血清细胞骨架相关蛋白4与慢性肾脏病患者血管钙化的关系

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (574 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between serum cytoskeleton-associated protein 4 (CKAP4) and vascular calcification in patients with chronic kidney disease (CKD). Methods A total of 153 CKD patients admitted to Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province from January 2019 to April 2021 were selected and they were divided into calcification group (52 cases) and non-calcification group (101 cases) according to the vascular calcification. The clinical data, serum calcium, serum phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-2 (MMP-2), and serum CKAP4 levels were compared between the two groups. Logistic regression model was used to analyze the relationship between serum CKAP4 level and vascular calcification in patients with CKD. The predictive value of serum CKAP4 level on vascular calcification in patients with CKD was analyzed by receiver operation characteristic (ROC) curve. Results The course of disease in calcified group was longer than that in non-calcified group, and the stage of CKD was higher than that in non-calcified group, the levels of serum CKAP4 in calcified group were lower than those in non-calcified group, and the levels of serum calcium, serum phosphorus, PTH, and MMP-2 were higher than those in non-calcified group, the differences were statistcally significant (P ＜ 0.05). Multivariate results showed that CDK stage, blood calcium, blood phosphorus, PTH, MMP-2, and CKAP4 were independent influencing factors of vascular calcification in patients with CKD (P ＜ 0.05). The area under the ROC curve for predicting vascular calcification in patients with CKD by serum CKAP4 level was 0.823 (P ＜ 0.05), the sensitivity was 84.62%, the specificity was 72.28%, the Youden index was 0.569, and the cut-off value was 173.50 pg/ml. Conclusion The decreased serum CKAP4 level in patients with CKD is an independent factor affecting the occurrence of vascular calcification, which can be used as a predictor of vascular calcification in CKD.

Key words： Chronic kidney disease Vascular calcification Cytoskeleton-associated protein 4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LU Hao1 ZHANG Lei1 ZHANG Xiaoyan2 XU Yongwei3 ZHOU Feixue4 LIU Xiaoju1▲

Cite this article:

LU Hao1 ZHANG Lei1 ZHANG Xiaoyan2 XU Yongwei3 ZHOU Feixue4 LIU Xiaoju1▲. Relationship between serum cytoskeleton-associated protein 4 and vascular calcification in patients with chronic kidney disease#br#[J]. 中国医药导报, 2022, 19(12): 75-78.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I12/75

[1] 中华医学会老年医学分会肾病学组，国家老年疾病临床医学研究中心.老年人慢性肾脏病诊治中国专家共识（2018）[J].中华老年医学杂志，2018，37（7）：725-731.
[2] Wan EYF，Yu EYT，Chin WY，et al. Association of visit-to-visit variability of systolic blood pressure with cardiovascular disease，chronic kidney disease and mortality in patients with hypertension [J]. J Hypertens，2020，38（5）：943-953.
[3] Shroff GR，Bangalore S，Bhave NM，et al. Evaluation and Management of Aortic Stenosis in Chronic Kidney Disease：A Scientific Statement From the American Heart Association [J]. Circulation，2021，143（25）：e1088-e1114.
[4] 国家肾脏疾病临床医学研究中心.中国慢性肾脏病矿物质和骨异常诊治指南概要[J].肾脏病与透析肾移植杂志，2019，28（1）：52-57.
[5] Zhang H，Chen J，Shen Z，et al. Indoxyl sulfate accelerates vascular smooth muscle cell calcification via microRNA-29b dependent regulation of Wnt/β-catenin signaling [J]. Toxicol Lett，2018，284：29-36.
[6] Shinno N，Kimura H，Sada R，et al. Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug [J]. Oncogene，2018，37（26）：3471-3484.
[7] 上海慢性肾脏病早发现及规范化诊治与示范项目专家组.慢性肾脏病筛查诊断及防治指南[J].中国实用内科杂志，2017，37（1）：28-34.
[8] Durham AL，Speer MY，Scatena M，et al. Role of smooth muscle cells in vascular calcification：implications in atherosclerosis and arterial stiffness [J]. Cardiovasc Res，2018，114（4）：590-600.
[9] 廖梅梅，陈森.血管钙化相关信号通路及分子机制的研究进展[J].中华老年医学杂志，2018，37（7）：831-836.
[10] Schunk SJ，Floege J，Fliser D，et al. WNT-β-catenin signalling-a versatile player in kidney injury and repair [J]. Nat Rev Nephrol，2021，17（3）：172-184.
[11] Cong J，Cheng B，Liu J，et al. RTEF-1 Inhibits Vascular Smooth Muscle Cell Calcification through Regulating Wnt/β-Catenin Signaling Pathway [J]. Calcif Tissue Int，2021，109（2）：203-214.
[12] 张晓宇，王平，刘爱峰，等.骨硬化蛋白与DKK1蛋白在慢性肾脏病-矿物质骨代谢紊乱中的研究进展[J].中国中西医结合外科杂志，2019，25（2）：237-241.
[13] Shao JS，Cheng SL，Pingsterhaus JM，et al. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals [J]. J Clin Invest，2005，115（5）：1210-1220.
[14] Klingenschmid G，Tschiderer L，Himmler G，et al. Associations of Serum Dickkopf-1 and Sclerostin With Cardiovascular Events：Results From the Prospective Bruneck Study [J]. J Am Heart Assoc，2020，9（6）：e014816.
[15] Li X，Wang J，Zhu S，et al. DKK1 activates noncanonical NF-κB signaling via IL-6-induced CKAP4 receptor in multiple myeloma [J]. Blood Adv，2021，5（18）：3656-3667.
[16] 刘锦燕，赵珺涛，王恒如，等.细胞骨架相关蛋白4对肿瘤诊断和预后的作用[J].上海交通大学学报（医学版），2020，40（2）：255-258.
[17] 拟钙剂在慢性肾脏病患者中应用共识专家组.拟钙剂在慢性肾脏病患者中应用的专家共识[J].中华肾脏病杂志，2018，34（9）：703-708.
[18] 黄东黎，李莹.钙化防御与高磷血症的相关性及治疗进展[J].中国医药科学，2020，10（8）：28-32.
[19] 周龙，胡春兰，吴泽成，等.慢性肾病患者血尿酸与动脉钙化的相关性研究[J].河北医学，2020，26（4）：589-594.
[20] Jiang W，Zhang Z，Yang H，et al. The miR-29b/Matrix Metalloproteinase 2 Axis Regulates Transdifferentiation and Calcification of Vascular Smooth Muscle Cells in a Calcified Environment [J]. Blood Purif，2020，49（5）：524-534.
[21] Chen Y，Zhao X，Wu H. Arterial Stiffness：A Focus on Vascular Calcification and Its Link to Bone Mineralization [J]. Arterioscler Thromb Vasc Biol，2020，40（5）：1078-1093.
[22] Pan JX，Xiong L，Zhao K，et al. YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling [J]. Bone Res，2018，6：18.
[23] Xu TH，Sheng Z，Li Y，et al. OGT knockdown counteracts high phosphate-induced vascular calcification in chronic kidney disease through autophagy activation by downregulating YAP [J]. Life Sci，2020，261：118121.
[24] Sun CM，Geng J，Yan Y，et al. Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling [J]. J Cancer，2017，8（19）：4018-4026.
[25] Hu S，Luo J，Fu M，et al. Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1 [J]. Am J Physiol Heart Circ Physiol，2021，321（2）：H353-H368.