|
|
|
| Research progress of surgical traumatic stress and proinflammatory cytokines |
| Subinuer Kurexi1 WANG Ke2 CHEN Tongyu1 |
1.Department of Cardio-Thoracic Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;
2.Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
|
|
|
|
Abstract Surgical traumatic stress can initiate the immune inflammatory response and promote the release of a large number of proinflammatory cytokines. Excess production of proinflammatory cytokines can cause further damage to tissues and organs, affecting the prognosis and outcome of surgical patients. In the acute stage of surgical trauma, the inhibition of excessive proinflammatory cytokines is the key to reduce postoperative complications and promote the recovery of patients. Among them, proinflammatory cytokines interleukin-6, tumor necrosis factor-α, high mobility group box 1, and C-reactive protein have important effects on surgical traumatic stress. This paper will focus on the above four typical proinflammatory cytokines and explore the potential clinical application value of corresponding cytokine antagonists.
|
|
|
|
|
|
[1] Koyuncu A，Yava A，Yamak B，et al. Effect of family presence on stress response after bypass surgery [J]. Heart Lung，2021，50（2）：193-201.
[2] Helander EM，Webb MP，Menard B，et al. Metabolic and the Surgical Stress Response Considerations to Improve Postoperative Recovery [J]. Curr Pain Headache Rep，2019，23（5）：33.
[3] Hildebrand F，Pape HC，Krettek C. The importance of cytokines in the posttraumatic inflammatory reaction [J]. Unfallchirurg，2005，108（10）：793-794，796-803.
[4] Haddadi K，Abediankenari S，Alipour A，et al. Association between Serum Levels of Interleukin-6 on Pain and Disability in Lumbar Disc Herniation Surgery [J]. Asian J Neurosurg，2020，15（3）：494-498.
[5] He L，Qing F，Li M，et al. Effects of laparoscopic and traditional open surgery on the levels of IL-6，TNF-alpha，and Gal-3 in patients with thyroid cancer [J]. Gland Surg，2021， 10（3）：1085-1092.
[6] Murakami M，Kamimura D，Hirano T. Pleiotropy and Specificity：Insights from the Interleukin 6 Family of Cytokines [J]. Immunity，2019，50（4）：812-831.
[7] Qiao Z，Wang W，Yin L，et al. Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients：a meta-analysis [J]. Eur J Trauma Emerg Surg，2018，44（5）：679-687.
[8] Tanaka T，Narazaki M，Kishimoto T. Interleukin（IL-6）Immu- notherapy [J]. Cold Spring Harb Perspect Biol，2018，10（8）：a028456
[9] Hu J，Feng X，Valdearcos M，et al. Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice [J]. Br J Anaesth，2018，120（3）：537-545.
[10] Micic D，Lalic N，Djukic V，et al. Influence of IL-6，TNF- alpha and Hs-CRP on Insulin Sensitivity in Patients after Laparoscopic Cholecystectomy or Open Hernia Repair[J]. J Med Biochem，2018，37（3）：328-335.
[11] Matata BM，Sosnowski AW，Galinanes M. Off-pump bypass graft operation significantly reduces oxidative stress and inflammation [J]. Ann Thorac Surg，2000，69（3）：785-791.
[12] Cinat ME，Waxman K，Granger GA，et al. Trauma causes sustained elevation of soluble tumor necrosis factor receptors [J]. J Am Coll Surg，1994，179（5）：529-537.
[13] Kurniawan VR，Islam AA，Adhimarta W，et al. The role of diphenhydramine HCl on tumor necrosis factor-alpha levels in wistar rats with traumatic brain injury：An in vivo study [J]. Ann Med Surg（Lond），2022，81：104399.
[14] Jiang L，Hu M，Lu Y，et al. The protective effects of dexmedetomidine on ischemic brain injury：A meta-analysis [J]. J Clin Anesth，2017，40：25-32.
[15] Maca J，Bursa F，Sevcik P，et al. Alarmins and Clinical Outcomes After Major Abdominal Surgery-A Prospective Study [J]. J Invest Surg，2017，30（3）：152-161.
