Jiangsu Province from January 2019 to February 2021 were selected and divided into ISR group (41 cases) and non-ISR group (141 cases) according to whether ISR occurred. The clinical data of the two groups were collected, and the serum levels of sICAM-1 and sCD163 were detected by enzyme-linked immunosorbent assay. Binary logistic regression was used to analyze the influencing factors of ISR in UAP patients after PCI. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum sICAM-1 and sCD163 levels for ISR in UAP patients after PCI. Results The levels of serum sICAM-1, sCD163, and low-density lipoprotein cholesterol (LDL-C) in the ISR group were higher than those in the non-ISR group, the stent length was longer than that in the non-ISR group, and the stent diameter was shorter than that in the non-ISR group (P＜0.05). Multivariate analysis showed that stent diameter (OR=0.877, 95%CI: 0.797-0.965), LDL-C (OR=1.006, 95%CI: 1.003- 1.009), sICAM-1 (OR=1.014, 95%CI: 1.006-1.023), and sCD163  (OR=1.121, 95%CI: 1.021-1.232) were independent influencing factors for ISR in UAP patients after PCI (P＜0.05). The results of ROC curve analysis showed that the area under the curve of serum sICAM-1 and sCD163 combined to predict ISR in UAP patients after PCI was higher than that of each index alone (P＜0.05). Conclusion Serum sICAM-1 and sCD163 levels are independent influencing factors of ISR in UAP patients after PCI, which can be used as predictors of ISR.
2023 Vol. 20 (17): 65-68 [Abstract] ( 18 ) HTML (1 KB)  PDF (672 KB)  ( 19 )
69 Comparative study on the clinical effect of Bisoprolol and Valsartan in the treatment of resistant hypertension
ZHANG Wei KANG Liming YE Ting
DOI: 10.20047/j.issn1673-7210.2023.17.15
Objective To compare the clinical efficacy of Bisoprolol and Valsartan in the treatment of resistant hypertension. Methods A total of 96 patients with resistant hypertension admitted to Suzhou Hospital of Traditional Chinese Medicine in Anhui Province from June 2019 to June 2021 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 48 cases in each group. The control group was treated with Valsartan, 80 mg/time, once a day on the basis of routine treatment. The experimental group was treated with Bisoprolol, 5 mg/time, once a day on the basis of routine treatment. Both groups were treated for four weeks. The clinical efficacy, and diastolic blood pressure (DBP), systolic blood pressure (SBP), inflammatory factors, lipid metabolism levels were compared between the two groups before and after treatment, and the occurrence of adverse drug reactions in the two groups was recorded. Results During the study, one case dropped out of the experimental group and two cases dropped out of the control group. There was no significant difference in clinical efficacy between the two groups (P＞0.05). After treatment, DBP and SBP of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the levels of high-sensitivity C-reactive protein, Salusin-β, and matrix metalloproteinase-3 in the two groups were lower than those before treatment, and those in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol between the two groups before and after treatment (P＞0.05). There was no significant difference in the total incidence of adverse drug reactions between the two groups (P＞0.05). Conclusion Bisoprolol and Valsartan have similar efficacy in the treatment of resistant hypertension, and they do not affect the blood lipid metabolism indexes of patients with resistant hypertension, with good safety, but Bisoprolol has more advantages in improving serum inflammatory factors in patients with resistant hypertension.
2023 Vol. 20 (17): 69-72,77 [Abstract] ( 15 ) HTML (1 KB)  PDF (666 KB)  ( 23 )
73 Impairment of small world network and degree centrality in relapse-remitting multiple sclerosis patients
LIN Dan1 ZHOU Li1 TAN Zhongjian2 ZHOU Ying1 HAN Xiao1 CUI Fangyuan1
DOI: 10.20047/j.issn1673-7210.2023.17.16
Objective To investigate the small-world network impairment and changes of degree centrality in patients with relapsing-remitting multiple sclerosis (RRMS). Methods A total of 20 patients with RRMS who were admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2014 to January 2020 were enrolled as the observation group, and 15 matched healthy volunteers were selected as the control group.  NMR data and neural scale data of all subjects were collected, functional brain network was constructed by GRETNA software, and degree centrality (DC) was extracted by RESTPLUS software. Results  Both groups of functional brain networks were consistent with small-world network properties. Compared with the control group, the global efficiency of shortest path length  in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05), the small world attribute, normalized cluster coefficient, and global efficiency were lower than those in the control group, and the differences were statistically significant (P＜0.05); in DC analysis, after FWEc correction, DC values in the middle frontal gyrus, precuneus, cuneus in the observation group were higher than those in the control group, and DC values in the inferior temporal gyrus, fusiform gyrus were lower than those in the control group, and the differences were highly statistically significant (P＜0.01). Conclusion Patients with RRMS show a decrease in small-world attributes and other network parameters, indicating a decrease in the efficiency of information transmission and interaction between brain regions, which provides objective imaging evidence for the neuropathological mechanism of RRMS patients.
2023 Vol. 20 (17): 73-77 [Abstract] ( 20 ) HTML (1 KB)  PDF (1000 KB)  ( 32 )
78 Influence of plantar motor feedback therapy on walking function in patients with stroke in convalescent period
DONG Weihua XU Ning LIU Guifeng
DOI: 10.20047/j.issn1673-7210.2023.17.17
Objective To explore the influence of plantar motor feedback therapy on walking function in patients with stroke in convalescent period. Methods A total of 82 patients with stroke in convalescent period admitted to Changzhou Wujin Traditional Chinese Medicine Hospital, Jiangsu Province from April 2020 to January 2022 were selected as the research objects. They were divided into control group and study group by random number table method, with 41 cases in each group. The control group was treated with repetitive transcranial magnetic stimulation (rTMS), and the study group was treated with plantar motor feedback therapy on the basis of the control group. The walking ability of lower limbs, walking balance ability, gait, and heel pressure trail were evaluated and compared between the two groups before treatment and six weeks after treatment. Results After six weeks of treatment, the Holden walking function rating of the two groups was better than that before treatment, and the study group was better than the control group, the differences were statistically significant (P＜0.05). After six weeks of treatment, the Berg balance scale score, gait speed, and peak value of heel pressure of affected side in the two groups were higher than those before treatment, and those of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After six weeks of treatment, the heel impulse of the affected side in the two groups was higher than that before treatment, and the difference was statistically significant (P＜0.05). Conclusion Plantar motor feedback combines with rTMS is helpful to improve the walking ability and gait balance of patients with stroke in the convalescent period.
