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2023 Vol. 20, No. 3 Published: 2023-01-25

	4	Study on medication rules in ancient Chinese Medical Code for the treatment of hypochondriac pain prescriptions based on data mining
		CUI Xinyi1 JIANG Xiaodan1 YOU Hongjie2 TANG Zuoqing2 MA Yun1 YANG Zheng1 CHE Niancong1 LIU Wenlan1
		DOI: 10.20047/j.issn1673-7210.2023.03.01
		Objective To explore the medication rules of the prescriptions for the treatment of hypochondriac pain contained in the Chinese Medical Code. Methods Prescriptions for the treatment of hypochondriac pain in the Chinese Medical Code were collected, prescription data and drug information were input by Excel (Microsoft Office 2019), and frequency statistics were made on drug efficacy, four nature of drugs and five flavours, and channel tropism. SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to calculate drug co-occurrence frequency and perform visual network display. Association rule analysis and visualization of the drugs in the screened prescriptions were performed using arules and arulesViz packages in R software, and clustering analysis of high-frequency drugs was performed using SPSS Statistics 19.0. Results A total of 359 effective prescriptions were screened, and 240 flavors of traditional Chinese medicine were used, with a total medication frequency of 3 032 times. The core drugs were Angelicae Sinensis Radix, Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Bupleuri Radix, Citri Reticulatae Pericarpium Viride, Citri Reticulatae Pericarpium, and so on. Three types of drugs were mainly used to tonify deficiency， regulate qi, and promote blood circulation for removing blood stasis. The four nature of drugs were mainly warm, the five flavours were mainly pungent, bitter, and sweet, and the channel tropism was mainly spleen, liver, lung, stomach, and heart channels. The association rule analysis yielded 15 groups of drug association rules, with the highest confidence level of Pinelliae Rhizoma, Zingiberis Rhizoma Recens and Glycyrrhizae Radix et Rhizoma. The efficacy of the 15 groups of drug association rules was mainly based on tonifying qi, nourishing blood, promoting qi, resolving blood stasis, and removing dampness and heat. High-frequency drugs could be clustered into five categories, mainly soothing liver-qi stagnation, clearing heat and promoting dampness, activating qi and relieving pain, promoting blood circulation and removing blood stasis. Conclusion The prescriptions recorded in Chinese Medical Code for the treatment of hypochondriac pain present a rule of prescriptions based on soothing liver and qi, activating blood circulation and resolving blood stasis, softening liver and relieving pain, resolving phlegm and drying dampness, supporting vital qi and tonifying deficiency, which is consistent with the core pathogenesis of hypochondriac pain and provides a reference for clinical traditional Chinese medicine treatment of hypochondriac pain.
		2023 Vol. 20 (3): 4-8,19 [Abstract] ( 16 ) HTML (1 KB) PDF (1992 KB) ( 95 )

	9	Discussion of the mechanism of Qixuan Yijianing in the treatment of Graves disease based on network pharmacology and animal experiments
		GAO Changjiu1 DING Song1 LU Fang2 LIU Changfeng2 YU Donghua2 LIU Shumin2
		DOI: 10.20047/j.issn1673-7210.2023.03.02
		Objective To explore the mechanism of Qixuan Yijianing in the treatment of Graves disease (GD) based on network pharmacology and animal experiments. Methods The active constituents and targets of Qixuan Yijianing were detected by traditional Chinese medicine systems pharmacology database and analysis platform, and chemical database, and GD related targets were detected from Genecards, online human Mendelian genetic database, etc. The common targets of drugs and diseases were introduced into STRING platform to construct protein-protein interaction (PPI) network and screen core targets. Cytoscape 3.8.2 software was used to map the drug-active ingredient-target network and screen core components. The core target was enriched by Metascape platform. Forty 6-week-old female BALB/c mice with SPF grade and body weight of (20±2) g were selected, ten of which were set as normal control group, and the remaining 30 were immunized with recombinant adenovirus Ad-TSHR-289 for three times to construct GD model. The mice that modeled successfully were divided into GD model group, Methimazole group, and Qixuan Yijianing group by random number table method, with eight mice in each group. Qixuan Yijianing group was intragastric administration of Qixuan Yijianing 50 g/kg, Methimazole group was intragastric administration of Methimazole Tablets 3.75 mg/kg, normal control group and GD model group were intragastric administration of drinking water of the same volume, once a day. After four weeks of continuous administration, serum vascular endothelial growth factor (VEGF) content was detected by enzyme-linked immunosorbent assay. The expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) in thyroid tissues of the four groups was detected by immunohistochemistry. Results A total of 63 active ingredients with 281 targets and 1 489 targets of GD were obtained. There were 124 targets of drugs and diseases. PPI obtained 21 core targets of signal transduction and transcription activator 3, serine/threonine protein kinase 1, VEGFA, etc. Eighteen core components including luteolin, kaempferol, quercetin, ursolic acid, and β-sitosterol were obtained by drug-target analysis. 954 items of inflammatory response, angiogenesis, and vascular morphogenesis were obtained GO by analysis, and 92 pathways including MAPK, PI3K/AKT, and VEGF were obtained by KEGG analysis. Animal experiments showed that the expression levels of serum VEGF and thyroid PECAM-1 in GD model group were higher than those in normal control group, and those in Qixuan Yijianing group were lower than those in GD model group, the differences were highly statistically significant (P＜0.01). Conclusion Qixuan Yijianing is able to treat GD by regulating MAPK, PI3K/AKT, VEGF, and other signaling pathways to inhibit angiogenesis.
		2023 Vol. 20 (3): 9-14 [Abstract] ( 15 ) HTML (1 KB) PDF (3298 KB) ( 48 )

	15	Analysis on the syndrome characteristics and medication rule of cancer - related fatigue
		SONG Jinjie1 LI Zhongyu2 ZHANG Zhongyue1 GUO Zhongning1 WU Yu1 ZANG Mingxuan1
		DOI: 10.20047/j.issn1673-7210.2023.03.03
		Objective To analyze the traditional Chinese medicine syndromes of cancer induced-related fatigue and the medication rule of traditional Chinese medicine prescription. Methods In this study, the relevant literature on traditional Chinese medicine treatment of cancer-related fatigue was retrieved from CNKI, CBM, Wanfang, VIP, and PubMed databases until April 2021, and the syndrome characteristics and medication rule were analyzed by means of the traditional Chinese medicine inheritance auxiliary platform V2.5 and the statistical analysis, association analysis, cluster analysis, and complex network analysis methods of system integration. Core drug compatibility and new formulation were obtained. Results A total of 76 literatures were collected. A total of 20 syndrome types were included in the analysis, involving 166 drugs. The main drug tastes were sweet and warm, and the channel transformation mainly concentrated in the spleen, liver, and lung. After the analysis of association rules, 12 association rules were obtained. The high frequency traditional Chinese medicine could be grouped into three categories. The core prescription was modified Buzhong Yiqi Decoction. Conclusion This study summarize the prescription medication rules of traditional Chinese medicine treatment of CRF through data mining, so as to provide reference and guidance for clinical medication.
		2023 Vol. 20 (3): 15-19 [Abstract] ( 18 ) HTML (1 KB) PDF (1019 KB) ( 79 )

	20	Visual analysis of traditional Chinese medicine treatment of perimenopausal syndrome based on CiteSpace
		WANG Tianlin1 HU Shiwan1 ZHAO Linhua2 ZHANG Wei3
		DOI: 10.20047/j.issn1673-7210.2023.03.04
		Objective To explore the research hotspot and development trend of traditional Chinese medicine treatment of perimenopausal syndrome (PMPS) in recent 20 years. Methods The literature on PMPS treated by traditional Chinese medicine from January 2000 to January 2022 was retrieved from CNKI data, CiteSpace software was used to visualize the authors, research institutions, and key words of the included literature. Results A total of 2 678 literatures were included, and the core authors were represented by Jin Yabei, Wang Jing, and Wang Xiuxia. The core team had not been formed in China, and the research institutions were mainly the university of traditional Chinese medicine, and its affiliated hospitals. Key words correlation atlas showed that the main means of traditional Chinese medicine treatment for PMPS were traditional Chinese medicine compound therapy led by Erxian Decoction and acupuncture therapy of non-drug therapy. The research focused on neuroendocrine immune network. Conclusion The research of PMPS treatment in traditional Chinese medicine mainly focuses on the clinical intervention effect of traditional Chinese medicine compound and proprietary medicine, and it is urgent to establish a standardized treatment scheme.
		2023 Vol. 20 (3): 20-23,28 [Abstract] ( 28 ) HTML (1 KB) PDF (2723 KB) ( 76 )

