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| Study on medication rules in ancient Chinese Medical Code for the treatment of hypochondriac pain prescriptions based on data mining |
| CUI Xinyi1 JIANG Xiaodan1 YOU Hongjie2 TANG Zuoqing2 MA Yun1 YANG Zheng1 CHE Niancong1 LIU Wenlan1 |
1.School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;
2.School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China |
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Abstract Objective To explore the medication rules of the prescriptions for the treatment of hypochondriac pain contained in the Chinese Medical Code. Methods Prescriptions for the treatment of hypochondriac pain in the Chinese Medical Code were collected, prescription data and drug information were input by Excel (Microsoft Office 2019), and frequency statistics were made on drug efficacy, four nature of drugs and five flavours, and channel tropism. SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to calculate drug co-occurrence frequency and perform visual network display. Association rule analysis and visualization of the drugs in the screened prescriptions were performed using arules and arulesViz packages in R software, and clustering analysis of high-frequency drugs was performed using SPSS Statistics 19.0. Results A total of 359 effective prescriptions were screened, and 240 flavors of traditional Chinese medicine were used, with a total medication frequency of 3 032 times. The core drugs were Angelicae Sinensis Radix, Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Bupleuri Radix, Citri Reticulatae Pericarpium Viride, Citri Reticulatae Pericarpium, and so on. Three types of drugs were mainly used to tonify deficiency， regulate qi, and promote blood circulation for removing blood stasis. The four nature of drugs were mainly warm, the five flavours were mainly pungent, bitter, and sweet, and the channel tropism was mainly spleen, liver, lung, stomach, and heart channels. The association rule analysis yielded 15 groups of drug association rules, with the highest confidence level of Pinelliae Rhizoma, Zingiberis Rhizoma Recens and Glycyrrhizae Radix et Rhizoma. The efficacy of the 15 groups of drug association rules was mainly based on tonifying qi, nourishing blood, promoting qi, resolving blood stasis, and removing dampness and heat. High-frequency drugs could be clustered into five categories, mainly soothing liver-qi stagnation, clearing heat and promoting dampness, activating qi and relieving pain, promoting blood circulation and removing blood stasis. Conclusion The prescriptions recorded in Chinese Medical Code for the treatment of hypochondriac pain present a rule of prescriptions based on soothing liver and qi, activating blood circulation and resolving blood stasis, softening liver and relieving pain, resolving phlegm and drying dampness, supporting vital qi and tonifying deficiency, which is consistent with the core pathogenesis of hypochondriac pain and provides a reference for clinical traditional Chinese medicine treatment of hypochondriac pain.
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