2023 Vol. 20 (17): 78-81 [Abstract] ( 24 ) HTML (1 KB)  PDF (554 KB)  ( 110 )
82 Comparison of Rapid software, CT angiography and digital subtraction angiography in evaluating collateral circulation
LEI Ming1 ZHAO Libo1 XU Liuyuan1 LIAO Juan2 LIU Qingjun1 WANG Yu3 DU Xiaoyan1 ZHAO Rui1
DOI: 10.20047/j.issn1673-7210.2023.17.18
Objective To investigate the consistency of assessment of collateral circulation among Rapid software, CT angiography (CTA) and digital subtraction angiography (DSA). Methods Seventy-five patients with unilateral middle cerebral artery occlusion admitted to Yongchuan Hospital of Chongqing Medical University from January 2020 to April 2022 were selected. Patients received CTA, CTP and DSA examination seperately after onset. Assessment of collateral circulation was automatically conducted by Rapid software, while the scores of CTA and DSA blood flow were assessed by two physicians blindly. DSA score was used as the gold standard to judge the accuracy of CTA and Rapid software evaluation. Kappa test was conducted to evaluate the consistency of blood flow score assessed by DSA, CTA and Rapid software. Results The blood flow scores of Rapid software accorded closely with DSA and CTA (rs=0.729, κ=0.516；rs=0.744, κ=0.543); blood flow scores of CTA and DSA were consistent (κ=0.768, rs=0.857). The sensitivity and specificity of Rapid software and CTA to determine good collateral circulation were 83.33%, 60.87% and 100.00%, 76.81%, respectively; the sensitivity and specificity of Rapid software and CTA were 46.67%, 100.00% and 86.67%, 100.00%, respectively; the sensitivity and specificity of Rapid software and CTA to determine the poor collateral circulation were 66.67%, 70.67% and 62.50%, 96.08% respectively. Conclusion CTA has high sensitivity and specificity, CTA and DSA assessment of collateral circulation results are highly consistent. The sensitivity and specificity of Rapid software are low, but it has a good consistency with DSA, so it can also be used as a check to evaluate collateral circulation.
2023 Vol. 20 (17): 82-85,131 [Abstract] ( 20 ) HTML (1 KB)  PDF (650 KB)  ( 31 )
86 Clinical effect of Maiguan Fukang Capsules combined with Nimergoline in treating post-stroke cognitive impairment with syndrome of internal blockade of static blood
WU Xiaoping1 MA Long2 WU Wei3 SANG Yuanyuan1 LIANG Hai1
DOI: 10.20047/j.issn1673-7210.2023.17.19
Objective To investigate the clinical effect of Maiguan Fukang Capsules combined with Nimergoline in treating post-stroke cognitive impairment (PSCI) with syndrome of internal blockade of static blood. Methods A total of 86 patients with PSCI with syndrome of internal blockade of static blood admitted to Bozhou People’s Hospital of Anhui Province from January 2021 to July 2022 were selected and divided into control group (43 cases) and observation group (43 cases) according to the random number table method. The control group was treated with Nimergoline, and the observation group was treated with Maiguan Fukang Capsules combined with Nimergoline. The two groups were treated for eight weeks. The clinical efficacy was compared between two groups, traditional Chinese medicine syndrome score, mini-mental state examination (MMSE) score, National Institutes of Health stroke scale (NIHSS) score, cerebral blood flow velocity, serum neuron specific enolase (NSE), superoxide dismutase (SOD), and malondialdehyde (MDA) were compared between the two groups before and after treatment, and the safety was evaluated. Results The curative effect of the observation group was better than that of the control group (P＜0.05). After treatment, the traditional Chinese medicine syndrome score, NIHSS score, and levels of NSE and MDA of the two groups were lower than those before treatment, and the MMSE score, SOD level, and blood flow velocity of left middle cerebral artery (LMCA), left posterior cerebral artery (LPCA), right posterior cerebral artery (RPCA) were higher than those before treatment, the traditional Chinese medicine syndrome score, NIHSS score, and levels of NSE and MDA of the observation group were lower than those of the control group, and the MMSE score, SOD level, and blood flow velocity of LMCA, LPCA, RPCA were higher than those of the control group (P＜0.05). No obvious adverse reactions occurred in the two groups during the treatment. Conclusion Maiguan Fukang Capsules combined with Nimergoline has a significant effect in the treatment of PSCI with syndrome of internal blockade of static blood, which can effectively improve cognitive impairment, neuronal damage, and cerebral blood flow, reduce oxidative stress response, and has high safety.
2023 Vol. 20 (17): 86-89 [Abstract] ( 18 ) HTML (1 KB)  PDF (626 KB)  ( 19 )
90 Effect of transcranial magnetic stimulation combined with surface electromyography in the treatment of dysphagia after stroke
ZHANG Yuan1 TANG Liying1 ZHU Lili1 ZHENG Xuelun1 DU Qian1 HE Ruoqi1 CHEN Miao2▲
DOI: 10.20047/j.issn1673-7210.2023.17.20
Objective To observe the effect of transcranial magnetic stimulation (TMS) combined with surface electromyography in the treatment of dysphagia after stroke. Methods A total of 86 patients with dysphagia after stroke admitted to Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from September 2021 to November 2022 were selected. The patients were divided into control group and combined group by random number table method, with 43 cases in each group. The control group was treated with TMS, and the combined group was treated with surface electromyography combined with TMS on the basis of the control group. The course of treatment in both groups was one month. The swallowing function, nutritional status (albumin [ALB], prealbumin [PA], total cholesterol [TC]), and quality of life were compared between the two groups before and after treatment. Results After treatment, the swallowing function grading of the two groups were better than those before treatment, and the combined group was better than the control group, and the differences were statistically significant (P＜0.05). After treatment, the TC levels of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the levels of ALB, PA, and each dimension scores of 36-item short form health survey in the two groups were higher than those before treatment, and the levels of ALB, PA, and scores of health status, life vitality, mental health in the combined group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion TMS combined with surface electromyography is effective in the treatment of dysphagia after stroke, which is worthy of promotion and application.
2023 Vol. 20 (17): 90-93 [Abstract] ( 17 ) HTML (1 KB)  PDF (551 KB)  ( 121 )
94 Clinical observation of Lactobacillus reuteri applied to premature infants
LI Xuran1 XING Meng1 ZHANG Yinzhu2 WANG Ruijuan1 HOU Xinlin3 YANG Ming2▲
DOI: 10.20047/j.issn1673-7210.2023.17.21
Objective To observe the therapeutic effects of Lactobacillus reuteri DSM 17938 on premature infants. Methods From January 2019 to July 2022, 63 cases of premature infants born and admitted to Neonatal Intensive Care Unit of Beijing United Family Hospital were selected as the study subjects. According to the random number table method, they were divided into with probiotics group and without probiotics group. The without probiotics group received general treatment; with probiotics group was given Lactobacillus reuteri DSM 17938 on the basis of general treatment, and continued to be administered until discharge. At the same time, according to gestational age, they were divided into≤28 weeks group (10 cases), ＞28 weeks group (53 cases), and according to weight, they were divided into≤1 500 g (26 cases) and ＞1 500 g (37 cases). The therapeutic effect of each group was observed. Results The time of vomiting disappearance, the time of reached total gastrointestinal nutrition, and the time to regain birth weight in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Gestational age ≤28 weeks, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group (P＜0.05). Gestational age ＞28 weeks, the time of vomiting disappearance and the time of reached total gastrointestinal nutrition in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Birth weight ≤1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜ 0.05). Birth weight ＞1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). No necrotizing enterocolitis or nosocomial infection occurred in two groups. Conclusion The use of Lactobacillus reuteri DSM 17938 can shorten the time of reached total gastrointestinal nutrition and the weight gain at the full moon, which has a definite effect on the treatment of premature infants.
