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2022 Vol. 19, No. 12 Published: 2022-04-25

	4	Effect of abdominal vibration on the projection temperature of uterus surface and prostaglandin E2 and prostaglandin F2α of cold coagulation dysmenorrhea rats#br#
		GENG Nan1 HU Hui1 XIE Dandan1 ZHAO Siyu1 WU Fan2 SHEN Qian1
		Objective To investigate the effect of abdominal vibration on the projection temperature of uterus surface and prostaglandin E2 and prostaglandin F2α of cold coagulation dysmenorrhea rats. Methods Thirty SD female six-week-old rats with body weight of (230±20) g were divided into control group, model group, and abdominal vibration group with ten rats in each group by random number table method. Model preparation was performed in model group and abdominal vibration group by freezing combined with subcutaneous injection of Estradiol Benzoate and intraperitoneal injection of Oxytocin combined with pain, while control group was injected with the same dose of normal saline. After the model was successfully prepared, abdominal vibration instrument was used to simulate the abdominal vibration method for treatment. After that, the writhing response of rats and the projection temperature of uterine surface were observed, and the levels of prostaglandin F2α and prostaglandin E2 in serum were detected by enzyme linked immunosorbent assay. Results The writhing incubation period of the model group was shorter than that of the control group, the writhing number of the model group was more than that of the control group, and the writhing score of the model group was higher than that of the control group, and the differences were highly statistically significant (P ＜ 0.01). The writhing incubation period of the abdominal vibration group were longer than those of the model group, the writhing number of the abdominal vibration group was less than that in the model group, and the writhing score of the abdominal vibration group was lower than that of the model group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The uterine surface projection temperature in the model group was lower than that in the control group and the uterine surface projection temperature in the abdominal vibration group was higher than that in the model group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Serum prostaglandin F2α in model group was higher than that in control group, and serum prostaglandin E2 was lower than that in control group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The serum prostaglandin F2α in abdominal vibration group was lower than that in model group, and the serum prostaglandin E2 was higher than that in model group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Abdominal vibration can improve the local temperature imbalance of the uterus, regulate the level of prostaglandin in serum, inhibit the spasm and contraction of the smooth muscle of the uterus, improve local tissue ischemia and hypoxia, and thus achieve the effect of “warming womb and channels and relieving pain”.
		2022 Vol. 19 (12): 4-7,25 [Abstract] ( 146 ) HTML (1 KB) PDF (706 KB) ( 101 )

	8	Effect of T₃ on proliferation of papillary carcinoma of thyroid cells TPC-1 and its mechanism#br#
		CHENG Yanan WANG Yan SUN Rongxin LANG Jianan CAO Bin YANG Longyan ZHAO Dong
		Objective To investigate the effect of triiodothyronine (T₃) on proliferation of papillary carcinoma of thyroid cells TPC-1 and its mechanism. Methods TPC-1 cells were divided into control group (0 ng/ml T3 treatment group), 12.5 ng/ml T₃ treatment group and 50 ng/ml T3 treatment group, and treated with corresponding T₃ concentration, respectively. Real-time unlabeled cell function analysis technique (RTCA) and clonal formation assay were used to detect the proliferation ability of the cells, and Western blot was used to detect the expression level of PDZK1 in the cells. TPC-1 cells were divided into knockout PDZK1 (shPDZK1) group, knockout control (shNC) group, overexpression PDZK1 (PDZK1) group and overexpression control (Vector) group by lentivirus transfection method. The expression level of PDZK1 in TPC-1 cells was detected by Western blot. Meanwhile, cells in each group were treated with different concentrations of T₃ (0, 12.5, 50 ng/ml), and the clonal formation ability of cells was detected by clonal formation assay. Results The cell index and clone formation number of TPC-1 in 12.5 and 50 ng/ml T₃ treatment groups were significantly higher than those in control group, and the differences were highly statistically significant (P ＜ 0.01). The expression levels of PDZK1 in 12.5 and 50 ng/ml T3 treatment groups were significantly higher than that in control group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Compared with shNC group, the expression level of PDZK1 in shPDZK1 group was significantly lower, and the difference was statistically significant (P ＜ 0.05). Compared with the Vector group, the expression level of PDZK1 in the PDZK1 group was significantly increased, and the difference was highly statistically significant (P ＜ 0.01). Compared with the shNC group, the clore formation number in the shPDZK1 group was significantly decreased after T₃treatment of 0, 12.5, and 50 ng/ml, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Compared with Vector group, the clone formation number in PDZK1 group was significantly increased in 0, 12.5, and 50 ng/ml T₃ treatments, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion T₃ may regulate TPC-1 cell proliferation by up-regulating PDZK1 expression.
		2022 Vol. 19 (12): 8-12 [Abstract] ( 95 ) HTML (1 KB) PDF (1463 KB) ( 223 )

	13	Expression level and clinical significance of SFRP4 in esophageal squamous cell carcinoma#br#
		HUANG Bin1 WANG Liping1 LIN Baoquan2
		Objective To observe the expression of secreted frizzled-related protein 4 (SFRP4) in esophageal squamous cell carcinoma (ESCC) cell lines, serums and tissues, and to discuess its clinical value. Methods The expression of SFRP4 in esophageal squamous cell line HET-1A and ESCC cell line were compared. The serum samples from 70 ESCC patients, 70 Barrett’s esophagus patients and 70 healthy subjects were collected in the 900th Hospital of the Joint Logistics Team (hereinafter referred to as “our hospital”) from June 2019 to October 2020, and the expression levels of SFRP4, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) in serum were detected. A total of 160 ESCC and paracancer paraffin tissue specimens were collected from the Department of Pathology in our hospital from March 2013 to April 2015 to detect the expression of SFRP4. Results The expression of SFRP4 in all ESCC cell lines were higher than that in esophageal squamous cell lines (P ＜ 0.05). The expression level of SFRP4 in the serum of ESCC patients was higher than that of Barrett’s esophagus and healthy subjects (P ＜ 0.05). The area under the curve of combined detection with SFRP4, CEA, and SCCA were all higher than that of the single test (P ＜ 0.05). The positive rate of SFRP4 in ESCC was 46.9% in paraffin tissue specimens, which was higher than 15.6% in normal adjacent tissues (P ＜ 0.05). The positive expression of SFRP4 was related to the pathological staging (P ＜ 0.05). Conclusion The SFRP4 could be used as an indicator for auxiliary diagnosis of ESCC, and might become a potential molecular marker for targeted therapy.
		2022 Vol. 19 (12): 13-16,29 [Abstract] ( 110 ) HTML (1 KB) PDF (1074 KB) ( 142 )

	17	Bibliometric analysis of the field of health education based on the Chinese database from the perspective of general practitioners#br#
		CHEN Dongran1 WANG Zhenbin2 LI Yuhua1▲
		Objective To explore the research status, hotspots, and development direction of health education from the perspective of general practitioners, and to provide a basis for further scientific research. Methods With “health education”, “health management”, and “general practitioner” as the key words, the retrieval strategies were developed according to the characteristics of China National Knowledge Infrastructure, Wanfang, VIP and China Biomedical Meducine disc, and relevant literatures from the establishment of the database to August 2021 were retrieved. CiteSpace software was used for visual analysis. Results A total of 1333 references were included. 2018 was the year with the most number of published papers, 123 articles were published; the core research team was concentrated in Jiangsu, Zhejiang, and Shanghai; the research hotspot had experienced four shifts since 1993. The core hotspots were “diabetes”, “hypertension”, and “community health service”, and the current hotspot was “hierarchical diagnosis and treatment”. Conclusion There is still development room for current research, and that the number of published papers has fluctuated in recent ycars, but it is insufficient; although stable research teams have been formed, there is a lack of collaboration; the regional development of related research is unbalanced; the trends of hot research topics are consistent with policy orientation. It is recommended that subsequent studies revolve around the needs of residents before health education from the perspective of general practitioners.
		2022 Vol. 19 (12): 17-20 [Abstract] ( 118 ) HTML (1 KB) PDF (1868 KB) ( 78 )

