葛根芩连汤治疗湿热阻络型糖尿病周围神经病变患者的效果

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Abstract Objective To explore and analyze the effect of Gegen Qinlian Decoction in the treatment of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals. Methods A total of 120 diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals were selected from Liaocheng Hospital of Traditional Chinese Medicine, Shandong Province from January 2019 to January 2021. They were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was given Prostaglandin E1 and Methylcobalamin, observation group was given Gegen Qinlian Decoction on the basis of control group, both groups were treated continuously for one month. The clinical efficacy in both groups was compared, the blood glucose levels, intestinal flora content, nerve conduction velocity, and total symptoms score before and after treatment were compared between two groups, while adverse reactions during treatment were observed. Results The total clinical effective rate in observation group was higher than that in the control group (P ＜ 0.05). After treatment, fasting blood glucose, fasting insulin, and glycosylated hemoglobin in the two groups were lower than those before treatment, and which in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, the content of Clostridium flora in the two groups was higher than that before treatment, and the observation group was higher than that in the control group; the content of Bacteroids flora in observation group was lower than that in the control group (P ＜ 0.05). After treatment, the motor conduction velocity and sensory conduction velocity of the two groups were higher than those before treatment, and which in the observation group were higher than those in the control group (P ＜ 0.05). TSS scores of the two groups after treatment were lower than those before treatment, and the observation group was lower than that in the control group (P ＜ 0.05). There were no serious adverse reactions in two groups during treatment. Conclusion Gegen Qinlian Decoction can effectively improve the clinical symptoms and signs of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals, regulate blood glucose levels, improve the content of intestinal flora, and there are no serious adverse reactions during treatment, the safety is guaranteed.

Key words： Intestinal flora Gegen Qinlian Decoction Syndrome of dampness and heat obstructing collaterals Diabetic peripheral neuropathy Blood glucose Adverse reactions

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	ZHENG Xiaodong1 FENG Yan2 HAN Lei3

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ZHENG Xiaodong1 FENG Yan2 HAN Lei3. Effect of Gegen Qinlian Decoction in the treatment of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals#br#[J]. 中国医药导报, 2022, 19(12): 61-65.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I12/61

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