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| Research progress on exosome targeted delivery of nucleic acid molecules |
| JIA Yue1 LI Yan2 WANG Yingji1 |
| 1.Inorganic Chemistry Teaching and Research Office, School of Pharmacy, Harbin Medical University, Heilongjiang Province, Harbin 150081, China; 2.Research Center of Traditional Chinese Medicine Translational Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Exosomes, as small nanoscale extracellular vesicles are an important mode of cellular information delivery in living organisms. Exosomes are characterized by high delivery efficiency, low immunogenicity, the ability to cross multiple biological barriers, and targeting properties. This has made exosomes an important member of drug delivery carriers to overcome the disadvantages of poor stability, insufficient bioavailability, low solubility, and high toxicity of some drugs. This article reviews the use of exosomes in vesicle form as novel drug delivery molecules, including microRNA, small interfering RNA and deoxyribo nucleic acid, which have received much attention in recent years. This article aims to provide a theoretical basis and design ideas for the development of efficient and safe delivery of exosome targeted nucleic acid like molecules and to facilitate their clinical translation.
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