	21	Expression of lipase member H in gastric cancer and its clinical significance#br#
		YU Dajun LI Zhixiang WANG Kai
		Objective To study the expression of lipase member H (LIPH) in gastric cancer and its clinical significance. Methods Normal gastric mucosa cells GES-1 and gastric cancer cell lines SGC-7901, AGS, MGC-803, BGC-823, and MKN-45 were selected, and the expression of LIPH in them was detected by Western blot. A total of 95 gastric cancer patients admitted to the First Affiliated Hospital of Bengbu Medical College from January 2014 to December 2015 were selected. Western blot and immunohistochemistry were used to detect LIPH expression levels in cancer tissues and adjacent tissues. LIPH was divided into positive group and negative group according to the expression of LIPH. The two groups were followed up for 60 months, and the clinical significance of LIPH in gastric cancer was analyzed by survival curve and Cox regression. Results The LIPH expression of gastric cancer cell lines MGC-803, AGS, MKN-45, BGC-823, and SGC-7901 was higher than that of normal gastric mucosa cells GES-1, and the differences were statistically significant (P ＜ 0.05). Immunohistochemical results showed that LIPH positive expression in gastric cancer tissues was brown or tan. The positive rate of LIPH expression in cancer tissues was higher than that in adjacent tissues, and the difference was statistically significant (P ＜ 0.05). The cumulative survival rate of 95 patients was 22.1%, the cumulative survival rate of positive group (56 cases) was lower than that of negative group (39 cases), the difference was statistically significant (P ＜ 0.05). Univariate analysis showed that LIPH expression, invasion depth, lymph node metastasis, TNM stage, and differentiation degree were correlated with prognosis of gastric cancer (P ＜ 0.05). Multivariate analysis showed that negative LIPH expression, invasion depth T1-T2, no lymph node metastasis, and TNM stage Ⅰ were prognostic protective factors for gastric cancer patients (HR ＜ 1, P ＜ 0.05). Conclusion LIPH is highly expressed in gastric cancer, which is related to the prognosis of gastric cancer.
		2022 Vol. 19 (12): 21-25 [Abstract] ( 147 ) HTML (1 KB) PDF (1304 KB) ( 65 )

	26	Application of seamless management in patients with percutaneous radiofrequency ablation of vascular malformations#br#
		ZHANG Fengmei1 CHEN Changxia2 YANG Liu2▲ TAI Maozhong1 LI Kelei1 QIN Zhongping1
		Objective To investigate the application effect of seamless management in percutaneous radiofrequency ablation (PRFA) in patients with vascular malformation (VM). Methods A total of 160 patients with VM treated with PRFA from March 2017 to December 2020 in Linyi Cancer Hospital of Shandong Province were selected and divided into control group (80 cases) and study group (80 cases) according to the random number table method. The control group was given clinical routine management methods, while the research group was given seamless management. The psychological state, pain level, and quality of life were compared between the two groups. Results After the intervention, the scores of the anxiety self-rating scale and the depression self-rating scale in the two groups were lower than those before the intervention, while the research group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). There were significant differences in visual analogue scale （VAS） score time, between groups and interaction between the two groups (P ＜ 0.05). Among them, the VAS scores at 12 and 24 hours after operation in the two groups were lower than those at 2 hours after operation, while the VAS scores at 24 hours after operation were lower than those at 12 hours after operation, and the differences were statistically significant (P ＜ 0.05). The VAS scores at 2, 12, and 24 h were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the scores of the short-form 36 item health survey dimensions in the two groups were higher than those before the intervention, while those of the study group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Seamless management can improve the negative emotions, relieve postoperative pain, and improve the quality of life in patients with VM treated with PRFA.
		2022 Vol. 19 (12): 26-29 [Abstract] ( 170 ) HTML (1 KB) PDF (559 KB) ( 138 )

	30	Research progress of refeeding syndrome in critical illnesses#br#
		WANG Qingyuan1 XIE Tuxiu2 WEI Jei1 LYU Jingjun1
		Refeeding syndrome (RFS) is a potentially life-threatening condition caused by the body’s return to eating after prolonged starvation that encompasses a range of signature laboratory abnormalities (e.g., hypophosphatemia, hypokalemia, hypomagnesemia, and Thiamine deficiency) and / or clinical symptoms. It involves intricate metabolic and nutritional transformations and is common in critical illnesses. In recent years, RFS has made some progress in critical diseases such as anorexia nervosa (AN), sepsis, and malignant tumor. To prevent and treat RFS, long-term hunger, malnutrition, low body mass index, and other related risk factors should be screened as early as possible. An initial high-calorie (30-40 kcal/[kg·d]) refeeding regimen is recommended for high-risk patients with AN, and an initial low-calorie (10-20 kcal/[kg·d]) refeeding regimen is recommended for other critically high-risk patients. This paper mainly focuses on the risk factors of RFS in critical diseases and the research progress of RFS in common critical diseases, so as to improve the attention of clinicians.
		2022 Vol. 19 (12): 30-33,60 [Abstract] ( 182 ) HTML (1 KB) PDF (631 KB) ( 36 )

	34	Research progress of animal experimental model of hepatic fibrosis#br#
		NAN Yang1 DONG Hui1 WANG Zhigang1 LIU Shumin2▲
		The pathogenesis of hepatic fibrosis is the progressive process of wound healing reaction, hepatic fibrosis can progress to cirrhosis, and further development of liver cancer. At present, researchers have paid considerable efforts in the research of hepatic fibrosis, hoping to clarify the pathogenesis of this disease and establish effective diagnosis and treatment plan. The purpose of this article is from the animal experimental model of theoretical basis, the selection of experimental animal, the operation method, the usage of reagents, the matters needing attention, and the advantages and disadvantages of the model, and its application, hoping to help in accordance with the different requirements of the scientific research personnel and make better choices in the study of liver fibrosis. The animal experimental model of hepatic fibrosis needs to be observed during the modeling to avoid excessive administration of drugs to form a more serious disease model such as cirrhosis. There are many animal experimental methods for hepatic fibrosis, including chemical methods, dietary methods, surgical methods, infection methods, and genetically modified mouse models. Through comparison and analysis of literature contents, it is found that carbon tetrachloride method is generally applicable and has the advantages of simple method, high reliability, and low price.
		2022 Vol. 19 (12): 34-37 [Abstract] ( 97 ) HTML (1 KB) PDF (572 KB) ( 302 )

	38	Research progress in the treatment of diabetic nephropathy with traditional Chinese medicine#br#
		GAO Yuwen QIU Changlong▲
		Diabetic nephropathy, also known as diabetic glomerulosclerosis, is a chronic microvascular complication of diabetes mellitus, which is an important factor leading to end-stage renal failure and even death in diabetic patients. However, there is still a lack of specific and effective treatment methods at present. In recent years, there has been some progress in the study of treatment based on syndrome differentiation, self-drafted prescriptions, acupuncture therapy, dietary therapy, and other aspects. This paper reviews the relevant literatures on traditional Chinese medicine treatment of diabetic nephropathy in recent years by collecting, searching and sorting out.
		2022 Vol. 19 (12): 38-41 [Abstract] ( 188 ) HTML (1 KB) PDF (659 KB) ( 235 )

	42	Research progress of non-surgical treatment of old ectopic pregnancy with traditional Chinese and Western medicine#br#
		ZHANG Guowei1 LIU Jinxing2 LIU Pengfei3
		Old ectopic pregnancy (OEP) is a special type of tubal pregnancy (TP). If it is not healed for a long time, it will have a serious impact on the physical and mental health of women. The purpose of the treatment of this disease is to eliminate the pelvic mass and preserve, restore and improve the function of the fallopian tubes. Conservative treatment can relieve the pain and risk of surgery. Western medicine is based on anticipatory therapy. Traditional Chinese medicine focuses on “removing blood stasis”, and traditional Chinese medicine, such as oral administration, external application, enema and comprehensive therapy, has the characteristics of less side effects, economical convenience, and clear effects in the treatment of this disease. At the same time, clinical trials have shown that the rational combination of traditional Chinese medicine with methotrexate, mifepristone, and low-dose antibiotics can also achieve good results.
		2022 Vol. 19 (12): 42-45 [Abstract] ( 91 ) HTML (1 KB) PDF (651 KB) ( 60 )

	46	Research progress on calcium overload related pathway in cerebral ischemia-reperfusion injury#br#
		LI Chuanpeng1 GAO Ying1,2 GAO Yonghong1,2 JIANG Ping1 DONG Xinglu1,2
		Ischemic stroke is one of the disease that seriously harm human’s health, and cerebral ischemia-reperfusion injury is its core pathological aspect. In recent years, many studies have found that calcium overload plays an important role in its pathological process. Through literature review, it was found that N-methyl-D-aspartic acid receptor, transient receptor potential melastatin 2, acid sensitive ion channels, ATP deficiency on affecting Na+/Ca2+ exchanger, participation of Golgi apparatus, and calmodulin mediate the occurrence of calcium overload, while calcium overload leads to the death of neurons through mitochondrial damage, oxidative stress, and activation of endoplasmic reticulum stress.
		2022 Vol. 19 (12): 46-50 [Abstract] ( 128 ) HTML (1 KB) PDF (622 KB) ( 182 )

