血浆纤维蛋白原、前列腺特异性抗原密度与前列腺癌骨转移关系研究

doi:10.20047/j.issn1673-7210.2023.17.25

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Abstract Objective To analyze the relationship between plasma fibrinogen (FIB) and prostate-specific antigen density (PSAD) levels and osseous metastasis of prostate cancer (PCa). Methods Data of 148 patients with PCa were retrospectively collected from Xuzhou Central Hospital of Jiangsu Province from January 2016 to December 2021. Among them, 85 (57.4%) patients with bone metastasis were the bone metastasis group, and 63 (42.6%) patients without bone metastasis were the no bone metastasis group. General information included prostate-specific antigen (PSA) levels, FIB levels, prostate volume, bone metastases, age, body mass index (BMI), and length of hospital stay. The relationship between FIB, PSAD, and PCa bone metastasis was analyzed. Results There were significant differences in FIB and PSAD levels between the two groups (P＜0.05). The optimal cut-off point was 3.840 g/L, sensitivity was 54.1%, and specificity was 81.0%. PSAD predicted that the optimal cut-off point of PCa was 0.393 ng/（ml·cm3）, the sensitivity was 83.5% and the specificity was 63.5%. Logistic regression analysis showed that FIB and PSAD were positively correlated with bone metastasis in PCa (OR=2.180, P＜0.001; OR=2.251, P＜0.001). Conclusion The levels of FIB and PSAD are positively correlated with the occurrence of osseous metastasis, which have high value in the diagnosis of osseous metastasis of prostate cancer.

Key words： Fibrinogen Prostate-specific antigen density Prostatecancer Osseous metastasis

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	ZHANG Peng1 LI Xinzhao2 LIANG Qing3 ZHANG Zhiguo3 LIU Lin3 HAN Conghui3 LIU Dachuang1▲

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ZHANG Peng1 LI Xinzhao2 LIANG Qing3 ZHANG Zhiguo3 LIU Lin3 HAN Conghui3 LIU Dachuang1▲. Study on the relationship between plasma fibrinogen, prostate-specific antigen density， and osseous metastasis of prostate cancer[J]. 中国医药导报, 2023, 20(17): 111-114.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.17.25 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I17/111

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