	24	Study on the improvement of quality standard for scutellriae Radix Scutellariae
		SUN Qiannan ZHANG Jianping QU Xiaoyan TA Na GAO Han GUO Baofeng
		DOI: 10.20047/j.issn1673-7210.2023.03.05
		Objective To improve the quality standard of the scutellriae Radix Scutellariae. Methods Six batches of scutellaria Radix Scutellariae samples were qualitatively identified by microscopy and thin-layer chromatography. The contents of moisture, total ash, acid insoluble ash and extract of six batches of samples were determined by referring to the general rules of Pharmacopoeia of the People’s Republic of China (2020 Edition). The quantitative analysis of baicalin and han baicalin in six batches of samples was carried out by high performance liquid chromatography. Results The average values of moisture, total ash, acid insoluble ash and extract were 9.8%, 8.0%, 3.2% and 48.5%, respectively. Baicalin had a good linear relationship with peak area in the range of 84.119 2-841.192 8 ng (r = 0.999 9), the recovery was 101.51%, RSD were 1.60%. Han baicalin had a good linear relationship with peak area in the range of 38.769 6-387.6960 ng, there was a good linear relationship with the peak area (r = 1.000 0). The recovery rate was 102.83%, RSD were 2.00%. The contents of baicalin and han baicalin in six batches of samples were 6.99%-10.19 % and 2.30%-2.72%, respectively. Conclusion The quality control method of scutellriae Radix Scutellariae is improved by qualitative and quantitative methods.
		2023 Vol. 20 (3): 24-28 [Abstract] ( 15 ) HTML (1 KB) PDF (1403 KB) ( 28 )

	29	Characteristics analysis of G6PD defect and gene mutation in Zhuang nationality hyperbilirubinemia neonates in Liuzhou, Guangxi Zhuang Autonomous Region
		LIU Yanping1 LI Kecheng1 HUANG Ting1 XIE Mengyue1 PAN Lizhen2 CHEN Dayu2
		DOI: 10.20047/j.issn1673-7210.2023.03.06
		Objective To analyze the activity and gene mutation types of glucose-6-phosphate dehydrogenase (G6PD) in neonates with hyperbilirubinemia in Liuzhou, Guangxi Zhuang Autonomous region, and to explore its value in the diagnosis and treatment of hyperbilirubinemia in ethnic minority areas. Methods A total of 353 full-term neonates diagnosed with hyperbilirubinemia from June 2018 to June 2021 in Liuzhou Maternal and Child Healthcare Hospital of Guangxi Zhuang Autonomous Region were selected as the study subjects, the total bilirubin, activities and the frequency and incidence of gene mutation types of G6PD were analyzed. Results In 353 hyperbilirubinemia children, 86 cases (24.36%) lacked G6PD activity. A total of 114 patients (32.29%) had genetic mutations, among them, there were 70 male hemizygotes, 4 female homozygotes, 9 female compound heterozygotes, and 31 female heterozygotes. The most frequent mutation site was c.1388G>A. Total bilirubin level was negatively correlated with G6PD activity (r=-0.65, P＜0.05). Conclusion G6PD deficiency is an important factor of neonatal hyperbilirubinemia in Liuzhou, Guangxi Zhuang Autonomous Region; the mutation sites of G6PD had certain regional and ethnic characteristics. Through the combined analysis of bilirubin level, G6PD activity and gene mutation characteristics of neonates with hyperbilirubinemia, it can provide the basis for clinical diagnosis and treatment.
		2023 Vol. 20 (3): 29-32 [Abstract] ( 11 ) HTML (1 KB) PDF (679 KB) ( 35 )

	33	Research progress on exosome targeted delivery of nucleic acid molecules
		JIA Yue1 LI Yan2 WANG Yingji1
		DOI: 10.20047/j.issn1673-7210.2023.03.07
		Exosomes, as small nanoscale extracellular vesicles are an important mode of cellular information delivery in living organisms. Exosomes are characterized by high delivery efficiency, low immunogenicity, the ability to cross multiple biological barriers, and targeting properties. This has made exosomes an important member of drug delivery carriers to overcome the disadvantages of poor stability, insufficient bioavailability, low solubility, and high toxicity of some drugs. This article reviews the use of exosomes in vesicle form as novel drug delivery molecules, including microRNA, small interfering RNA and deoxyribo nucleic acid, which have received much attention in recent years. This article aims to provide a theoretical basis and design ideas for the development of efficient and safe delivery of exosome targeted nucleic acid like molecules and to facilitate their clinical translation.
		2023 Vol. 20 (3): 33-36,49 [Abstract] ( 10 ) HTML (1 KB) PDF (543 KB) ( 372 )

	37	Research advances in brain metastasis of non-small cell lung cancer
		MA Li ZHU Ya WANG Zhaoxia
		DOI: 10.20047/j.issn1673-7210.2023.03.08
		Lung cancer is a common malignant tumor with high morbidity and mortality. Many patients die of distant metastases, especially to the brain. Due to the existence of blood-brain barrier and blood-tumor barrier, drug therapy is not effective. Many studies have shown that imbalanced expression of molecules plays an important role in the progression of malignant tumors. Epidermal growth factor receptor, non-coding RNA, cell adhesion molecules and others are reported to participate in regulating the process of brain metastases from non-small cell lung cancer, they also have high clinical translational value in diagnosis, treatment and evaluation of patient prognosis. This paper summarizes the recent progress of brain metastasis in non-small cell lung cancer, hoping to provide ideas and clues for future research.
		2023 Vol. 20 (3): 37-40,54 [Abstract] ( 11 ) HTML (1 KB) PDF (552 KB) ( 125 )

	41	Research progress of Chinese and western medicine intervention on platelet transfusion refractoriness in patients with liver cancer
		NONG Yaobin1 HUANG Hongna2 HUANG Jingjing3 DONG Zhixin4 SONG Wenxuan1 XIAO Xiyu1 DU Yuanqin1
		DOI: 10.20047/j.issn1673-7210.2023.03.09
		The occurrence of liver cancer is often evolved from the progression of viral hepatitis, cirrhosis, aflatoxin contamination, and so on. Most patients with liver cancer are complicated with hyperplenism, which leads to the reduction of their platelets in peripheral blood to varying degrees. At the same time, targeted drug therapy can produce strong inhibition on megakaryocytes and bone marrow function, and can also lead to a decrease in the number of platelets. In the treatment of platelet transfusion in patients with liver cancer, there may be several times of infusion but the ideal effect can not be achieved, the bleeding status is not alleviated, and even platelet transfusion refractoriness (PTR) occurs. Abnormal bleeding in patients with liver cancer is closely related to platelets level. Therefore, it is very important to explore the regulation of platelets by Chinese and western medicine in the treatment of PTR in patients with liver cancer. In this paper, platelet generation, PTR mechanism in patients with liver cancer, regulation and intervention measures of Chinese and western medicine are briefly reviewed, so as to provide reference for the clinical treatment of PTR in patients with liver cancer and broaden treatment ideas.
		2023 Vol. 20 (3): 41-44 [Abstract] ( 10 ) HTML (1 KB) PDF (572 KB) ( 37 )

	45	Research progress of gut-brain-microbiota axis in post-stroke depression
		CHEN Kun WANG Zonghua LUO Yu
		DOI: 10.20047/j.issn1673-7210.2023.03.10
		Post-stroke depression is one of the most common neurological and mental symptoms after stroke, the unsafe and inaccurate efficacy of drug treatment in the past, often results in patients with prolonged disease, which seriously affects the quality of life of patients. The discovery of the unique regulation of gut microbiota on the gut-brain axis provides a breakthrough for the prevention and treatment of post-stroke depression. The gut microbiota can regulate the gut-brain axis through neuroendocrine, immune and metabolic system pathways to form positive and negative feedback, allowing patients to obtain neuro- and gut-protective benefits, allowing them to play a precise regulatory role in the prevention and treatment of post-stroke depression. This paper attempts to summarize the interaction mechanism between gut microbiota and the gut-brain axis, the correlation between intestinal microbiota and post-stroke depression, new methods and interventions in the treatment, and their mechanism. To provide new ideas for the prevention, and treatment of post-stroke depression.
		2023 Vol. 20 (3): 45-49 [Abstract] ( 11 ) HTML (1 KB) PDF (653 KB) ( 77 )

	50	Research progress of non-drug intervention for poststroke cognitive impairment
		XING Weizu MAI Yongmeng SU Qingjie▲
		DOI: 10.20047/j.issn1673-7210.2023.03.11
		Poststroke cognitive impairment (PSCI) refers to any type of cognitive deterioration that occurs after stroke, they range from mild impairment to Alzheimer. Stroke survivors have a significantly increased risk of cognitive impairment, this can affect independence of daily activities, social participation and quality of life. Due to the limited effectiveness of medications for patients with PSCI, therefore, many scholars attach great importance to the exploration of non-drug treatment methods. There are many kinds of non-drug treatment methods, which are safe, economical, effective, convenient and practical. At present, many studies have confirmed that non-drug methods have certain effects in improving motor and cognitive functions of PSCI patients, and different non-drug interventions have different mechanisms of action. In this paper, non-drug methods for the treatment of PSCI patients including exercise therapy, acupuncture therapy, physical therapy, and computer aided cognitive training were reviewed, to provide reference for selecting non-drug intervention methods for PSCI patients.
		2023 Vol. 20 (3): 50-54 [Abstract] ( 9 ) HTML (1 KB) PDF (632 KB) ( 117 )