2023 Vol. 20 (17): 94-98 [Abstract] ( 17 ) HTML (1 KB)  PDF (583 KB)  ( 24 )
99 Analysis of risk factors for poor clinical prognosis in children with human adenovirus type 7 pneumonia and construction of correlative prediction model
MA Zhao1 YANG Tong1 NIE Yijun1 LAO Jinquan2 CHEN Liujuan1 LAN Qiuhui1 QIN Tingting1 HUANG Xianwen1▲
DOI: 10.20047/j.issn1673-7210.2023.17.22
Objective To investigate the risk factors of poor clinical prognosis in children with human adenovirus type 7 (HAdV-7) pneumonia and to construct the correlative prediction model. Methods A total of 160 children with HAdV-7 pneumonia treated in Liuzhou People’s Hospital of Guangxi Zhuang Autonomous Region from January 2018 to January 2022 were selected. According to the prognosis, they were divided into good prognosis group (130 cases) and poor prognosis group (30 cases). The risk factors of poor prognosis of HAdV-7 pneumonia in children were analyzed, and the risk prediction model was established, the receiver operation characteristic curve was drew to test the prediction effect of the model. Results The duration of fever ≥38.5℃ in poor prognosis group was longer than that in good prognosis group, C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin(PCT), and aspartate aminotransferase(AST) were higher than those in good prognosis group, and the proportion of pleural effusion was higher than that in good prognosis group (P＜0.05). CRP (OR=1.314), LDH (OR=1.018), PCT (OR=7.268), AST (OR=1.148), and  lactate dehydrogenase (LDH), procalcitonin(PCT), and aspartate aminotransferase(AST) pleural effusion (OR=31.406) were independent risk factors for poor prognosis of children with HAdV-7 pneumonia (P＜0.05). The prediction model equation was Y=-43.761+0.273×CRP+0.018×LDH+1.983×PCT+0.138×AST+3.447× pleural effusion. The area under the curve of the model was 0.979 (95%CI: 0.950-1.000), the sensitivity was 93.3%, the specificity was 95.4%, the Yoden index was 0.887, and the cut-off value was 0.360. Conclusion The poor prognosis of children with HAdV-7 is related to CRP, LDH, PCT, AST, and pleural effusion, so the prediction model is constructed and contributed to effectively predict the prognosis of children with HAdV-7 pneumonia.
2023 Vol. 20 (17): 99-102,110 [Abstract] ( 18 ) HTML (1 KB)  PDF (874 KB)  ( 20 )
103 Effect of autoimmune thyroid disease on IVF-ET assisted pregnancy outcome
BAI Lipeng WANG Xinxin WEI Jingyan DING Lirong MAO Shuwen
DOI: 10.20047/j.issn1673-7210.2023.17.23
Objective To explore the effect of autoimmune thyroid disease on in vitro fertilization-embryo transfer (IVF-ET) assisted pregnancy outcome. Methods From October 2019 to December 2021, 94 infertile patients with anti-thyroid autoantibodies positive (ATA+) who received IVF-ET treatment in Reproductive Medical Center, Chifeng Maternity Hospital, Inner Mongolia Autonomous Region were selected as the ATA+ group, and 100 infertile patients without autoimmune thyroid disease in the same period were selected as the control group. Both groups received IVF-ET treatment, and gonadotropin releasing hormone antagonist (GnRH-a) long regimen was used. Ovarian stimulation was compared between the two groups, and the number of dominant follicles (≥14 mm), and the levels of estradiol (E2), luteinizing hormone (LH), progesterone (P) on the day of human chorionic gonadotropin (HCG) day between the two groups were analyzed, and the levels of serum Th1 cells and Th2 cells on the day of egg collection day and the fifth day of transplantation were analyzed; and the embryonic development potential and pregnancy outcome between the two groups were observed. Results There were no significant differences in the number of dominant follicles, and the levels of E2 and P on HCG day between the two groups (P＞0.05); the level of LH on HCG day in the ATA+ group was lower than that in the control group (P＜0.01). On the fifth day of transplantation, Th1, Th2, and Th1/Th2 in both groups were lower than those in egg collection day (P＜0.01). On egg collection day and the fifth day of transplantation, Th1 in the ATA+ group was higher than that in the control group, but Th2 and Th1/Th2 in the ATA+ group were lower than those in the control group (P＜0.01). There were no significant differences in the number of eggs, fertilization rate, and cleavage rate between the two groups (P＞0.05); the number of high-quality embryos and the rate of high-quality embryos in the ATA+ group were lower than those in the control group (P＜0.01). There were no significant differences in the number of transplanted embryos and clinical pregnancy rate between the two groups (P＞0.05). The abortion rate in the ATA+ group was higher than that in the control group, and the live birth rate was lower than that in the control group (P＜0.05). Conclusion The combination of autoimmune thyroid disease will affect the quality of embryonic development and increase the risk of abortion in IVF-ET patients, and its mechanism may be related to the immune changes of patients.
2023 Vol. 20 (17): 103-106 [Abstract] ( 17 ) HTML (1 KB)  PDF (562 KB)  ( 23 )
107 Effect of electrical stimulation biofeedback therapy on pelvic floor functional rehabilitation in early postpartum period
WANG Yingchun1 ZHAO Xinrui2
DOI: 10.20047/j.issn1673-7210.2023.17.24
Objective To explore the clinical value and significance of electrical stimulation biofeedback therapy on pelvic floor functional rehabilitation in early postpartum period. Methods Forty-eight patients with mild pelvic floor dysfunction admitted to the Department of Gynecology of the Third People’s Hospital of Hefei from January 2020 to January 2021 were selected as the study objects. According to the principle of simple randomization, the patients were divided into control group and observation group, with 24 cases in each group. The control group was provided with conventional rehabilitation therapy (Kegel training method), and the observation group was treated with electrical stimulation biofeedback therapy on this basis. The the grade of pelvic floor muscle strength, pelvic floor impact questionnaire-7 (PFIQ-7) score, and incontinence quality of life questionnaire (I-QOL) score were compared between two groups before and after treatment. Results After treatment, the grade of pelvic floor muscle strength in two groups was better than that before treatment, and observation group was better than control group (P＜0.01). After treatment, PFIQ-7 scores between two groups were lower than those before treatment, I-QOL scores between two groups were higher than those before treatment, and PFIQ-7 score in observation group was lower than that in control group, I-QOL score was higher than that in control group (P＜0.05 or P＜0.01). Conclusion Electrical stimulation biofeedback therapy has good early effect on postpartum patients with pelvic floor dysfunction and has high clinical application value.