	51	Analysis of the current situation and influencing factors of breastfeeding guidance knowledge, attitude and practice among obstetric medical staff#br#
		HUANG Dongdi1 GAO Yulin2 XU Na1 MURONG Shaowen3
		Objective To understand the current situation and influencing factors of breastfeeding guidance knowledge, attitude, and practice among obstetric medical staff in Guangdong Province, and to provide a basis for improving the level of breastfeeding in China. Methods From April to June 2020, a survey of 256 obstetric medical staff in the second-level and above hospitals in Guangdong Province was conducted using the breastfeeding knowledge, attitude, and practice scale for obstetric medical staff. Results A total of 260 questionnaires were recovered in this survey, of which 256 were valid, with an effective recovery rate of 98.4%. There were statistically significant differences in the scores of knowledge, attitude, and practice among different professional titles, working years in obstetrics, duration of breastfeeding, in baby-friendly hospital (P ＜ 0.05). The score of breastfeeding guidance knowledge of obstetric medical staff was (52.43±6.81) points; the score of attitude was (41.28±5.15) points; the score of behavior was (40.73±5.39) points. Multiple linear regression analysis showed that professional title, years of working in obstetrics, and in baby-friendly hospital were the main factors affecting the score of knowledge (P ＜ 0.05); years of working in obstetrics and duration of breastfeeding were the main factors affecting the score of attitude (P ＜ 0.05); the main factors affecting the behavior score were in baby-friendly hospital and duration of breastfeeding (P ＜ 0.05). Conclusion The breastfeeding guidance knowledge, attitude, and practice of obstetric medical staff in obstetrics is at a moderate level. The breastfeeding training for obstetric medical staff should be further strengthened, and a practical breastfeeding guidance plan should be formulated to increase the exclusive breastfeeding rate in China and promote maternal and infant health.
		2022 Vol. 19 (12): 51-55 [Abstract] ( 112 ) HTML (1 KB) PDF (653 KB) ( 104 )

	56	Research on the current situation and correlation between adversity quotient and professional identity level of undergraduate nursing students#br#
		RONG Huan ZHANG Limei LI Yanjun REN Pan QU Haimei CHEN Xiaoju
		Objective To explore the current situation of undergraduate nursing students’ adversity quotient and professional identity level, and to analyze their correlation. Methods Convenience sampling method was used to select 569 undergraduate nursing students from Chengdu Medical College, Southwest Medical University, and Chongqing Medical University from October to December 2019. The survey was conducted using general information questionnaire, adversity consultation scale, and nursing student professional identity questionnaire. Results A total of 569 questionnaires were distributed in this survey, of which 538 were valid, and the effective recovery rate was 94.5%. The score of nursing students’ adversity quotient was (130.61±14.66) points, and the score of professional identity was (56.21±10.79) points. There was a statistically significant difference in the scores of adversity quotient among the most important qualities and conscious anti-stress ability of students engaged in nursing majors (P ＜ 0.05). There were statistically significant differences in the college entrance examination voluntary order of different nursing majors, the reasons for choosing nursing majors, whether they were interested in nursing majors, whether the school carried out stress-related education, and students’ professional identity scores of conscious stress-resistant ability (P ＜ 0.05). Multiple linear regression showed that the college entrance examination voluntary order and stress resistance were the influencing factors of the adversity quotient of undergraduate nursing students (P ＜ 0.01). Whether they were interested in nursing, the order of college entrance examination volunteers, whether the school had carried out anti-stress education, and anti-stress ability were the influencing factors of undergraduate nursing students’ professional identity (P ＜ 0.01). The results of Pearson correlation analysis showed that the total score of professional identity of nursing undergraduates was positively correlated with the score of adversity quotient and its various dimensions (r ＞ 0, P ＜ 0.05). Conclusion The scores of adversity quotient and professional identity of undergraduate nursing students are at the middle level. Nursing educators should pay attention to the cultivation of adversity quotient and enhance their professional identity.
		2022 Vol. 19 (12): 56-60 [Abstract] ( 133 ) HTML (1 KB) PDF (586 KB) ( 151 )

	61	Effect of Gegen Qinlian Decoction in the treatment of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals#br#
		ZHENG Xiaodong1 FENG Yan2 HAN Lei3
		Objective To explore and analyze the effect of Gegen Qinlian Decoction in the treatment of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals. Methods A total of 120 diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals were selected from Liaocheng Hospital of Traditional Chinese Medicine, Shandong Province from January 2019 to January 2021. They were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was given Prostaglandin E1 and Methylcobalamin, observation group was given Gegen Qinlian Decoction on the basis of control group, both groups were treated continuously for one month. The clinical efficacy in both groups was compared, the blood glucose levels, intestinal flora content, nerve conduction velocity, and total symptoms score before and after treatment were compared between two groups, while adverse reactions during treatment were observed. Results The total clinical effective rate in observation group was higher than that in the control group (P ＜ 0.05). After treatment, fasting blood glucose, fasting insulin, and glycosylated hemoglobin in the two groups were lower than those before treatment, and which in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, the content of Clostridium flora in the two groups was higher than that before treatment, and the observation group was higher than that in the control group; the content of Bacteroids flora in observation group was lower than that in the control group (P ＜ 0.05). After treatment, the motor conduction velocity and sensory conduction velocity of the two groups were higher than those before treatment, and which in the observation group were higher than those in the control group (P ＜ 0.05). TSS scores of the two groups after treatment were lower than those before treatment, and the observation group was lower than that in the control group (P ＜ 0.05). There were no serious adverse reactions in two groups during treatment. Conclusion Gegen Qinlian Decoction can effectively improve the clinical symptoms and signs of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals, regulate blood glucose levels, improve the content of intestinal flora, and there are no serious adverse reactions during treatment, the safety is guaranteed.
		2022 Vol. 19 (12): 61-65 [Abstract] ( 129 ) HTML (1 KB) PDF (695 KB) ( 73 )

	66	Relationship between serum lipocalin 2, bone morphogenetic protein 4 levels and osteoporosis in elderly patients with type 2 diabetes mellitus#br#
		WU Jing JIANG Hui WANG Li
		Objective To investigate the relationship between serum lipocalin 2 (LCN2), bone morphogenetic protein 4 (BMP4), and osteoporosis (OP) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 231 elderly T2DM patients admitted to Zhenjiang First People’s Hospital from January 2019 to December 2020 were selected, and divided into OP group (n = 95) and non-OP group (n = 136) according to whether they were combined with OP. The general data and serum LCN2 and BMP4 levels of the two groups were compared. The influencing factors of OP in elderly T2DM patients were analyzed by multivariate logistic regression, the predictive value of the serum LCN2 and BMP4 in predicting OP in elderly T2DM patients were analyzed by receiver operating characteristic curve (ROC). Results The proportion of gender and smoking history, and fasting blood glucose, glycated hemoglobin, total cholesterol, and LCN2 levels in the OP group were higher than those in the non-OP group, and the course of disease was longer than that in the non-OP group, the BMP4 level was lower than that in the non-OP group (P ＜ 0.05). Multifactor logistics regression analysis showed that male and high BMP4 level were independent protective factors for OP in elderly T2DM patients (P < 0.05), while disease duration≥10 years and high LCN2 level were independent risk factors (P ＜ 0.05). ROC curve showed that the AUC predicted by combination of OP in elderly T2DM patients was more than that predicted by LCN2 and BMP4 alone(P < 0.05). Conclusion The increase of serum LCN2 level and the decrease of serum BMP4 level in elderly patients with T2DM complicated with OP were independent influencing factors of OP, and combined detection could improve the predictive value of OP.
		2022 Vol. 19 (12): 66-69,74 [Abstract] ( 127 ) HTML (1 KB) PDF (701 KB) ( 32 )

	70	Meta-analysis of the clinical efficacy and safety of Mycophenolate Mofetil combined with hormone in the treatment of cryptogenic membranous glomerulonephritis#br#
		JIANG Xinyu1 WANG Yu2 ZHANG Xiaofeng2 CHENG Xiaohong2
		Objective To systematically evaluate the efficacy and safety of Mycophenolate Mofetil combined with hormone in the treatment of cryptogenic membranous glomerulonephritis. Methods The literatures related to Mycophenolate Mofetil combined with hormone in the treatment of cryptogenic membranous glomerulonephritis were searched from CNKI, Wanfang Data, VIP, SinoMed, PubMed, Embase, and The Cochrane Library, the retrieval period was from the inception to March 2021. Literatures were screened and data were extracted by two researchers, and meta-analysis was performed using R 4.0.3. Results A total of 12 literatures were included, including 789 patients. The complete response rate (OR = 2.27, 95%CI: 1.49-3.45, P ＜ 0.05) and total response rate (OR = 1.90, 95%CI: 1.26-2.85, P ＜ 0.05) in the combined group were higher than those in the control group at six months, and the complete response rate (OR = 1.86, 95%CI: 1.14-3.03, P ＜ 0.05) and total response rate (OR = 1.95, 95%CI: 1.20-3.14, P ＜ 0.05) were higher than those in control group at 12 months. There was no significant difference in the incidence of adverse reactions between the combined group and the control group (OR = 0.57, 95%CI: 0.31-1.05, P ＞ 0.05). Albumin (SMD = -0.25, 95%CI: -1.00-0.51, P ＞ 0.05), serum creatinine (SMD = -0.01, 95%CI: -0.23-0.25, P ＞ 0.05), 24 h urinary protein (SMD = 0.09, 95%CI: -0.08-0.26, P ＞ 0.05) in the combined group at six months compared with the control group, the difference was not statistically significant. Albumin (SMD = 0.15, 95%CI: -0.08-0.38, P ＞ 0.05), serum creatinine (SMD = -0.02, 95%CI: -0.21-0.26, P ＞ 0.05), and 24h urine protein (SMD = -0.19, 95%CI: -0.42--0.04, P ＞ 0.05) in the combined group at 12 months compared with the control group, the difference was not statistically significant. The incidence of adverse reactions was P ＞ 0.05 by Egger and Begg test, and there was no publication bias. Conclusion The effect of Mycophenolate Mofetil combined with hormone in the treatment of cryptogenic membranous glomerulonephritis is better, which is worthy of further study and confirmation in clinic.
		2022 Vol. 19 (12): 70-74 [Abstract] ( 88 ) HTML (1 KB) PDF (1323 KB) ( 89 )

