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| Effect of autoimmune thyroid disease on IVF-ET assisted pregnancy outcome |
| BAI Lipeng WANG Xinxin WEI Jingyan DING Lirong MAO Shuwen |
Reproductive Medicine Center, Chifeng Maternity Hospital, Inner Mongolia Autonomous Region, Chifeng 024000, China
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Abstract Objective To explore the effect of autoimmune thyroid disease on in vitro fertilization-embryo transfer (IVF-ET) assisted pregnancy outcome. Methods From October 2019 to December 2021, 94 infertile patients with anti-thyroid autoantibodies positive (ATA+) who received IVF-ET treatment in Reproductive Medical Center, Chifeng Maternity Hospital, Inner Mongolia Autonomous Region were selected as the ATA+ group, and 100 infertile patients without autoimmune thyroid disease in the same period were selected as the control group. Both groups received IVF-ET treatment, and gonadotropin releasing hormone antagonist (GnRH-a) long regimen was used. Ovarian stimulation was compared between the two groups, and the number of dominant follicles (≥14 mm), and the levels of estradiol (E2), luteinizing hormone (LH), progesterone (P) on the day of human chorionic gonadotropin (HCG) day between the two groups were analyzed, and the levels of serum Th1 cells and Th2 cells on the day of egg collection day and the fifth day of transplantation were analyzed; and the embryonic development potential and pregnancy outcome between the two groups were observed. Results There were no significant differences in the number of dominant follicles, and the levels of E2 and P on HCG day between the two groups (P＞0.05); the level of LH on HCG day in the ATA+ group was lower than that in the control group (P＜0.01). On the fifth day of transplantation, Th1, Th2, and Th1/Th2 in both groups were lower than those in egg collection day (P＜0.01). On egg collection day and the fifth day of transplantation, Th1 in the ATA+ group was higher than that in the control group, but Th2 and Th1/Th2 in the ATA+ group were lower than those in the control group (P＜0.01). There were no significant differences in the number of eggs, fertilization rate, and cleavage rate between the two groups (P＞0.05); the number of high-quality embryos and the rate of high-quality embryos in the ATA+ group were lower than those in the control group (P＜0.01). There were no significant differences in the number of transplanted embryos and clinical pregnancy rate between the two groups (P＞0.05). The abortion rate in the ATA+ group was higher than that in the control group, and the live birth rate was lower than that in the control group (P＜0.05). Conclusion The combination of autoimmune thyroid disease will affect the quality of embryonic development and increase the risk of abortion in IVF-ET patients, and its mechanism may be related to the immune changes of patients.
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