	55	Research progress on the effect of iliac fascia block on early analgesia and rapid recovery after total hip replacement in the elderly
		YANG Honghong1 LIU Rongrong1 LU Hongxiu2
		DOI: 10.20047/j.issn1673-7210.2023.03.12
		Total hip arthroplasty is a successful procedure for people with hip fractures to reduce chronic pain and enhance joint function. However, how to effectively relieve postoperative pain in elderly patients with poor cardiopulmonary function and multiple complications, and accelerate postoperative rehabilitation has become an important problem that anesthesiologists pay attention to. This paper reviews the studies on iliac fascia block in PubMed, CNKI, and Wanfang Data. It is found that ultrasound-guided iliac fascia space block based on the concept of accelerated rehabilitation surgery, especially the superior inguinal ligament approach, has significant postoperative analgesic effect and little impact on joint motor function. It has obvious advantages in early analgesia and rapid recovery after total hip replacement in the elderly.
		2023 Vol. 20 (3): 55-58 [Abstract] ( 6 ) HTML (1 KB) PDF (619 KB) ( 140 )

	59	Application of mesoporous silica nanoparticles in drug delivery
		OUYANG Xianjin KANG Xu GUO Tingting LIU Yueping CHANG Mingming
		DOI: 10.20047/j.issn1673-7210.2023.03.13
		Mesoporous silica nanoparticles with ordered mesoporous structure, large specific surface area, easy surface modification, and high colloidal stability have attracted more and more attention in the field of drug targeted therapy and controlled-release. As a drug carrier, unmodified mesoporous silica has a relatively obvious “sudden release” effect, by modifying small organic molecules, inorganic nanoparticles, and ring molecules on its surface, the drug release efficiency can be effectively improved, which is beneficial to improve the stability and biocompatibility of the system, and promote the further application of mesoporous silica nanoparticles in the field of drug delivery.
		2023 Vol. 20 (3): 59-62 [Abstract] ( 9 ) HTML (1 KB) PDF (947 KB) ( 90 )

	63	Correlation analysis of mental resilience and pain in senile patients with osteoporosis and compression fracture
		WU Wencong LIU Xiaoyan▲ LEI Fei GAO Min LIU Xiaolan
		DOI: 10.20047/j.issn1673-7210.2023.03.14
		Objective To investigate the relationship between mental resilience and pain in senile patients with osteoporosis compression fracture. Methods A total of 189 elderly patients with osteoporosis and compression fracture admitted to the Affiliated Hospital of Southwest Medical University from October 2019 to October 2021 were selected by convenience sampling method. General data questionnaire, mental resilience scale, and visual analogue scale score were adopted to conduct a questionnaire survey. Results The mental resilience score of the subjects was (51.29±8.67) points, which was at a low level; there were statistically significant differences in psychological resilience scores among patients with different body mass index (BMI), location, education level, and T value of osteoporosis (P＜0.05). There was a negative correlation between the score of mental resilience and the score of all dimensions and the visual analog scale score of pain assessment in the aged patients with osteoporosis and compression fracture (r＜0, P＜0.05). Multifactor linear regression analysis showed that T value of osteoporosis, site of occurrence, BMI, and the total score of entered the equation, and the equation had statistical significance (P＜0.05). T value of osteoporosis, site of occurrence, BMI, and the total score of mental resilience together explained 25.2% of the variation in pain score. Conclusion The mental resilience and pain levels of elderly patients with osteoporosis and compression fracture are both at a low level, and the degree of pain can be relieved when the mental resilience is increased.
		2023 Vol. 20 (3): 63-66 [Abstract] ( 8 ) HTML (1 KB) PDF (538 KB) ( 55 )

	67	Effect of cognitive behavioral therapy assisted Sertraline on type 2 diabetes mellitus patients combined with depression
		ZHANG Hongyan1 ZHANG Yuping2 ZHANG Yanjiao1 ZHENG Jingjing1 BIAN Rui1 WANG Qina3 LI Wenhui4 REN Weidong5
		DOI: 10.20047/j.issn1673-7210.2023.03.15
		Objective To investigate the effect of cognitive behavioral therapy assisted Sertraline on type 2 diabetes mellitus patients combined with depression. Methods Sixty patients with type 2 diabetes mellitus patients combined with depression admitted to the First Affiliated Hospital of Hebei North University from January 2019 to December 2020 were selected, and they were divided into control group (30 cases) and experimental group (30 cases) according to the random number table method. The control group took Sertraline Hydrochloride Tablets orally, experimental group was given cognitive behavioral therapy on the basis of control group, and the course of treatment was eight weeks. The clinical efficacy was compared between two groups; the heart rate variability (HRV), fasting insulin (FINS), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and total score of Hamilton depression scale (HAMD) were compared between two groups before and after treatment. Results There were four cases dropped out of control group and two cases dropped out of experimental group. The clinical efficacy of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). Intertemporal population standard deviation of HPV change (SDNN), the mean square root mean square difference of successive sinus R-R intervals of parasympathetic activity (rMSSD), the standard deviation of successive interval difference of parasympathetic accommodation (SDSD), and the high frequency power for parasympathetic modulatory capacity (HF) were higher than those before treatment, low-frequency power for sympathetic activity predominant (LF) and LF/HF were lower than those before treatment, and the differences were statistically significant (P＜0.05); the SDNN, rMSSD, SDSD, and HF of experimental group were higher than those of control group, and LF and LF/HF were lower than those of control group, and the differences were statistically significant (P＜0.05). After treatment, FINS, FBG, HOMA-IR, total score of HAMD, and CRP of two groups were lower than those before treatment, and those of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in HbA1c between two groups before and after treatment (P＞0.05). Conclusion Cognitive behavioral therapy assisted Sertraline is more effective in the treatment of type 2 diabetes mellitus patients combined with depression, and it has better improvement on HRV, blood glucose, insulin function, and CRP.
		2023 Vol. 20 (3): 67-70,83 [Abstract] ( 11 ) HTML (1 KB) PDF (644 KB) ( 33 )

	71	Clinical study of low frequency neuromuscular stimulation for mild to moderate stress urinary incontinence
		DONG Shiqiu1 GAO Xiao2 GUO Jing3 CHEN Yingchao3 DU Lin3 YU Liang3 YANG Dan3
		DOI: 10.20047/j.issn1673-7210.2023.03.16
		Objective To observe the clinical effect of low frequency neuromuscular stimulation on mild to moderate stress urinary incontinence. Methods All 60 enrolled female patients were enrolled from Harbin First Hospital from October 2019 to May 2021, they were divided into control group (30 cases) and treatment group (30 cases) by random number table method. The control group was treated by simple pelvic floor muscle training, and the treatment group was treated by low frequency neuromuscular stimulation. After 15 days of treatment, the efficacy was evaluated by comparing the surface electromyography and pressure value of type Ⅰmuscle fibre, surface electromyography and pressure value of type Ⅱmuscle fibre, urine leakage volume, frequency of urine leakage, and the degree of influence on patients’ life before and after treatment. Results After treatment, the levels of stress Ⅰ and stress Ⅱ in both groups were higher than those before treatment, while those of the treatment group were higher than those of the control group, the differences were statistically significant (P＜0.05). The levels of electromyography Ⅰ and Ⅱ in both groups were higher than before treatment, while those of the treatment group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, 1 h pad test urine leakage, average 24 h urine leakage frequency and the score of international consultation on incontinence questionnaire urinary incontinence short form of the two groups were lower than before treatment, while those of the treatment group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Low-frequency neuromuscular stimulation can increase the surface electromyography and pressure values of muscle fibers of type I and Ⅱ, inhibit overactivity of detrusor muscle, and improve the clinical symptoms of patients with mild to moderate stress incontinence.
		2023 Vol. 20 (3): 71-75 [Abstract] ( 6 ) HTML (1 KB) PDF (556 KB) ( 57 )

	75	Effects of Sanjin Decoction combined with western medicine on renal function and oxidative stress level in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder
		JIANG Kun LIU Jun▲ FANG Yong
		DOI: 10.20047/j.issn1673-7210.2023.03.17
		Objective To investigate the effect of Sanjin Decoction combined with western medicine on renal function and oxidative stress level in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder. Methods A total of 165 patients with obstructive nephropathy treated in the Bengbu Traditional Chinese Medicine Hospital, Anhui Province from December 2018 to December 2021 were selected and divided into Sanjin Decoction group, western medicine group, and combined group by random number table method, with 55 cases in each group. All the three groups received surgery and conventional drug treatment, Sanjin Decoction group received Sanjin Decoction after surgery, western medicine group received Enalapril after surgery, combined group received Sanjin Decoction and Enalapril after surgery, the course of treatment was three months. The levels of blood urea nitrogen (BUN), serum creatinine (SCr), superoxide dismutase (SOD), malondialdehyde (MDA), and scores of short form 36 (SF-36), kidney disease-related quality of life scale before and after treatment were compared among the three groups. Results After treatment, BUN, SCr, and SOD of the three groups were lower than those before treatment, MDA, and scores of SF-36, kidney disease-related quality of life scale were higher than those before treatment. In addition, BUN, SCr, and SOD in combined group were lower than those in Sanjin Decoction group and western medicine group, MDA, and scores of SF-36, kidney disease-related quality of life scale were higher than those in Sanjin Decoction group and western medicine group, the differences were statistically significant (P＜0.05). Conclusion Sanjin Decoction combined with western medicine can better protect renal function and inhibit oxidative stress in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder after surgery, which is worthy of clinical application.
		2023 Vol. 20 (3): 75-78 [Abstract] ( 9 ) HTML (1 KB) PDF (592 KB) ( 21 )