	75	Relationship between serum cytoskeleton-associated protein 4 and vascular calcification in patients with chronic kidney disease#br#
		LU Hao1 ZHANG Lei1 ZHANG Xiaoyan2 XU Yongwei3 ZHOU Feixue4 LIU Xiaoju1▲
		Objective To investigate the relationship between serum cytoskeleton-associated protein 4 (CKAP4) and vascular calcification in patients with chronic kidney disease (CKD). Methods A total of 153 CKD patients admitted to Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province from January 2019 to April 2021 were selected and they were divided into calcification group (52 cases) and non-calcification group (101 cases) according to the vascular calcification. The clinical data, serum calcium, serum phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-2 (MMP-2), and serum CKAP4 levels were compared between the two groups. Logistic regression model was used to analyze the relationship between serum CKAP4 level and vascular calcification in patients with CKD. The predictive value of serum CKAP4 level on vascular calcification in patients with CKD was analyzed by receiver operation characteristic (ROC) curve. Results The course of disease in calcified group was longer than that in non-calcified group, and the stage of CKD was higher than that in non-calcified group, the levels of serum CKAP4 in calcified group were lower than those in non-calcified group, and the levels of serum calcium, serum phosphorus, PTH, and MMP-2 were higher than those in non-calcified group, the differences were statistcally significant (P ＜ 0.05). Multivariate results showed that CDK stage, blood calcium, blood phosphorus, PTH, MMP-2, and CKAP4 were independent influencing factors of vascular calcification in patients with CKD (P ＜ 0.05). The area under the ROC curve for predicting vascular calcification in patients with CKD by serum CKAP4 level was 0.823 (P ＜ 0.05), the sensitivity was 84.62%, the specificity was 72.28%, the Youden index was 0.569, and the cut-off value was 173.50 pg/ml. Conclusion The decreased serum CKAP4 level in patients with CKD is an independent factor affecting the occurrence of vascular calcification, which can be used as a predictor of vascular calcification in CKD.
		2022 Vol. 19 (12): 75-78 [Abstract] ( 89 ) HTML (1 KB) PDF (574 KB) ( 81 )

	79	Changes and clinical significance of urinary angiotensinogen and neutrophil gelatinase-associated lipocalin levels in hypertensive nephropathy#br#
		CHEN Jiao CUI Ying▲ CHU Hong JIANG Qian
		Objective To explore the changes and clinical significance of urinary angiotensinogen (UAGT) and neutrophil gelatinase-associated lipocalin (NGAL) levels in hypertensive nephropathy. Methods A total of 130 hypertensive patients admitted to Yixing People’s Hospital, Jiangsu Province from March 2018 to March 2021 were selected. According to whether they had hypertensive nephropathy, they were divided into simple hypertension group (74 cases) and hypertensive nephropathy group (56 cases). The clinical data, UAGT, and NGAL levels of the two groups were compared. Logistic regression model was used to analyze the influencing factors of hypertensive nephropathy, and the diagnostic value of UAGT and NGAL levels in hypertensive nephropathy was analyzed by receiver operating characteristic curve. Results Levels of urinary microalbumin, serum creatinine, UAGT, and NGAL in hypertensive nephropathy group were higher than those in simple hypertension group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that UAGT, NGAL, and urinary microalbumin were independent influencing factors of hypertensive nephropathy (P ＜ 0.05). UAGT and NGAL had certain diagnostic value for hypertensive nephropathy, and the area under the curve was 0.862 and 0.869, respectively (P ＜ 0.05). Conclusion UAGT and NGAL levels are abnormally elevated in hypertensive nephropathy patients, and both of them are independent influencing factors of hypertensive nephropathy. Detection of changes in UAGT and NGAL levels can be used as sensitive indicators for evaluation of hypertensive nephropathy.
		2022 Vol. 19 (12): 79-81,87 [Abstract] ( 90 ) HTML (1 KB) PDF (568 KB) ( 70 )

	82	Compare of rehabilitation efficacy between early and delayed passive motion in patients undergoing arthroscopic rotator cuff repair：a meta-analysis#br#
		GAO Kai1 WANG Xiaofei1 LI Yufu1 WANG Huajun2 GAO Yanping2 ZHENG Wei1 LI Jia3 LI Ling3
		Objective To systematically evaluate the effect of early and delayed passive motion programs on postoperative functional rehabilitation after arthroscopic rotator cuff repair. Methods Cochrane Library (Issue 5, 2021), PubMed, EMbase, CNKI, VIP, Wanfang, and Chinese biomedical literature database were searched by computer. The retrieval time was set from the earliest time provided by the database to May 2021. Randomized controlled trials (RCT) were conducted to determine the efficacy of early and delayed passive motion after arthroscopic rotator cuff repair. This study was divided into the early passive motion group and the delayed passive motion group. The maximum flexion angle of shoulder joint, maximum external rotation angle of shoulder joint, American Shoulder and Elbow Surgeons (ASES) score, simple shoulder test (SST) score and the incidence of rotator cuff retear in the last follow-up were compared between the two groups twelve months after surgery. Meta-analysis was performed using RevMan 5.3. Results A total of 443 patients were included in five RCTs. Meta-analysis results showed that: twelve months after surgery, the maximum flexion angle of shoulder joint of the early passive motion group was higher than that of the delayed passive motion group, the difference was statistically significant (MD = 1.22, 95%CI: 0.21 to 2.23, P = 0.02); there was no significant difference in the maximum external rotation angle of shoulder joint between the two groups (MD = 2.30, 95%CI: -2.31 to 6.92, P = 0.33); there was no significant difference in ASES scores between the two groups (MD = -2.71, 95%CI: -6.99 to 1.58, P = 0.22); there was no significant difference in SST score between the two groups (MD = 0.15, 95%CI: -0.55 to 0.84, P = 0.68). There was no significant difference in rotator cuff tear rate between the two groups at the last follow-up (RR = 0.79, 95%CI: 0.54 to 1.15, P = 0.22). Conclusion Early passive motion can obtain more satisfactory shoulder function than delayed passive motion, and the safety of both is similar.
		2022 Vol. 19 (12): 82-87 [Abstract] ( 108 ) HTML (1 KB) PDF (2082 KB) ( 99 )

	88	Effect of open reduction and internal fixation on patients with open and closed AO/OTA-C type distal humeral fractures#br#
		HUANG Meiquan XU Hong LI Yanjun ZHANG Xiping QIU Eryue▲ WANG Biao
		Objective To investigate the effect of open reduction and internal fixation (ORIF) on patients with open and closed AO/OTA-C type distal humeral fractures. Methods A total of 90 patients with AO/OTA-C type distal humeral fractures who underwent ORIF in Zhuzhou Central Hospital, Hunan Province from January 2017 to June 2020 were enrolled and divided into open fracture group (40 cases) and closed fracture group (50 cases) according to fracture type. Postoperative follow-up was at least 12 months. Operation time, intraoperative blood loss, length of hospital stay, fracture healing time, upper limb function evaluation indexes, postoperative complications and reoperation were compared between the two groups. Results There were no significant differences in operation time, intraoperative blood loss and length of hospital stay between the two groups (P ＞ 0.05)； the fracture healing time of open fracture group was significantly longer than that of closed fracture group, and the difference was statistically significant (P ＜ 0.05). Both groups were followed up for 12-55 months, with median follow-up time of 35.60 months. There were no significant differences in flexion and extension activity, rotation activity, Mayo elbow performance score, disabilities of the arm, shoulder and hand score, excellent and good rate, incidence of postoperative complications, and reoperation rate between the two groups (P ＞ 0.05). Conclusion There is no significant difference in upper limb function and prognosis between open and closed AO/OTA-C type distal humeral fractures after ORIF, but open fracture healing is delayed.
		2022 Vol. 19 (12): 88-91 [Abstract] ( 80 ) HTML (1 KB) PDF (862 KB) ( 36 )

