|
|
|
| Study on medication rules of skin-type henoch-schonlein purpura in Chinese Medical Code based on data mining |
| CUI Zhengjiu1 ZHOU Xu2 WANG Xinxin3 MA Yunhong4 WANG Shuangyi1 DIAO Juanjuan2 PAN Yueli2 |
1.The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China;
2.Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250013, China; 3.Department of Pediatrics, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
4.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China |
|
|
|
Abstract Objective To explore the medication characteristics and prescription rules of skin-type henoch-schonlein purpura prescription in Chinese Medical Code. Methods The prescriptions for the treatment of skin-type henoch-schonlein purpura in the whole database of the Chinese Medical Code were retrieved, and the drug database was screened and established. The Traditional Chinese Medicine Inheritance Computing Platform V3.0 was used for data mining, and drug frequency, nature and flavour, channel tropism, efficacy, and high-frequency drug combination were analyzed, and association rules and cluster analysis were carried out. Results A total of 232 prescriptions for the treatment of skin-type henoch-schonlein purpura were obtained, including 228 traditional Chinese medicines, 34 herbs were used with a frequency of≥20 times. Most of the drugs used were cold, warm, and plain nature; bitter, sweet, and pungent flavours. They mainly belonged to the lung, stomach, spleen, heart, and liver channels. Most of the effects were clearing heat, tonifying deficiency, relieving surface, resolving phlegm, relieving cough and asthma, regulating qi-flowing classes. Through analysis,17 high-frequency drug combinations, four association rules between drugs and three types of new prescriptions were obtained. Conclusion With clearing the defensive qi, nutrient-blood, and heat pathogen as the core, supplemented by promoting blood circulation, drying dampness, invigorating qi to relieve surface, regulating qi and eliminating phlegm and other treatment methods is the prescription medication rules of Chinese Medical Code for the treatment of skin-type henoch-schonlein purpura.
|
|
|
|
|
|
[1] 王卫平，孙锟，常立文.儿科学[M].北京：人民卫生出版社，2018.
[2] 燕晶晶，邱洞仙，边莉.玉屏风颗粒联合盐酸西替利嗪片治疗皮肤型过敏性紫癜的临床观察[J].河北中医，2018， 40（4）：555-558.
[3] 穆静，王耀献，郝静，等.儿童过敏性紫癜D-二聚体水平与中医证候相关性研究[J].中国临床医生杂志，2022，50（3）：371-373.
[4] 姜盈盈，白晗，吴静静，等.中医药治疗儿童过敏性紫癜的研究进展[J].现代中西医结合杂志，2022，31（6）：859- 863.
[5] 张煦，张伟.伏气消癜汤治疗血热妄行证儿童过敏性紫癜的临床研究[J].实用药物与临床，2022，25（2）：151- 154.
[6] 黄义，卢益萍.过敏性紫癜中医历史溯源[J].辽宁中医药大学学报，2021，23（5）：193-196.
[7] 裘沛然，邓铁涛，王永炎.中华医典[M].5版.长沙：湖南电子音像出版社，2014.
[8] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2020.
[9] 吴婷婷，李孝忠，刘徐洲.基于K-means的改进协同过滤算法[J].天津科技大学学报，2021，36（6）：44-48，54.
[10] 马融.中医儿科学[M].4版.北京：中国中医药出版社，2016：238-241.
[11] 郑文华，曹琳琳，朱荣华，等.过敏性紫癜的中医防治源流探析[J].中医临床研究，2021，13（20）：115-117.
[12] 刘萍.甘草功效和临床用量的本草考证[J].中华中医药杂志，2020，35（1）：73-77.
[13] 夏毅如，陈振华，冯显富.糖皮质激素应用于儿童腹型过敏性紫癜中的最佳时机及效果分析[J].中国实用医药，2021，16（20）：141-144.
[14] 吴缠婷，周良良，邹婉清，等.黄芩苷的药理特性及其作用机制研究进展[J].中华中医药学刊，2022，40（2）：63- 67.
[15] 沈银红，沈红，冶雪凤.霉酚酸酯对过敏性紫癜小鼠模型皮肤血管炎性水平及免疫功能的影响[J].临床和实验医学杂志，2021，20（22）：2361-2364.
[16] 李盼飞，刘晨笑.升麻的功效源流、变迁及其分析[J].中国实验方剂学杂志，2022，28（7）：218-226.
[17] 彭丽倩，陈教全，尹忠浩，等.天然抗氧化剂及其在皮肤科的应用进展[J].中国美容医学，2020，29（6）：174-176.
[18] 巢元方.诸病源候论[M].南京中医学院，校释.北京：人民卫生出版社，1982：962.
[19] 姚舜宇，刘志明，常兴，等.国医大师刘志明谈石膏的临床运用体会[J].时珍国医国药，2021，32（4）：978-980.
[20] 李时珍.本草纲目[M].北京：华夏出版社，2013：1854.
[21] 何松蔚，王俊宏，赵骞.王俊宏教授治疗过敏性紫癜经验[J].世界中医药，2021，16（8）：1293-1296.
[22] 李玉洁，张为佳，Tantisira M，等.“苦寒”方药性效解[J].中医杂志，2014，55（19）：1630-1634.
[23] 付海波，刘亚，霍秀云，等.朱珊教授从温病理论分期论治小儿过敏性紫癜经验[J].中国医药导报，2021，18（13）： 129-132.
[24] 张仲景.金匮要略[M].陈纪藩，编校.北京：人民卫生出版社，2000：10-41.
[25] 缪希雍.神农本草经疏[M].郑金生，校注.北京：中医古籍出版社，2002：563-564.
[26] Piram M，Maldini C，Biscardi S，et al. Incidence of IgA vas- culitis in children estimated by four-source capture- recapture analysis：a population-based study [J]. Rhe- umatology（Oxford），2017, 56（8）：1358-1366.
[27] 李泽宇，郝二伟，李卉，等.甘草配伍应用的药理作用及机制分析[J].中国实验方剂学杂志，2022，28（14）：13.
[28] 张建，翟文生，李广，等.以特征性要素为辨证要点治疗小儿过敏性紫癜[J].河南中医，2021，41（7）：1034-1037. |
|
|
|
