|
|
|
| Analysis on the syndrome characteristics and medication rule of cancer - related fatigue |
| SONG Jinjie1 LI Zhongyu2 ZHANG Zhongyue1 GUO Zhongning1 WU Yu1 ZANG Mingxuan1 |
1.Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;
2.College of Graduate, China Academy of Chinese Medical Sciences, Beijing 100700, China |
|
|
|
Abstract Objective To analyze the traditional Chinese medicine syndromes of cancer induced-related fatigue and the medication rule of traditional Chinese medicine prescription. Methods In this study, the relevant literature on traditional Chinese medicine treatment of cancer-related fatigue was retrieved from CNKI, CBM, Wanfang, VIP, and PubMed databases until April 2021, and the syndrome characteristics and medication rule were analyzed by means of the traditional Chinese medicine inheritance auxiliary platform V2.5 and the statistical analysis, association analysis, cluster analysis, and complex network analysis methods of system integration. Core drug compatibility and new formulation were obtained. Results A total of 76 literatures were collected. A total of 20 syndrome types were included in the analysis, involving 166 drugs. The main drug tastes were sweet and warm, and the channel transformation mainly concentrated in the spleen, liver, and lung. After the analysis of association rules, 12 association rules were obtained. The high frequency traditional Chinese medicine could be grouped into three categories. The core prescription was modified Buzhong Yiqi Decoction. Conclusion This study summarize the prescription medication rules of traditional Chinese medicine treatment of CRF through data mining, so as to provide reference and guidance for clinical medication.
|
|
|
|
|
|
[1] 谢晓冬，张潇宇.癌因性疲乏最新进展——NCCN（2018版）癌因性疲乏指南解读[J].中国肿瘤临床，2018，45（16）：817-820.
[2] 吴人杰，谢长生.癌因性疲乏发病机制及治疗的研究进展[J].肿瘤学杂志，2020，26（3）：240-244.
[3] 李天苗，李爽，米硕，等.健脾益气方治疗肺脾气虚型非小细胞肺癌患者化疗后癌因性疲乏的随机对照研究[J].辽宁中医杂志，2021，48（8）：126-129.
[4] 宁博彪，李宝花，郝淑兰，等.加味补中益气汤治疗非小细胞肺癌术后脾气虚弱型癌因性疲乏的临床研究[J].时珍国医国药，2020，31（11）：2685-2688.
[5] 高学敏.中药学[M].北京：中国中医药出版社.
[6] 国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版.
[7] 潘国凤，冯虹，覃小龙，等.基于癌因性疲乏探讨抗肿瘤中药新药的立题与临床优势[J].中国新药杂志，2022，31（8）：729-733.
[8] 《中成药治疗优势病种临床应用指南》标准化项目组.中成药治疗癌因性疲乏临床应用指南（2020年）[J].中国中西医结合杂志，2021，41（5）：534-541.
[9] Berger AM，Abernethy AP，Atkinson A，et al. NCCN Clinical Practice Guidelines Cancer-related fatigue [J]. J Natl Compr Canc Netw，2010，8（8）：904-931.
[10] 周婷，吴泳蓉，熊家青，等.癌因性疲乏的中医病因探析[J].中华中医药杂志，2022，37（2）：982-985.
[11] 常悦，阎丽珠，赵丽，等.阎丽珠从肺、脾、肾三脏论治癌因性疲乏经验[J].内蒙古中医药，2021，40（2）：86-88.
[12] 王一苇，李艳.国医大师李济仁治疗癌因性疲乏用药经验[J].国际中医中药杂志，2020（2）：167-169.
[13] 张涛，夏黎明.癌因性疲乏的中医病因病机及辨治研究进展[J].中国民族民间医药，2014，23（24）：24-25.
[14] 杜梦楠，易丹.《金匮要略》虚劳论治体系在癌因性疲乏中的应用[J].中医肿瘤学杂志，2019，1（5）：14-17.
[15] 张永慧，林丽珠.癌因性疲乏患者的中医证候聚类分析[J].广州中医药大学学报，2016，33（4）：485-489.
[16] 祝利民，郭玲建，毛竹君，等.健脾益肾解毒方联合化疗对中晚期胃癌患者癌因性疲乏及免疫功能的影响[J].微循环学杂志，2019，29（3）：39-44，48.
[17] 邓桃妹，彭灿，彭代银，等.甘草化学成分和药理作用研究进展及质量标志物的探讨[J].中国中药杂志，2021， 46（11）：1-22.
[18] 彭筱娴，张培彤，何杰.从《虚损启微》探析癌因性疲乏的诊治[J].环球中医药，2020，13（7）：1243-1245.
[19] Liu B，Bai C. Regulatory Mechanisms of Coicis Semen on Bionetwork of Liver Cancer Based on Network Pharmacology [J]. Biomed Res Int，2020，2020：5860704.
[20] 左文英，丁宏娟，浦斌红，等.健脾扶正方对轻中度贫血肿瘤患者癌因性疲乏的影响研究[J].上海医药，2022， 43（6）：30-33.
[21] 崔艺馨，米继伟，冯宇，等.黄芪四君子汤治疗乳腺癌癌因性疲乏的疗效及机制：基于94例临床随机对照试验和网络药理学[J].南方医科大学学报，2022，42（5）：649- 657.
[22] 苏婉，王中奇，邓海滨，等.抗瘤减毒方联合参芪扶正注射液改善中晚期非小细胞肺癌患者癌因性疲乏的疗效观察[J].上海中医药杂志，2019，53（5）：53-56，75.
[23] 侯崧，李文娟，冯光凌.黄芪与白术临床配伍机制及应用效果评价[J].亚太传统医药，2015，11（15）：119-120.
[24] 高广超，陈宗燕，姬艳博，等.消化道肿瘤患者癌因性疲乏与血清炎性因子及下丘脑-垂体-肾上腺素轴水平的相关性[J].国际肿瘤学杂志，2017，44（7）：508-511.
[25] 夏天卫，李若颀，刘金柱，等.托法常用辛、温、热药中活性成分的抗炎研究进展[J].中华中医药学刊，2020，38（1）：96-100. |
|
|
|