	92	Clinical effect of Yishen Juanbi Pills combined with Methotrexate Tablets in the treatment of rheumatoid arthritis#br#
		XUE Hongwei ZHAO Heyi MA Guoju
		Objective To investigate the clinical effect of Yishen Juanbi Pills combined with Methotrexate Tablets in the treatment of rheumatoid arthritis (RA). Methods A total of 96 RA patients admitted to Baoding Second Central Hospital from April 2020 to May 2021 were selected and they were divided into control group and observation group according to random number table method, with 48 patients in each group. The control group was treated with Methotrexate Tablets, and the observation group was treated with Yishen Juanbi Pills on the basis of the control group for six months. Clinical efficacy, clinical symptoms, and adverse reactions were compared between the two groups, and serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) titer, matrix metalloproteinase-1 (MMP-1), MMP-3, and anti streptolysin “O” (ASO) were detected and compared before and after six months of treatment. Results After six months of treatment, rest pain time, morning stiffness time, joint swelling number and joint tenderness index in both groups were lower than those before treatment, and those in the observation group was lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, the hand grip strength of both groups was increased compared with that before treatment, and that of observation group was higher than that of control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, CRP, ESR, RF, MMP-1, MMP-3, and ASO in both groups were lower than before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). After six months of treatment, the clinical effect of observation group was better than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Yishen Juanbi Pills combined with Methotrexate Tablets has significant efficacy in the treatment of RA patients, which can effectively improve the clinical symptoms of patients and reduce the level of inflammatory factors, with good safety.
		2022 Vol. 19 (12): 92-95 [Abstract] ( 90 ) HTML (1 KB) PDF (622 KB) ( 47 )

	96	Clinical effect of blade needle on knee osteoarthritis#br#
		XU Panfeng* ZHOU Yuanlin* YANG Shangrong WEI Yanguo LIANG Jiongwen
		Objective To investigate the therapeutic effect of blade on knee ostsoarthritis (KOA). Methods A total of 80 KOA patients admitted to the Department of Outpatient, Liuzhou Traditional Chinese Medicine Hospital (Liuzhou Zhuang Medical Hospital) Guangxi Zhuang Autonomous Region from August 2017 to February 2020 were selected and divided into blade needle group and acupuncture group according to the random number table method, with 40 patients in each group. The blade needle group was given blade needle release treatment, and the acupuncture group was given ordinary acupuncture treatment, the course of treatment was four weeks. The knee joint of the two groups after treatment was scored by comprehensive clinical efficacy evaluation of knee joint. Visual analogue scale (VAS) and hospital for special surgery knee score (HSS) were used to evaluate the pain of patients before treatment and two and four weeks after treatment. Results There were statistically significant differences in time, intergroup and interaction of VAS, HSS score between the two groups (P < 0.05). Comparison in the group: compared with before treatment, VAS score was decreased and HSS score was increased in both group after two and four weeks of treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: after four weeks of treatment, VAS score of blade needle group was significantly lower than that of acupuncture group, and HSS score was significantly higher than that of acupuncture group, and the differences were statistically significant (P ＜ 0.05). The total effective rate of blade needle group was significantly higher than that of acupuncture group, and the difference was statistically significant (P ＜ 0.05). Conclusion Blade needle can obviously relieve knee joint pain and improve joint activity function, and the effect is better than acupuncture.
		2022 Vol. 19 (12): 96-99 [Abstract] ( 133 ) HTML (1 KB) PDF (566 KB) ( 50 )

	100	Comparison of the application effect of cervical single lumen dilation balloon and COOK cervical dilation balloon in promoting cervical maturity during full-term pregnancy#br#
		LI Xiaorong1 LYU Yuping1 HE Bikai2 CHEN Huishan2
		Objective To compare the application effect of domestic cervical single lumen dilation balloon and COOK cervical dilation balloon in promoting cervical maturity during full-term pregnancy. Methods A total of 268 singleton primiparas who were hospitalized for delivery in Nanhai Maternal and Child Health Hospital of Foshan City, Guangdong Province from January 2015 to December 2019 were selected as the research subjects. According to the random number table method, they were divided into domestic cervical single lumen dilation balloon (single balloon group) 136 cases and imported COOK cervical dilation balloon group (COOK double balloon group) 132 cases. The average placement time of cervical single lumen dilation balloon or COOK cervical dilation balloon in each group, the cervical Bishop score after placement, the effective in promoting cervical maturity, the natural birth rate after placement, vaginal delivery rate, vaginal delivery of maternal balloon placement until delivery time, oxytocin use condition, neonatal birth weight, and the incidence of neonatal asphyxia, postpartum hemorrhage, urgent sexual chorioamnitis, and cervical laceration were recorded. Results The average placement time of single balloon group was shorter than that of COOK double balloon group, the cervical Bishop score after placement, the effective in promoting cervical maturity were higher than those of COOK double balloon group, and the differences were statistically significant (P < 0.05); there were no significant differences in the natural birth rate after placement, vaginal delivery rate between two groups (P > 0.05). The vaginal delivery of maternal balloon placement until delivery time in single balloon group was shorter than in COOK double balloon group, and the difference was statistically significant (P < 0.05); there was no significant difference in oxytocin use condition between two groups (P > 0.05). The cervical laceration rate in single balloon group was lower than that in COOK double balloon group, and the difference was statistically significant (P < 0.05); there were no significant differences in the incidence of postpartum hemorrhage and urgent sexual chorioamnitis between two groups (P > 0.05). There were no significant differences in neonatal birth weight and the incidence of neonatal asphyxia between two groups (P > 0.05). Conclusion Compared with COOK cervical dilatation balloon, cervical single lumen dilation balloon has better clinical effect, and can be popularized in clinic to promote cervical maturity and induce labor at full-term.
		2022 Vol. 19 (12): 100-103,107 [Abstract] ( 93 ) HTML (1 KB) PDF (673 KB) ( 184 )

	104	Clinical effect of early postpartum medical gymnastics combined with neuromuscular electrical stimulation in the treatment of postpartum rectus abdominis separation#br#
		ZHAO Yang1 CHENG Fang2 LIU Weiping2 LI Xiaowei2 CHEN Wei3▲
		Objective To explore the clinical effect of early postpartum medical gymnastics combined with neuromuscular electrical stimulation in the treatment of postpartum rectus abdominis separation. Methods A total of 68 patients with postpartum rectus abdominis separation who received treatment in Huaian Maternal and Child Health Hospital of Jiangsu Province from August 2019 to June 2020 were selected as the research objects. They were divided into group A (PHENIX neuromuscular electrical stimulation treatment, 34 cases) and group B (early medical gymnastics+PHENIX neuromuscular electrical stimulation therapy, 34 cases) by random number table method. The rectus abdominis separation distance, rectus abdominis muscle strength, rectus abdominis myoelectric value and the angle of upper abdomen angle were compared between two groups before treatment, the second week after treatment, and the fifth week after treatment. Results The rectus abdominis separation distance, rectus abdominis myoelectric value, and the angle of upper abdomen angle were compared between two groups at different time points, and the differences were statistically significant (P < 0.05). The second and the fifth week after treatment, rectus abdominis separation distance and the angle of upper abdomen angle in group B were smaller than those in group A; rectus abdominis muscle strength was better than that of group A; rectus abdominis myoelectric value was higher than that of group A, and the differences were statistically significant (P < 0.05). Conclusion Early postpartum medical gymnastics combined with neuromuscular electrical stimulation for postpartum rectus abdominis separation can significantly reduce the rectus abdominis separation distance and the angle of the upper abdomen angle, restore the rectus abdominis muscle strength faster and better, and increase the rectus abdominis myaelectric value.
		2022 Vol. 19 (12): 104-107 [Abstract] ( 82 ) HTML (1 KB) PDF (504 KB) ( 55 )

	108	Effects of meibomian gland massage combined with Croma corneal protector on dry eyes after phacoemulsification for cataract#br#
		ZHU Min CHEN Yubing ZENG Jun AO Sichun YU Dan
		Objective To investigate the effects of meibomian gland massage combined with Croma corneal protector in the treatment of dry eye after phacoemulsification. Methods According to the random number table method, 82 patients with dry eye after phacoemulsification in Foshan First People’s Hospital from October 2018 to April 2020 were divided into study group and control group, with 41 cases in each group. The control group was treated with meibomian gland massage, and the study group was treated with Croma corneal protector in addition to the control group, all were treated for two weeks. The clinical efficacy, dry eye before and after treatment, disease remission and incidence of adverse events were compared between the two groups. Results After treatment, the total effective rate of study group was higher than that of control group (P ＜ 0.05); the objective scattering index (OSI), corneal fluorescein staining (CFL), ocular surface signs, and sensory symptom scores of the two groups were lower than those before treatment, and the OSI, CFL, ocular surface signs and sensory symptom scores of study group were lower than those of control group (P ＜ 0.05); the Schirmer I test (SIt) value in two groups was higher than that before treatment, and the SIt value in study group was higher than that in control group (P ＜ 0.05); there was no significant difference in the incidence of adverse events between two groups (P ＞ 0.05). Conclusion Meibomian gland massage and Croma corneal protector can effectively prevent dry eye symptoms after phacoemulsification with definite curative effect and high safety.
		2022 Vol. 19 (12): 108-111 [Abstract] ( 103 ) HTML (1 KB) PDF (609 KB) ( 101 )

