早产儿应用罗伊氏乳杆菌的临床观察

doi:10.20047/j.issn1673-7210.2023.17.21

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (583 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the therapeutic effects of Lactobacillus reuteri DSM 17938 on premature infants. Methods From January 2019 to July 2022, 63 cases of premature infants born and admitted to Neonatal Intensive Care Unit of Beijing United Family Hospital were selected as the study subjects. According to the random number table method, they were divided into with probiotics group and without probiotics group. The without probiotics group received general treatment; with probiotics group was given Lactobacillus reuteri DSM 17938 on the basis of general treatment, and continued to be administered until discharge. At the same time, according to gestational age, they were divided into≤28 weeks group (10 cases), ＞28 weeks group (53 cases), and according to weight, they were divided into≤1 500 g (26 cases) and ＞1 500 g (37 cases). The therapeutic effect of each group was observed. Results The time of vomiting disappearance, the time of reached total gastrointestinal nutrition, and the time to regain birth weight in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Gestational age ≤28 weeks, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group (P＜0.05). Gestational age ＞28 weeks, the time of vomiting disappearance and the time of reached total gastrointestinal nutrition in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Birth weight ≤1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜ 0.05). Birth weight ＞1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). No necrotizing enterocolitis or nosocomial infection occurred in two groups. Conclusion The use of Lactobacillus reuteri DSM 17938 can shorten the time of reached total gastrointestinal nutrition and the weight gain at the full moon, which has a definite effect on the treatment of premature infants.

Key words： Lactobacillus reuteri DSM 17938 Premature infant Total gastrointestinal nutrition Weight gain

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Xuran1 XING Meng1 ZHANG Yinzhu2 WANG Ruijuan1 HOU Xinlin3 YANG Ming2▲

Cite this article:

LI Xuran1 XING Meng1 ZHANG Yinzhu2 WANG Ruijuan1 HOU Xinlin3 YANG Ming2▲. Clinical observation of Lactobacillus reuteri applied to premature infants[J]. 中国医药导报, 2023, 20(17): 94-98.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.17.21 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I17/94

[1] Vandenplas Y，Gutierrez-Castrellon P，Velasco-Benitez C，et al. Practical algorithms for managing common gastrointestinal symptoms in infants [J]. Nutrition，2013，29（1）：184-194.
[2] 何洋，李文星，唐军，等.早产儿喂养不耐受临床诊疗指南（2020）[J].中国当代儿科杂志，2020，22（10）：1047-1055.
[3] Dani C，Ciarcià M，Luzzati M，et al. Feeding intolerance during phototherapy in preterm infants [J]. J Matern Fetal Neonatal Med，2021，35（25）：6610-6614.
[4] Fanaro S. Feeding intolerance in the preterm infant [J]. Early Hum Dev，2013，89（2）：13-20.
[5] Lucchini R，Bizzarri B，Giampietro S，et al. Feeding intolerance in preterm infants. How to understand the warning signs [J]. J Matern Fetal Neonatal Med，2011，24（1）：72-74.
[6] Wejryd E，Marchini G，Frimmel V，et al. Probiotics promoted head growth in extremely low birthweight infants in a double-blind placebo-controlled trial [J]. Acta Paediatr，2019， 108（1）：62-69.
[7] 邵肖梅，叶鸿瑁，丘小汕.实用新生儿学[M].5版.北京：人民卫生出版社，2019：632-639.
[8] 蔡威，汤庆娅，王莹，等.中国新生儿营养支持临床应用指南[J].临床儿科杂志，2013，31（12）：1177-1182.
[9] Hay WW Jr，Lucas A，Heird WC，et al．Workshop summary：nutrition of the extremely low birth weight infant [J]. Pediatrics，1999，104（6）：1360-1368.
[10] Schanler RJ，Garza C，Nichols BL. Fortified mothers’ milk for very low birth weight infants：results of growth and nutrient balance studies [J]. J Pediatr，1985，107（3）：437-445.
[11] Butte NF，Garza C，Smith EO，et al. Human milk intake and growth in exclusively breast-fed infants [J]. J Pediatr，1984， 104（2）：187-195.
[12] Dusick AM，Poindexter BB，Ehrenkranz RA，et al. Growth failure in the preterm infant：can we catch up? [J]. Semin Perinatol，2003，27（4）：302-310.
[13] Sartor RB，Wu GD. Roles for Intestinal Bacteria，Viruses，and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches [J]. Gastroenterology，2017， 152（2）：327-339.
[14] Vanderpool C，Yan F，Polk DB．Mechanisms of probiotic action：Implications for therapeutic applications in inflammatory bowel diseases [J]. Inflamm Bowel Dis，2008，14（11）：1585-1596.
[15] Seth A，Yan F，Polk DB，et al. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC-and MAP kinase-dependent mechanism [J]. Am J Phy- siol Gastrointest Liver Physiol，2008，294（4）：1060-1069.
[16] Yan F，Cao H，Cover TL，et al. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism [J]. J Clin Invest，2011，121（6）：2242-2253.
[17] Dalmasso G，Cottrez F，Imbert V，et al. Saccharomyces boulardii inhibits inflammatory bowel disease by trapping T cells in mesenteric lymph nodes [J]. Gastroenterology，2006， 131（6）：1812-1825.
[18] Rousseaux C，Thuru X，Gelot A，et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors [J]. Nat Med，2007，13（1）：35-37.
[19] Litvak Y，Byndloss MX，Tsolis RM，et al. Dysbiotic Proteobacteria espansion：a microbial signature of epithelial dysfunction [J]. Curr Opin Microbiol，2017，10（39）：1-6.
[20] 陈艺丹，姜春明.早产儿喂养不耐受与肠道菌群关系的研究进展[J].中国微生态学杂志，2021，33（3）：361-364.
[21] Athalye-Jape G，Rao S，Patole S. Lactobacillus reuteri DSM 17938 as a Probiotic for Preterm Neonates：A Strain-Specific Systematic Review [J]. JPEN J Parenter Enteral Nutr，2016，40（6）：783-794.
[22] Van den Akker CHP，Van Goudoever JB，Szajewska H，et al. Probiotics for preterm infants：a strainspecific systematic review and network meta-analysis [J]. J Pediatr Gastroenterol Nutr，2018，67（1）：103-122.
[23] Indrio F，Riezzo G，Tafuri S，et al. Probiotic supplementation in preterm：feeding intolerance and hospital cost [J]. Nutrients，2017，9（9）：965.
[24] Oncel MY，Sari FN，Arayici S，et al. Lactobacillus reuteri for the prevention of necrotising enterocolitis in very low birth-weight infants：A randomised controlled trial [J]. Arch Dis Child Fetal Neonatal Ed，2014，99（2）：110-115.
[25] 崔雪薇，富建华.罗伊氏乳杆菌在早产儿早期喂养耐受及感染预防中的临床应用（附93例报告）[J].中国实用儿科杂志，2019，34（11）：917-921.