	79	Clinical effect of intraspecular injection of platelet-rich plasma in the treatment of advanced knee osteoarthritis
		GUO Feng1 SONG Bing2 XIE Huanxin1 ZHANG Yaohua1 LIU Xiaolei3 ZHANG Hongyue1 YANG Huaqing1
		DOI: 10.20047/j.issn1673-7210.2023.03.18
		Objective To explore and analyze the clinical effect of injecting platelet-rich plasma into subchondral cancellous bone and articular cavity for advanced knee osteoarthritis. Methods A total of 72 patients with knee osteoarthritis admitted to Beijing Rehabilitation Hospital Affiliated to Capital Medical University and Dezhou Hospital of Qilu Hospital of Shandong University from January 2019 to December 2020 were selected and they were divided into two groups according to random number table method, with 36 cases in each group. The articular injection group received intra articular injection of platelet-rich plasma and the articular + cancellous bone injection group received intra articular injection of plaletet plasmas combined with cancellous bone injection. Visual analogue scale (VAS) scores, Western Ontario and McMaster University osteoarthritis index scores (WOMAC) were compared between the two groups before treatment and one, three, six, and twelve months after treatment. Results VAS and WOMAC scores at three, six and twelve months after treatment in the two group were lower than before treatment, and the differences were statistically significant (P＜0.05). One month after treatment, the WOMAC score of the articular + cancellous bone injection group was lower than that of the articular injection group, and the difference was statistically significant (P＜0.05). At three, six and twelve months after treatment, VAS and WOMAC scores in the articular + cancellous bone injection group were lower than those in the articular injection group, with statistical significances (P＜0.05). Conclusion PRP combined with cancellous bone injection can effectively delay the development of severe knee osteoarthritis, reduce pain and improve knee function without serious side effects. It is expected to be widely used in clinical practice, but further clinical trials are needed.
		2023 Vol. 20 (3): 79-83 [Abstract] ( 14 ) HTML (1 KB) PDF (754 KB) ( 25 )

	84	Effect of bone cement distribution on curative effect after percutaneous vertebroplasty for osteoporotic thoracolumbar fractures
		GAO Chao1 YU Chun1▲ GUAN Lian2 CHENG Yedong2
		DOI: 10.20047/j.issn1673-7210.2023.03.19
		Objective To explore the effect of bone cement distribution on the curative effect of percutaneous vertebroplasty (PVP) for osteoporotic thoracolumbar fractures. Methods A total of 83 patients with osteoporotic thoracolumbar fractures treated by PVP in Huaian Medical District of the Eastern Theater General Hospital of the Chinese People’s Liberation Army from January 2018 to December 2020 were selected as the research object, CT was rechecked 72 hours after operation to detect the distribution of bone cement, they were divided into bone cement diffusion group and bone cement non diffusion group, including 42 cases in bone cement non diffusion group and 41 cases in bone cement diffusion group. The degree of pain, vertebral body function, vertebral body correction and complications before and after operation were compared between the two groups. Results Visual analog scale score and lumbar dysfunction index score were lower in both groups after surgery than before surgery, and the bone cement diffusion group was lower than the bone cement non-diffusion group (P＜0.05). The relative height of the injured vertebral midline and the relative height of the injured vertebral front were higher than those before surgery, and the Cobb angle after local injured vertebral was lower than that before surgery (P＜0.05). There was no significant difference in the postoperative bone cement leakage rate between the two groups (P＞0.05). Conclusion In patients with osteoporotic thoracolumbar fractures, the dispersion distribution of bone cement after PVP is more conducive to reduce the degree of postoperative pain and improve the related motor function of vertebral body than the non dispersion distribution of bone cement, the clinical effect is better.
		2023 Vol. 20 (3): 84-87 [Abstract] ( 7 ) HTML (1 KB) PDF (529 KB) ( 29 )

	88	Contrastive interpretation of diagnosis and treatment norms of pelvic inflammatory diseases in China and the United States
		LI Ting LIU Zhaohui
		DOI: 10.20047/j.issn1673-7210.2023.03.20
		Pelvic inflammatory disease (PID) is one of the common diseases of women of childbearing age, which can lead to sequelae such as tubal infertility, ectopic pregnancy, and chronic pelvic pain, and cause great harm to female reproductive health. In 2021, the Centers for Disease Control and Prevention (CDC) issued Sexually Transmitted Infections Treatment Guidelines, 2021 (“2021 CDC guidelines” for short), completing a significant update to Sexually Transmitted Diseases Treatment Guidelines, 2015 (“2015 CDC guidelines” for short), most of the symptoms and signs of PID are mild or latent, so the diagnosis still relies on the minimum clinical standards. The treatment is mainly based on the use of broad spectrum, empirical antibiotics covering all possible pathogens, emphasizing the addition of metronidazole to cover anaerobic bacteria. Different intravenous and non-intravenous drug regimens have shown good efficacy. This paper compares the 2021 CDC guidelines, 2015 CDC guidelines, and Chinese Guidelines for Diagnosis and Treatment of Pelvic Inflammatory Diseases (2019 Revision), in order to provide reference and help for the current clinical practice of PID in China.
		2023 Vol. 20 (3): 88-92 [Abstract] ( 13 ) HTML (1 KB) PDF (647 KB) ( 60 )

	93	Influencing factors of health education effect in children with tethered cord syndrome
		ZHENG Yinli
		DOI: 10.20047/j.issn1673-7210.2023.03.21
		Objective To discuss the influencing factors of health education effect in children with tethered cord syndrome. Methods A total of 120 children with tethered cord syndrome in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2020 to December 2021 were selected. According to the effect of health education, they were divided into satisfied group and unsatisfied group. The factors that influence the effect of health education were analyzed. Results A total of 90 cases were satisfied with the effect of health education. There were statistically significant differences in the course of disease, guardian education, guardian status, mental resilience, and family function between two groups (P＜0.05). The course of disease, guardian education, guardian status, mental resilience, and family function were the factors influencing the effect of health education (P＜0.05). Conclusion There are many factors influencing the effect of health education for children with tethered cord syndrome. It is of great significance to give health education to different groups.
		2023 Vol. 20 (3): 93-96 [Abstract] ( 7 ) HTML (1 KB) PDF (582 KB) ( 34 )

	97	Effect and influence of hemorheology and safety of Methylprednisolone local injection behind the ear in patients with low frequency descending sudden deafness
		MA Yongchi ZHU Wenyan▲ JIN Xin
		DOI: 10.20047/j.issn1673-7210.2023.03.22
		Objective To investigate the effect and influence of hemorheology and safety of Methylprednisolone local injection behind the ear injection in patients with low frequency descending sudden deafness. Methods A total of 93 patients with low-frequency descending sudden deafness admitted to Huaian First Hospital Affiliated to Nanjing Medical University from November 2016 to November 2021 were selected and divided into control group (47 patients receiving Methylprednisolone intravenous infusion) and observation group (46 patients receiving Methylprednisolone local injection behind the ear) by random number table method. The course of treatment in both groups was 14 days. The auditory threshold of the two groups before and after treatment was detected and compared, and the clinical efficacy of the two groups was analyzed. The hemorheology indexes and plasma homocysteine (Hcy) levels of the two groups were detected and compared before and after treatment, and the occurrence of adverse reactions during treatment were analyzed. Results After treatment, the hearing threshold in both groups was lower than that before treatment (P＜0.05). The curative effect of the observation group was better than that of the control group (P＜0.05). After treatment, plasma viscosity, whole blood high tangential viscosity, whole blood low tangential viscosity, and Hcy levels in two groups were lower than those before treatment, and observation group was lower than control group (P＜0.05). The total incidence of adverse reactions in observation group was lower than that in control group (P＜0.05). Conclusion The Methylprednone local injection behind the ear in patients with low frequency descending sudden deafness has significant effect, which can improve the hemorheology index of patients and reduce the occurrence of adverse reactions, so it is recommended to be widely used in clinic.
		2023 Vol. 20 (3): 97-99,103 [Abstract] ( 6 ) HTML (1 KB) PDF (578 KB) ( 23 )