2023 Vol. 20 (17): 107-110 [Abstract] ( 18 ) HTML (1 KB)  PDF (595 KB)  ( 168 )
111 Study on the relationship between plasma fibrinogen, prostate-specific antigen density， and osseous metastasis of prostate cancer
ZHANG Peng1 LI Xinzhao2 LIANG Qing3 ZHANG Zhiguo3 LIU Lin3 HAN Conghui3 LIU Dachuang1▲
DOI: 10.20047/j.issn1673-7210.2023.17.25
Objective To analyze the relationship between plasma fibrinogen (FIB) and prostate-specific antigen density (PSAD) levels and osseous metastasis of prostate cancer (PCa). Methods Data of 148 patients with PCa were retrospectively collected from Xuzhou Central Hospital of Jiangsu Province from January 2016 to December 2021. Among them, 85 (57.4%) patients with bone metastasis were the bone metastasis group, and 63 (42.6%) patients without bone metastasis were the no bone metastasis group. General information included prostate-specific antigen (PSA) levels, FIB levels, prostate volume, bone metastases, age, body mass index (BMI), and length of hospital stay. The relationship between FIB, PSAD, and PCa bone metastasis was analyzed. Results There were significant differences in FIB and PSAD levels between the two groups (P＜0.05). The optimal cut-off point was 3.840 g/L, sensitivity was 54.1%, and specificity was 81.0%. PSAD predicted that the optimal cut-off point of PCa was 0.393 ng/（ml·cm3）, the sensitivity was 83.5% and the specificity was 63.5%. Logistic regression analysis showed that FIB and PSAD were positively correlated with bone metastasis in PCa (OR=2.180, P＜0.001; OR=2.251, P＜0.001). Conclusion The levels of FIB and PSAD are positively correlated with the occurrence of osseous metastasis, which have high value in the diagnosis of osseous metastasis of prostate cancer.
2023 Vol. 20 (17): 111-114 [Abstract] ( 18 ) HTML (1 KB)  PDF (523 KB)  ( 16 )
115 Comparison of clinical effect and dosimetry between synchronous and sequential tumor bed complementary radiotherapy after breast conserving surgery for breast cancer
LU Feng ZHANG Fei LI Taiping
DOI: 10.20047/j.issn1673-7210.2023.17.26
Objective To study the clinical effect and dosimetry comparison between synchronous supplement of tumor bed in whole breast and sequential tumor bed supplementation in whole breast radiotherapy after breast conserving surgery for breast cancer. Methods Seventy-four patients with breast cancer in Department of Radiotherapy, Fuyang Tumor Hospital from January 2017 to April 2021 were selected and treated with breast conserving surgery for breast cancer. After surgery, they were divided into sequential group and synchronous group according to the random number table method, with 37 cases in each group. The sequential group received sequential tumor bed complementary radiotherapy, and the synchronous group received synchronous tumor bed complementary radiotherapy. The clinical effects, target dose of tumor bed dose, radiation dose endangering organs, and adverse radiation reactions were compared between the two groups. Results There was no significant difference in clinical effect between the two groups (P＞0.05). The average dose and maximum dose of tumor bed addition planned target area in synchronous group were lower than those in sequential group, and the differences were statistically significant (P＜0.05). The maximum doses of heart V30, lung V20, and spinal cord in the synchronous group were lower than those in the sequential group, and the differences were statistically significant (P＜0.05). The incidence of radiation pneumonia in the synchronous group was lower than that in the sequential group, and the difference was statistically significant (P＜0.05). Conclusion Compared with sequential tumor bed complementary radiotherapy, synchronous tumor bed complementary radiotherapy after breast conserving surgery for breast cancer can reduce the target dose, reduce the damage to the heart, lung, spinal cord, and other dangerous organs, and reduce the incidence of adverse radiation reactions.
2023 Vol. 20 (17): 115-118 [Abstract] ( 14 ) HTML (1 KB)  PDF (542 KB)  ( 147 )
119 Effect of Xihuang Capsules on liver function and cellular immune function in patients with primary liver cancer after transcatheter arterial chemoembolization
LIU Lina1 QIU Xingdong1 LI Xianchao1 ZHANG Guojing2▲
DOI: 10.20047/j.issn1673-7210.2023.17.27
Objective To observe the effects of Xihuang Capsules on liver function and cellular immunity in patients with primary liver cancer after transcatheter arterial chemoembolization (TACE). Methods From November 2020 to June 2022, 80 patients with primary liver cancer who underwent TACE treatment in the Department of Oncology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University were selected as the research objects, all patients had liver function damage. They were divided into experimental group and control group by random number table method, with 40 cases in each group. The control group were given two courses (14 days as a course) conventional liver protection treatment. The experimental group were given Xihuang Capsules adjuvant therapy on the basis of the control group. Liver function indicators including alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBil), and direct bilirubin were contrasted before and after treatment. T lymphocyte subsets(CD4+, CD8+, CD4+/CD8+) and natural killer (NK) cells levels were collected and contrasted before and after intervention. Clinical symptoms were contrasted before and after treatment. Results Before treatment, there were no significant difference in ALT, AST, TBil, and direct bilirubin between the two groups (P＞0.05). After treatment, the levels of CD4+, CD4+/CD8+ and NK cells in experimental group were higher than before treatment, while CD8+ was lower than before treatment, and the levels of CD4+, CD4+/CD8+ and NK cells in experimental group were higher than those in control group (P＜0.05), and CD8+ cells in experimental group were lower than those in control group (P＜0.05). After treatment, the levels of CD4+/CD8+ and NK cells in control group were higher than those before treatment (P＜0.05). There was no significant difference in clinical symptoms (loss of appetite, gastrointestinal reaction and fatigue) between the two groups (P＞0.05). Conclusion Xihuang Capsules has obvious anti-tumor effect, improves liver function, and has significant immune regulation ability for tumor patients, which is worthy of further study.
2023 Vol. 20 (17): 119-122 [Abstract] ( 18 ) HTML (1 KB)  PDF (571 KB)  ( 35 )
123 Analysis of influencing factors of complications in patients undergoing laparoscopic colorectal cancer surgery
GONG Xi LU Yeqing WU Xiufang SUN Mei▲
DOI: 10.20047/j.issn1673-7210.2023.17.28
Objective To explore the risk factors of complications in patients undergoing laparoscopic colorectal cancer surgery. Methods A total of 292 patients with colorectal cancer who underwent laparoscopic surgery admitted to Changhai Hospital Affiliated to Naval Medical University were selected from June to December 2021. The clinical data including gender, age, type of underlying disease, TNM stage, previous abdominal surgery history, surgery time, intraoperative blood loss, and conversion to laparotomy were collected, the occurrence of complications were recorded. Patients were divided into occurrence group and non-occurrence group according to whether complications occurred, and the risk factors of postoperative complications were analyzed. Results Complications occurred in 57 of 292 patients, with pulmonary infection being the most common. There were statistically significant differences in the proportion of pulmonary disease, surgery time, intraoperative blood loss, and the proportion of preoperative antibiotic use between two groups (P＜0.05). Pulmonary disease (OR=2.587), surgery time ≥180 min (OR=2.417), intraoperative blood loss ≥200 ml (OR=2.873) were risk factors for postoperative complications in patients underwent laparoscopic colorectal cancer surgery(P＜0.05)； preoperative antibiotic use (OR= 0.722) was a protective factor for postoperative complications in patients underwent laparoscopic colorectal cancer surgery (P＜0.05). Conclusion Pulmonary disease, intraoperative blood loss, operative time, and preoperative antibiotic use are the factors affecting postoperative complications in patients with colorectal cancer surgery, perioperative nursing and complication prevention and observation should be done well in clinic.
