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| Influence of acupuncture on neurotransmitter level and cognitive function in patients with depressive episode of bipolar Ⅱ disorder |
| ZHOU Xin1 LIU Quanliang2 LI Xiaojuan3 ZHANG Xueying4 LI Xianzhou5#br# |
1.Department of Laboratory, Tangshan Fifth Hospital, Hebei Province, Tangshan 063000, China;
2.Department of Laboratory, Tangshan Fengrun People’s Hospital, Hebei Province, Tangshan 063000, China;
3.Clinical Pharmacy Room, Department of Pharmacy, Tangshan Fengnan District Hospital, Hebei Province, Tangshan 063000, China;
4.Project Office, Tangshan Fifth Hospital, Hebei Province, Tangshan 063000, China;
5.Department of Pharmacy, Tangshan Fifth Hospital, Hebei Province, Tangshan 063000, China
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Abstract Objective To explore the influence of acupuncture on neurotransmitter levels and cognitive function in patients with depressive episode of bipolar Ⅱ disorder. Methods A total of 72 patients with depressive episode of bipolar Ⅱ disorder admitted to Tangshan Fifth Hospital, Hebei Province, from January 2017 to December 2021 were selected, and divided into observation group (36 cases) and control group (36 cases) according to the random number table method. The control group was treated with Lithium Carbonate Tablets and Paroxetine Hydrochloride Tablets, and the observation group was treated with acupuncture on the basis of control group. The treatment lasted for eight weeks. The levels of serum neurotransmitters dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) were compared between two groups before and after treatment. The cognitive function of two groups before and after treatment was evaluated by the Hopkins verbal learning test-revised (HVLT-R), Wisconsin card sorting test (WCST), and continuous performance test (CPT) scores. Results After treatment, the levels of DA, NE, and 5-HT in two groups were higher than those before treatment, and those of observation group were higher than those of control group, the differences were statistically significant (P＜0.05). After treatment, the scores of HVLT-R, WCST, and CPT in two groups were higher than those before treatment, and the CPT scores in observation group were higher than those in control group, the differences were statistically significant (P＜0.05). Conclusion Acupuncture has a definite effect on patients with depressive episode of bipolar Ⅱ disorder, and is helpful to improve the serum neurotransmitter levels and cognitive function, which is worthy of clinical application.
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