肝纤维化动物实验模型的研究进展

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Abstract The pathogenesis of hepatic fibrosis is the progressive process of wound healing reaction, hepatic fibrosis can progress to cirrhosis, and further development of liver cancer. At present, researchers have paid considerable efforts in the research of hepatic fibrosis, hoping to clarify the pathogenesis of this disease and establish effective diagnosis and treatment plan. The purpose of this article is from the animal experimental model of theoretical basis, the selection of experimental animal, the operation method, the usage of reagents, the matters needing attention, and the advantages and disadvantages of the model, and its application, hoping to help in accordance with the different requirements of the scientific research personnel and make better choices in the study of liver fibrosis. The animal experimental model of hepatic fibrosis needs to be observed during the modeling to avoid excessive administration of drugs to form a more serious disease model such as cirrhosis. There are many animal experimental methods for hepatic fibrosis, including chemical methods, dietary methods, surgical methods, infection methods, and genetically modified mouse models. Through comparison and analysis of literature contents, it is found that carbon tetrachloride method is generally applicable and has the advantages of simple method, high reliability, and low price.

Key words： Hepatic fibrosis Animal model Stellate cell Carbon tetrachloride

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	NAN Yang1 DONG Hui1 WANG Zhigang1 LIU Shumin2▲

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NAN Yang1 DONG Hui1 WANG Zhigang1 LIU Shumin2▲. Research progress of animal experimental model of hepatic fibrosis#br#[J]. 中国医药导报, 2022, 19(12): 34-37.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I12/34

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