2023 Vol. 20 (17): 123-126 [Abstract] ( 16 ) HTML (1 KB)  PDF (561 KB)  ( 172 )
127 Correlation analysis of serum Hepc, s-HJV, and disease activity in patients with rheumatoid arthritis and anemia in northern Xinjiang area
ZHANG Daoyu LIU Xin TANG Qi XUE Mengmeng LIU Yongfeng OUYANG Wenbo ZHANG Hechao
DOI: 10.20047/j.issn1673-7210.2023.17.29
Objective To detect serum iron regulator (Hepc) and soluble iron regulator protein (s-HJV) in patients with rheumatoid arthritis complicated with chronic anemia (RA-ACD) in northern Xinjiang area, and to explore the role of Hepc and s-HJV in the pathogenesis of RA-ACD, to analyze the relationship between HEPC, S-HJV, and disease activity (DAS28). Methods From March 2021 to May 2022, a total of 120 RA-ACD patients(RA-ACD group), 120 RA patients(RA group), and 80 healthy physical examination patients(health control group) were collected from the Fourth Affiliated Hospital of Xinjiang Medical University, Altay Kazakh Medical Hospital, Altay Regional People’s Hospital, Tori Kazakh Medical Hospital, and Tori County People’s Hospital. The levels of serum Hepc, s-HJV, serum iron (SI), transferrin (Tf), ferritin (SF), interleukin 6 (IL-6), C-reactive protein (CRP), and erythrocyte settlement rate (ESR) in the above three groups were determined by double-antibody sandwich enzymosorbent immunosorbent assay, and DAS28 score was calculated. Results There were statistically significant differences in Hepc, s-HJV and Hb levels among the three groups (P＜0.05). Hepc of RA-ACD and RA groups were lower than that of control group, and RA-ACD group was lower than that of RA group; those of s-HJV in RA-ACD and RA groups were higher than that in healthy control group, and RA group was higher than that in healthy control group; Hb in RA-ACD group was lower than that in RA group and healthy control group, and the differences were statistically significant (P＜0.05). There were statistically significant differences in SI, Tf, and SF levels among the three groups (P＜0.05). The SI of RA-ACD group and RA group was lower than that of healthy control group, and RA-ACd group was higher than that of RA group; Tf in RA-ACD group and RA group was lower than that in healthy control group; The SF level of RA-ACD group was lower than that of RA group and healthy control group, and the differences were statistically significant (P＜0.05). The levels of IL-6, ESR, and CRP among the three groups were statistically significant (P＜0.05). IL-6, ESR, and CRP in RA-ACD and RA groups were higher than those in healthy control group, ESR, CRP, and DAS28 in RA-ACD group were higher than those in RA group, and the differences were statistically significant (P＜0.05). Correlation analysis showed that Hepc was positively correlated with IL-6 (r＞0, P＜0.05), and negatively correlated with DAS28 (r＜0, P＜0.05). s-HJV was positively correlated with SI, Tf, IL-6, and ESR (r＞0, P＜0.05), and negatively correlated with Hb (r＜0, P＜0.05). DAS28 was positively correlated with SI, ESR, and CRP (r＞0, P＜0.05), and negatively correlated with Hb (r＜0, P＜0.05). Hb was negatively correlated with SI, SF, ESR, CRP, and s-HJV (r＜0, P＜0.05). Conclusion Hepc and s-HJV are involved in the progression of RA-ACD disease, and s-HJV may reverse the promoting effect of inflammatory factors on Hepc expression in a compensatory way. The disease activity of RA is closely related to inflammation and anemia. The higher the level of inflammation, the more serious the disease will be, and anemia will aggravate the disease. Serum Hepc level decreased with the increase of DAS28 level, suggesting a certain correlation between Hepc and disease activity in RA patients.
2023 Vol. 20 (17): 127-131 [Abstract] ( 26 ) HTML (1 KB)  PDF (635 KB)  ( 19 )
132 Analysis on risk factors of delayed bleeding after endoscopic mucosal resection of colon polyps
YAN Zhen　SUN Yamei　GAO Feng　LANG Haibo　ZHANG Jie
DOI: 10.20047/j.issn1673-7210.2023.17.30
Objective To investigate the risk factors of delayed bleeding after endoscopic mucosal resection (EMR) of colon polyps. Methods A total of 1 863 patients with colon polyp who were admitted to Beijing Anzhen Hospital Affiliated to Capital Medical University from January 2020 to December 2021 and received EMR treatment were selected and divided into hemorrhage group and non-hemorrhage group according to whether delayed hemorrhage occurred. Clinical data of patients were retrospectively collected to analyze the risk factors of delayed bleeding after colon polyp EMR surgery. Results Among the 1 863 patients, 36 had delayed hemorrhage (1.93%). The proportion of polyp diameter ≥1 cm, pedicled polyp and rectal polyp in bleeding group were higher than those in non-bleeding group, and the differences were statistically significant (P＜0.05). Multivariate logistic regression analysis showed that using antithrombotic drugs (OR [95%CI] =2.248 [1.054-4.793]), polyps  in diameter ≥1 cm (OR [95%CI] =3.074 [1.338-7.061]), and rectal polyps (OR [95%CI] =5.577 [2.572-12.093]) were independent risk factors for delayed hemorrhage (P＜0.05). Conclusion Application of antithrombotic drugs, polyp size and polyp site are important risk factors for delayed bleeding after EMR surgery. Active and effective treatment should be carried out for high-risk patients in clinical practice to reduce the occurrence of delayed bleeding.
2023 Vol. 20 (17): 132-135 [Abstract] ( 24 ) HTML (1 KB)  PDF (665 KB)  ( 34 )
136 Influence of acupuncture on neurotransmitter level and cognitive function in patients with depressive episode of bipolar Ⅱ disorder
ZHOU Xin1 LIU Quanliang2 LI Xiaojuan3 ZHANG Xueying4 LI Xianzhou5
DOI: 10.20047/j.issn1673-7210.2023.17.31
Objective To explore the influence of acupuncture on neurotransmitter levels and cognitive function in patients with depressive episode of bipolar Ⅱ disorder. Methods A total of 72 patients with depressive episode of bipolar Ⅱ disorder admitted to Tangshan Fifth Hospital, Hebei Province, from January 2017 to December 2021 were selected, and divided into observation group (36 cases) and control group (36 cases) according to the random number table method. The control group was treated with Lithium Carbonate Tablets and Paroxetine Hydrochloride Tablets, and the observation group was treated with acupuncture on the basis of control group. The treatment lasted for eight weeks. The levels of serum neurotransmitters dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) were compared between two groups before and after treatment. The cognitive function of two groups before and after treatment was evaluated by the Hopkins verbal learning test-revised (HVLT-R), Wisconsin card sorting test (WCST), and continuous performance test (CPT) scores. Results After treatment, the levels of DA, NE, and 5-HT in two groups were higher than those before treatment, and those of observation group were higher than those of control group, the differences were statistically significant (P＜0.05). After treatment, the scores of HVLT-R, WCST, and CPT in two groups were higher than those before treatment, and the CPT scores in observation group were higher than those in control group, the differences were statistically significant (P＜0.05). Conclusion Acupuncture has a definite effect on patients with depressive episode of bipolar Ⅱ disorder, and is helpful to improve the serum neurotransmitter levels and cognitive function, which is worthy of clinical application.
