老年2型糖尿病患者血清脂质运载蛋白2、骨形态发生蛋白4与骨质疏松的关系

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Abstract Objective To investigate the relationship between serum lipocalin 2 (LCN2), bone morphogenetic protein 4 (BMP4), and osteoporosis (OP) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 231 elderly T2DM patients admitted to Zhenjiang First People’s Hospital from January 2019 to December 2020 were selected, and divided into OP group (n = 95) and non-OP group (n = 136) according to whether they were combined with OP. The general data and serum LCN2 and BMP4 levels of the two groups were compared. The influencing factors of OP in elderly T2DM patients were analyzed by multivariate logistic regression, the predictive value of the serum LCN2 and BMP4 in predicting OP in elderly T2DM patients were analyzed by receiver operating characteristic curve (ROC). Results The proportion of gender and smoking history, and fasting blood glucose, glycated hemoglobin, total cholesterol, and LCN2 levels in the OP group were higher than those in the non-OP group, and the course of disease was longer than that in the non-OP group, the BMP4 level was lower than that in the non-OP group (P ＜ 0.05). Multifactor logistics regression analysis showed that male and high BMP4 level were independent protective factors for OP in elderly T2DM patients (P < 0.05), while disease duration≥10 years and high LCN2 level were independent risk factors (P ＜ 0.05). ROC curve showed that the AUC predicted by combination of OP in elderly T2DM patients was more than that predicted by LCN2 and BMP4 alone(P < 0.05). Conclusion The increase of serum LCN2 level and the decrease of serum BMP4 level in elderly patients with T2DM complicated with OP were independent influencing factors of OP, and combined detection could improve the predictive value of OP.

Key words： The elderly Type 2 diabetes mellitus Osteoporosis Lipocalin 2 Bone morphogenetic protein 4

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	WU Jing JIANG Hui WANG Li

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WU Jing JIANG Hui WANG Li. Relationship between serum lipocalin 2, bone morphogenetic protein 4 levels and osteoporosis in elderly patients with type 2 diabetes mellitus#br#[J]. 中国医药导报, 2022, 19(12): 66-69,74.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I12/66

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