[16] Muire PJ，Schwacha MG，Wenke JC. Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1（HMGB1）Driven Hyper-Inflammation in a Polytrauma Rat Model [J]. Cells，2021，10（7）：1646.
[17] Wen S，Li X，Ling Y，et al. HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats [J]. FASEB J，2020，34（3）：4384-4402.
[18] Zhang S，Feng Z，Gao W，et al. Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/ TLR-4/NF-kappaB Signaling Pathway，Oxidative Stress，and Apoptosis [J]. Front Pharmacol，2020，11：544124.
[19] Yang Z，Simovic MO，Edsall PR，et al. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in Trauma [J]. Biomolecules，2022，12（1）：101.
[20] Zhai Y，Zhu Y，Liu J，et al. Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group（HMGB1）/Toll-Like Receptor 4（TLR4）/Nuclear Factor kappa B（NF-kappaB） Signaling Pathway [J]. Med Sci Monit， 2020，26：e918617.
[21] Le K，Chibaatar Daliv E，Wu S，et al. SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction：A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury [J]. Int Immunopharmacol，2019，75：105779.
[22] Remy KE，Cortes-Puch I，Solomon SB，et al. Haptoglobin improves shock，lung injury，and survival in canine pneumonia [J]. JCI Insight，2018，3（18）：e123013.
[23] Yang H，Wang H，Andersson U. Targeting Inflammation Dri- ven by HMGB1 [J]. Front Immunol，2020，11：484.
[24] Black S，Kushner I，Samols D. C-reactive Protein [J]. J Biol Chem，2004，279（47）：48487-48490.
[25] Rezac T，Stasek M，Zboril P，et al. The role of CRP in the diagnosis of postoperative complications in rectal surgery [J]. Pol Przegl Chir，2021，93（5）：1-7.
[26] Aalto K，Osterman K，Peltola H，et al. Changes in erythrocyte sedimentation rate and C-reactive protein after total hip arthroplasty [J]. Clin Orthop Relat Res，1984（184）：118- 120.
[27] Luo K，Li JS，Li LT，et al. Operative stress response and ene- rgy metabolism after laparoscopic cholecystectomy compared to open surgery [J]. World J Gastroenterol，2003，9（4）： 847-850.
[28] Kojima S，Uchiyama K，Yokota N，et al. C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia：Post-hoc Analysis of a Randomized Controlled Study [J]. Cardiovasc Drugs Ther，2022.
[29] Zhang X，Wang S，Fang S，et al. Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction [J]. Front Cardiovasc Med，2021，8：659446.
[30] Chen G，Wu D，Guo W，et al. Clinical and immunological features of severe and moderate coronavirus disease 2019 [J]. J Clin Invest，2020，130（5）：2620-2629.
[31] Mueller AA，Tamura T，Crowley CP，et al. Inflammatory Biomarker Trends Predict Respiratory Decline in COVID- 19 Patients [J]. Cell Rep Med，2020，1（8）：100144.
[32] Tan C，Huang Y，Shi F，et al. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early [J]. J Med Virol，2020，92（7）：856-862.
[33] Sheriff A，Kayser S，Brunner P，et al. C-Reactive Protein Triggers Cell Death in Ischemic Cells [J]. Front Immunol，2021， 12：630430.
[34] Kayser S，Brunner P，Althaus K，et al. Selective Apheresis of C-Reactive Protein for Treatment of Indications with Elevated CRP Concentrations [J]. J Clin Med，2020，9（9）：2947.
[35] Thiele JR，Zeller J，Bannasch H，et al. Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes [J]. Mediators Inflamm，2015，2015：372432.
[36] Noack M，Miossec P. Selected cytokine pathways in rheumatoid arthritis [J]. Semin Immunopathol，2017，39（4）：365- 383.
[37] Berraondo P，Sanmamed MF，Ochoa MC，et al. Cytokines in clinical cancer immunotherapy [J]. Br J Cancer，2019，120（1）：6-15. |
|
|
|
