脑缺血再灌注损伤中钙超载相关通路研究进展

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Abstract Ischemic stroke is one of the disease that seriously harm human’s health, and cerebral ischemia-reperfusion injury is its core pathological aspect. In recent years, many studies have found that calcium overload plays an important role in its pathological process. Through literature review, it was found that N-methyl-D-aspartic acid receptor, transient receptor potential melastatin 2, acid sensitive ion channels, ATP deficiency on affecting Na+/Ca2+ exchanger, participation of Golgi apparatus, and calmodulin mediate the occurrence of calcium overload, while calcium overload leads to the death of neurons through mitochondrial damage, oxidative stress, and activation of endoplasmic reticulum stress.

Key words： Cerebral ischemia-reperfusion Calcium overload Related pathway

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	Articles by authors
	LI Chuanpeng1 GAO Ying1
	2 GAO Yonghong1
	2 JIANG Ping1 DONG Xinglu1
	2

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LI Chuanpeng1 GAO Ying1,2 GAO Yonghong1,2 JIANG Ping1 DONG Xinglu1, et al. Research progress on calcium overload related pathway in cerebral ischemia-reperfusion injury#br#[J]. 中国医药导报, 2022, 19(12): 46-50.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I12/46

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