	112	Determination of three constituents in Niaoduqing Particles by high performance liquid chromatography #br#
		ZHAO Lei LI Qiong
		Objective To establish a method for simultaneous determination of three active components (paeoniflorin, stilbene glycoside, salvianolic acid B) in Niaoduqing Particles. Methods Agilent 1200 high performance liquid chromatograph was used to determine three active components in Niaoduqing Particles. Chromatographic column was Agilent-ZORBAX SB-C18 (4.6 mm×250 mm, 5 μm); the mobile phase consisted of acetonitrile-0.1% phosphoric acid water with gradient elution; the flow rate was 1.0 ml/min; the detection wavelength was 230, 320 nm. Results The linear relationships of paeoniflorin, stilbene glycoside, and salvianolic acid B were 24.96-249.61 μg/ml, 12.38-123.76 μg/ml, 24.84-248.42 μg/ml; the average recovery rate were 100.21%, 100.62%, and 99.87%，respectively. Conclusion The experimental method can effectively and conveniently determine the content of three index components, with good reproducibility, and provide a theoretical basis for the quality control and clinical efficacy of Niaoduqing Particles.
		2022 Vol. 19 (12): 112-115 [Abstract] ( 89 ) HTML (1 KB) PDF (633 KB) ( 72 )

	116	Discussing on the diagnosis and treatment of the adverse gastrointestinal reactions of Methotrexate based on the theory of “unstopping for use, reduction for harmony”#br#
		XU Haodong CHENG Zengyu TANG Xiaopo ZHOU Xinyao JIANG Wen LI Da PANG Fengtao
		Methotrexate is the basic medicine for the treatment of rheumatoid arthritis, and its gastrointestinal side effects are prominent. Traditional Chinese medicine believes that adverse reactions are common, and reasonable compatibility of medicines can reduce toxicity and increase efficacy. “unstopping for use, reduction for harmony” is a condensing of the physiological characteristics of the six fu viscera. “unstopping” and “descending” are the core of the physiological function of the six fu organs, unstopping and descending disharmony is the core of gastrointestinal adverse reactions after Methotrexate. The relationship between “spleen” and “stomach”, “lung” and “large intestine”, and “liver” and “gallbladder” are the specific pathogenesis of unstopping and descending disharmony, the method of dispersing with pungent medicinals and descending with bitter medicinals, clearing lung and big intestines, soothing liver and fortifying spleen can guide clinical practice.
		2022 Vol. 19 (12): 116-119,133 [Abstract] ( 83 ) HTML (1 KB) PDF (831 KB) ( 25 )

	120	Discussion on prevention and treatment of epidemic disease with ancient traditional Chinese medicine#br#
		GUAN Linyu XIAO Yongzhi
		Epidemic disease occurred frequently in ancient China. In the struggle against the epidemic disease, the ancient people accumulated rich experience in the prevention of the epidemic disease, and established and gradually improved the system of epidemic disease and treatment and treatment. Medical books such as Zhouhou Beiji Fang, Beiji Qianjin Yao Fang, Taiping Shenghui Fang recorded the prescriptions and methods of prevention of epdemic disease, including the methods of internal and external drugs, most of the internal prescriptions are powder and pills, TuSu Wine Prescription is widely used. Representative external prescriptions, Taiyi Liujin Fang, in order to make sweet bursa and burn and avoid the epidemic disease, also have Realgar Powder, Fenshen Powder, and Medicated Bath Prescriptions. Theories of treating epidemic went through three stages of change, in Han, Wei, and Jin Dynasties, Treatise on Typhoid Disease was composed for syndrome differentiation and treatment epidemic disease, used the typhoid theory to govern febrile disease, syndrome differentiation by six disease, prescription and syndrome contrasted with each other. From Sui, Tang to Jin, Yuan Dynasties, typhoid fever, warm disease, and epidemic disease were separated treatment, there were different etiology, pathogenesis, and conversion. In Ming and Qing Dynasties, Wu Youke created pestilence theory, defense-qi-nut and syndrome differentiation of triple energizer lead to treat epidemic. The theory and technology of syndrome differentiation and treatment of epidemic disease were constantly improved.
		2022 Vol. 19 (12): 120-123 [Abstract] ( 85 ) HTML (1 KB) PDF (696 KB) ( 212 )

	124	Analysis and research of international communication of traditional Chinese medicine culture#br#
		YIN Lu1* XU Rong2* GAO Ang2 GAO Xuecheng1 WANG Xiaopin1
		Traditional Chinese medicine culture contains rich humanities and philosophical ideas, it is an important part of the outstanding traditional culture of the Chinese nation, and it’s also an important label of the soft power of Chinese culture. The international communication of traditional Chinese medicine culture is of great significance to enhance the confidence of traditional Chinese medicine culture, promote the international development of traditional Chinese medicine, and promote cultural mutual learning, and connection with other countries. This paper summarizes the main research directions of domestic scholars in the field of international communication of traditional Chinese medicine culture in recent years, it combines the important events of communication and cooperation between the government and non-governmental organizations to summarize the current situation of international communication of traditional Chinese medicine culture, and showes the development situation of international communication of traditional Chinese medicine culture. At the same time, this paper analyzes the problems in the international communication of traditional Chinese medicine culture, and puts forward suggestions for constructing collaborative innovation platform for international communication of traditional Chinese medicine culture, communication methods of traditional Chinese medicine culture, talent training, and public opinion monitoring for international communication of traditional Chinese medicine culture.
		2022 Vol. 19 (12): 124-128 [Abstract] ( 154 ) HTML (1 KB) PDF (763 KB) ( 793 )

	129	Discussing the syndrome differentiation and treatment of edema based on the theory of “qi” in traditional Chinese medicine#br#
		WANG Mengmeng GUO Hongwei WANG Chaozhong
		This article mainly discusses the syndrome differentiation and treatment of edema based on the theory of “qi” in traditional Chinese medicine. By analyzing the physiological function and pathological changes of qi of zang-fu viscera related to edema, and combining with the literatures of ancient and modern doctors in the syndrome differentiation and treatment of edema, it puts forward the dysfunction of qi movement (disordered qi movement) and qi deficiency are the pathogenesis of edema. Among them, the dysfunction of qi movement includes lung qi loss in diffusion and descending, liver qi loss in conveyance and dispersion, qi movement stagnation of triple energizer; qi deficiency includes qi deficiency of spleen and kidney, and yang qi insufficiency. It is suggested that regulating qi movement and tonifying qi deficiency are the key points in the treatment of edema. It has certain theoretical and clinical guiding value to enrich and expand the traditional Chinese medicine syndrome differentiation and treatment of edema in modern medicine based on the theory of “qi” in traditional Chinese medicine.
		2022 Vol. 19 (12): 129-133 [Abstract] ( 91 ) HTML (1 KB) PDF (751 KB) ( 98 )

	134	Summary on Professor Li Huilin’s experience in treating alopecia with classical formulas#br#
		CHEN Meiyan1 ZENG Lin1 LI Maosheng2 LU Zhaoqi1 LI Huilin2
		The pathogenesis of alopecia is mainly the dysfunction of five zang viscera, such as unsmoothness of lung qi, stagnation of liver qi and deficiency of spleen and kidney, along with pathological factors such as phlegm, dampness, blood stasis and turbidity that affect the flow of qi and blood, leading to hair loss. Professor Li Huilin has been working for more than 30 years. He is good at using traditional prescriptions in treating alopecia, such as Xiaochaihu Decoction, Maziren Pills, Mahuang Xingren Gancao Shigao Decoction, Danggui Sini Decoction, Jingui Shenqi Pills and other traditional prescriptions, which attains favorable clinical effects. The treatment provides novel ideas for treating alopecia. This paper introduces the clinical experience of Professor Li Huilin, a famous traditional Chinese medicine doctor in Guangdong Province, in treating hair loss, and presents two cases.
		2022 Vol. 19 (12): 134-137,146 [Abstract] ( 89 ) HTML (1 KB) PDF (854 KB) ( 484 )

	138	Analysis on Professor Liu Huanqiang’s experience in treating vitiligo#br#
		YU Yahua1 CHEN Yue1 LIAO Lanfei1 DU Weijuan1 LIU Huanqiang2
		Vitiligo is a common depigmentation disease, which is mainly characterized by the skin color fading or whitening at the lesion, which seriously affects the appearance of patient and brings a greater psychological burden to the patient. Because the treatment of vitiligo costs more and takes longer, the compliance of patient is relatively poor and can’t be adhered to, which directly affects the treatment effect. According to years of clinical practice and dialectical thinking of traditional Chinese medicine, Professor Liu Huanqiang sums up that vitiligo has the pathogenesis of deficiency of liver and kidney, qi stagnation and blood stasis, and deficiency of blood and wind, and puts forward the treatment methods of tonifying liver and kidney, regulating qi and promoting blood circulation, dispelling wind and nourishing blood, and advocates the treatment of vitiligo with hot compress of traditional Chinese medicine. The method is simple to operate, cost-saving, safe and effective, thus improving compliance of patients and having clinical populari zation significance.
		2022 Vol. 19 (12): 138-141 [Abstract] ( 90 ) HTML (1 KB) PDF (615 KB) ( 157 )