2023 Vol. 20 (17): 136-139 [Abstract] ( 24 ) HTML (1 KB)  PDF (570 KB)  ( 27 )
140 Experience summary of Zhou Ling’s experience in treating senility neurological tinnitus from the perspective of spleen and kidney with acupuncture and traditional Chinese medicine combined
GAO Xuejiao1 LIU Ganggang2 ZHOU Ling1▲
DOI: 10.20047/j.issn1673-7210.2023.17.32
This paper summarizes the experience of Professor Zhou Ling, a famous old Chinese doctor, in treating senility neurological tinnitus from the perspective of spleen and kidney with acupuncture and traditional Chinese medicine combined. Through the analysis of Professor Zhou’s understanding of the etiology and pathogenesis of senility neurological tinnitus, the composition, prescription meaning, and function of the empirical formula “tinnitus No.1” are analyzed, combined with acupuncture treatment point selection and techniques, and the attached clinical case is verified. Professor Zhou believes that senility neurological tinnitus should be treated from the perspective of spleen and kidney because of its deficiency and blood stasis. The treatment is invigorating spleen for benefiting kidney, promoting blood circulation for removing obstruction in collaterals, while acupuncture and traditional Chinese medicine combined are applied together, giving consideration to both manifestation and root cause. The internal administration of decoction invigorating spleen for benefiting kidney, the external application of acupuncture and moxibustion for removing obstruction in collaterals, conditioning qi and blood, acupuncture and traditional Chinese medicine combined, both internal and external treatment, giving consideration to both manifestation and root cause, its experience is worth clinical study and promotion, and with a case, to discuss with like-minded friends.
2023 Vol. 20 (17): 140-143 [Abstract] ( 20 ) HTML (1 KB)  PDF (660 KB)  ( 46 )
144 Clinical effect of scalp acupuncture in the treatment of primary insomnia based on the theory of “brain as marrow sea”
DING Dingming LI Sikang WANG Zhongju▲ WANG Xun QU Yuqiang
DOI: 10.20047/j.issn1673-7210.2023.17.33
Objective To evaluate the effect of scalp acupuncture in the treatment of primary insomnia based on the theory of “brain as marrow sea”. Methods A total of 90 primary insomnia patients admitted to the Department of Acupuncture and Moxibustion, Wuhu Hospital of Traditional Chinese Medicine, Anhui Province, from February 2021 to July 2022 were selected and divided into scalp acupuncture group, conventional acupuncture group, and western medicine group according to random number table method, with 30 patients in each group. Scalp acupuncture treatment, conventional acupuncture treatment, and oral Esazolam Tablets were respectively given. Each group was treated for two courses. the sleep scale scores, traditional Chinese medicine syndrome scores, and clinical efficacy of each group were compared before and after treatment. Results The time point comparison and interaction of Pittsburgh sleep quality index (PSQI) score and traditional Chinese medicine syndrome score between scalp acupuncture group and conventional acupuncture group were statistically significant (P＜0.05). Intra-group comparison: after treatment and during follow-up, PSQI scores and traditional Chinese medicine syndrome scores of scalp acupuncture group and conventional acupuncture group were lower than those before treatment, and the differences were statistically significant (P＜ 0.05). Comparison between groups: there were no statistical significances in PSQI score and traditional Chinese medicine syndrome score between scalp acupuncture group and conventional acupuncture group (P＞0.05). The PSQI score and traditional Chinese medicine syndrome score of scalp acupuncture group and western medicine group were compared between groups, time point comparison and interaction, and the differences were statistically significant (P＜0.05). Intra-group comparison: after treatment and during follow-up, PSQI score and traditional Chinese medicine syndrome score of scalp acupuncture group and western medicine group were lower than those before treatment, and the differences were statistically significant (P＜0.05). Comparison between groups: after treatment and during follow-up, PSQI score and traditional Chinese medicine syndrome score of scalp acupuncture group were lower than those of western medicine group, and the differences were statistically significant (P＜0.05). The clinical effect of scalp acupuncture group was better than that of western medicine group, and the difference was statistically significant (P＜0.05), but there was no statistically significant difference in clinical effect between scalp acupuncture group and conventional acupuncture group (P＞0.05). Conclusion For the treatment of primary insomnia, scalp acupuncture has the advantages of direct action and precise acupoint selection, which can effectively improve the clinical symptoms of primary insomnia patients, improve the quality of life, and further clinical promotion.
2023 Vol. 20 (17): 144-148 [Abstract] ( 23 ) HTML (1 KB)  PDF (695 KB)  ( 37 )
149 Li Dongyuan’s experience in treating perimenopausal syndrome based on Yin fire theory
KONG Lingyuan HAN Xinyuan WU Yue SONG Xiaobin
DOI: 10.20047/j.issn1673-7210.2023.17.34
The Yin fire theory put forward by Li Dongyuan, a famous physician in the Jin Dynasty
, takes “damage to the qi of the spleen and stomach, malfunction of the rising of qi; deficiency of primordial qi, and internal flourishing of yin fire” as the fundamental pathogenesis, which can explain the pathogenesis of perimenopausal syndrome more completely. Based on the analysis of yin fire theory, the basic pathogenesis of perimenopausal syndrome includes “deficiency of primordial qi, yin fire flaming upward”, “malfunction of the rising of qi, stagnation of fire and internal knot”, and “internal flourishing of yin fire, depletion of kidney water”. Li Dongyuan creates the removing heat with sweet-warm natured medicine method for treating yin and fire syndrome, which uses pungent-warm natured medicine for dispersing and penetrating, sweet-warm and sweet-calm natured medicine to benefit qi for tranquillization, and sweet-cold natured medicine to nourish yin for clearing fire, which is important for the treatment of perimenopausal syndrome, and can be used flexibly in the clinical treatment of perimenopausal syndrome according to this method.
2023 Vol. 20 (17): 149-152 [Abstract] ( 24 ) HTML (1 KB)  PDF (574 KB)  ( 35 )
153 Application effect of Newman system nursing in patients with carotid artery stenosis after stent implantation
GUI Jinmin ZHAO Donghong▲ LIU Qinglin ZHANG Qian
DOI: 10.20047/j.issn1673-7210.2023.17.35
Objective To analyze the application effect of Newman system nursing in patients with carotid artery stenosis after stent implantation. Methods A total of 120 patients with carotid artery stenosis admitted to Beijing Tiantan Hospital, Capital Medical University from March 2021 to May 2022 were selected. According to random number table method, they were divided into control group and experimental group, with 60 cases in each group. The control group was given routine nursing, and the experimental group was given Newman system nursing. The psychological status, self-management ability, sleep quality, and medication compliance of the two groups were compared. Results After intervention, self-rating anxiety scale and self-rating depression scale scores of both groups were lower than those before intervention, and the experimental group was lower than the control group (P＜0.05); Pittsburgh sleep quality index scores in both groups were lower than those before intervention, and the experimental group was lower than the control group(P＜0.05); the self-care ability score of the two groups was higher than those before intervention, and the experimental group was higher than the control group (P＜0.05); the compliance of experimental group was better than that of control group (P＜0.05). Conclusion Newman system nursing can relieve the negative emotion of patients after carotid artery stenosis stent implantation, improve the self-care ability, sleep quality and medication compliance of patients.
