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| Research progress of Chinese and western medicine intervention on platelet transfusion refractoriness in patients with liver cancer |
| NONG Yaobin1 HUANG Hongna2 HUANG Jingjing3 DONG Zhixin4 SONG Wenxuan1 XIAO Xiyu1 DU Yuanqin1 |
1.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China;
2.Teaching and Research Section of Internal Medicine of Chinese Medicine, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China;
3.Department of Lienal, Gastric, and Hepatic Disease, Xianhu Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China;
4.Ward Two, Department of Oncology, Xianhu Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China |
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Abstract The occurrence of liver cancer is often evolved from the progression of viral hepatitis, cirrhosis, aflatoxin contamination, and so on. Most patients with liver cancer are complicated with hyperplenism, which leads to the reduction of their platelets in peripheral blood to varying degrees. At the same time, targeted drug therapy can produce strong inhibition on megakaryocytes and bone marrow function, and can also lead to a decrease in the number of platelets. In the treatment of platelet transfusion in patients with liver cancer, there may be several times of infusion but the ideal effect can not be achieved, the bleeding status is not alleviated, and even platelet transfusion refractoriness (PTR) occurs. Abnormal bleeding in patients with liver cancer is closely related to platelets level. Therefore, it is very important to explore the regulation of platelets by Chinese and western medicine in the treatment of PTR in patients with liver cancer. In this paper, platelet generation, PTR mechanism in patients with liver cancer, regulation and intervention measures of Chinese and western medicine are briefly reviewed, so as to provide reference for the clinical treatment of PTR in patients with liver cancer and broaden treatment ideas.
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