北疆地区类风湿关节炎合并贫血患者血清中Hepc、s-HJV水平与疾病活动的相关性分析

doi:10.20047/j.issn1673-7210.2023.17.29

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Abstract Objective To detect serum iron regulator (Hepc) and soluble iron regulator protein (s-HJV) in patients with rheumatoid arthritis complicated with chronic anemia (RA-ACD) in northern Xinjiang area, and to explore the role of Hepc and s-HJV in the pathogenesis of RA-ACD, to analyze the relationship between HEPC, S-HJV, and disease activity (DAS28). Methods From March 2021 to May 2022, a total of 120 RA-ACD patients(RA-ACD group), 120 RA patients(RA group), and 80 healthy physical examination patients(health control group) were collected from the Fourth Affiliated Hospital of Xinjiang Medical University, Altay Kazakh Medical Hospital, Altay Regional People’s Hospital, Tori Kazakh Medical Hospital, and Tori County People’s Hospital. The levels of serum Hepc, s-HJV, serum iron (SI), transferrin (Tf), ferritin (SF), interleukin 6 (IL-6), C-reactive protein (CRP), and erythrocyte settlement rate (ESR) in the above three groups were determined by double-antibody sandwich enzymosorbent immunosorbent assay, and DAS28 score was calculated. Results There were statistically significant differences in Hepc, s-HJV and Hb levels among the three groups (P＜0.05). Hepc of RA-ACD and RA groups were lower than that of control group, and RA-ACD group was lower than that of RA group; those of s-HJV in RA-ACD and RA groups were higher than that in healthy control group, and RA group was higher than that in healthy control group; Hb in RA-ACD group was lower than that in RA group and healthy control group, and the differences were statistically significant (P＜0.05). There were statistically significant differences in SI, Tf, and SF levels among the three groups (P＜0.05). The SI of RA-ACD group and RA group was lower than that of healthy control group, and RA-ACd group was higher than that of RA group; Tf in RA-ACD group and RA group was lower than that in healthy control group; The SF level of RA-ACD group was lower than that of RA group and healthy control group, and the differences were statistically significant (P＜0.05). The levels of IL-6, ESR, and CRP among the three groups were statistically significant (P＜0.05). IL-6, ESR, and CRP in RA-ACD and RA groups were higher than those in healthy control group, ESR, CRP, and DAS28 in RA-ACD group were higher than those in RA group, and the differences were statistically significant (P＜0.05). Correlation analysis showed that Hepc was positively correlated with IL-6 (r＞0, P＜0.05), and negatively correlated with DAS28 (r＜0, P＜0.05). s-HJV was positively correlated with SI, Tf, IL-6, and ESR (r＞0, P＜0.05), and negatively correlated with Hb (r＜0, P＜0.05). DAS28 was positively correlated with SI, ESR, and CRP (r＞0, P＜0.05), and negatively correlated with Hb (r＜0, P＜0.05). Hb was negatively correlated with SI, SF, ESR, CRP, and s-HJV (r＜0, P＜0.05). Conclusion Hepc and s-HJV are involved in the progression of RA-ACD disease, and s-HJV may reverse the promoting effect of inflammatory factors on Hepc expression in a compensatory way. The disease activity of RA is closely related to inflammation and anemia. The higher the level of inflammation, the more serious the disease will be, and anemia will aggravate the disease. Serum Hepc level decreased with the increase of DAS28 level, suggesting a certain correlation between Hepc and disease activity in RA patients.

Key words： Rheumatoid arthritis Anemia of chronic diseases Hepcidin Soluble hemojuvelin

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	ZHANG Daoyu LIU Xin TANG Qi XUE Mengmeng LIU Yongfeng OUYANG Wenbo ZHANG Hechao

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ZHANG Daoyu LIU Xin TANG Qi XUE Mengmeng LIU Yongfeng OUYANG Wenbo ZHANG Hechao. Correlation analysis of serum Hepc, s-HJV, and disease activity in patients with rheumatoid arthritis and anemia in northern Xinjiang area[J]. 中国医药导报, 2023, 20(17): 127-131.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.17.29 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I17/127

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