肠道-大脑-微生物群轴在卒中后抑郁的研究进展

doi:10.20047/j.issn1673-7210.2023.03.10

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Abstract Post-stroke depression is one of the most common neurological and mental symptoms after stroke, the unsafe and inaccurate efficacy of drug treatment in the past, often results in patients with prolonged disease, which seriously affects the quality of life of patients. The discovery of the unique regulation of gut microbiota on the gut-brain axis provides a breakthrough for the prevention and treatment of post-stroke depression. The gut microbiota can regulate the gut-brain axis through neuroendocrine, immune and metabolic system pathways to form positive and negative feedback, allowing patients to obtain neuro- and gut-protective benefits, allowing them to play a precise regulatory role in the prevention and treatment of post-stroke depression. This paper attempts to summarize the interaction mechanism between gut microbiota and the gut-brain axis, the correlation between intestinal microbiota and post-stroke depression, new methods and interventions in the treatment, and their mechanism. To provide new ideas for the prevention, and treatment of post-stroke depression.

Key words： Intestinal flora Brain-gut axis Post-stroke depression Intestinal barrier

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	CHEN Kun WANG Zonghua LUO Yu

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CHEN Kun WANG Zonghua LUO Yu. Research progress of gut-brain-microbiota axis in post-stroke depression[J]. 中国医药导报, 2023, 20(3): 45-49.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.03.10 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I3/45

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