	100	Analysis of influencing factors of prognosis of patients with open eye injury with orbital fracture
		ZHANG Miao DONG Haili ZHANG Fangni PANG Rui▲
		DOI: 10.20047/j.issn1673-7210.2023.03.23
		Objective To investigate the prognostic factors of patients with open eye injury with orbital fracture. Methods Sixty-six patients with open eye injury with orbital fracture in Tangdu Hospital, Air Force Military Medical University from January 2020 to January 2021 were selected as the research objects, and they were divided into poor prognosis group (25 cases) and good prognosis group (41 cases) according to different prognosis. The clinical data of the two groups were compared. Logistic regression model was used to analyze the prognostic factors of patients with open eye injury with orbital fracture. Results The proportion of age＜60 years old, the proportion of no intraocular foreign body, the proportion of no intraorbital, external, and superior bone wall fractures, and the proportion of eye trauma rating of 3-5 at the time of treatment in the poor prognosis group were lower than those in the good prognosis group, and the proportion of non-blunt trauma was higher than that in the good prognosis group, the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that age, cause of injury, foreign body in the eye, fracture site, and evaluation grade of eye trauma at the time of treatment were all factors influencing the prognosis of patients with open eye injury and orbital fracture (P＜0.05). Conclusion By analyzing the prognostic factors of patients with open eye injury with orbital fracture, this study provides a reliable theoretical basis for improving the clinical therapeutic effect and prognostic recovery of this disease.
		2023 Vol. 20 (3): 100-103 [Abstract] ( 10 ) HTML (1 KB) PDF (548 KB) ( 18 )

	104	Comparative study of Guangchenpi and Chenpi under the influence of planting environment on secondary metabolites
		SHI Hongchao1 SHANG Xueying1 CHEN Mingquan1 LUO Zhuoya2 QIN Ren’an1 HE Fenglei1 SUN Dong1
		DOI: 10.20047/j.issn1673-7210.2023.03.24
		Objective To compare the effects of planting environment on secondary metabolites between Guangchenpi and Chenpi. Methods Liquid chromatography-mass spectrometry was used to analyze and identify the differential components in Chenpi samples from different varieties. The peak area ratio of the differential flavonoid components between Guangchenpi and Chenpi at 283 nm, the peak area ratio of the differential components in Chenpi from different regions was analyzed. Results There were six differential components Chenpi samples from different regions, including hesperidin, sinensetin, 6-demethoxyhesperetin, nobiletin, hesperetin, and 5-demethylnobiletin. The ratio sinensetin/6-demethoxy- hesperidin＞0.60 or hesperidin/5-demethoxyhesperidin＞7.00 was Guangchenpi, and the ratio sinensetin/6-deme-thoxyhesperidin≤0.60 or hesperidin/5-demethoxyhesperidin≤7.00 was Chenpi. Conclusion In this study, the peak area ratio of sinensetin/6-demethoxyhesperidin>0.60 or hesperidin/5-demethylnobiletin>7.00 at 283 nm wavelength is used as the basis for the determination of Guangchenpi, which can improve the convenience and universality of the classification index of Chenpi origin.
		2023 Vol. 20 (3): 104-108,117 [Abstract] ( 13 ) HTML (1 KB) PDF (1550 KB) ( 29 )

	109	Analysis on characteristics of syndrome and treatment of dysentery with cold syndrome in Beiji Qianjin Yao Fang by Sun Simiao
		XING Yunqi HAN Haixiao SUN Zhongmei LI Junxiang YUAN Yali SHI Xiaojun ZHANG Wenji MAO Tangyou
		DOI: 10.20047/j.issn1673-7210.2023.03.25
		Beiji Qianjin Yao Fang on dysentery with cold syndrome causes and pathogenesis, treatment principles, and prescription drugs are detailed. This paper summarizes the characteristics of syndrome and treatment of Sun Simiao’s treatment of dysentery with cold syndrome by analyzing the medication rules of dysentery with cold syndrome articles. Sun Simiao believes that the disease is “more cold” and “more deficiency”. In clinical treatment, Aconiti Lateralis Radix Praeparata, Zingiberis Rhizoma, Cinnamomi Cortex, and other warm and hot drugs are used to “treating cold syndrome with heat methods”. and Ginseng Radix Et Rhizoma, Glycyrrhizae Radix Et Rhizoma, Angelicae Sinensis Radix, Asini Corii Colla, and so on are used to “treating deficiency syndrome with tonifying methods”. At the same time, dysentery is often stagnant. A small amount of Rhei Radix Et Rhizoma and Coptidis Rhizoma should be increased, that are also used to clear away accumulated stagnation, such as “treating retardation syndrome with dredging methods”. Chronic diarrhea separation, should add Mume Fructus, Halloysitum Rubrum that are used to relieve diarrhea with astringents. In addition, the dysentery with cold syndrome more virtual labor, when necessary should be added with nourishing drugs. Through systematic analysis of dysentery with cold syndrome in Beiji Qianjin Yao Fang, this paper summarizes the medication rules of Sun Simiao’s treatment of dysentery with cold syndrome and discusses its syndrome and treatment characteristics, in order to provide new ideas for clinical treatment of diarrhea.
		2023 Vol. 20 (3): 109-112 [Abstract] ( 12 ) HTML (1 KB) PDF (598 KB) ( 20 )

	113	Study on medication rules of skin-type henoch-schonlein purpura in Chinese Medical Code based on data mining
		CUI Zhengjiu1 ZHOU Xu2 WANG Xinxin3 MA Yunhong4 WANG Shuangyi1 DIAO Juanjuan2 PAN Yueli2
		DOI: 10.20047/j.issn1673-7210.2023.03.26
		Objective To explore the medication characteristics and prescription rules of skin-type henoch-schonlein purpura prescription in Chinese Medical Code. Methods The prescriptions for the treatment of skin-type henoch-schonlein purpura in the whole database of the Chinese Medical Code were retrieved, and the drug database was screened and established. The Traditional Chinese Medicine Inheritance Computing Platform V3.0 was used for data mining, and drug frequency, nature and flavour, channel tropism, efficacy, and high-frequency drug combination were analyzed, and association rules and cluster analysis were carried out. Results A total of 232 prescriptions for the treatment of skin-type henoch-schonlein purpura were obtained, including 228 traditional Chinese medicines, 34 herbs were used with a frequency of≥20 times. Most of the drugs used were cold, warm, and plain nature; bitter, sweet, and pungent flavours. They mainly belonged to the lung, stomach, spleen, heart, and liver channels. Most of the effects were clearing heat, tonifying deficiency, relieving surface, resolving phlegm, relieving cough and asthma, regulating qi-flowing classes. Through analysis,17 high-frequency drug combinations, four association rules between drugs and three types of new prescriptions were obtained. Conclusion With clearing the defensive qi, nutrient-blood, and heat pathogen as the core, supplemented by promoting blood circulation, drying dampness, invigorating qi to relieve surface, regulating qi and eliminating phlegm and other treatment methods is the prescription medication rules of Chinese Medical Code for the treatment of skin-type henoch-schonlein purpura.
		2023 Vol. 20 (3): 113-117 [Abstract] ( 13 ) HTML (1 KB) PDF (1525 KB) ( 39 )

	118	Experience of traditional Chinese medicine master Professor Wang Lie in treating recurrent respiratory tract infections in children
		ZHU Jinpu1 WANG Lie2 SUN Liping2
		DOI: 10.20047/j.issn1673-7210.2023.03.27
		This paper summarizes the clinical experience of Professor Wang Lie, a traditional Chinese medicine master, in treating recurrent respiratory tract infections in children. According to the pathogenesis and morbidity characteristics, Professor Wang divides the disease into three phases: the acute infection phase, the non-acute infection phase and the consolidation treatment phase. Professor Wang believes that during the acute infection phase, the intertwining of external evils and internal toxins is the main pathogenesis that leads to persistent fever. The treatment should clearly distinguish between the excess and the deficiency. The patient who is suffering from excess should be given the modified Qinggan Decoction which could clear sense and toxic materials. For the patient who is suffering from deficiency, medicines that clear deficiency heat and nourish yin should be used. During the non-acute infection phase, the lung, spleen and kidney are mainly to be regulated, and the treatment relies on the syndrome differentiation and the identification of deficiencies and excesses. For the patient with food accumulation and lung heat, Professor Wang matches Scutellariae Radix and other herbs to transport the spleen. In this way, the lung heat could be cleared and accumulation and stagnation could be eliminated. If there is deficiency in the lung, spleen, and kidney, Professor Wang uses modified Yiqi Qiangshen Decoction to benefit qi and strengthen the vital qi. In the case of lung yin in deficiency syndrome, Professor Wang uses modified Bufei Decoction to moisten the lung and nourish yin. During the consolidation treatment phase, great attention should be paid to the prevent recurrence of disease after treatment, and therefore Professor Wang adopts combined internal external therapy. In this situation, the Pediatric Longmu Capsules and Yiqi Guben Capsules are commonly used in combination with the Fangfu Sachet. Scientific maintenance methods and a balanced diet are advocated as well. The clinical results are significant, and one medical record is attached to prove our view.
		2023 Vol. 20 (3): 118-121,125 [Abstract] ( 20 ) HTML (1 KB) PDF (801 KB) ( 22 )