	142	Professor Liu Huayi’s experience in treating chronic atrophic gastritis from the theory of “phlegm stasis and turbid toxin”#br#
		BAN Yanran1 ZHANG Nannan1 LI Yupeng2 LIU Huayi2
		Based on the mechanism of inflammation and cancer transformation of chronic atrophic gastritis, this paper discusses and summarizes Professor Liu Huayi’s experience in treating chronic atrophic gastritis from the theory of “phlegm stasis and turbid toxin”. Professor Liu Huayi believes that the inflammatory and cancerous transformation stage of chronic atrophic gastritis not only has the deficiency of spleen and stomach qi and yin, but also has the connotation of blood stasis, phlegm, and turbid toxin. Professor Liu Huayi puts forward three principles of cancer prevention and treatment of chronic atrophic gastritis in treating this disease: first, strengthening spleen and body resistance; second, removing blood stasis and phlegm; third, detoxification and elimination of abdominal mass. Fuzheng Xiaoyu Huazhuodu Prescription is added and subtracted with syndrome, which can effectively control or even reverse the degree of gastric mucosal atrophy, intestinal metaplasia and atypical hyperplasia, so as to delay and control the transformation of chronic atrophic gastritis to cancer. A medical case is attached to provide a new idea in treating precancerous lesions of chronic atrophic gastritis.
		2022 Vol. 19 (12): 142-146 [Abstract] ( 133 ) HTML (1 KB) PDF (815 KB) ( 112 )

	147	Effect of nursing intervention based on Roy’s adaptation model on pain control and quality of life of patients with bone cancer pain#br#
		XU Jin HUANG Ying WANG Tingting▲
		Objective To explore the effect of nursing intervention based on Roy’s adaptation model on pain control and quality of life of bone cancer. Methods A selection of 88 patients with bone cancer pain admitted to the Department of Pain, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medicine School from January 2018 to October 2019, according to the random number table method, they were divided into control group and intervention group, with 44 cases in each group. The control group carried out routine nursing, and the intervention group carried out nursing intervention based on Roy’s adaptation model on the basis of control group, the pain relief, psychological state, quality of life and adaptability of the two groups were compared. Results After intervention, the rate of pain relief in the intervention group was higher than that in the control group (P ＜ 0.01); the scores of visual simulation of pain and psychological state (self-rating anxiety scale and self-rating depression scale) in both groups were lower than before intervention, and those of the scores of intervention group were lower than control group (P ＜ 0.01); the quality of life scale scores of the two groups were higher than before intervention, and the intervention group was higher than the control group (P ＜ 0.01); the adaptability of the two groups was better than before, and the intervention group was better than the control group (P ＜ 0.05 or P ＜ 0.01). Conclusion Nursing intervention based on Roy’s adaptation mode for patients with bone cancer pain is helpful to relieve pain, eliminate bad emotions, improve life quality and adaptability, and is worth promoting.
		2022 Vol. 19 (12): 147-150,155 [Abstract] ( 161 ) HTML (1 KB) PDF (697 KB) ( 159 )

	151	Application effect of Teach back education mode in family health guidance of children with congenital heart disease after interventional surgery#br#
		JIANG Hongjuan WU Jie▲ LUO Xiaoyan LIU Xiaoyu
		Objective To explore the effect of Teach back instruction sheet in family health guidance of children with congenital heart disease after interventional operation. Methods A total of 124 children with congenital heart disease who received surgical treatment in Wuxi Children’s Hospital of Jiangsu Province from February 2019 to February 2021 and their families were selected as the research subjects, and they were divided into control group and observation group by random number table method, with 62 cases in each group. The control group received routine postoperative health guidance, and the observation group received postoperative health guidance with family members’ Teach back instruction sheet. Before and three months after operation for the family members of the children with congenital heart disease knowledge, general self-efficacy, coping style, heart function grading and complication incidence were compared between the two groups. Results Three months after operation, the scores of the families of the children in the two groups on the knowledge about congenital heart disease were higher than those before operation, and the observation group was higher than the control group (P ＜ 0.05); the general self-efficacy scores of the families of the two groups were higher than before operation, and the observation group was higher than the control group (P ＜ 0.05); the family members of the observation group face score were higher than before operation, and avoidance and yield scores were lower than before operation; the face scores of family members of the observation group were higher than control group, and avoidance and yield scores were lower than control group (P ＜ 0.05); the postoperative cardiac function grading score of the two groups were lower than those before operation, and those of the observation group were lower than the control group (P ＜ 0.05). The incidence of complications in observation group was lower than that in control group (P ＜ 0.05). Conclusion Teach back instruction sheet has a significant effect on family health guidance of children with congenital heart disease after operation.
		2022 Vol. 19 (12): 151-155 [Abstract] ( 153 ) HTML (1 KB) PDF (696 KB) ( 126 )

	156	Research status and hot spots of oral care for patients with mechanical ventilation at home and abroad in the past ten years#br#
		LIU Hongxia1 TANG Li1▲ TIAN Yongming2 LIU Guangdi1
		Objective To analyze the home and abroad on oral care of patients with mechanical ventilation in recent ten years, discuss the research hotspots, and provide reference for the follow-up development of this field. Methods CNKI and Web of Science core collection databases were searched to analyze the oral care related studies of patients with mechanical ventilation from January 2011 to December 2020. CiteSpace software was used to visually analyze the number of publications, journals, institutions, keywords, research cooperation and highly cited literatures. Results A total of 728 Chinese and 171 English literatures were included. Contemporary Nurses, Nursing Research, and Nursing in Critical Care were the journals with high volumes of articles. The school of nursing at Fudan University and the School of Medicine at Isfahan University published the most papers. Authors Cao Yanpei and Costa published the most frequently, and Munro published the most cited literatures in 2009. Key words co-occurrence results showed that ventilator-associated pneumonia, oral care, mechanical ventilation, chlorhexidine, and prevention were more frequent at home and abroad. The structure of clustering network is obvious and the result is reasonable. Conclusion Domestic and foreign research focus on the prevention of ventilator-associated pneumonia, oral care improvement, bacterial colonization and clinical efficacy, but the high-yield team and yield concentration is low, it is still necessary to strengthen multi-center collaboration and multi-technology combination to promote the depth and breadth of research in this field.
		2022 Vol. 19 (12): 156-159,172 [Abstract] ( 111 ) HTML (1 KB) PDF (2626 KB) ( 99 )

	160	Effects of postoperative prone position nursing on incision healing of lumbosacral spinal canal tumors#br#
		YU Li FAN Yanzhu ZHANG Yaowu DIAN Huijuan XU Xiaoying JIA Wenqing
		Objective To investigate the effects of postoperative prone position nursing on incision healing of lumbosacral spinal canal tumors. Methods A total of 80 patients with lumbosacral intraspinal tumors undergoing surgical treatment in the spinal cord and spinal ward of the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University from January to April 2021 were selected as the study subjects, they were divided into experimental group (40 cases) and control group (40 cases) according to random number table method. The experimental group was given prone position nursing after surgery, while the control group was given supine position nursing after surgery. The differences in incidence of postoperative cerebrospinal fluid leakage, wound healing rate, length of hospital stay and patient comfort were compared between the two groups. Results The wound healing degree of the experimental group was better than that of the control group, and the incidence of cerebrospinal fluid leakage, length of hospital stay and comfort level of the experimental group were lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Prone position nursing can reduce cerebrospinal fluid leakage, promote incision healing and shorten hospital stay in patients with lumbosacral intraspinal tumor.
		2022 Vol. 19 (12): 160-163 [Abstract] ( 78 ) HTML (1 KB) PDF (666 KB) ( 18 )

	164	Application of multidisciplinary cooperation and lean management method in hemodialysis infection management of patients with nephropathy#br#
		HOU Kejun QI Yongfen ZHANG Fengqin MA Yan
		Objective To explore the role of multidisciplinary cooperation and lean management method in hemodialysis infection management of patients with nephropathy. Methods A total of 90 patients with hemodialysis nephropathy in the Fifth People’s Hospital of Qinghai Province from April 2019 to March 2021 were selected as the research subjects, according to random number table method, the patients were divided into control group and observation group, with 45 cases in each group. The control group received traditional nephrotic hemodialysis infection management, and the observation group received multidisciplinary collaborative lean management. Clinical efficacy, physiological indicators, survival status, complication rate, and satisfaction were compared between the two groups. Results After intervention, the clinical efficacy of observation group was better than control group, the difference was statistically significant (P ＜ 0.05). Systolic blood pressure (SBP) in both groups decreased compared with before treatment, while diastolic blood pressure (DBP), hemoglobin (HGB), and albumin (ALB) in observation group increased compared with before treatment, and SBP in observation group was lower than control group, while DBP, HGB and ALB were higher than control group, the differences were statistically significant (P ＜ 0.05). The psychological state, physical recovery, and social status scores of the two groups were higher than those before intervention, and the psychological state, physical recovery, and social status scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The satisfaction of observation group was better than control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Multidisciplinary cooperation combined with lean management can significantly enhance the clinical efficacy of nephrotic hemodialysis patients, improve their physiological indexes and survival status, reduce the incidence of complications and improve patient satisfaction.
		2022 Vol. 19 (12): 164-167 [Abstract] ( 89 ) HTML (1 KB) PDF (579 KB) ( 12 )

