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| A case of Creutzfeldt-Jakob disease treated by traditional Chinese medicine combined with brain functional network evaluation |
| HOU Xiaoying1 ZHONG Liqun2 ZHANG Qian3 CHEN Cheng2 ZHANG Hua2 MA Dayong2 ZHAO Zijun2 WEI Jingpei2 |
1.The First Clinical Medical School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
3.the First Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
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Abstract Creutzfeldt-Jakob disease is a rare neurodegenerative encephalopathy induced by prion protein. The patient’s average survival time is six months with high mortality and poor prognosis. This report retrospectively analyzed a case of Creutzfeldt-Jakob disease admitted to Dongzhimen Hospital, Beijing University of Chinese Medicine, the patient presented with rapidly progressive dementia, visual impairment, apparent extrapyramidal impairment, and rapid progression to coma and death from severe pneumonia, with a total duration of one year and four months. Western medicine lacks effective treatment methods. The homologous brain function network analysis based on individual showed that traditional Chinese medicine differentiation and treatment could delay the progression of the disease. This article shared the traditional Chinese medicine diagnosis and treatment process of a patient with Creutzfeldt-Jakob disease, and reviewed the literature in order to strengthen the understanding of this disease and explore the advantages of traditional Chinese medicine treatment.
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[1] Hermann P，Appleby B，Brandel J，et al. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease [J]. Lancet Neurology，2021，20（3）：235-246.
[2] Ladogana A，Puopolo M，Croes EA，et al. Mortality from Cre- utzfeldt-Jakob disease and related disorders in Europe，Australia，and Canada [J]. Neurology，2005，64（9）：1586-1591.
[3] 辛浩琳.散发性克雅氏病研究进展[J].医学理论与实践，2022，35（7）：1105-1106.
[4] Krasnianski A，Meissner B，Schulz-Schaeffer W，et al. Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt-Jakob disease [J]. Arch Neurol，2006， 63（6）：876-880.
[5] Pocchiari M，Puopolo M，Croes EA，et al. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies [J]. Brain，2004， 127（Pt 10）：2348-2359.
[6] Tan Y，Qing J，Wu G，et al. Correlation between serum uric acid levels and carotid plaque neovascularisation assessed by contrast-enhanced ultrasound [J]. Clin Radiol，2021，76（12）：941-942.
[7] Javier PF，Alexandre GE，ángel PC. Visual disturbance as an initial manifestation of Creutzfeldt-Jakob disease [J]. Medicina Clinica，2021，157（11）：e335-e336.
[8] 杨林，董春波，杨皓程，等.9例散发型克雅病患者的临床表现和脑电图特点分析[J].卒中与神经疾病，2019，26（6）：743-747.
[9] 邹梅，韩玺河，肖艳，等.散发性克雅病临床特点、脑电图及影像学分析[J].兵团医学，2022，20（1）：8-11.
[10] 易传伟.糖基化修饰调控人朊蛋白错误折叠机制研究[D].武汉：武汉大学，2017.
[11] Pelayo-Salazar ME，Salazar-Castillo OA，de la Torre-Rendon FE，et al. Rapidly progressive encephalopathy with evidence of spongiform encephalopathy through biopsy [J]. J Taibah Univ Med Sci，2022，17（6）：1047-1050.
[12] 曾晓舟，杨建中.以精神障碍为首发症状的克雅氏病1例[J].国际精神病学杂志，2022，49（2）：381-383.
[13] Rabinovici GD，Wang PN，Levin J，et al. First symptom in sporadic Creutzfeldt-Jakob disease [J]. Neurology，2006，66（2）：286-287.
[14] Tavares-Junior J，Carvalho RO，Feitosa R，et al. Diagnostic approach in a patient with Creutzfeldt-Jakob disease[J]. Dement Neuropsychol，2022，16（3）：361-364.
[15] 崔志明.散发型克雅氏病1例并文献复习[J].影像研究与医学应用，2021，5（14）：235-236.
[16] 周燕，李燕飞，贾延劼.散发型克雅氏病脑18F-FDG PET的影像学特点[J].牡丹江医学院学报，2021，42（4）：74-77.
[17] 黄欣莹.脑脊液标志物在散发型克雅氏病诊断的作用[D].北京：北京协和医学院，2020.
[18] Zerr I. Laboratory Diagnosis of Creutzfeldt-Jakob Disease [J]. N Engl J Med，2022，386（14）：1345-1350.
[19] Lattanzio F，Abu-Rumeileh S，Franceschini A，et al. Prion-specific and surrogate CSF biomarkers in Creutzfeldt- Jakob disease：diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and Abeta42 levels [J]. Acta Neuropathol，2017，133（4）：559-578.
[20] Atarashi R，Satoh K，Sano K，et al. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion [J]. Nat Med，2011，17（2）：175-178.
[21] Miranda L，Oliveira A，Carvalho DM，et al. Systematic review of pharmacological management in Creutzfeldt-Jakob disease：no options so far? [J]. Arq Neuropsiquiatr，2022， 80（8）：837-844.
[22] Raut A，Thapa A，Shrestha A，et al. Creutzfeldt-Jakob disease：A case report and differential diagnoses [J]. Clin Case Rep，2022，10（8）：e6239.
[23] 翟小珊.陈士铎郁证辨治思想研究[D].北京：北京中医药大学，2019.
[24] 马焕瑞，董增浩，周爱民，等.叶天士透热养阴思想及用药规律浅析[J].河北中医药学报，2022，37（1）：6-8.
[25] Li M，Wang D，Ren J，et al. Performing group-level functional image analyses based on homologous functional regions mapped in individuals [J]. PLoS Biol，2019，17（3）：e2007032. |
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