	122	Experience summary of Professor Wang Junge in the differentiation and treatment of allergic rhinitis with classical prescriptions
		DONG Hanyi1 WANG Junge2
		DOI: 10.20047/j.issn1673-7210.2023.03.28
		This article introduces Professor Wang Junge’s experience in treating allergic rhinitis with classical prescriptions. Professor Wang Junge has inherited Zhongjing’s academic system, and has been engaged in clinical medicine and clinical research for decades. He is good at using classical prescriptions in the differentiation and treatment of allergic rhinitis otolaryngology diseases. Professor Wang Junge uses “three views of the classical prescriptions” to interpret the pathogenesis of allergic rhinitis as “deficient vital qi and cold-dampness encumbering the exterior”, dual disease of the exterior and interior, and take the exterior as the anxious and suffering. The treatment should be based on the method of “warm yang and secure the exterior, dissipate cold and eliminate dampness”. According to the clinical performance, allergic rhinitis is divided into wind-cold and rheum-inverse syndrome, yang-deficiency and rheum-inverse syndrome, cold rheum transform into heat syndrome, exterior vacuity without securing and containing syndrome. Classification of pathogenesis based on six meridians syndrome differentiation, identifies the state of body fluid distribution clutch. And applying classical prescriptions based on the principle of yin and yang. To take the prescription with the principle and method, and the clinical effect is good.
		2023 Vol. 20 (3): 122-125 [Abstract] ( 14 ) HTML (1 KB) PDF (601 KB) ( 36 )

	126	Professor Lin Guohua’s subtlety of experience in the treatment of pruritic skin diseases with cotton moxibustion
		XIAO Qing’e1 LIN Shiyu2 WEI Yongzheng3 ZHAN Sha4 CHEN Siyu5 JIAO Junyue1 LIN Guohua2
		DOI: 10.20047/j.issn1673-7210.2023.03.29
		Professor Lin Guohua’s clinical experience in applying cotton moxibustion in the treatment of pruritic skin diseases is summarized and typical cases are introduced in this paper. Professor Lin often uses cotton moxibustion to treat skin diseases. He believes that the four main contradictions of “wind pathogen”, “fire stagnation”, “dampness and turbidity” and “blood stasis” run through the whole process of pruritus. The treatment is based on the principles of “internal treatment for internal and external treatment for external” in the Sincerely True Theories of Suwen, with the theory of “searching wind and dredging collaterals”, “fire stagnation requiring dissipation” and “removing blood stasis and generating new”. Therefore, Professor Lin skillfully applies cotton moxibustion therapy, combines with pricking-cupping, fire needle therapy, cotton moxibustion and other external therapy with traditional Chinese medicine characteristics, so as to further achieve the function of promoting yang and eliminating dampness, wind expelling, fire dispersing, dampness clearing, stasis removing, and itching stopping.
		2023 Vol. 20 (3): 126-129 [Abstract] ( 10 ) HTML (1 KB) PDF (673 KB) ( 19 )

	130	Analysis of knowledge graph of acupuncture in the treatment of vertigo based on CiteSpace
		QIN Shuya1 LI Ling2 HUANG Wenbo1 DENG Hua2
		DOI: 10.20047/j.issn1673-7210.2023.03.30
		Objective To analyze the research hotspots and research trends in the field of acupuncture in the treatment of vertigo. Methods The research object was the literature related to the treatment of “vertigo” with “acupuncture” from the inception of the CNKI to December 2021. The number of documents, authors, organizations and keywords in turn were analyzed, relevant atlas was drawn. Results A total of 883 articles were included, and the number of documents issued increased year by year. In the past 20 years, four major research teams had been formed, 28 keywords with frequency more than ten times. Among them, there were seven high-frequency keywords with intermediary centrality more than 0.1. There were 15 emerging keywords, and the keywords were grouped into 12 categories. Conclusion The field of acupuncture in the treatment of vertigo mainly focus on the types of common vertigo diseases, the treatment methods of acupuncture, acupoint selection tendency, other therapies, and the types of academic research to carry out research changes in different time periods. However, research on the targets and experimental mechanisms of acupuncture is relatively lacking.
		2023 Vol. 20 (3): 130-133,138 [Abstract] ( 7 ) HTML (1 KB) PDF (2570 KB) ( 88 )

	134	Experience summary of Professor Li Peiwen in differential treatment of dry eyes related to chemotherapy for breast cancer based on xuanfu theory
		NAN Yunxin1 ZHANG Lei1 CHEN Hongyang1 SU Fei2 WAN Donggui2
		DOI: 10.20047/j.issn1673-7210.2023.03.31
		Breast cancer is currently the highest incidence of malignant tumor. Chemotherapy is one of the commonly used treatments and many drugs can cause dry eyes, which seriously affects the quality of life and treatment compliance of patients. At present, there is no recommendation in the guidelines and most of the methods such as suspending chemotherapy and symptomatic treatment have great limitations. While traditional Chinese medicine has significant advantages in this aspect. Through many years of clinical observation and practice, Professor Li Peiwen has accumulated rich experience in the treatment of dry eyes related to chemotherapy for breast cancer, and believes that its basic pathogenesis is xuanfu occlusion. In terms of treatment, Professor Li Peiwen takes opening xuanfu as the method and puts forward the basic treatment of “soothing liver and regulating qi, opening xuanfu; nourishing liver and kidney, nourishing xuanfu; wind medicine rising and dispersing, clearing xuanfu”, throughout the treatment. According to different pathological factors, it is supplemented by removing dampness and heat, resolving phlegm and coagulation, removing blood stasis treatments, adding or decreasing with the syndrome. Professor Li Peiwen persists in the combination of disease differentiation and syndrome differentiation, and has achieved satisfactory clinical results.
		2023 Vol. 20 (3): 134-138 [Abstract] ( 30 ) HTML (1 KB) PDF (782 KB) ( 24 )

	139	Application effect of pestle needle therapy in nerve-root type cervical spondylosis patients with qi stagnation and blood stasis syndrome
		XU Xiaoxia ZHENG Yaojie WU Cailan▲
		DOI: 10.20047/j.issn1673-7210.2023.03.32
		Objective To investigate the application effect of pestle needle therapy in nerve-root type cervical spondylosis patients with qi stagnation and blood stasis syndrome. Methods A total of 85 nerve-root type cervical spondylosis patients with qi stagnation and blood stasis syndrome treated in Changzhou Traditional Chinese Medicine Hospital from November 2020 to April 2021 were selected and divided into control group (42 cases) and observation group (43 cases) according to random number table method. The control group was treated with acupuncture combined with cervical traction, and the observation group was treated with pestle needle therapy combined with cervical traction, with a course of treatment of two weeks. The clinical symptom score, clinical efficacy, and sleep quality between the two groups were compared. Results Two weeks after treatment, the scores of shoulder neck arm pain, neck tenderness, neck mobility, upper limb mobility, limb numbness, tendon reflex, upper limb muscle strength, coping test, brachial plexus traction test, and total scores in two groups were lower than those before treatment, the scores of shoulder neck arm pain, limb numbness, coping test, brachial plexus traction test and total scores in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Clinical efficacy of the observation group was better than that of the control group, the difference was statistically significant (P＜0.05). Two weeks after treatment, sleep quality, sleep latency, sleep time, sleep efficiency, sleep disorder, hypnotic drugs, daytime dysfunction scores, and total scores of the two groups were lower than those before treatment, sleep efficiency score and total score in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Pestle needle therapy can help to improve the clinical symptoms, treatment effect and sleep quality of nerve-root type cervical spondylosis patients with qi stagnation and blood stasis syndrome.
		2023 Vol. 20 (3): 139-142 [Abstract] ( 9 ) HTML (1 KB) PDF (541 KB) ( 21 )

	143	Effect of multi-scale evaluation on quality of life, nutritional status, and sleep quality in elderly patients with chronic diseases
		DENG Haiting CAI Xiaoyan
		DOI: 10.20047/j.issn1673-7210.2023.03.33
		Objective To observe the effect of multiple scales evaluation on the functional of elderly patients with chronic diseases. Methods A total of 100 elderly patients with chronic diseases admitted to the Geriatric Department of Nanjing Drum Tower Hospital from January 2018 to January 2021 were selected as the research objects. Random number table method was adopted to divide them into study group and control group, with 50 cases in each group. The control group was given nursing care under the assessment of quality of life questionnaire-core 30 (QLQ-C30), while the study group was given nursing care based on the assessment of nutritional risk scale (NRS2002), and Pittsburgh sleep quality index (PSQI). At admission and one month after admission, QLQ-C30 scale, nutritional status, and immune function were used to evaluate the patients. Results After intervention, the scores of physical function, role function, social function, cognitive function, emotional function, and overall quality of life in the study group were higher than those before intervention, and higher than those in the control group; the scores of burnout, nausea and vomiting, pain, dyspnea, insomnia, loss of appetite, constipation, and diarrhea were lower than those before intervention, and the differences were statistically significant (P＜0.05). After intervention, the body mass index, albumin, and total protein levels in the study group were higher than before intervention, and higher than those in the control group, with statistical significances (P＜0.05). After intervention, the levels of immunoglobulin (Ig)G, IgM, and IgA in both groups were higher than before intervention, while those of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Intervention after the multi-scale assessment can enhance immune function and nutritional status of patients with chronic diseases in geriatrics department, and maintain good quality of life in later life.
		2023 Vol. 20 (3): 143-146,151 [Abstract] ( 8 ) HTML (1 KB) PDF (653 KB) ( 48 )