2023 Vol. 20 (17): 153-156 [Abstract] ( 27 ) HTML (1 KB)  PDF (623 KB)  ( 28 )
157 Application effect of stage functional training on prognosis and rehabilitation of patients with craniocerebral injury under evidence-based theory
XU Jingming FANG Huie▲
DOI: 10.20047/j.issn1673-7210.2023.17.36
Objective To explore the application effect of stage functional training on prognosis and rehabilitation of patients with craniocerebral injury under evidence-based theory. Methods A total of 100 patients with craniocerebral injury admitted to the Affiliated Hospital of Yangzhou University from January 2019 to January 2021 were randomly divided into the control group and the experimental group, with 50 cases in each group. The control group received routine functional training, while the experimental group received staged functional training based on evidence-based theory. Both groups were trained for two weeks. The cognitive function, limb motor function, and quality of life of the two groups were compared. Results After training, the cognitive function scores and motor function scores of the two groups were higher than those before training, and the experimental group was higher than the control group, the difference were statistically significant (P＜0.05). The quality of life scores of the two groups were higher than those before training, and the experimental group was higher than the control group, the differences were statistically significant (P＜0.05). Conclusion The staged functional training based on evidence-based theory is helpful to improve cognitive function and limb motor function of patients with craniocerebral trauma, and improve their quality of life.
2023 Vol. 20 (17): 157-160,165 [Abstract] ( 20 ) HTML (1 KB)  PDF (733 KB)  ( 33 )
161 Effect of systematic nursing model based on color psychology concept on psychological state and quality of life of patients with subarachnoid hemorrhage
CHENG Qian LI Zhengming YANG Menglan LU Tingting YANG Yan
DOI: 10.20047/j.issn1673-7210.2023.17.37
Objective To explore the effect of systematic nursing model based on color psychology concept on psychological state and quality of life of patients with subarachnoid hemorrhage (SAH). Methods A total of 120 patients with SAH admitted from March 2019 to June 2021 in the Department of Neurosurgery, the Affiliated to Huaian NO.1 People’s Hospital of Nanjing Medical University were selected as the study objects, and they were divided into control group and observation group by random number table method, with 60 cases in each group. The control group received routine nursing, and the observation group received systematic nursing model based on color psychology concept. The psychological state and quality of life of the two groups were observed at enrollment and eight weeks after intervention. Results After eight weeks of intervention, the score and total score of negative emotion domain on the profile of mood state (POMS) of both groups were lower than that of the enrollment, and the score of POMS positive emotion domain was higher than that of the enrollment, and the score and total score of POMS in the observation group were lower than that of the control group, and those of the score of POMS in the positive emotion domain was higher than that of the control group (P＜0.05); at eight weeks of intervention, the total scores of quality of life scale in both groups were higher than those in the enrollment, and those of the observation group was higher than the control group (P＜0.05). Conclusion The systematic nursing model based on color psychology concept can promote the elimination of negative emotions in SAH patients, and has a positive effect on improving their quality of life.
2023 Vol. 20 (17): 161-165 [Abstract] ( 18 ) HTML (1 KB)  PDF (991 KB)  ( 49 )
166 Effect of family continuity care on quality of life of patients with oral cancer after surgery
WEN Wen ZHOU Hongyan WANG Qin LEI Xiaolin
DOI: 10.20047/j.issn1673-7210.2023.17.38
Objective To explore the effect of family continuity nursing on the quality of life of patients with oral cancer after operation. Methods A total of 180 patients with oral cancer admitted to Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine of Sichuan Province from May 2018 to April 2021 were selected and divided into intervention group (90 cases) and control group (90 cases) according to random number table method. The control group was given routine follow-up nursing intervention, while the intervention group was given family continuity nursing intervention on basis of the control group. Oral comfort level, family function score, self-management ability, survival quality, and complication rate were compared between the two groups. Results The oral comfort of the intervention group was better than that of the control group, and the difference was statistically significant (P＜0.05). After intervention, family intimacy, and family fitness scores of the two groups were higher than before intervention, while those of the intervention group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, scores of scientific diet, reasonable exercise, and periodic review in two groups were higher than before intervention, while those of the intervention group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the scores of physical function, social function, and emotional function in two groups were higher than before intervention, while those of the intervention group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the intervention group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Application of family continuity nursing in postoperative intervention of patients with oral cancer can improve oral comfort, improve family intimacy and family fitness, enhance self-management ability and quality of life, and reduce the incidence of complications.
2023 Vol. 20 (17): 166-169 [Abstract] ( 21 ) HTML (1 KB)  PDF (615 KB)  ( 30 )
170 Effects of guided imagination training on hope level, coping style and negative emotion in patients with depression
SUN Yan1 ZHANG Lei2▲ DIAO Yanyun3 CHANG Xiao1 WANG Chunxia1 BO Lina1
DOI: 10.20047/j.issn1673-7210.2023.17.39
Objective To explore the effects of guided imagination training on hope level, coping style and negative emotion in patients with depression. Methods A total of 100 male patients with depression admitted to Zibo City Mental Health Center of Shandong Province from February 2021 to February 2022 were selected and divided into observation group and control group according to random number table method, with 50 cases in each group. The control group was received routine nursing for depression, while the observation group was received guided imagination training on the basis of routine nursing. After four weeks of intervention, hope level, coping style, and anxiety and depression level were compared between the two groups before and after intervention. Results After four weeks of intervention, the scores of realistic and future attitudes, adopting positive actions, and maintaining close relationships with others in the two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After four weeks of intervention, the scores of positive coping and negative coping in two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After four weeks of intervention, anxiety and depression scores of the two groups were higher than before intervention, while those of the observation group was higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Guided imagination training can improve the hope level of depression patients, enhance the ability of patients to deal with the disease, and reduce the degree of anxiety and depression.
2023 Vol. 20 (17): 170-173 [Abstract] ( 24 ) HTML (1 KB)  PDF (523 KB)  ( 98 )
174 Application of initial comprehensive intervention on feeding and growth status of low body weight children with feeding intolerance
HUAN Yaqin ZHOU Jingxia ZHANG Lingli
DOI: 10.20047/j.issn1673-7210.2023.17.40
Objective To explore the application analysis of initial comprehensive intervention on feeding and growth status of low body weight children with feeding intolerance. Methods A total of 78 children with low body weight were selected from the Rugao of People’s Hospital, Jiangsu Province from April 2018 to March 2022. They were divided into two groups according to random number table method, with 39 cases in each group. The control group was treated with routine feeding nursing, while the observation group was treated with early and initial comprehensive intervention on the basis of the control group. The feeding intolerance time, the time needed to recover to birth weight, the time to achieve sufficient gastrointestinal feeding and the growth status of the two groups were compared. Results The duration of feeding intolerance, recovery of birth weight, and adequate gastrointestinal feeding in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The disappearance time of vomiting, diarrhea and gastric retention in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). After intervention, the body weight, body length, and head circumference of the two groups were higher than before intervention, while those of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Early comprehensive intervention nursing for low body weight infants with feeding intolerance can effectively improve the absorption of gastrointestinal function, reduce the time of occurrence of feeding intolerance, quickly recover to birth weight, and promote the growth of children, worthy of clinical promotion and adoption.
