|
|
|
| Application of mesoporous silica nanoparticles in drug delivery |
| OUYANG Xianjin KANG Xu GUO Tingting LIU Yueping CHANG Mingming |
| College of Bioscience and Resources Environment, Beijing University of Agriculture, Key Laboratory of Urban Agriculture in North China, Ministry of Agriculture and Rural Affairs，Beijing 102206, China |
|
|
|
Abstract Mesoporous silica nanoparticles with ordered mesoporous structure, large specific surface area, easy surface modification, and high colloidal stability have attracted more and more attention in the field of drug targeted therapy and controlled-release. As a drug carrier, unmodified mesoporous silica has a relatively obvious “sudden release” effect, by modifying small organic molecules, inorganic nanoparticles, and ring molecules on its surface, the drug release efficiency can be effectively improved, which is beneficial to improve the stability and biocompatibility of the system, and promote the further application of mesoporous silica nanoparticles in the field of drug delivery.
|
|
|
|
|
|
[1] Geng S，Qin L，He Y，et al. Effective and safe delivery of GLP-1AR and FGF-21 plasmids using amino-functionalized dual-mesoporous silica nanoparticles in vitro and in vivo [J]. Biomaterials，2021，271（9）：120763.
[2] Dineshkumar S，Raj A，Srivastava A，et al. Facile Incorporation of “Aggregation-Induced Emission”-active conjugated polymer into mesoporous silica hollow nanospheres：synthesis，characterization，photophysical studies，and application in bioimaging [J]. ACS Appl Mater Interfaces，2019，11（34）： 31270-31282.
[3] Trewyn BG，Giri S，Slowing II，et al. Mesoporous silica nanoparticle based controlled release，drug delivery，and biosensor systems [J].Chem Commun（Camb），2007（31）：3236-3245.
[4] Gomes M，Zadeh P，Palmqvist A，et al. Spatial distribution of enzymes immobilized in mesoporous silicas for biocatalysis [J]. ACS Appl Nano Mater，2019，2：7245-7254.
[5] Wang J，Yu J，Yan Y，et al. Biodegradable polyester/modified mesoporous silica composites for effective bone repair with self-reinforced properties [J]. Polym Adv Technol，2019，30（6）：1461-1472.
[6] Mackowiak SA，Schmidt A，Weiss V，et al. Targeted drug delivery in cancer cells with red-light photoactivated mesoporous silica nanoparticles [J]. Nano Lett，2013，13（6）：2576-2583.
[7] Jia L，Li Z，Shen J，et al. Multifunctional mesoporous silica nanoparticles mediated co-delivery of paclitaxel and tetrandrine for overcoming multidrug resistance [J]. Int J Pharm，2015，489（1/2）：318-330.
[8] Xiong Y，Tang H，Liu W，et al. Characterization and evaluation of a folic acid receptor-targeted norcantharidin/tetrandrine dual-drug loaded delivery system [J]. J Nanomater，2019， 2019：1-15.
[9] Wu J，Wei J，Shen Y，et al. Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepers for pH-sensitive controlled release of doxorubicin [J]. Mater Sci Eng C Mater Biol App，2016，70：132- 140.
[10] Zhao Y，Trewyn BG，Slowing II，et al. Mesoporous silica nanoparticle-based double drug delivery system for glucose-responsive controlled release of insulin and cyclic amp [J]. J Am Chem Soc，2009，131（24）：8398-8400.
[11] Mal NK，Fujiwara M，Tanaka Y. Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica [J]. Nature，2003，421（6921）：350-353.
[12] Liu X，Wang Q，Li C，et al. Cu2-xSe@mSiO2-PEG core- shell nanoparticles：A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density [J]. Nanoscale，2014，6（8）：4361-4370.
[13] Pan Q，Chen TT，Nie CP，et al. In Situ synthesis of ultrathin ZIF-8 film-coated MSNs for co-delivering Bcl-2 siRNA and doxorubicin to enhance chemothera-peutic efficacy in drug-resistant cancer cells [J]. ACS Appl Mater Interfaces，2018，10（39）：33070-33077.
[14] Chang D，Gao Y，Wang L，et al. Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy [J]. J Colloid Interface Sci，2015，463：279-287.
[15] Guo T，Kang X，Ren S，et al. Construction of a nano-controlled release methotrexate delivery system for the treatment of theumatoid arthritis by local percutaneous administration [J]. Nanomaterials，2021，11（11）：2812.
[16] Liu C，Qing Z，Zheng J，et al. DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intracellular GSH-controlled release [J]. Chem Commun（Camb），2015，51（30）：6544-6547.
[17] Gan Q，Lu X，Yuan Y，et al. A magnetic，reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica [J]. Biomaterials，2011，32（7）：1932-1942.
[18] Hta B，Mthm A，Zs C，et al. pH-responsive and CD44-targeting by Fe3O4 /MSNs-NH2 nanocarriers for oxaliplatin loading and colon cancer treatment [J]. Inorg Chem Commun，2020：108430.
[19] He K，Li J，Shen Y，et al. pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles （Gd2O3@MSNs） for synergistic drug delivery and magnetic resonance imaging enhancement [J]. J Mater Chem B，2019，7（43）：6840-6854.
[20] Flak D，Przysiecka ?覵，Nowaczyk G，et al. GQDs-MSNs nanocomposite nanoparticles for simultaneous intracellular drug delivery and fluorescent imaging [J]. J Nanopart Res，2018，20（11）：306.
[21] Liu R，Zhang Y，Zhao X，et al. pH-responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker [J]. J Am Chem Soc，2010，132（5）：1500-1501.
[22] Xing L，Zheng H，Cao Y，et al. Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release [J]. Adv mater，2012，24（48）：6433-6437.
[23] Meng H，Xue M，Xia T，et al. Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves [J]. J Am Chem Soc，2010，132（36）：12690-12697.
[24] Guillet-Nicolas R，Popat A，Bridot JL，et al. pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability [J]. Angew Chem Int Ed Engl，2013，52（8）：2318-2322.
[25] Yilmaz MD，Xue M，Ambrogio MW，et al. Sugar and pH dual-responsive mesoporous silica nanocontainers based on competitive binding mechanisms [J]. Nanoscale，2014，7（3）：1067-1072.
[26] Chen L，Wen Y，Su B，et al. Programmable DNA switch for bioresponsive controlled release [J]. J Mater Chem，2011， 21（36）：13811.
[27] Bernardos A，Mondragón L，Aznar E，et al. Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with “saccharides” [J]. Acs Nano，2010，4（11）：6353-6368.
[28] Ashley CE，Carnes EC，Epler KE，et al. Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers [J]. Acs Nano，2012， 6（3）：2174-2188.
[29] Akinc A，Thomas M，Klibanov AM，et al. Exploring polyethy- lenimine-mediated DNA transfection and the proton sponge hypothesis [J]. J Gene Med，2005，7（5）：657-663. |
|
|
|