	147	Management effect of intensive nursing in hyperbaric oxygen assisted treatment of acute myelitis in children
		TANG Lin1 LIU Yan1▲ LI Xiaofang1 HUANG Xiantao2
		DOI: 10.20047/j.issn1673-7210.2023.03.34
		Objective To analyze the management effect of intensive nursing in hyperbaric oxygen assisted treatment of acute myelitis in children. Methods A total of 60 children with acute myelitis treated in Heze Municipal Hospital of Shandong Province from January 2019 to January 2021 were selected as research objects and divided into study group and control group by random number table method, with 30 cases in each group. The control group was given hyperbaric oxygen assisted therapy and routine nursing management, while the study group was given hyperbaric oxygen assisted therapy and refined nursing management. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), and body motor function (Fugl-Meyer) scores of the two groups were compared before intervention and two weeks after intervention. Family satisfaction and children’s compliance were evaluated after intervention. Results After intervention, HAMD and HAMA scores of the two groups were lower than those before intervention, while those of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the scores of upper limb function and lower limb function in two groups were higher than before intervention, while those of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The nursing satisfaction of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion On the basis of hyperbaric oxygen assisted treatment in children with acute myelitis, combined with refined nursing management intervention, can significantly relieve patients’ negative emotions, improve limb function, enhance children’s compliance and family satisfaction.
		2023 Vol. 20 (3): 147-151 [Abstract] ( 12 ) HTML (1 KB) PDF (740 KB) ( 35 )

	152	Application effect of quantitative diet exercise formulation in patients with gestational diabetes mellitus
		ZHANG Juan ZHI Fenfang▲
		DOI: 10.20047/j.issn1673-7210.2023.03.35
		Objective To explore the application effect of quantitative diet exercise formulation in patients with gestational diabetes mellitus. Methods A total of 98 patients with gestational diabetes mellitus treated in Huaian First People’s Hospital, Jiangsu Province from January 2019 to August 2021 were selected as subjects, the patients were divided into control group and observation group by computer stratified sampling, with 49 cases in each group. Routine nursing intervention was carried out in both groups, and the observation group formulated intervention based on quantitative diet exercise. The self-management ability, blood glucose level and maternal and infant complications were compared before and after the intervention. Results After intervention, the blood glucose monitoring scores of eating vegetables and fruits and following medical advice were all higher than before intervention, and the observation group was higher than the control group, the scores of healthy diet, 30 min exercise and eating fatty food were lower than before intervention, and the observation group was lower than the control group (P＜0.05). Fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin in two groups were lower than those before intervention, and observation group was lower than control group (P＜0.05). The total incidence of maternal and infant complications in observation group was lower than that in control group (P＜0.05). Conclusion Quantitative diet exercise intervention can improve their self-management, reduce blood glucose, and postpartum maternal and infant complications.
		2023 Vol. 20 (3): 152-155 [Abstract] ( 9 ) HTML (1 KB) PDF (583 KB) ( 41 )

	156	Effects of music prosodic perception therapy combined with rTMS on communication ability and intellectual development of speech disorders combined with mental retardation
		PAN Juanjuan XIE Qingfeng GUO Fayan CHEN Xueer
		DOI: 10.20047/j.issn1673-7210.2023.03.36
		Objective To explore the effects of music prosodic perception therapy combined with repetitive transcranial magnetic stimulation (rTMS) on communication ability and intellectual development of speech disorders combined with mental retardation. Methods A total of 106 children with language disorder combined with mental retardation admitted to the Second Affiliated Hospital of Wenzhou Medical University from June 2020 to November 2021 were selected for a prospective study. They were divided into control group (53 cases, rTMS treatment) and observation group (53 cases, musical prosodic perception +rTMS treatment) according to random number table method. Communication abilities in daily living (CADL), intelligence development, speech improvement, and intelligence improvement were compared between the two groups. Results After treatment, CADL score in two groups was higher than that before treatment, and the observation group was higher than control group, and the difference was statistically significant (P＜0.05). The scores of language ability, adaptability, gross motor, personal social interaction, and fine motor were all increased in the two groups, and the scores in the observation group were higher than those in the control group, and the difference were statistically significant (P＜0.05). The speech improvement effect of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). The improvement effect of intelligence in observation group was better than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Music prosodic perception therapy combined with rTMS has a significant effect in the treatment of children with speech disorders combined with mental retardation, which can better improve the communication ability and intellectual development of children, and is worthy of clinical promotion.
		2023 Vol. 20 (3): 156-159 [Abstract] ( 14 ) HTML (1 KB) PDF (551 KB) ( 68 )

	160	Effect of total controlled nursing on clinical prognosis and nutritional status of patients with end-stage renal disease undergoing hemodialysis
		MEI Zhu ZHOU Lan LIN Lu YUAN Haichuan▲
		DOI: 10.20047/j.issn1673-7210.2023.03.37
		Objective To explore the effect of comprehensive control nursing on the clinical prognosis and nutritional status of patients with end-stage renal disease undergoing hemodialysis. Methods Eighty patients with end-stage renal disease in the First Affiliated Hospital of Nanjing Medical University from January 2018 to December 2020 were selected as the subjects of this study. Control group and observation group were set up according to random number method, with 40 cases in each group. The control group received routine nursing, and the observation group received comprehensive control nursing. The adverse mood performance, quality of life score, nursing compliance, and nutritional indexes before and after nursing were analyzed. Results After intervention, serum total protein, albumin, and hemoglobin levels in both groups were higher than before intervention, while those of observation group were lower than those of control group, and the differences were statistically significant (P＜0.05). After intervention, anxiety and depression scores of the two groups were lower than before intervention, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the scores of compliance and quality of life in two groups were lower than before intervention, while those of the observation group were lower than those of control group, and the differences were statistically significant (P＜0.05). Conclusion In the face of end-stage renal disease patients to analyze, the use of comprehensive control nursing measures can effectively improve the quality of life of patients at the same time, reduce patients’ bad mood, improve nursing compliance, and enhance the nutritional performance of patients, it is worth each department to adopt for reference.
		2023 Vol. 20 (3): 160-163 [Abstract] ( 11 ) HTML (1 KB) PDF (548 KB) ( 31 )

	164	Application effect of the nine-grid mental model in improving the nursing quality in the operating room
		ZHAO Qinghua1 LI Jin2 ZHANG Li1
		DOI: 10.20047/j.issn1673-7210.2023.03.38
		Objective To explore the application effect of the nine-grid mental model in improving the nursing quality in the operating room. Methods A total of 60 operating room nurses from the First People’s Hospital of Jinzhong, Shanxi Province from April 2019 to April 2021 were prospectively selected as study subjects, according to the random number table method, they were divided into study group and control group, with 30 nurses in each group. The control group received conventional mode management, and the study group received nine-grid mental model management. The differences of operating room theory and operating skill scores, core competence scores, judgment thinking scores and nursing quality were compared between the two groups after three months. Results After intervention, the scores of theoretical and operational skills in both groups were higher than those before intervention, and the study group was higher than the control group (P＜0.05); the scores and total scores of all dimensions of core competence in both groups were higher than those before intervention, and the study group were higher than the control group (P＜0.05); the scores and total scores of critical thinking ability in both groups were higher than those before intervention, and the study group were higher than the control group (P＜0.05); the scores and total scores of all dimensions of nursing quality in both groups were higher than those before intervention, and the intervention group were higher than the control group (P＜0.05). Conclusion The application of nine-grid mental model in operating room nursing can effectively improve the professional core competence and critical thinking ability of operating room nurses and improve nursing quality.
		2023 Vol. 20 (3): 164-167,175 [Abstract] ( 13 ) HTML (1 KB) PDF (654 KB) ( 70 )

	168	Research on quality control present situation and refined management of rehabilitation institutions
		JIN Feng ZHANG Shuyan WANG Xue GU Lili MI Zhongxiang
		DOI: 10.20047/j.issn1673-7210.2023.03.39
		With the rapid development of rehabilitation medicine in recent years, this paper analyzes the current situation of rehabilitation quality control and refined management in rehabilitation institutions in China from many aspects, include the international situation of rehabilitation quality control, construction of quality control system in domestic rehabilitation institutions, management of key links of rehabilitation quality control etc. It is believed that the quality control system construction of rehabilitation institutions in China is generally perfect. However, the rehabilitation quality management system is still lacking, there is lack of unified standards as a whole, and it is not refined and informative enough. Even in some work, it is contrary to national policies. It also requires administrative departments at all levels, rehabilitation academic groups, and management organizations of rehabilitation institutions to actively carry out research and practical exploration around the fine management of quality control in rehabilitation institutions. Then we can form a modern rehabilitation quality control system suitable for the current situation and future development of rehabilitation services in China, and help the comprehensive and high quality development of rehabilitation.
		2023 Vol. 20 (3): 168-171 [Abstract] ( 15 ) HTML (1 KB) PDF (565 KB) ( 128 )