	168	Application of aerobic-resistance exercise combined with stratified intervention in maintenance hemodialysis patients#br#
		LI Yinan MA Tao ZHANG Lei
		Objective To analyze the application effect of aerobic-resistance exercise combined with stratified intervention in maintenance hemodialysis (MHD) patients. Methods A total of 100 patients with MHD who were treated in NO.2 People’s Hospital of Fuyang City, Anhui Province from March 2018 to March 2021 were selected and divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group was given routine intervention, while the observation group was given aerobic-resistance exercise combined with stratified intervention for five consecutive months. Before the intervention and five months after the intervention, the cardiorespiratory endurance of the two groups was detected and compared; the times of sitting, standing and grip strength within 60 s were evaluated; the occurrence of complications during the intervention was recorded. Results After five months of intervention, the maximal oxygen uptake and metabolic equivalent of the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). At five months of intervention, the 60 s sit-standing times and grip strength in the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of dialysis hypotension in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Aerobic-resistance exercise combined with stratified intervention is more conducive to improving the cardiorespiratory endurance of MHD patients, increasing the number of 60 s sitting-standing and grip strength, and reducing the incidence of dialysis hypotension.
		2022 Vol. 19 (12): 168-172 [Abstract] ( 175 ) HTML (1 KB) PDF (681 KB) ( 218 )

	173	Influence of health education model based on health awareness on the medical compliance behavior and quality of life of patients after coronary stenting#br#
		XUE Jinghui1 SUN Ting2 MA Dan3
		Objective To explore the effect of health education model based on health awareness on the medical compliance behavior and quality of life of patients after coronary stenting. Methods A total of 110 patients with coronary heart disease who underwent coronary stenting in the Department of Cardiology Medicine, Tangdu Hospital, Air Force Military Medical University from January to December 2020 were selected. The patients were divided into control group and observation group by random number table method, with 55 cases in each group. The control group was given routine health education, while the observation group was given a health education model based on health awareness. The medical compliance behavior, general self-efficacy scale (GSES), self-rating anxiety scale (SAS), self-rating depression scale (SDS), and seattle angina scale (SAQ) were compared between the two groups. Results The compliance of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After the intervention, the GSES scores of the two groups were higher than those before the intervention, while the observation group was higher than the control group; the SAS and SDS scores of the two groups were lower than those before the intervention, while those of the observation group were lower than those of the control group, with statistical significances (P ＜ 0.05). After the intervention, the physical activity limitation, stable state of angina pectoris, angina pectoris attack, treatment satisfaction, and disease cognition scores in the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of the health education model based on health awareness can enhance the self-efficacy of patients after coronary stenting, relieve anxiety and depression, improve medical compliance, and improve the quality of life. It is worthy of widespread clinical promotion and application.
		2022 Vol. 19 (12): 173-176,189 [Abstract] ( 108 ) HTML (1 KB) PDF (715 KB) ( 209 )

	177	A case of acupuncture assisted treatment of acute sensory neuropathy#br#
		WANG Mina1 LIU Lu2 LI Bin2
		A patient with acute sensory neuropathy was reported. The patient was a 61-year-old male, with acute symmetrical numbness of limbs, subjective swelling, slow movement, fatigue, panting. Tongue and pulse in traditional Chinese medicine showed: with dull-red tongue, and string-like and rough pulse. Superficial sensation disappeared below C3 level, and tendon reflex attenuated or even abssented. Electromyogram studies represented injured sensory nerve of the limbs. The diagnosis of modern medicine was acute sensory neuropathy, and that of traditional Chinese medicine was numbness, and the syndrome was qi deficiency and heat stasis. Modern treatment included high-dose hormone and nerve nourishment. The treatment of acupuncture and moxibustion is divided into two stages: first, bloodletting and acupuncture reduction manipulation technique was used to clear heat and remove blood stasis, then, replenishing acupuncture technique and moxibustion was used to replenish qi and eliminate stasis. After treatment, the numbness of the patient's limbs gradually eased, and the condition became stable. The electromyogram studies indicated that the injured nerve was well recovered. This study demonstrates that acupuncture is effective in treating acute sensory neuropathy as an alternative therapy, which can be referenced for future study.
		2022 Vol. 19 (12): 177-180 [Abstract] ( 161 ) HTML (1 KB) PDF (562 KB) ( 66 )

	181	Thyroid sarcomatoid carcinoma: a case report #br#
		HUI Cancan SUN Yan WU Qingbin WANG Yanli WANG Fen
		Thyroid sarcomatoid carcinoma is classified as anaplastic thyroid carcinoma, with high malignancy and poor prognosis, they are rare in thyroid cancer, and few studies have been reported in recent years. The author reports a 65-year-old man with bilateral hard thyroid glands, Ⅲ dtgree swelling, color doppler ultrasound negative, freezing during surgical exploration negative, and finally relying on postoperative pathological diagnosis of left thyroid sarcomatoid carcinoma with lymph node metastasis. Through this case, it can be seen that color doppler ultrasound can be negative for thyroid sarcomatoid carcinoma, and the final diagnosis depends on pathological features and immunohistochemistry. Clinicians need to strengthen their understanding of the disease in patients with suspected anaplastic thyroid cancer to avoid delayed diagnosis or misdiagnosis.
		2022 Vol. 19 (12): 181-184 [Abstract] ( 163 ) HTML (1 KB) PDF (769 KB) ( 106 )

	185	Research on the efficiency of health resource allocation in the cities and prefectures of Hunan#br#
		WANG Jingyu ZHANG Jiaqi ZHOU Liangrong LI Ling
		Objective To analyze the efficiency of health resources allocation and the influence of environmental factors in the cities and prefectures of Hunan Province in 2019, and to provide references for optimizing health resource allocation in Cities and prefectures. Methods The input index was selected, and the input index data of 14 cities and states were obtained from “Hunan Statistical Yearbook” published on the official website of Hunan Provincial Bureau of Statistics, and the efficiency was analyzed by using three-stage data envelopment model. Results The comprehensive technical efficiency values of changsha and Huaihua in the first and third stages were 1.000, which had not changed, and the values of other cities and states were all changed. In the third stage, there were effective data envelopment analysis (DEA) in three cities, weak effective DEA in five cities, and invalid DEA in six cities. Conclusion The allocation efficiency of health resources in Hunan Province needs to be improved urgently, and in most cities and prefectures, it is affected by environmental factors. The government should fully consider its impact when optimizing the allocation of health resources in various cities and prefectures.
		2022 Vol. 19 (12): 185-189 [Abstract] ( 84 ) HTML (1 KB) PDF (917 KB) ( 60 )

	190	Practice and exploration of Hebei Province Institute of Medical Information in carrying out novelty search consulting service of traditional Chinese medicine and health science and technology#br#
		LIU Yuhua YANG Zhenru ZHNAG Xiuju ZHAO Xiaodong ZHAI Junxia
		Firstly, this paper expounds the urgent need of traditional Chinese medicine health science and technology update consulting service. Including health China program for traditional Chinese medicine health science and technology novelty search services provides a new platform and state of development of Chinese medicine is becoming more and more attention to the challenges of health science and technology novelty search consulting services of traditional Chinese medicine, Chinese medicine health science and technology novelty search consulting services for the development of medical informatics and the province construction and the institute of enterprise development is of great significance. Then the characteristics of traditional Chinese medicine health science and technology novelty seeking consulting services are analyzed, including the trend of increasing service objects, the development of services to the grass-roots level, high requirements for comprehensive quality of novelty seeking personnel, more heavy work, high requirements for data resources. In view of the above characteristics, the author carried out practice and exploration in five aspects, including popularizing novelty search knowledge in novelty search institutions and grass-roots health institutions, enriching database resources, giving full play to the advantages of Chinese medicine specialty, integrating novelty search personnel into Chinese medicine scientific research, and hiring Chinese medicine experts as auditors.
		2022 Vol. 19 (12): 190-193 [Abstract] ( 85 ) HTML (1 KB) PDF (604 KB) ( 38 )

	194	Multinity health education system for acute myocardial infarction#br#
		CAI Han1 WU Feng2 GAO Jing3▲ MA Jing3 XIAO Jianyong4 WANG Jing4 LIU Yin4
		Relying on the cardiovascular disease expert database, this study established an acute myocardial infarction health education team with chest pain experts as the main body, including clinicians, researchers, nurses, and hospital managers, gave full play to the characteristics of “special disease”and “first aid” in the central hospital of chest pain, formulated the strategy of “from point to area, two key points” and built a multinity health education system for acute myocardial infarction. The implementation of this system can improve the awareness rate of acute myocardial infarction prevention and control knowledge among key groups, transition to popularization to the whole population, improve the acute myocardial infarction prevention and control and diagnosis and treatment ability of grass-roots medical institutions, and share high-quality medical resources with the community as the basic unit; it is conducive to establish a standardized publicity, education and training mechanism, and improve residents’ awareness of disease early warning and medical compliance.
		2022 Vol. 19 (12): 194-封三 [Abstract] ( 111 ) HTML (1 KB) PDF (1238 KB) ( 108 )

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