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| Research advances in brain metastasis of non-small cell lung cancer |
| MA Li ZHU Ya WANG Zhaoxia |
| Oncology Medical Center, the Second Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210011, China |
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Abstract Lung cancer is a common malignant tumor with high morbidity and mortality. Many patients die of distant metastases, especially to the brain. Due to the existence of blood-brain barrier and blood-tumor barrier, drug therapy is not effective. Many studies have shown that imbalanced expression of molecules plays an important role in the progression of malignant tumors. Epidermal growth factor receptor, non-coding RNA, cell adhesion molecules and others are reported to participate in regulating the process of brain metastases from non-small cell lung cancer, they also have high clinical translational value in diagnosis, treatment and evaluation of patient prognosis. This paper summarizes the recent progress of brain metastasis in non-small cell lung cancer, hoping to provide ideas and clues for future research.
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