2023 Vol. 20 (17): 174-177 [Abstract] ( 26 ) HTML (1 KB)  PDF (575 KB)  ( 15 )
178 Effects of continuous rehabilitation nursing on mental stress state, nutritional index and limb function recovery of stroke patients
HUANG Chang1 HE Xinru1 YU Huiyun1 LI Yuju2
DOI: 10.20047/j.issn1673-7210.2023.15.41
Objective To explore the effects of continuous rehabilitation nursing on mental stress state, nutritional index, and limb function recovery of stroke patients. Methods A total of 128 stroke patients admitted to the Department of Rehabilitation, the Fourth Hospital of Changsha, Hunan Province from January 2019 to December 2021 were selected. They were divided into control group and experimental group by random number table method, with 64 cases in each group. The control group implemented routine rehabilitation nursing intervention countermeasures, and the experimental group implemented continuous rehabilitation nursing intervention countermeasures on the basis of the control group, before intervention and four weeks after intervention, the mental stress state, nutritional index, and limb function recovery were observed and compared between the two groups. Results After four weeks of intervention, the positive experience scores of both groups were higher than those of before intervention, while the negative experience scores were lower than those of before intervention, and the score of positive experience in experimental group was higher than that in control group, while the score of negative experience was lower than that in control group (P＜0.05); comprehensive nutritional status of experimental group was better than that of control group (P＜0.05); neurologic deficit scores (NDS) of both groups were lower than those before intervention, and simple mental state examination scale (MMSE) score was higher than those before intervention, and NDS score of experimental group was lower than control group, MMSE score was higher than that of control group (P＜0.05). Conclusion Continuous rehabilitation nursing intervention measures should be taken to strengthen the subjective well-being of stroke patients, improve the nutritional status of the body and enhance limb function.
2023 Vol. 20 (17): 178-181 [Abstract] ( 18 ) HTML (1 KB)  PDF (585 KB)  ( 45 )
182 A case of Creutzfeldt-Jakob disease treated by traditional Chinese medicine combined with brain functional network evaluation
HOU Xiaoying1 ZHONG Liqun2 ZHANG Qian3 CHEN Cheng2 ZHANG Hua2 MA Dayong2 ZHAO Zijun2 WEI Jingpei2
DOI: 10.20047/j.issn1673-7210.2023.17.42
Creutzfeldt-Jakob disease is a rare neurodegenerative encephalopathy induced by prion protein. The patient’s average survival time is six months with high mortality and poor prognosis. This report retrospectively analyzed a case of Creutzfeldt-Jakob disease admitted to Dongzhimen Hospital, Beijing University of Chinese Medicine, the patient presented with rapidly progressive dementia, visual impairment, apparent extrapyramidal impairment, and rapid progression to coma and death from severe pneumonia, with a total duration of one year and four months. Western medicine lacks effective treatment methods. The homologous brain function network analysis based on individual showed that traditional Chinese medicine differentiation and treatment could delay the progression of the disease. This article shared the traditional Chinese medicine diagnosis and treatment process of a patient with Creutzfeldt-Jakob disease, and reviewed the literature in order to strengthen the understanding of this disease and explore the advantages of traditional Chinese medicine treatment.
2023 Vol. 20 (17): 182-185 [Abstract] ( 24 ) HTML (1 KB)  PDF (1216 KB)  ( 88 )
186 Metagenomic next-generation sequencing assisted diagnosis of Q fever bloodstream infection: a case report
CHEN Ping1 WU Wenbing2 GOU Hui3 REN Sichong4
DOI: 10.20047/j.issn1673-7210.2023.17.43
Q fever bloodstream infection is an infection caused by Coxiella burnetii, because its clinical cases are rare, the clinical manifestations lack specificity and traditional detection methods are difficult to obtain its etiological evidence, resulting in the misdiagnosis rate is extremely high. In severe cases, multiple organs of the patient’s may be involved, which is life-threatening. Early diagnosis and precise treatment are still huge clinical challenges. Metagenomic next-generation sequencing has shown great potential in the diagnosis of rare pathogens infection, which makes the detection rate of Q fever pathogens continuously improve. This article reports one case of Q fever bloodstream infection successfully detected by metagenomic next-generation sequencing and timely treatment with reasonable antibiotics, the patient had good prognosis.
2023 Vol. 20 (17): 186-188,196 [Abstract] ( 20 ) HTML (1 KB)  PDF (618 KB)  ( 121 )
189 Practice and exploration of PDCA cycle theory in the establishment of hospital medical association referral practice style risk prevention and control operation
ZHANG Yi1 GUO Li2 YU Feng1 WANG Manwei1 YANG Minghui3
DOI: 10.20047/j.issn1673-7210.2023.17.44
Objective To explore application effect of PDCA cycle theory in the establishment of hospital medical association referral practice style risk prevention and control operation. Methods The medical consortium referral was the research contents. Based on the existing referral system and medical information system, the system was revised and information technology was upgraded, including the establishment of informed consent forms, referral process prompts, referral information collection, and other risk prevention and control operation settings. The awareness rate evaluation of referral risk prevention and control management system among 318 doctors in the referral department was compared before the implementation (April 2021) and after the implementation (September 2021) in Beijing Jishuitan Hospital. Results After implementation, the awareness rates of doctors about doctor referral system and process, the content of the doctor’s informed consent form, doctor signs informed consent form and standardize referral into medical ethics assessment were higher than those before implementation, and the differences were statistically significant (P<0.05). Conclusion Establishing practice style risk prevention and control based on PDCA cycle theory can effectively improve the awareness rate of referral processes and informed consent forms, standardize medical behavior of medical personnel, and improve medical quality and safety.
2023 Vol. 20 (17): 189-192 [Abstract] ( 18 ) HTML (1 KB)  PDF (1146 KB)  ( 30 )
193 Research and practice of personnel training system construction in first class general hospital based on multi-district hospitals development
CHEN Zhihang1 ZHU Wei2
DOI: 10.20047/j.issn1673-7210.2023.17.45
With the rapid development of China’s economy and society and the gradual deepening of the reform of medical and health system, the development of multi-hospitals of first class general hospital has become the inevitable trend. This not only promotes the continuous development of China’s healthcare industry and improves the quality of medical treatment for the people, but also brings new opportunities and challenges to the construction and practice of hospital talent training systems. This paper will be based on the talent training status of Beijing Chaoyang Hospital, Capital Medical University in recent years,  and analyze the problems faced by the talent cultivation system of first class general hospital from multiple perspectives and levels under the current situation. Thoroughly analyze the reasons and propose corresponding construction plans, in order to provide reference for the evaluation and reform of the talent training system of first class general hospital in multi-district hospitals.
2023 Vol. 20 (17): 193-196 [Abstract] ( 17 ) HTML (1 KB)  PDF (592 KB)  ( 93 )
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