	172	Exploration and research on high quality development of work injury rehabilitation institutions in China
		MI Zhongxiang1 CHEN Dajun2 CHEN Xu2 LIU Haibing2 ZHANG Huanjin2 LIU Siwen3 DENG Wenhua4 LIN Yueqing4
		DOI: 10.20047/j.issn1673-7210.2023.03.40
		Work injury rehabilitation is an important part of the work injury insurance system. During “the 14th Five-Year Plan” period, China’s work injury rehabilitation development has entered a new era. Work injury rehabilitation institutions are the most important part of work injury rehabilitation. How to develop to meet the requirements of the new era is a major issue at this stage. This study focuses on the needs of work injury rehabilitation and the development of rehabilitation institutions. A number of aspects are considered, including the form and content of service, personnel training, hospital management and work injury rehabilitation policy. Also considered are the developmental status of work injury rehabilitation institutions in China and the restrictive factors of its high quality development. Countermeasures to restrictive factors are proposed that can stimulate high quality development of work injury rehabilitation and promote a fair and excellent environment for employees and patients in work injury rehabilitation.
		2023 Vol. 20 (3): 172-175 [Abstract] ( 17 ) HTML (1 KB) PDF (579 KB) ( 68 )

	176	Practice and enlightenment of rehabilitation medical alliance construction
		LU Yao1 ZHANG Shuyan1 WANG Qiang1 MI Zhongxiang2,3
		DOI: 10.20047/j.issn1673-7210.2023.03.41
		China’s rehabilitation medical started late, and there are problems such as insufficient total amount, lack of professionals and so on. It is urgent to strengthen the construction of the rehabilitation medical service system and innovate the rehabilitation service model. In this article, the concrete practice of the construction of “zhong-kang medical alliance”, a rehabilitation specialist medical alliance, is taken as the research object. By fully sorting out and discussing its basic situation, operation mechanism, work development, preliminary results obtained and deficiencies, combined with the detailed elaboration of the policy background of the medical alliance construction and the era significance of the construction of rehabilitation medical alliance, this article demonstrated that under the existing conditions, taking the establishment of rehabilitation medical alliance as a gripper, by means of the construction of hierarchical medical system, to realize the connection of high quality rehabilitation medical resources, ultimately improved the service capacity of grassroots rehabilitation medical institutions and provided patients with better rehabilitation medical services.
		2023 Vol. 20 (3): 176-179 [Abstract] ( 12 ) HTML (1 KB) PDF (568 KB) ( 40 )

	180	Practice and effect analysis of detailed budget management of drug expenses in a class A general hospital in Beijing
		ZHANG Yang LI Zhe CHENG Sheng GUO Heng SHEN Su LI Xingang
		DOI: 10.20047/j.issn1673-7210.2023.03.42
		Objective To summarize the practice and effect of pharmaceutical administration in Beijing Friendship Hospital, Capital Medical University (“our hospital” for short), and to provide reference for drug management in public hospitals under the new situation. Methods The main measures of drug cost management in our hospital were introduced, and the total amount of outpatient drugs, inpatient drugs, adjuvant drugs, total number of outpatients and discharged patients were analyzed statistically from 2016 to 2019. The proportion of average outpatient drug cost, average inpatient drug cost and adjuvant drugs cost in the four years was compared, and the management effectiveness was comprehensively evaluated. Results From 2016 to 2019, the average drug cost per outpatient in our hospital gradually decreased, and decreased by 4.86%, 1.67% and 9.20% in 2017, 2018 and 2019 compared with the previous year (P＜0.05). The average drug cost per hospitalization decreased year by year, and decreased by 5.31%, 0.05% and 1.65% in 2017, 2018 and 2019, respectively, compared with the previous year (P＜0.05). The expense proportion of auxiliary drugs was decreased year by year, and decreased by 18.45%, 24.82% and 5.83% in 2017, 2018 and 2019 compared with the previous year. Conclusion Through multi-department co-management in our hospital, a new drug expense management mode is formed, which can be summed up as “budget leading, performance ending, to departments, overall management”. The management effectively reduces the average drug expenses per outpatient and inpatient as well as the expense proportion of auxiliary drugs, and improves the level of rational drug use in the hospital.
		2023 Vol. 20 (3): 180-183 [Abstract] ( 13 ) HTML (1 KB) PDF (583 KB) ( 28 )

	184	Analysis of problems and suggestions for optimization in the training of Western medicine learning from traditional Chinese medicine based on in-depth interviews
		CAO Yu1 LIU Gang2 ZHAO Danyang1 PANG Bo3 LI Ming2 LI Fusheng2 ZHANG Chuanlong3▲
		DOI: 10.20047/j.issn1673-7210.2023.03.43
		Objective To discuss the problems in the training and management of “Western medicine learning from traditional Chinese medicine” (hereinafter referred to as “Western-learns-Chinese”), and to provide reference for optimizing the practice of “Western-learns-Chinese” in the future. Methods A total of 12 experts in the field of training and management of “Western-learns-Chinese” in Beijing were selected for the study, and personal one-on-one in-depth interviews were conducted with experts from the management of the institute, clinicians and university teachers. NVivo 12 Plus was used to conduct a qualitative study of the original interview data, using a three-level coding approach, and the interviews were conducted at three levels: trainee development, trainee management, and trainee certification of the “Western-learns- Chinese” training. Results Three themes at the trainee management level: the lack of perfect management standardization, the importance of establishing a sound assessment and evaluation system, and the fact that personnel selection and threshold setting should be both standardized and flexible. Four themes at the trainee training level: the training process of trainees with or without teachers needs to be further discussed, the practicality of the curriculum needs to be improved, different levels of training should be set for different trainees, and the teaching model still lacks innovation. Three themes at the trainee certification level: the lack of policy-level certification and recognition after the training of “Western-learns- Chinese” trainees relies on the introduction of relevant policies by government management departments and the strengthening of communication and collaboration between “Western-learns-Chinese” training and management- related departments. Conclusion The study proposes suggestions for improvement of the problems in the cultivation of “Western-learn-Chinese” talents. Only through the standardization, practicalization, and specialization of “Western-learns- Chinese” education can we train more medical talents with the highest level of sophistication and sincerity for the country.
		2023 Vol. 20 (3): 184-187,196 [Abstract] ( 13 ) HTML (1 KB) PDF (832 KB) ( 51 )

	188	Clinical application of pharmacy service model based on clinical pharmacy workstation in elderly patients with chronic heart failure
		LI Xiaoxiao WANG Yang BAI Limiao SUN Tian TANG Miaomiao▲
		DOI: 10.20047/j.issn1673-7210.2023.03.44
		Objective To explore the clinical application value of pharmacy service model based on clinical pharmacy workstation in elderly patients with chronic heart failure. Methods The clinical data of 203 elderly patients with chronic heart failure (control group) admitted to Xingtai General Hospital, North China Medical Health Group (hereinafter referred to as “our Hospital”) from January to December 2019 and 215 elderly patients with chronic heart failure (study group) admitted to our hospital from January to December 2020 were retrospectively analyzed. The control group received routine medication guidance and education pharmacy workstation, while the study group used the pharmacy service model based on the clinical pharmacy workstation. The general data, medication economy, safety, medication compliance, and patient satisfaction were compared between the two groups. Results There were no significant differences in gender, age, number of drugs taken, and underlying diseases between the two groups (P＞0.05). The cost of drugs in the study group was lower than that in the control group (P＜0.05). The medication error rate, the rate of irrational doctor’s orders, the rate of adverse drug reactions, and the rate of unreasonable prescriptions in the research group were lower than those in the control group (P＜0.05). The medication compliance in the study group was higher than that in the control group (P＜0.05), and patient satisfaction in the study group was better than that in the control group (P＜ 0.05). Conclusion The clinical application of the pharmacy service model based on the clinical pharmacy workstation in the elderly patients with chronic heart failure has a significant clinical effect, which can improve medication economy, medication safety, medication compliance and patient satisfaction.
		2023 Vol. 20 (3): 188-191 [Abstract] ( 9 ) HTML (1 KB) PDF (521 KB) ( 37 )

	192	Practice research on telemedicine platform based on cross-regional new medical alliance to assist medical aid to Xinjiang
		MAO Guohua1 DI Jizhou2 LI Jitong3 YU Bihua4
		DOI: 10.20047/j.issn1673-7210.2023.03.45
		Using telemedicine to build cross-regional new medical alliance is an important means to improve the effectiveness of medical aid to Xinjiang. In order to better introduce Ningbo high-quality medical resources, improve the local medical level of Kuqa, with Ningbo-Kuqa precision assistance telemedicine system as the technical means, build the “Yongkou Telemedicine Service Platform”, establish the Ningbo-Kuqa cross-regional new medical alliance, and realize the comprehensive sharing of expert resources and multi-disciplinary “group” cooperation service. All grass-roots hospitals are connected to provide all-round precise assistance for medical services in Kuqa, and greatly improve the accessibility and convenience of quality medical resources for the people in Kuqa. The construction of Ningbo-Kuqa cross-regional medical consortium is based on platform construction and supported by scientific and technological means, through innovation and practice, the means and connotation of medical aid to Xinjiang are enriched. This aid mode can effectively improve the system, level, timeliness and continuity of medical aid to Xinjiang, and is an exploratory upgrade and supplement to the “group” aid mode.
		2023 Vol. 20 (3): 192-196 [Abstract] ( 11 ) HTML (1 KB) PDF (731 KB) ( 65 )

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